The latest respiratory articles
ClinOwl brings you the latest respiratory articles from the leading medical journals in a single view.
Respiratory latest
- RAGE-induced ILC2 expansion in acute lung injury due to haemorrhagic shock.Type 2 immune dysfunction contributes to acute lung injury and lethality following haemorrhagic shock (HS) and trauma. Group 2 innate lymphoid cells (ILC2s) play a significant role in … Read more
- Impact of respiratory muscle training on respiratory muscle strength, respiratory function and quality of life in individuals with tetraplegia: a randomised clinical trial.Respiratory complications remain a leading cause of morbidity and mortality in people with acute and chronic tetraplegia. Respiratory muscle weakness following spinal cord injury-induced tetraplegia impairs lung function … Read more
- Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1.Translation of genomic alterations to protein changes in chronic obstructive pulmonary disease (COPD) is largely unexplored. Using integrated proteomic and RNA sequencing analysis of COPD and control lung … Read more
- A 38-Year-Old Man With Well Treated OSA on CPAP With Persistent Nocturnal Hypoxemia.A 38-year-old male with a prior diagnosis of severe OSA (apnea-hypopnea index [AHI] 99/h) presented for transfer of care. He was successfully titrated to CPAP of 10 cm H2O … Read more
- A 59-Year-Old Man With Chronic Kidney Disease After Kidney Transplantation Presents With Chronic Dyspnea.A 59-year-old man presented to the ED with a chief complaint of shortness of breath. His past medical history was significant for end-stage renal disease secondary to lithium … Read more
Asthma
- Association of asthma and smoking with lung function impairment in adolescence and early adulthood; the Isle of Wight Birth Cohort Study.We investigated associations of asthma and smoking with lung function and airway reversibility from childhood to early adulthood.The population-based Isle of Wight Birth Cohort (n=1456) was assessed at … Read more
- Nonidentical Twins With Asthma: Spatially Matched CT Airway and MRI Ventilation Abnormalities.Recent pulmonary functional MRI findings of spatially and temporally persistent ventilation abnormalities in patients with asthma contrast with previous in silico modeling studies that suggest that in asthma, ventilation … Read more
- Targeting Treatable Traits in Severe Asthma: A Randomised Controlled Trial.Treatable traits have been proposed as a new paradigm for airway disease management.To characterise treatable traits in a severe asthma population and to determine the efficacy of targeting … Read more
- Early Life Exposure to Air Pollution and Incidence of Childhood Asthma, Allergic Rhinitis and Eczema.There is growing evidence that air pollution may contribute to the development of childhood asthma and other allergic diseases. In this follow-up of the Toronto Child Health Evaluation … Read more
- Characterization of severe asthma worldwide: data from the International Severe Asthma Registry (ISAR).To date, clinical characteristics of the international severe asthma population are unknown. Inter-country comparisons are hindered by variable data collection within regional/national severe asthma registries. Our aim was … Read more
Chronic Obstructive Pulmonary Disease (COPD)
- High-sensitivity troponin I and all-cause mortality in patients with stable COPD: An analysis of the COSYCONET study.Chronic obstructive pulmonary disease (COPD) is a leading cause of death with a considerable part of the population dying from cardiovascular diseases. High-sensitivity troponin I (hs-TnI) might help … Read more
- Comparative effects of LAMA-LABA-ICS versus LAMA-LABA for COPD: Cohort study in real world clinical practice: LAMA-LABA-ICS versus LAMA-LABA in COPD.Triple therapy combinations of a long-acting muscarinic antagonist, a long-acting beta2-agonist and an inhaled corticosteroid (LAMA-LABA-ICS) for chronic obstructive pulmonary disease (COPD) were studied in randomized trials and … Read more
- Cardiovascular Risk in COPD: Deciphering the Contribution of Tobacco Smoking.The observation that chronic obstructive pulmonary disease (COPD) is an independent risk factor for cardiovascular disease (CVD) comes from comparisons between smokers with COPD and smokers without COPD. … Read more
- EVALUATION OF CHANGES IN CONTROL STATUS IN COPD: AN OPPORTUNITY FOR EARLY INTERVENTION: Control status is useful for clinical assessment.Control has been proposed as a dynamic tool that can capture changes in the clinical status of patients with COPD.Prospective, multicenter, observational study aimed to compare changes in … Read more
- Inhaled corticosteroid use and the incidence of lung cancer in COPD.Inhaled corticosteroids (ICS) are suggested as potential chemoprevention of lung cancer. Several observational studies in patients with COPD reported inconsistent results, either significant reductions in lung cancer incidence … Read more
Lung cancer
- Entrectinib for ROS1 fusion-positive NSCLC and NTRK fusion-positive solid tumours.Click here to read the full article @ The Lancet. Oncology
- Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials.Recurrent gene fusions, such as ROS1 fusions, are oncogenic drivers of various cancers, including non-small-cell lung cancer (NSCLC). Up to 36% of patients with ROS1 fusion-positive NSCLC have … Read more
- Lung Cancer Surveillance After Definitive Curative-Intent Therapy: ASCO Guideline.To provide evidence-based recommendations to practicing clinicians on radiographic imaging and biomarker surveillance strategies after definitive curative-intent therapy in patients with stage I-III non-small-cell lung cancer (NSCLC) and … Read more
- Randomized Phase III Study of Ganetespib, a Heat Shock Protein 90 Inhibitor, With Docetaxel Versus Docetaxel in Advanced Non-Small-Cell Lung Cancer (GALAXY-2).Ganetespib, a highly potent heat shock protein 90 inhibitor, blocks multiple oncogenic pathways, resulting in antitumor activity. We evaluated the combination of ganetespib and docetaxel for second-line therapy … Read more
- Osimertinib for Patients With Non-Small-Cell Lung Cancer Harboring Uncommon EGFR Mutations: A Multicenter, Open-Label, Phase II Trial (KCSG-LU15-09).Approximately 10% of patients with epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC) harbor uncommon mutations. Here, we report the efficacy and safety of osimertinib in … Read more
Sleep apnea
- Responsiveness of Patient Reported Outcomes to Treatment among Patients with Type 2 Diabetes Mellitus and Obstructive Sleep Apnea.The Patient Reported Outcomes Information System (PROMIS) includes two instruments to quantify sleep symptoms (sleep disturbance, SDA; sleep-related impairment, SRI) in diverse populations across a wide symptom spectrum. … Read more
- Circulating Plasma Exosomes in Obstructive Sleep Apnea and Reverse-Dipping Blood Pressure.Obstructive Sleep Apnea (OSA) increases the risk of abnormal non-dipping 24-hour blood pressure profile, an independent risk factor for cardiovascular disease (CVD). We examined differential exosomal miRNA expression … Read more
- Redesigning Care for Obstructive Sleep Apnea.Abstract: Constrained by a limited supply of specialized personnel, health systems face a challenge in caring for the large number of patients with obstructive sleep apnea (OSA). The … Read more
- Bilateral Hypoglossal Nerve Stimulation for Treatment of Adult Obstructive Sleep Apnea.Abstract: Hypoglossal Nerve Stimulation (HNS) decreases Obstructive Sleep Apnea (OSA) severity via genioglossus muscle activation and decreased upper airway collapsibility. This study assessed the safety and effectiveness at … Read more
- Bilateral Hypoglossal Nerve Stimulation for Treatment of Adult Obstructive Sleep Apnea.Abstract: Hypoglossal Nerve Stimulation (HNS) decreases Obstructive Sleep Apnea (OSA) severity via genioglossus muscle activation and decreased upper airway collapsibility. This study assessed the safety and effectiveness at … Read more