The latest pharmacology articles
- Glaucoma: Management and Future Perspectives for Nanotechnology-Based Treatment Modalities.Glaucoma, being asymptomatic for relatively late stage, is recognized as a worldwide […]
- Particle properties and drug metastable solubility of simvastatin containing PVP matrix particles prepared by electrospraying technique.In this work the preparation of drug loaded polymeric nanoparticles using electrospraying […]
- Protective effect of suppressor of cytokine signalling 1-based therapy in experimental abdominal aortic aneurysm.Abdominal aortic aneurysm (AAA) is a multifactorial disease characterized by chronic inflammation, […]
- PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR.Specific cellular functions mediated by G protein-coupled receptors (GPCR) are often associated […]
- 18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand.With the ambition of improving the management of pancreatic neuroendocrine tumors (P-NETs), […]
- Enhancing anti-melanoma outcomes in mice using novel chitooligosaccharide nanoparticles loaded with therapeutic survivin-targeted siRNA.Melanoma anti-tumor therapy remains a challenge. SiRNA-based therapies provide a powerful means, […]
- Safety, Tolerability and Pharmacokinetics of Bencycloquidium Bromide, a Novel Inhaled Anticholinergic Bronchodilator, in Healthy Subjects: Results from Phase I Studies.Bencycloquidium bromide (BCQB) is a novel inhaled anticholinergic bronchodilator with high selectivity […]
- The Evidence REVEAL study: exploring the use of real-world evidence and complex clinical trial design by the European pharmaceutical industry.The rapid evolution of science and technology allows innovative approaches to generate […]
- How Does the Dissimilarity of Screw Geometry Impact Twin-screw Melt Granulation?Using a model formulation of 80% gabapentin and 20% hydroxypropyl cellulose (KlucelTM), […]
- Fifteen years of NaV 1.7 as an analgesic target: why has excellent in vitropharmacology not translated into in vivo analgesic efficacy?In 2006, humans with a congenital insensitivity to pain (CIP) were found […]
- First-Order Linear Mechatronics Model for Closed-Loop MEMS Disk Resonator Gyroscope.In this paper, a first-order closed-loop mechatronics model of a micro-electromechanical system […]
- A digital phoswich detector using time-over-threshold for depth of interaction in PET.We present the performance of a digital phoswich PET detector, composed by […]
- Flexible organic field-effect transistor arrays for wearable neuromorphic device applications.With the advent of wearable microelectronic devices in the interdisciplinary bio-electronics research […]
- Blockade of Acid-Sensing Ion Channels Increases Urinary Bladder Capacity With or Without Intravesical Irritation in Mice.We conducted this study to examine whether acid-sensing ion channels (ASICs) are […]
- Increase in neuropeptide Y activity impairs social behaviour in association with glutamatergic dysregulation in diabetic mice.Patients with diabetes mellitus are reported to show a raised prevalence of […]
- Evaluation of the hypoglycemic effect of exendin-4’s new oral self-nanoemulsifying system in rats.The objective of this study is to develop a new self-nanoemulsifying system […]
- Population Pharmacokinetics of Intraventricular Vancomycin in Neonatal Ventriculitis, A Preterm Pilot Study.Intraventricular vancomycin is an effective treatment for neonatal ventriculitis, as the cerebrospinal […]
- The Influence of Solidification on the in vitro Solubilisation of Blonanserin Loaded Supersaturated Lipid-Based Oral Formulations.Supersaturated silica-lipid hybrids have previously demonstrated improved in vitro solubilisation and in […]
- Evaluation of rivaroxaban amorphous solid dispersions physical stability via molecular mobility studies and molecular simulations.The present study evaluates the effect of molecular mobility and molecular interactions […]
- Evaluation of a pilot vancomycin precision dosing advisory service on target exposure attainment using an interrupted time series analysis.This study evaluated the ability of a pilot therapeutic drug monitoring (TDM) […]
- Reduction in Tamoxifen Metabolites Endoxifen and N-desmethyltamoxifen With Chronic Administration of Low Dose Cannabidiol: A CYP3A4 and CYP2D6 Drug Interaction.Cannabidiol (CBD) serves as a promising medicine, with few known adverse effects […]
- Population pharmacokinetic modelling of indium-based quantum dot nanoparticles: preclinical in vivo studies.There is considerable interest in biomedical applications of quantum dot (QD) nanoparticles, […]
- Endothelin-1 potentiates TRPV1-mediated vasoconstriction of human adipose arterioles in a protein kinase C-dependent manner.Vascular transient receptor potential vanilloid (TRPV) channels have emerged as important regulators […]
- Upregulation of acid sensing ion channel 1a (ASIC1a) by hydrogen peroxide through the JNK pathway.Oxidative stress is intimately tied to neurodegenerative diseases, including Parkinson’s disease and […]
- Nanocarriers Mediated Cutaneous Drug Delivery.The cutaneous drug delivery represents an attractive option for the management of […]
- Low-dose salinomycin inhibits breast cancer metastasis by repolarizing tumor hijacked macrophages toward the M1 phenotype.Macrophages are sentinels of the immune system, which are often hijacked by […]
- Assessing Transporter-Mediated Natural Product-Drug Interactions via In vitro-In vivo Extrapolation: Clinical Evaluation with a Probe Cocktail.The botanical natural product goldenseal can precipitate clinical drug interactions by inhibiting […]
- Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old.Old patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver […]
- Linaclotide, lubiprostone and tenapanor improve gut fluidity and alkalinity in CFTR-deficient and F508del mutant mice via NHE3 inhibition.Constipation and intestinal obstructive episodes are major health problems in cystic fibrosis […]
- Screening for Hypertension in Children and Adolescents: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.Childhood hypertension can result in adverse outcomes during adulthood; identifying and treating […]
- Inhibition of NLRP3-inflammasome mediated IL-1β release by phenylpropanoic acid derivatives: in-silico and in-vitro approach.NLRP3 inflammasome activation and subsequent release of IL-1β are being explored as […]
- Nutrient-induced hyperosmosis evokes vasorelaxation via TRPV1-mediated endothelium-dependent hyperpolarization in healthy and colitis mice.Although human blood perfusion is largely redistributed into the mesenteric circulation after […]
- Exploiting oxidized lipids and the lipid-binding GPCRs against CMD.Lipids govern several vital cellular processes, in addition to drive profound physiological […]
- Neutrophils in respiratory syncytial virus infection: from harmful effects to therapeutic opportunities.Respiratory syncytial virus (RSV) is an important infectious agent in infants and […]
- Chronic fluoxetine treatment impairs motivation and reward learning by affecting neuronal plasticity in the central amygdala.Background and Purpose The therapeutic effects of fluoxetine (FLX) are believed to […]
- The DPP4 inhibitor linagliptin ameliorates renal injury and accelerated resolution in a rat model of crescentic nephritis.Dipeptidyl peptidase 4 (DPP4) inhibitors are a class of oral glucose lowering […]
- Enzyme kinetics and inhibition parameters of human leukocyte glucosylceramidase.Glucosylceramidase (GCase) is a lysosomal enzyme that catalyzes the cleavage of β-glucosidic […]
- Predicting budesonide performance in healthy subjects and patients with Crohn’s disease using biorelevant in vitro dissolution testing and PBPK modeling.Drug product performance might be affected in Crohn’s disease (CD) patients compared […]
- Clinical Response and Cost-Savings Associated With Generic Fluticasone Propionate/Salmeterol Multidose, Dry-Powder Inhaler in Asthma Patients Managed in an Ambulatory Care Practice Setting.Fluticasone propionate/salmeterol multidose, dry powder inhaler (MDPI) was the first and only […]
- Pet Medications: A Tail of Caution.A case report of pet medications appearing along with the patient’s medications […]
- Effect of postprandial triglycerides on DDT/ppDDE levels in subjects with varying degree of glucose intolerance.Organochlorine pesticides such as DDT as well as postprandial hypertriglyceridemia have been […]
- Predictive Identification of Co-formers in Co-amorphous Systems.This work aims to understand the properties of co-formers that form co-amorphous […]
- ThermoTRPV channels: structural insights into ligand-dependent activation.Temperature-sensitive Transient Receptor Potential Vanilloid ion channel subtypes 1-4 (thermoTRPV1-4) play important […]
- Early or deferred initiation of efavirenz during rifampicin-based TB therapy has no significant effect on CYP3A induction in TB-HIV infected patients.In TB-HIV coinfection, prompt initiation of TB therapy is recommended but Antiretroviral […]
- Impact of Pharmacist-Led Patient Education in an Ambulatory Cancer Center: A Pilot Quality Improvement Project.Although pharmacist-driven patient education has been shown to increase adherence, reduce medication […]
- Evaluation of Erythropoietin Stimulating Agents (ESA) and Their Effect on Blood Optimization for Cardiac Surgery.Cardiovascular surgeries increase the risk of receiving blood transfusions. Erythropoietin stimulating agents […]
- Is intranasal administration an opportunity for direct brain delivery of lacosamide?Lacosamide is well-known as an effective and safe anticonvulsant drug. Nevertheless, there […]
- Pharmacology-guided rule-based adaptive dose escalation in first-in-human studies.First-in-human (FIH) studies typically progress through cohorts of fixed, standard size throughout […]
- Model-informed drug development for antimicrobials: Translational PK and PKPD modelling to predict an efficacious human dose for apramycin.Apramycin represents a subclass of aminoglycoside antibiotics that has been shown to […]
- GPCRs as an emerging host-directed therapy against mycobacterial infection: From notion to reality.Mycobacterium tuberculosis (M. tb) is one of the successful pathogens that claim […]
- Mechanisms of Enzalutamide Resistance in Castration-Resistant Prostate Cancer and Therapeutic Strategies to Overcome It.Prostate cancer (PCa) is the second most common malignancy in men, and […]
- Emerging Therapies for Peanut Allergy.Peanut allergy (PA) is a food allergy that causes an IgE-mediated type […]
- Ophthalmic delivery of hydrophilic drugs through drug-loaded oleogels.Delivering ophthalmic drugs to the target tissues in eye is challenging due […]
- The oxysterol receptor GPR183 in inflammatory bowel diseases.Immune cell trafficking is an important mechanism for the pathogenesis of inflammatory […]
- Emerging Insights into the Structure and Function of Ionotropic GluD Receptors.GluD1 and GluD2 receptors belong to the orphan GluD subfamily of ionotropic […]
- Myasthenia Gravis Associated With Programmed Death-1 (PD-1) Receptor Inhibitor Pembrolizumab: A 40-day Case Report.This case report describes myasthenia gravis-like symptoms after treatment with a programmed […]
- Quantification of microdialysis related variability in humans: Clinical trial design recommendations.Target-site concentrations obtained via the catheter-based minimally invasive microdialysis technique often exhibit […]
- Decanoic acid modification enhances the antibacterial activity of PMAP-23RI-Dec.Antimicrobial peptides are a new type of antibacterial drugs with a broad […]
- Differential Effects of Clopidogrel with or without Aspirin on Platelet Reactivity and Coagulation Activation: a randomized trial in healthy volunteers.Dual antiplatelet therapy (DAPT) is standard in acute coronary syndrome but confers […]
- Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters.Variability in individual capacity for hepatic elimination of therapeutic drugs is well […]
Toxicology
- Clinical characteristics and outcome of drug-induced liver injury in the older patients: from the young-old to the oldest-old.Old patients with hepatotoxicity have been scarcely studied in idiosyncratic drug-induced liver injury (DILI) cohorts. We sought for the distinctive characteristics of DILI in older patients across age […]
- Decanoic acid modification enhances the antibacterial activity of PMAP-23RI-Dec.Antimicrobial peptides are a new type of antibacterial drugs with a broad antibacterial spectrum. Based on our previous research, PMAP-23RI-Dec was designed by modifying the C-terminal of PMAP-23RI […]
- Characterization of gastrointestinal transit and luminal conditions in pigs using a telemetric motility capsule.Within preclinical research, the pig has become an important model in regulatory toxicology and pharmacokinetics, to assess oral dosage forms and to compare different formulation strategies. In addition, […]
- Incorporation of indomethacin into a mesoporous silica nanoparticle enhances the anti-inflammatory effect Indomethacin into a mesoporous silica.We therefore evaluated the analgesic, anti-inflammatory and toxicological effects of indomethacin incorporated into mesoporous silica nanoparticles (IND+NP).Nociception was evaluated by the formalin assay. The anti-inflammatory potential was assessed […]
- Effects of protein and calorie restriction on the metabolism and toxicity profile of irinotecan in cancer patients.Preclinical data suggests that protein and calorie restriction (PCR) might improve treatment tolerability without impairing antitumor effect. Therefore, we have studied the influence of PCR on irinotecan pharmacokinetics […]
- Effects of NT5C2 germline variants on 6-mecaptopurine metabolism in children with acute lymphoblastic leukemia.6-mercaptopurine (6-MP) is widely used in the treatment of acute lymphoblastic leukemia (ALL), and its cytotoxicity is primarily mediated by thioguanine nucleotide metabolites (TGN). Recent genome-wide association study […]
- Depletion of LAG-3+ T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781.Activated T cells drive a range of immune-mediated inflammatory diseases. Lymphocyte activation gene-3 (LAG-3) is transiently expressed on recently activated CD4+ and CD8+ T cells. We describe the […]
- Countermeasures for preventing and treating opioid overdose.The only medication available currently to prevent and treat opioid overdose (naloxone) was approved by the Food and Drug Administration (FDA) nearly 50 years ago. Because of its […]