The latest pharmacology articles

• Vasopressor Discontinuation Order in Septic Shock With Reduced Left Ventricular Function.12th May 2021
  The optimal vasopressor management for septic patients with left ventricular (LV) dysfunction […]
• Normalisation of glucose metabolism by Exendin-4 in the chronic phase after stroke promotes functional recovery in male diabetic mice.11th May 2021
  Glucagon-like peptide-1 receptor (GLP-1R) activation decreases stroke risk in people with type […]
• Preclinical rodent models of cardiac fibrosis.11th May 2021
  Cardiac fibrosis (scarring), characterised by an increased deposition of extracellular matrix (ECM) […]
• Uncovering the signaling, structure and function of the 20-HETE-GPR75 pairing: Identifying CCL5 as a negative regulator of GPR75.11th May 2021
  The G-protein coupled receptor GPR75 (Gq) and its ligand, the cytochrome P450-derived […]
• Cost-sharing increase, medication adherence and hospitalizations in schizophrenia patients: a natural experiment.11th May 2021
  Increases in medication cost-sharing rates remain a controversial system-wide cost-containment measure for […]
• Inactivation of sGC in living cells proceeds without heme loss and involves heterodimer dissociation as a common step.11th May 2021
  Nitric oxide (NO) activates sGC for cGMP production, but in disease sGC […]
• Inhaled bacteriophage therapy in a porcine model of pneumonia caused by Pseudomonas aeruginosa during mechanical ventilation.11th May 2021
  Pseudomonas aeruginosa is a main cause of ventilator-associated pneumonia (VAP) with drug-resistant […]
• Lorlatinib Exposure-Response Analyses for Safety and Efficacy in a Phase 1/2 Trial to Support Benefit-Risk Assessment in Non-Small Cell Lung Cancer.11th May 2021
  Lorlatinib is a small molecule inhibitor of anaplastic lymphoma kinase (ALK) and […]
• Development and Evaluation of a Pharmacist-Driven Screening Tool to Identify Patients Presenting to the Emergency Department Who Are Eligible for Outpatient Treatment of Deep Vein Thrombosis.10th May 2021
  Deep vein thrombosis (DVT) is a critical and costly health issue. Treatment […]
• The Role of the Pharmacist in Optimizing Cancer Immunotherapy: A Retrospective Study of Nivolumab Adverse Events.10th May 2021
  Immune checkpoint inhibitors (ICIs) are an emerging treatment in cancer therapy for […]
• In vitro and in vivo combinatorial anticancer effects of oxaliplatin- and resveratrol-loaded N,O-carboxymethyl chitosan nanoparticles against colorectal cancer.9th May 2021
  Oxaliplatin (OXE) combined with other chemotherapy drugs against colorectal cancer had been […]
• Angiotensin II augments renal vascular smooth muscle sGC expression via an AT1 R – FoxO transcription factor signaling axis.8th May 2021
  Reduced renal blood flow triggers activation of the renin-angiotensin-aldosterone system (RAAS) leading […]
• The Impact of Cocaine Exposure in Adolescence: Behavioral Effects and Neuroplastic Mechanisms in Experimental Models.8th May 2021
  Drug addiction is a devastating disorder with a huge economic and social […]
• Macrophage Extracellular Traps Aggravate Iron Overload-Related Liver Ischemia/Reperfusion Injury.7th May 2021
  Macrophages regulate iron homeostasis in the liver and play important role in […]
• The Impact of Anticoagulation on COVID-19 (SARS CoV-2) Patient Outcomes: A Systematic Review.7th May 2021
  Emerging data suggest that coagulopathy, cytokine storm, and acute respiratory distress syndrome […]
• Therapeutic strategies to fight COVID-19: Which is the status artis?7th May 2021
  COVID-19 is a complex disease, and many difficulties are faced today especially […]
• Discovery of Non-racemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders.7th May 2021
  In contrast to the dose-occupancy relationship in the treatment of schizophrenia, the […]
• Preparation and in-vitro evaluation of mesoporous biogenic silica nanoparticles obtained from rice and wheat husk as a biocompatible carrier for anti-cancer drug delivery.6th May 2021
  In this study, mesoporous silica nanocarriers were synthesized from natural sources such […]
• Analysis of Omega-3 Fatty Acid Content in Fish Oil Products.6th May 2021
  Omega-3 fatty acids eicosapentaenoic acid (EPA) and docosehexaenoic acid (DHA), often found […]
• Evaluation of a Pharmacy-Driven Calcitonin Protocol for Treating Hypercalcemia in Hospitalized Patients: A Multisite Study.6th May 2021
  The dramatic increase in the acquisition cost of injectable calcitonin led to […]
• GPER: A Novel Target To Treat Cardiovascular Disease In A Sex-Specific Manner?5th May 2021
  As an agonist of the classical nuclear receptors, ERα and ERβ, estrogen […]
• Paradoxical changes in brain reward status during oxycodone self-administration in a novel test of the negative reinforcement hypothesis.5th May 2021
  The extra-medical use of, and addiction to, prescription opioid analgesics is a […]
• Population Pharmacokinetics-Pharmacodynamics of Ceftazidime in Neonates and Young Infants: Dosing Optimization for Neonatal Sepsis.5th May 2021
  Ceftazidime is a third-generation cephalosporin with high activity against many pathogens. But […]
• Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films.5th May 2021
  Buccal films containing a pH modifying excipient may be able to increase […]
• cGMP signalling in dorsal root ganglia and the spinal cord: Various functions in development and adulthood.3rd May 2021
  Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and […]
• Muscarinic M4 and M5 receptor subtypes in the ventral subiculum differentially modulate alcohol seeking vs consumption in male alcohol preferring rats.3rd May 2021
  Muscarinic acetylcholine receptors (mAChRs) mediate alcohol consumption and seeking in rats, and […]
• Gut microbiota contributes to the development of hypertension in a genetic mouse model of systemic lupus erythematosus.1st May 2021
  Hypertension is an important cardiovascular risk factor that is prevalent in the […]
• Involvement of 3′,5’cyclic inosine monophosphate in cystathionine γ-lyase -dependent regulation of the vascular tone.1st May 2021
  L-Cysteine or hydrogen sulfide (H2 S) donors induce a biphasic effect on […]
• The search for anti-oxytotic/ferroptotic compounds in the plant world.1st May 2021
  Oxytosis/ferroptosis is a form of non-apoptotic regulated cell death characterized by glutathione […]
• When Can We Trust Real-World Data To Evaluate New Medical Treatments?1st May 2021
  Concerns regarding both the limited generalizability and the slow pace of traditional […]
• Blocking metabotrobic glutamate receptor 5 by the negative allosteric modulator CTEP improves disease course of ALS in SOD1G93A mice.1st May 2021
  The pathogenesis of amyotrophic lateral sclerosis (ALS) is not fully clarified, although […]
• Comprehensive allele genotyping in critical pharmacogenes reduces residual clinical risk in diverse populations.30th April 2021
  Genomic-guided pharmaceutical prescribing is increasingly recognized as an important clinical application of […]
• Evaluation of GLP-1 Receptor Agonists in Combination With Multiple Daily Insulin Injections for Type 2 Diabetes.30th April 2021
  To assess the available literature evaluating the efficacy and safety of glucagon-like […]
• Nanocomposite gels of poloxamine and Laponite for β-Lapachone release in anticancer therapy.30th April 2021
  Nano-hybrid systems have been shown to be an attractive platform for drug […]
• Systematic Review of Black Cohosh (Cimicifuga racemosa) for Management of Polycystic Ovary Syndrome-Related Infertility.30th April 2021
  Polycystic ovary syndrome (PCOS) is a common cause of female infertility. To […]
• Embolia Cutis Medicamentosa (Nicolau Syndrome) Secondary to Intramuscular Fulvestrant Injection: A Case Report.29th April 2021
  A case of embolia cutis medicamentosa (Nicolau syndrome) in a patient receiving […]
• Anti-stress effects of combined glucocorticoid and mineralocorticoid receptor blockade in the paraventricular nucleus of the hypothalamus.28th April 2021
  Mineralocorticoid receptors (MRs), glucocorticoid receptors (GRs) and corticotropin-releasing factor (CRF) in the […]
• Quercetin Relieves D-Amphetamine induced Manic-like Behavior through Activating TREK-1 Potassium Channels in Mice.28th April 2021
  Quercetin is a prominent neuroprotective compound from flavonoids. Previous studies found it […]
• Statin-boosted cellular uptake and endosomal escape of penetratin due to reduced membrane dipole potential.28th April 2021
  Cell penetrating peptides are promising tools for delivery of cargo into cells, […]
• The Rise and Fall of Hydroxychloroquine and Chloroquine in COVID-19.28th April 2021
  On March 11th, the World Health Organization (WHO) announced the unprecedented outbreak […]
• Assessment of the Implementation of AUC Dosing and Monitoring Practices With Vancomycin at Hospitals Across the United States.27th April 2021
  The latest vancomycin therapeutic drug monitoring guidelines for serious MRSA infections have […]
• Cerebroprotection by dioscin after experimental subarachnoid hemorrhage via inhibiting NLRP3 inflammasome through SIRT1-dependent pathway.27th April 2021
  Dioscin possesses multiple biologic activities and is beneficial for cardiovascular and cerebral […]
• Exploiting D2R β-arrestin2-biased signaling to suppress tumor growth of pituitary adenomas.27th April 2021
  Dopamine agonists (DAs) targeting dopamine receptor D2 (D2R) have been used for […]
• Performance evaluation of a staggered 3-layer DOI PET detector using a 1 mm LYSO pitch with PETsys TOFPET2 ASIC: comparison of HAMAMATSU and KETEK SiPMs.27th April 2021
  In this study, we propose a staggered 3-layer depth-of-interaction (DOI) detector with […]
• BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer.26th April 2021
  Advances in the treatment of triple-negative breast cancer (TNBC) and ovarian cancer […]
• Model Informed Therapeutic Dose Optimization Strategies for Antibody-Drug Conjugates (ADCs) in Oncology: What Can We Learn from FDA-Approved ADCs?26th April 2021
  Antibody-Drug Conjugates (ADCs) combine the specificity of an antibody with the cytotoxicity […]
• Prelimbic Cortical Stimulation Disrupts Fear Memory Consolidation through Ventral Hippocampal Dopamine 2 Receptors.26th April 2021
  Anxiety disorders pose one of the biggest threats to mental health worldwide, […]
• Protective properties of GLP-1 and associated peptide hormones in neurodegenerative disorders.26th April 2021
  Type 2 diabetes (T2DM) and the associated de-sensitisation of insulin signalling has […]
• Supersaturating drug delivery systems containing fixed-dose combination of two antihypertensive drugs: formulation, in vitro evaluation and molecular metadynamics simulations.26th April 2021
  The purpose of this study was to associate the poorly water-soluble antihypertensive […]
• When Can We Rely on Real-World Evidence to Evaluate New Medical Treatments?25th April 2021
  Concerns regarding both the limited generalizability and the slow pace of traditional […]
• A disease progression model to quantify the non-motor symptoms of Parkinson’s disease in participants with leucine-rich repeat kinase 2 mutation.24th April 2021
  Leucine-rich repeat kinase 2 (LRRK2) inhibitors are currently in clinical development as […]
• Clinical Pharmacology Worldwide: A Global Health Perspective.24th April 2021
  Low- and middle-income countries (LMICs) have the highest rates of mortality and […]
• Comparative EPR spectroscopy analysis of amphotericin B and miltefosine interactions with Leishmania, erythrocyte and macrophage membranes.24th April 2021
  Electron paramagnetic resonance (EPR) spectroscopy of spin labels was used to study […]
• Targeted use of placebo effects decreases experimental itch in atopic dermatitis patients: a randomized controlled trial.24th April 2021
  Evidence from pain research shows that the effectiveness of active pharmacological treatments […]
• Understanding Use of Real-World Data (RWD) and Real-World Evidence (RWE) to Support Regulatory Decisions on Medical Product Effectiveness.23rd April 2021
  RWE has potential to provide efficient and relevant information on the effectiveness […]
• Citric acid in drug formulations causes pain by potentiating acid-sensing ion channel 1.23rd April 2021
  Pain at the injection site is a common complaint of patients receiving […]
• Effectiveness of intermittent preventive treatment with dihydroartemisinin-piperaqunine against malaria in pregnancy in Tanzania: A Randomized Controlled Trial.23rd April 2021
  Intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) to prevent malaria and […]
• Acute Diuretic-Sparing Effects of Sacubitril-Valsartan: Staying in the Loop.22nd April 2021
  Previous literature has suggested a potential diuretic sparing effect as early as […]
• Microwave induced in situ amorphisation facilitated by crystalline hydrates.22nd April 2021
  Amorphisation within the final dosage form, i.e. in situ amorphisation, seeks to […]
• Scorpion venom peptide SVHRSP ameliorates 6-OHDA-induced neurotoxicity and neuroinflammation: potential role of Nav 1.6 inhibition in microglia.22nd April 2021
  Microglia-related inflammation is associated with the pathology of Parkinson’s disease (PD). Functional […]

Toxicology

• Population pharmacokinetics and individual analysis of daptomycin in kidney transplant recipients.27th March 2021
  Little is known about the population pharmacokinetics (PPK) of daptomycin in kidney transplant patients. The present study established a pharmacokinetic model for daptomycin in kidney transplant patients in […]
• Sex-specific classification of drug-induced Torsade de Pointes susceptibility using cardiac simulations and machine learning.26th March 2021
  Torsade de Pointes (TdP), a rare but lethal ventricular arrhythmia, is a toxic side effect of many drugs. To assess TdP risk, safety regulatory guidelines require quantification of […]
• Searching for new anxiolytic agents among derivatives of 11-dialkylaminoethyl-2,3,4,5-tetrahydrodiazepino[1,2-a]benzimidazole.12th March 2021
  A study on the anxiolytic activity of the new derivatives of 11-dialkylaminoethyl-2,3,4,5-tetrahydrodiazepino[1,2-a]benzimidazole, containing privileged scaffolds of benzodiazepine and benzimidazole in their structure, was conducted. The cytotoxic properties of […]
• Antibody Conjugated Lipid Nanoparticles as a Targeted Drug Delivery System for Hydrophobic Pharmaceuticals.1st March 2021
  Cancer remains a significant health issue worldwide. The most common group of chemotherapeutic agents are small-molecule drugs, which often are associated with toxic side-effects and non-specific delivery, leading […]
• Chitosan nanoparticles for enhancing drugs and cosmetic components penetration through the skin.19th February 2021
  Chitosan nanoparticles (CT NPs) have attractive biomedical applications due to their unique properties. This present research aimed at development of chitosan nanoparticles to be used as skin delivery […]
• Short peptide sequence enhances epithelial permeability through interaction with protein kinase C.14th February 2021
  We have identified a short peptide sequence (L-R5) acting as partial inhibitor of intracellular protein kinase C, capable of tight junction modulation in terms of reversible and non-toxic […]
• Untapped potential: Therapeutically targeting eicosanoids and endocannabinoids in the lung.10th January 2021
  Inflammation of the airway involves the recruitment of highly active immune cells to combat and clear microbes and toxic factors, however this inflammatory response can result in unintended […]
• Size-shrinkable and protein kinase Cα-recognizable nanoparticles for deep tumor penetration and cellular internalization.31st December 2020
  In the present study, the three functions, including enhanced permeability and retention (EPR) effect, deep penetration within tumor, and receptor-mediated endocytosis, were integrated into a single platform in […]