The Latest Upper GI Journal Articles

Keep up to date with the latest in Upper GI. Check out the latest Upper GI articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily

• UTILITY AND COST-EFFECTIVENESS OF A NON-ENDOSCOPIC APPROACH TO BARRETT’S ESOPHAGUS SURVEILLANCE AFTER ENDOSCOPIC THERAPY.13th February 2021
  A non-endoscopic approach to Barrett’s esophagus (BE) surveillance after radiofrequency ablation (RFA) would offer a less invasive method for monitoring. We assessed the test characteristics and cost-effectiveness of the Cytosponge® in post-RFA patients.We performed a multicenter study of dysplastic BE patients after at least one round of RFA. A positive Cytosponge® before endoscopy was defined […]
• Validation of the Short Form Esophageal Hypervigilance and Anxiety Scale.21st December 2020
  Esophageal hypervigilance and anxiety are emerging as important drivers of dysphagia symptoms and reduced quality of life across esophageal diagnoses. The esophageal hypervigilance and anxiety scale (EHAS) is a validated measure of these cognitive-affective processes. However, its length may preclude it from use in clinical practice. We aimed to create a short form version of […]
• Integrated genomic profiling and modelling for risk stratification in patients with advanced oesophagogastric adenocarcinoma.18th December 2020
  Prognosis of patients with advanced oesophagogastric adenocarcinoma (mEGAC) is poor and molecular determinants of shorter or longer overall survivors are lacking. Our objective was to identify molecular features and develop a prognostic model by profiling the genomic features of patients with mEGAC with widely varying outcomes.We profiled 40 untreated mEGACs (20 shorter survivors <13 months […]
• Integrated genomic profiling and modelling for risk stratification in patients with advanced oesophagogastric adenocarcinoma.18th December 2020
  Prognosis of patients with advanced oesophagogastric adenocarcinoma (mEGAC) is poor and molecular determinants of shorter or longer overall survivors are lacking. Our objective was to identify molecular features and develop a prognostic model by profiling the genomic features of patients with mEGAC with widely varying outcomes.We profiled 40 untreated mEGACs (20 shorter survivors <13 months […]
• Diet and cancer of the esophagus and stomach.14th December 2020
  Dietary factors have been linked to cancers. This review focuses on several nutrients, which have strong evidence showing increase in cancer risks in the esophagus and stomach.Obesity is an important risk factor in upper gastrointestinal cancers. High sugar content in food and sugary drinks are the main drivers of obesity. Proinflammatory diet is another dietary […]
• Epigenetic alterations in the gastrointestinal tract: Current and emerging use for biomarkers of cancer.6th December 2020
  Colorectal cancer, liver cancer, stomach cancer, pancreatic cancer, and esophageal cancer are leading causes of cancer related deaths worldwide. A fundamental trait of virtually all gastrointestinal cancers is genomic and epigenomic DNA alterations. Cancer cells acquire genetic and epigenetic alterations that drive the initiation and progression of the cancers by altering the molecular and cell […]
• Computational modelling suggests that Barrett’s oesophagus may be the precursor of all oesophageal adenocarcinomas.25th November 2020
  Barrett’s oesophagus (BE) is a known precursor to oesophageal adenocarcinoma (OAC) but current clinical data have not been consolidated to address whether BE is the origin of all incident OAC, which would reinforce evidence for BE screening efforts. We aimed to answer whether all expected prevalent BE, diagnosed and undiagnosed, could account for all incident […]
• Esophageal Eosinophilia Common Among Relatives.22nd November 2020
  Familial clustering of eosinophilic esophagitis (EoE) has been described, but biopsy-assessed prevalence of esophageal eosinophilia (EE) in first degree family members has never been reported. The aim was to determine the prevalence of esophageal eosinophilia (EE) in first degree adult relatives (FDRs) of EoE patients.Index EoE patients diagnosed by esophageal eosinophilia (> 15 eos/hpf) and […]
• Comparative Outcomes of Cap Assisted Endoscopic Resection and Endoscopic Submucosal Dissection in Dysplastic Barrett’s Esophagus.21st November 2020
  Endoscopic resection (ER) is an important component of the endoscopic treatment of Barrett’s Esophagus (BE) with dysplasia and intramucosal adenocarcinoma (IMC). ER can be performed by cap assisted endoscopic mucosal resection (cEMR) or endoscopic submucosal dissection (ESD). We compared the histological outcomes of ESD versus cEMR, followed by ablation.We queried a prospectively maintained database of […]
• Esophagitis in patients without gastroesophageal reflux disease or eosinophilic esophagitis: diagnostic considerations.20th November 2020
  A multitude of inflammatory diseases other than gastroesophageal reflux disease (GERD) and eosinophilic esophagitis can affect the esophagus. Despite the deceptively simple organization of squamous mucosa and its limited number of inflammatory responses, a wide array of histologic patterns can be seen in inflammatory disorders involving the esophagus. Each such histologic pattern is associated with […]
• EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers.17th November 2020
  Epidermal growth factor receptor (EGFR) inhibition may be effective in biomarker-selected populations of advanced gastro-oesophageal adenocarcinoma (aGEA) patients. Here, we tested the association between outcome and EGFR copy number (CN) in pretreatment tissue and plasma cell-free DNA (cfDNA) of patients enrolled in a randomised first-line phase III clinical trial of chemotherapy or chemotherapy plus the […]
• HIGH-RESOLUTION MANOMETRY THRESHOLDS AND MOTOR PATTERNS AMONG ASYMPTOMATIC INDIVIDUALS.4th November 2020
  High-resolution manometry (HRM) is the current standard for characterization of esophageal body and esophagogastric junction (EGJ) function. We aimed to examine the prevalence of abnormal esophageal motor patterns in health, and to determine optimal thresholds for software metrics across HRM systems.Manometry studies from asymptomatic adults were solicited from motility centers worldwide, and were manually analyzed […]
• Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts.3rd November 2020
  We aimed to determine the predictive capacity and diagnostic yield of a 10-fold increase in serum IgA antitissue transglutaminase (tTG) antibody levels for detecting small intestinal injury diagnostic of coeliac disease (CD) in adult patients.The study comprised three adult cohorts. Cohort 1: 740 patients assessed in the specialist CD clinic at a UK centre; cohort […]
• Population-Based Prevalence of Gastrointestinal Abnormalities at Colon Capsule Endoscopy.1st November 2020
  The population prevalence of gastrointestinal (GI) disease is unclear and difficult to assess in an asymptomatic population. The aim of this study was to determine prevalence of GI lesions in a largely asymptomatic population undergoing colon capsule endoscopy (CCE).Participants aged between 50-75years were retrieved from the Rotterdam Study, a longitudinal epidemiological study, between 2017-2019. Participants […]
• Constipation in Patients with Symptoms of Gastroparesis: Analysis of Symptoms and Gastrointestinal Transit.1st November 2020
  Constipation can be an important symptom in some patients with gastroparesis. The aims were to: 1) Determine prevalence of constipation and delayed colonic transit in patients with symptoms of gastroparesis; 2) Correlate severity of constipation to severity of symptoms of gastroparesis; and 3) Relate severity of constipation to GI transit delays assessed by gastric emptying […]
• Standalone performance of artificial intelligence for upper GI neoplasia: a meta-analysis.31st October 2020
  Artificial intelligence (AI) may reduce underdiagnosed or overlooked upper GI (UGI) neoplastic and preneoplastic conditions, due to subtle appearance and low disease prevalence. Only disease-specific AI performances have been reported, generating uncertainty on its clinical value.We searched PubMed, Embase and Scopus until July 2020, for studies on the diagnostic performance of AI in detection and […]
• Baveno VI criteria and spleen stiffness measurement rule out high-risk varices in virally suppressed HBV-related cirrhosis.11th October 2020
  To prospectively validate the performance of spleen stiffness measurement (cut-off 46 kPa) combined with Baveno VI criteria in ruling out high-risk varices in HBV-related cirrhotic patients with maintained viral suppression.Cirrhotic patients were enrolled from April to December 2019 (ClinicalTrials.gov:NCT04123509). Liver and spleen transient elastography and esophagogastroduodenoscopy were performed at enrollment. Antiviral regimen(s) and virological responses, […]
• Efficacy of surgical or endoscopic treatment of idiopathic achalasia: a systematic review and network meta-analysis.9th October 2020
  Treatment of achalasia has changed substantially over the past 20 years. Therapeutic options offered to patients vary, depending on access to both resources and expertise, and include pneumatic dilation (PD), laparoscopic Heller’s myotomy (LHM), or per-oral endoscopic myotomy (POEM). Although there are head-to-head trials of these interventions, many of these are small and underpowered, so […]
• Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis.2nd October 2020
  Esophageal remodeling in eosinophilic esophagitis (EoE) can lead to esophageal rigidity with eventual luminal compromise and stenoses. Gauging esophageal functional alterations in EoE is challenging. An epithelial marker of functional remodeling would impact EoE management.Esophageal biopsy specimens from children with and without EoE and primary human esophageal epithelial cells were used for PAI-1 immunohistochemistry, and […]
• Prediction, identification and progression of histopathological liver disease activity in children with intestinal failure.1st October 2020
  Diagnostic criteria, progression risk and optimal monitoring for intestinal failure (IF) associated liver disease (IFALD) remain undefined. We assessed predictors, non-invasive identification and progression of histopathological liver disease in patients with IF.In total, 77 children with IF and median age of 1.7 years underwent diagnostic liver biopsy, which was repeated in 48 patients after 2.9 […]
• Treatment for eosinophilic esophagitis.29th September 2020
  To summarize current dietary and pharmacologic approaches in the treatment of eosinophilic esophagitis (EoE).Studies comparing dietary approaches in EoE treatment support empiric elimination diets as the preferred approach to dietary EoE treatment, with no data to support use of currently available allergy tests to guide specific food elimination diets. Swallowed topical corticosteroid therapy is the […]
• Baseline Predictors of Longitudinal Changes in Symptom Severity and Quality of Life in Patients with Suspected Gastroparesis.24th September 2020
  Whether gastric emptying tests predict longitudinal outcomes in patients with symptoms of gastroparesis is unclear. We aimed to determine whether baseline gastric emptying tests and gut motility parameters could impact longitudinal symptom(s) and quality of life (QOL) in a prospective, observational cohort study of patients with symptoms of gastroparesis.One hundred fifty patients with gastroparesis symptoms […]
• AMBULATORY REFLUX MONITORING GUIDES PROTON PUMP INHIBITOR DISCONTINUATION IN PATIENTS WITH GASTROESOPHAGEAL REFLUX SYMPTOMS: A CLINICAL TRIAL.19th September 2020
  Proton pump inhibitor (PPI) therapy fails to provide adequate symptom control in up to 50% of patients with gastroesophageal reflux symptoms. While a proportion do not require ongoing PPI therapy, a diagnostic approach to identify candidates appropriate for PPI cessation is not available. This study aimed to examine the clinical utility of prolonged wireless reflux […]
• Sex-Specific Genetic Associations for Barrett’s Esophagus and Esophageal Adenocarcinoma.12th September 2020
  Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett’s esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence of up to 6:1). Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for these conditions. However, potential sex differences in genetic associations with BE/EA remain […]
• Acute upper GI bleeding: good night, sleep tight, endoscopy can wait until morning light.12th September 2020
  Gastrointestinal hemorrhage is the leading cause of hospitalization in gastroenterology (Gastroenterology 2019;156:254-272). Prognostic scoring systems for acute upper GI bleeding (AUGIB), such as the Glasgow-Blatchford score (GBS) or Rockall score, can help predict which patients require intervention (Lancet 2000;356:1318-21, Gut 1996;38:316-21). Evidence does not strongly favor one particular index, but the GBS has good sensitivity […]
• Performance and predictors of migration of partially and fully covered esophageal self-expanding metal stents for malignant dysphagia.8th September 2020
  Self-expanding metal stents (SEMS) are routinely used to palliate malignant dysphagia. However esophageal SEMS can migrate or obstruct due to epithelial hyperplasia.To evaluate the rates and factors predicting migration and obstruction, and the nutritional outcomes in partially covered (pc) vs. fully covered (fc) SEMS vs. fcSEMS with antimigration fins (AF) placed for malignant dysphagia.A retrospective […]
• Advances in the treatment of gastric cancer.5th September 2020
  To provide an up-to-date review on the management of cancers of the stomach and esophagogastric junction (EGJ).Microsatellite instable (MSI) high status in gastric cancer may portend a relatively good prognosis and indicate that adjuvant chemotherapy is of no added benefit to primary surgical management. In the preoperative treatment of HER2 (ErbB2)-positive EGJ adenocarcinoma with chemoradiotherapy, […]
• Endoscopic diagnosis and management of gastric subepithelial lesions.5th September 2020
  The purpose of this manuscript is to provide an in-depth review of gastric subepithelial lesions (SELs) and describe the current approach to endoscopic diagnosis and management of these lesions.Gastric SELs are a relatively frequent finding on routine endoscopy (incidence 0.2-3%). A systematic approach to diagnosis and management is key because many SELs are of little […]
• Masquerading in the midgut: a rare diagnosis in a patient with recurrent abdominal pain.4th September 2020
  A 38-year-old woman who had been previously diagnosed with irritable bowel syndrome was seen in the outpatient clinic with a 2-year history of intermittent cramp-like abdominal pain which was often followed by watery diarrhoea. She had presented several times previously to the emergency department with episodes of severe pain and collapse although on arrival examination […]
• Incomplete Response of Gastroesophageal Reflux Symptoms Poorly Predicts Erosive Esophagitis or Barrett’s Esophagus.25th August 2020
  Many patients with symptoms of gastroesophageal reflux disease (GERD) not responding to proton pump inhibitor (PPI) undergo upper endoscopy. We hypothesized that incomplete response to PPI is not associated with findings of esophageal pathology on endoscopy, and that psychological distress is inversely associated with pathology.We enrolled consecutive individuals aged 40-79 with prior heartburn or regurgitation. […]
• EFFeCtiveness AND SAFETY OF High versus low dose swallowed TopICal STEROIDs for Maintenance Treatment of Eosinophilic Esophagitis: A Multi-Center Observational Study.18th August 2020
  Data evaluating efficacy of different doses of swallowed topical corticosteroids (STC) in the long-term management of eosinophilic esophagitis (EoE) are lacking. We assessed long-term effectiveness and safety of different STC doses for adults with EoE after achievement of histological remission.We performed a retrospective multicenter study at five EoE referral centers (US and Switzerland). We analyzed […]
• Mast Cell and Eosinophil Counts in Gastric and Duodenal Biopsies From Patients With and Without Eosinophilic Gastroenteritis.18th August 2020
  Mast cells are believed to contribute to development of eosinophilic gastrointestinal disorders (EGIDs). We quantified mast cells and eosinophils in biopsies from patients with EGIDs and without known esophageal or gastrointestinal disease to investigate associations between these cell types and EGID and its features.We conducted a retrospective study of patients with EGID (n=52) and of […]
• STAT6 Variants Associate With Relapse of Eosinophilic Esophagitis in Patients Receiving Long-Term Proton Pump Inhibitor Therapy.18th August 2020
  Variants in STAT6 associate with a poor initial response, based on histologic features, to proton pump inhibitor (PPI) therapy in pediatric patients with eosinophilic esophagitis (EoE). We investigated whether these genetic variants associate with a poor long-term response in children with EoE who initially responded to PPI therapy.We performed a prospective, longitudinal cohort study of […]
• Achalasia and Obstructive Motor Disorders Are Not Uncommon in Patients with Eosinophilic Esophagitis.9th August 2020
  An association has been reported between achalasia and eosinophilic esophagitis (EoE). We performed a retrospective study of high-resolution manometry (HRM) patterns in a large cohort of patients with EoE.We collected data from consecutive patients with a new diagnosis of EoE from 2012 through 2019 undergoing HRM during the initial assessment at different centers in Italy. […]
• Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial.5th August 2020
  There is a lack of robust data on significant gastrointestinal bleeding in older people using aspirin. We calculated the incidence, risk factors and absolute risk using data from a large randomised, controlled trial.Data were extracted from an aspirin versus placebo primary prevention trial conducted throughout 2010-2017 (‘ASPirin in Reducing Events in the Elderly (ASPREE)’, n=19 114) […]
• Global prevalence of Barrett’s oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis.1st August 2020
  Chronic gastro-oesophageal reflux might lead to the development of Barrett’s oesophagus (BO) or even oesophageal adenocarcinoma. There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of BO or oesophageal adenocarcinoma in individuals with gastro-oesophageal reflux.We searched MEDLINE, Embase and Embase Classic to identify cross-sectional surveys that reported prevalence of […]
• Global prevalence of Barrett’s oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis.1st August 2020
  Chronic gastro-oesophageal reflux might lead to the development of Barrett’s oesophagus (BO) or even oesophageal adenocarcinoma. There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of BO or oesophageal adenocarcinoma in individuals with gastro-oesophageal reflux.We searched MEDLINE, Embase and Embase Classic to identify cross-sectional surveys that reported prevalence of […]
• Budesonide Orodispersible Tablets Maintain Remission in a Randomized, Placebo-Controlled Trial of Patients With Eosinophilic Esophagitis.30th July 2020
  Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder. Swallowed topical-acting corticosteroids are effective in bringing active EoE into remission. However, it is not clear if these drugs are effective for long-term maintenance of remission.We performed a double-blind trial to compare the efficacy and safety of 2 doses of a budesonide orodispersible tablet (BOT) vs placebo […]
• Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype.27th July 2020
  Eosinophilic esophagitis (EoE) is an antigen-mediated eosinophilic disease of the esophagus that involves fibroblast activation and progression to fibrostenosis. Cytokines produced by T-helper 2 (Th2) cells and transforming growth factor beta 1 (TGFB1) contribute to development of EoE, but other cytokines involved in pathogenesis are unknown. We investigate the effects of TNF superfamily member 14 […]
• Factors Associated With Adequate Lamina Propria Sampling and Presence of Lamina Propria Fibrosis in Children with Eosinophilic Esophagitis.25th July 2020
  Esophageal biopsies in children with eosinophilic esophagitis (EoE) are often inadequate for assessment of lamina propria and lamina propria fibrosis (LPF). For children with EoE, little is known about the factors associated with adequate lamina propria (aLP) sampling or the relationship among epithelial features in esophageal biopsies with and without LPF. We aimed to evaluate […]
• Neoplasia Detection Rate (NDR) in Barrett’s Esophagus and Its Impact on Missed Dysplasia: Results from a Large Population-Based Database.25th July 2020
  It is a challenge to detect dysplasia in Barrett’s esophagus (BE) and esophageal adenocarcinomas (EACs) are missed in 25%-33% of cases. The neoplasia detection rate (NDR), defined as the rate of high-grade dysplasia (HGD) or EAC detection during initial surveillance endoscopy, has been proposed as a quality metric for endoscopic evaluation of patients with BE. […]
• A Model Using Clinical and Endoscopic Characteristics Identifies Patients at Risk for Eosinophilic Esophagitis According to Updated Diagnostic Guidelines.8th July 2020
  Updated diagnostic guidelines for eosinophilic esophagitis (EoE) have eliminated the requirement for a proton pump inhibitor (PPI) trial, but there are no models to identify patients with EoE based on these new criteria. We aimed to develop a predictive model for diagnosis of EoE based on the updated EoE diagnostic guidelines.We performed a secondary analysis […]
• STATE OF EVIDENCE IN MINIMALLY INVASIVE MANAGEMENT OF GASTROESOPHAGEAL REFLUX: Findings of a Scoping Review.5th July 2020
  s and Aims: Endoscopic management of gastroesophageal reflux disease (GERD) are increasingly employed. The aim of this scoping review was to assess the volume of available evidence on benefit of endoscopic and minimally surgical therapies for GERD.A priori criteria were employed to perform an extensive literature search of data regarding the reported benefit of endoscopic […]
• Flexible endoscopic strategies for the difficult esophageal stricture.4th July 2020
  Benign strictures of the esophagus, caused by various causes, are frequently encountered in clinical practice. Although endoscopic dilation is still the standard and first-line therapy, complex and difficult esophageal strictures are still encountered and remain a challenge to endoscopists. The main scope of this review article is to offer a closer look at the different […]
• TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines.4th July 2020
  We investigated the transcriptome of esophageal squamous cell carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and the effects of blocking epigenetic regulatory proteins.We performed chromatin immunoprecipitation sequencing with antibodies against H3K4me1, H3K4me3, and H3K27ac and an assay for transposase accessible chromatin to map the enhancer regions and accessible chromatin in 8 […]
• Global burden of oesophageal and gastric cancer by histology and subsite in 2018.2nd July 2020
  To provide updated estimates of the global burden of oesophageal and gastric cancer by subsite and type.Using data from population-based cancer registries, proportions of oesophageal adenocarcinoma (OAC) and squamous cell carcinoma (OSCC) out of all oesophageal as well as cardia gastric cancer (CGC) and non-CGC (NCGC) out of all gastric cancer cases were computed by […]
• Quality indicators for Barrett’s endotherapy (QBET): UK consensus statements for patients undergoing endoscopic therapy for Barrett’s neoplasia.27th June 2020
  Endoscopic therapy for the management of patients with Barrett’s oesophagus (BE) neoplasia has significantly developed in the past decade; however, significant variation in clinical practice exists. The aim of this project was to develop expert physician-lead quality indicators (QIs) for Barrett’s endoscopic therapy.The RAND/UCLA Appropriateness Method was used to combine the best available scientific evidence […]
• Including Ratio of Platelets to Liver Stiffness Improves Accuracy of Screening for Esophageal Varices That Require Treatment.21st June 2020
  Based on platelets and liver stiffness measurements, the Baveno VI criteria (B6C), the expanded B6C (EB6C), and the ANTICIPATE score can be used to rule out varices needing treatment (VNT) in patients with compensated chronic liver disease. We aimed to improve these tests by including data on ratio of platelets to liver stiffness.In a retrospective […]
• Effects of Primary Biliary Cholangitis on Quality of Life and Health Care Costs in the United Kingdom.21st June 2020
  There have been few high-quality studies of the costs, preference-based health-related quality of life (HRQoL) and cost effectiveness of treatments for primary biliary cholangitis (PBC). We aimed to estimate the marginal effects of PBC complications and symptoms, accounting for treatment, on HRQoL and the annual cost of health care in the United Kingdom (UK). These […]
• Determinants of mortality in patients with cirrhosis and uncontrolled variceal bleeding.21st June 2020
  Failure to control oesophago-gastric variceal bleeding (OGVB) and acute-on-chronic liver failure (ACLF) are both important prognostic factors in liver cirrhosis. The aims of this study were to determine whether ACLF and its severity define the risk of death in OGVB and whether insertion of rescue transjugular intrahepatic stent-shunt (TIPSS) improves the survival of patients with […]
• Endoscopic eradication therapy for Barrett’s oesophagus: state of the art.4th June 2020
  Barrett’s oesophagus is the only identifiable precursor lesion to oesophageal adenocarcinoma. The stepwise progression of Barrett’s oesophagus to dysplasia and invasive carcinoma provides the opportunity to intervene and reduce the morbidity and mortality associated with this lethal cancer. Several studies have demonstrated the efficacy and safety of endoscopic eradication therapy (EET) for the management of […]
• Management of regurgitation in patients with gastroesophageal reflux disease.4th June 2020
  Precision treatment of medically-refractory regurgitation differs from that of heartburn. Regurgitation is an often-overlooked symptom characterized as a bitter taste in the mouth or a sense of fluid moving up from the stomach occurring in approximately 80% of gastroesophageal reflux disease (GERD) patients with varying severity. Its response to standard medical therapy is significantly less […]
• Risks, Benefits, and Effects on Management for Biopsy of the Papilla in Patients with Familial Adenomatous Polyposis.4th June 2020
  Ampullary and duodenal cancer are the leading causes of death in patients with familial adenomatous polyposis (FAP) after colectomy has been performed. Risk of duodenal cancer is determined based on Spigelman stage (SS) of duodenal polyposis. Guidelines recommend endoscopic surveillance of the duodenum and visualization of the papilla to stage duodenal polyposis. There is no […]
• Number of reflux episodes on pH-impedance monitoring associates with improved symptom outcome and treatment satisfaction in gastro-oesophageal reflux disease (GERD) patients with regurgitation.30th May 2020
  Number of reflux episodes, an adjunctive metric on pH-impedance monitoring, is incompletely studied. We aimed to determine if number of reflux episodes associates with therapeutic outcome in regurgitation predominant gastro-oesophageal reflux disease (GERD).We performed post hoc analysis of postintervention pH-impedance data from adult patients with moderate/severe regurgitation despite QD proton pump inhibitor (PPI), randomised to […]
• Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer.30th May 2020
  Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate consisting of an anti-HER2 (human epidermal growth factor receptor 2) antibody, a cleavable tetrapeptide-based linker, and a cytotoxic topoisomerase I inhibitor. The drug may have efficacy in patients with HER2-positive advanced gastric cancer.In an open-label, randomized, phase 2 trial, we evaluated trastuzumab deruxtecan as compared with chemotherapy in […]
• Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies.25th May 2020
  Full-field optical coherence tomography (FFOCT) is an imaging technique of biological tissue based on tissue light reflectance analysis. We evaluated the feasibility of imaging fresh digestive mucosal biopsies after a quick mounting procedure (5 min) using two distinct modalities of FFOCT. In static FFOCT mode, we gained high-resolution images of general gut tissue-specific architecture, such as […]
• Reflux symptoms and oesophageal acidification in treated achalasia patients are often not reflux related.23rd May 2020
  After treatment, achalasia patients often develop reflux symptoms. Aim of this case-control study was to investigate mechanisms underlying reflux symptoms in treated achalasia patients by analysing oesophageal function, acidification patterns and symptom perception.Forty treated achalasia patients (mean age 52.9 years; 27 (68%) men) were included, 20 patients with reflux symptoms (RS+; Gastro-Oesophageal Reflux Disease Questionnaire […]
• Gastrointestinal Eosinophil Responses in a Longitudinal, Randomized Trial of Peanut Oral Immunotherapy.21st May 2020
  Gastrointestinal side effects are common during oral immunotherapy (OIT) and eosinophilic esophagitis (EoE) is a potential complication. We aimed to characterize eosinophilic gastrointestinal responses to peanut OIT, in which peanut protein is given orally, with incremental increases in dose over time.Twenty adults with IgE-mediated peanut allergy were randomly assigned to groups given peanut OIT (n=15) […]
• Barrett’s Epithelial Thickness, Assessed by Volumetric Laser Endomicroscopy, is Associated with Response to Radiofrequency Ablation.21st May 2020
  Radiofrequency ablation (RFA) is the most common treatment for flat Barrett’s esophagus (BE), but reasons for varying outcomes are poorly understood. A recently developed contrast-enhancement algorithm allows reliable measurement of Barrett’s epithelial thickness (BET) from volumetric laser endomicroscopy (VLE) images and correlation with response to RFA. Using this algorithm, we investigated whether patients with thicker […]
• Patient experience of gastrointestinal endoscopy: informing the development of the Newcastle ENDOPREM™.19th May 2020
  Measuring patient experience is important for evaluating the quality of patient care, identifying aspects requiring improvement and optimising patient outcomes. Patient Reported Experience Measures (PREMs) should, ideally, be patient derived, however no such PREMs for gastrointestinal (GI) endoscopy exist. This study explored the experiences of patients undergoing GI endoscopy and CT colonography (CTC) in order […]