Efficacy of Transnasal Endoscopic Fine-Needle Aspiration Biopsy in Diagnosing Submucosal Nasopharyngeal Carcinoma.
The routine practices of examining submucosal lesions are not suitable for deep lesions. Therefore, we evaluated the efficacy of non-real-time image-guided transnasal endoscopic fine-needle aspiration biopsy (FNAB) in diagnosing nasopharyngeal carcinoma (NPC) with submucosal lesions.The effectiveness evaluation of diagnostic methods.Fifty suspected NPC patients who failed in conventional biopsies were enrolled in this study. The efficacy, maneuverability, and safety of FNAB in diagnosing these intractable cases were evaluated.The definitive diagnostic results of these 50 patients were NPC (34/50, 68.0%), nasopharyngeal necrosis (1/50, 2.0%), nasopharyngeal mucositis (12/50, 24.0%), and other cancers (3/50, 6.0%), respectively. The results of the diagnostic efficacy of FNAB were sensitivity, 89.2%; specificity, 100.0%; positive predictive value, 100.0%; negative predictive value, 76.5%; and accuracy, 92.0%, respectively. The area under the receiver operating characteristic curves was 0.946 (95% confidence interval = 0.884-1.00, P
Authors: Qing-Nan Tang, Lin-Quan Tang, Li-Ting Liu, Dong-Xiang Wen, Zi-Jian Lu, Guo-Ping Ou, Jin-Jie Yan, Jin-Hao Yang, Ji-Bin Li, Yue-Feng Wen, Shan-Shan Guo, Sai-Lan Liu, Hao-Jun Xie, Xue-Song Sun, Xiao-Yun Li, Qiu-Yan Chen, Hai-Qiang Mai