Danger-associated molecular pattern molecules and the receptor for advanced glycation end products enhance ANCA-induced responses. 11th May 2021 The pro-inflammatory activities of the calgranulins and HMGB1 can be counteracted by […]
Significance of Sjögren’s syndrome and anti-cN1A antibody in myositis patients. 11th May 2021 We recently recorded a high prevalence of inclusion body myositis (IBM) in […]
“Non-criteria antiphospholipid antibodies”: bridging the gap between seropositive and seronegative Antiphospholipid Syndrome. 10th May 2021 We aimed to analyze the prevalence of non-criteria anti-phospholipid (aPL) antibodies and […]
2021 EULAR recommendations for the implementation of self-management strategies in patients with inflammatory arthritis. 8th May 2021 An important but often insufficient aspect of care in people with inflammatory […]
Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study. 8th May 2021 The FORWARD (FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses) trial […]
SARS-CoV-2 vaccination responses in untreated, conventionally treated and anticytokine-treated patients with immune-mediated inflammatory diseases. 7th May 2021 To better understand the factors that influence the humoral immune response to […]
Continuing versus withdrawing ixekizumab treatment in patients with axial spondyloarthritis who achieved remission: efficacy and safety results from a placebo-controlled, randomised withdrawal study (COAST-Y). 7th May 2021 The objective of COAST-Y was to evaluate the effect of continuing versus […]
Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints. 7th May 2021 Several lines of evidence point towards the central role of interleukin 23 […]
Current favourable 10-year outcome of patients with early rheumatoid arthritis: data from the ESPOIR cohort. 7th May 2021 To report the 10-year outcome of an inception cohort of patients with […]
Drug survival of anakinra and canakinumab in monogenic autoinflammatory diseases: observational study from the International AIDA Registry. 7th May 2021 To investigate survival of interleukin (IL)-1 inhibitors in monogenic autoinflammatory disorders (mAID) […]
Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial. 7th May 2021 To compare the benefits of a tight-control/treat-to-target strategy (TC/T2T) in axial spondyloarthritis […]
Sexual Function in Patients with Idiopathic Inflammatory Myopathies: A Cross-sectional Study. 6th May 2021 To date, there is almost no information concerning the sexual health of […]
Abdominal arterial lesions associated with antiphospholipid antibodies: A comparative cross sectional magnetic resonance angiography study. 6th May 2021 Case reports and small case series suggest that stenotic lesions of the […]
Phase 2, Randomized, Placebo-Controlled Trial of Dapirolizumab Pegol in Patients with Moderate-to-Severe Active Systemic Lupus Erythematosus. 6th May 2021 To evaluate dose-response, efficacy and safety of dapirolizumab pegol (DZP) in patients […]
Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know? 5th May 2021 Systemic lupus erythematosus (SLE) can affect any part of the gastrointestinal (GI) […]
The safety of JAK-1 inhibitors. 5th May 2021 As efficacy and safety data emerge, differences between JAK inhibitor subclasses are […]
Clinical use of Jak 1 inhibitors for rheumatoid arthritis. 5th May 2021 The uptake of Jak inhibitors in the RA space has been among […]
Early phase studies of JAK1 selective inhibitors in rheumatoid arthritis. 5th May 2021 The first approved Janus kinase (JAK) inhibitors for treatment of RA targeted […]
JAK1 inhibition and inflammatory bowel disease. 5th May 2021 Primary non-response and secondary loss of response remain a significant issue with […]
JAK1 selective inhibitors for the treatment of spondyloarthropathies. 5th May 2021 As our understanding of the pathogenesis of SpA improves, focus has turned […]
JAK1: Number one in the family; number one in inflammation? 5th May 2021 Several cytokines involved in inflammatory pathologies signal via the Janus kinase-signal transducer […]
Phase III trials of JAK1 selective inhibitors in rheumatoid arthritis. 5th May 2021 Upadacitinib and filgotinib, two JAK1 selective drugs have undergone extensive phase III […]
Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial. 4th May 2021 Proactive therapeutic drug monitoring (TDM), defined as individualized drug dosing based on […]
The synergistic efficacy of hydroxychloroquine with methotrexate is accompanied by increased erythrocyte mean corpuscular volume. 4th May 2021 To determine whether concomitant hydroxychloroquine modulates the increase in erythrocyte mean corpuscular […]
Therapeutic options for cutaneous polyarteritis nodosa: a systematic review. 4th May 2021 Cutaneous polyarteritis nodosa (CPAN) is a necrotizing vasculitis of the middle-size vessels, […]
Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial. 4th May 2021 Sustained remission has become an achievable goal for patients with rheumatoid arthritis […]
A Systematic Review and Meta-Analysis of the Incidence Rate of Takayasu Arteritis. 4th May 2021 Takayasu arteritis (TAK), is a rare autoimmune rheumatic disease causing large vessel […]
Changes in Treatments and Outcomes After Implementation of a National Universal Access Program for Juvenile Idiopathic Arthritis. 2nd May 2021 To evaluate the clinical and demographic characteristics of patients with juvenile idiopathic […]
Correlation between Subjective and Objective Severity of Oral and Ocular Dryness in Primary Sjögren’s Syndrome. 2nd May 2021 Sjögren’s Syndrome is a common, autoimmune disease primarily affecting the eyes and […]
Development of an instrument for patient self-assessment in psoriatic arthritis. 2nd May 2021 Due to the recent pandemic, in person scheduled rheumatology appointments in many […]
Impact of coping strategies on patient and physician perceptions of disease severity and disability in systemic sclerosis. 2nd May 2021 Systemic sclerosis (SSc) results in impaired function, disability, and reduced health-related quality […]
Pooled Safety Results Through One Year of Two Phase-3 Trials of Guselkumab in Patients with Psoriatic Arthritis. 2nd May 2021 Evaluate safety of guselkumab (monoclonal antibody targeting IL-23p19) in psoriatic arthritis (PsA) […]
Predicting Response to Tocilizumab Monotherapy in Rheumatoid Arthritis: A Real-World Data Analysis Using Machine Learning. 2nd May 2021 Tocilizumab (TCZ) had similar efficacy when used as monotherapy or in combination […]
Safety of the Methotrexate-leflunomide Combination in Rheumatoid Arthritis: Results of a Multicentric, Registry-based, Cohort Study (Biobadabrasil). 2nd May 2021 To evaluate the safety of the methotrexate (MTX)-leflunomide (LEF) combination in rheumatoid […]
Comparative effectiveness of two adalimumab biosimilars in 1318 real-world patients with inflammatory rheumatic disease mandated to switch from originator adalimumab: nationwide observational study emulating a randomised clinical trial. 30th April 2021 In 2018, a nationwide mandatory switch from originator to biosimilar adalimumab was […]
Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain. 30th April 2021 Chronic widespread musculoskeletal pain (CWP) is a symptom of fibromyalgia and a […]
Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial. 30th April 2021 Although causality remains to be established, targeting dysbiosis of the intestinal microbiota […]
The association between increased body mass index and response to conventional synthetic DMARD treatment in rheumatoid arthritis: Results from the METEOR database. 30th April 2021 Few data exist on the association between increased BMI and response to […]
The Role of PD-1/PD-Ls in the Pathogenesis of IgG4-RD. 30th April 2021 To investigate the role of Programmed cell death protein 1 (PD-1) and […]
Prevalence and predictors of adverse events with methotrexate mono- and combination- therapy for rheumatoid arthritis: a systematic review. 28th April 2021 This systematic review aims to summarise rates of adverse events (AEs) in […]
The challenge of early diagnosis of autoimmune lymphoproliferative syndrome in children with suspected autoinflammatory/autoimmune disorders. 28th April 2021 To test the usefulness of an extended panel of lymphocyte subsets (LS) […]
Tofacitinib for the treatment of ankylosing spondylitis: a phase III, randomised, double-blind, placebo-controlled study. 28th April 2021 To assess the efficacy/safety of tofacitinib in adult patients with active ankylosing […]
Autoantibody Predictors of Gastrointestinal Symptoms in Systemic Sclerosis. 28th April 2021 To assess the prevalence and burden of systemic sclerosis- (SSc) related gastrointestinal […]
Identifying Parameters Associated with Delayed Diagnosis in Axial Spondyloarthritis: Data from the European Map of Axial Spondyloarthritis. 28th April 2021 To identify the parameters associated with self-reported diagnostic delay (DD) in axial […]
Immunosuppressive therapy withdrawal after remission achievement in patients with lupus nephritis. 28th April 2021 Whether immunosuppressive therapy (IS) may be safely withdrawn in lupus nephritis (LN) […]
Anticardiolipin and other antiphospholipid antibodies in critically ill COVID-19 positive and negative patients. 27th April 2021 Reports of severe COVID-19 being associated with thrombosis, antiphospholipid antibodies (APLA), and […]
Clinical and biomechanical factors associated with falls and rheumatoid arthritis: baseline cohort with longitudinal nested case-control study. 27th April 2021 To identify the clinical and biomechanical characteristics associated with falls in people […]
Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis. 27th April 2021 To determine how gene expression profiles in osteoarthritis joint tissues relate to […]
Root Joint Involvement in Spondyloarthritis: A Post-hoc Analysis from the International ASAS-PerSpA Study. 27th April 2021 Primary objective was to compare the clinical characteristics of spondyloarthritis (SpA) patients […]
X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc). 27th April 2021 X-linked inhibitor of apoptosis protein (XIAP) is a multifunctional protein with important […]
Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging? 25th April 2021 To investigate the association between clinical joint tenderness and intra- and periarticular […]
Towards sex-specific osteoarthritis risk models: evaluation of risk factors for knee osteoarthritis in males and females. 25th April 2021 The aim of this study was to identify sex-specific prevalence and strength […]
A Novel Fluorescence Optical Imaging Scoring System for Hand Synovitis in Rheumatoid Arthritis – validity and agreement with ultrasound. 23rd April 2021 To develop and validate a new semiquantitative Fluorescence Optical Imaging (FOI) scoring […]
Antiviral proinflammatory phenotype of monocytes in anti-MDA5 antibody-associated interstitial lung disease. 23rd April 2021 To evaluate upstream and downstream regulators leading to macrophage activation and subsequent […]
The sFlt-1 to PlGF Ratio in Pregnant Women with Rheumatoid Arthritis: Impact of Disease Activity and Sulfasalazine Use. 23rd April 2021 An elevated sFlt-1/PlGF-ratio has been validated as a significant predictor of preeclampsia, […]
Mortality in patients with primary Sjögren’s syndrome: A systematic review and meta-analysis. 20th April 2021 It remains debated whether patients with primary Sjögren’s syndrome (pSS) are at […]
Patient and Rheumatologist Perspectives on Tapering DMARDs in Rheumatoid Arthritis: A Qualitative Study. 20th April 2021 To understand the perspectives of patients and rheumatologists for tapering DMARDs in […]
Patients with early-onset primary Sjögren’s syndrome have distinctive clinical manifestations and circulating lymphocyte profiles. 20th April 2021 To further investigate the clinical characteristics and circulating lymphocyte profiles of patients […]
Altered CD4+ T cell and cytokine levels in peripheral blood and skin samples from systemic sclerosis patients and IL35 in CD4+ T cell growth. 20th April 2021 This study explored the role of IL-35 in CD4+ T lymphocyte and […]
Association of adalimumab trough concentrations and treatment response in patients with Juvenile Idiopathic Arthritis. 20th April 2021 To assess the relationship of adalimumab trough concentrations and treatment response in […]
