The latest pharmacology articles
- Assuring Access to Safe Medicines in Pregnancy and Breastfeeding.Scientists and regulators in Europe and the United States (U.S.) continue to […]
- Defining Clinically-Relevant Target Populations Using Real-World Data to Guide the Design of Representative Antidiabetic Drug Trials.The United States Food and Drug Administration is considering replacing cardiovascular outcome […]
- In silico identification of available drugs targeting cell surface BiP to disrupt SARS-CoV-2 binding and replication: Drug repurposing approach.Cell surface binding immunoglobin protein (csBiP) is predicted to be susceptible to […]
- Reapproaching old treatments: considerations for PK/PD studies on phage therapy for bacterial respiratory infections.Antibiotic resistant bacterial respiratory infections are a significant global health burden, and […]
- Ex vivo model of human skin (hOSEC) for assessing the dermatokinetics of the anti-melanoma drug Dacarbazine.Alternative models to replace animals in experimental studies remain a challenge in […]
- Modeling the Coating Layer Thickness in a Pharmaceutical Coating Process.Although mechanistic numerical simulations can offer great insights into a process, they […]
- Emerging role of RNAi in immune cells engineering and its therapeutic synergism in immunotherapy.RNAi effectors (e.g., siRNA, shRNA, and miRNA) can efficiently trigger the silencing […]
- G-CSFR antagonism reduces mucosal injury and airways fibrosis in a virus-dependent model of severe asthma.Asthma is a chronic disease that displays heterogeneous clinical and molecular features. […]
- Bioactive Zinc(II) Complex Incorporated PCL/gelatin Electrospun Nanofiber Enhanced Bone Tissue Regeneration.Bone tissue regeneration is augmented by biocompatible nanofiber scaffolds, that supports reliable […]
- Chitosan nanoparticles for enhancing drugs and cosmetic components penetration through the skin.Chitosan nanoparticles (CT NPs) have attractive biomedical applications due to their unique […]
- Anti-inflammatory effects of alpha 7 nicotinic acetylcholine receptors through interacting with adenylyl cyclase 6.Alpha 7 nicotinic acetylcholine receptors (CHRNA7) suppress inflammation through diverse pathways in […]
- A thick semi-monolithic scintillator detector for clinical PET scanner.Both monolithic and semi-monolithic scintillator PET detectors can measure the depth of […]
- IL-17 induced inflammation modulates mPGES-1/PPAR-γ pathway in monocytes/macrophages.Recent biochemical and pharmacological studies have reported that in several tissues and […]
- Insulin Dosage Adjustments After Initiation of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes.Combination of insulin and GLP-1RAs have shown reductions in the HbA1c, body […]
- Spider Web-like Flexible Tactile Sensor for Pressure-Strain Simultaneous Detection.Multiparameter integrated sensors are required for the next generation of flexible wearable […]
- Inactivation of SERCA2 Cys674 accelerates aortic aneurysms by suppressing PPARγ.Inactivation of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) […]
- An Ultrafast WSe2 Photodiode Based on a Lateral p-i-n Homojunction.High-quality homogeneous junctions are of great significance for developing transition metal dichalcogenides […]
- Anti-inflammatory activity of ortho-trifluoromethoxy-substituted 4-piperidione-containing mono-carbonyl curcumin derivatives in vitro and in vivo.Curcumin was reported as an anti-inflammatory agent. However, curcumin’s poor bioavailability limited […]
- Development of a simple QSAR model for reliable evaluation of acetylcholinesterase inhibitor potency.With the aging of the western population, more and more people are […]
- Impact of powder-binder interactions on 3D printability of pharmaceutical tablets using drop test methodology.In this study, a pre-screening test has been developed for the binder-jet […]
- Latanoprost-loaded cyclodextrin microaggregate suspension eye drops for enhanced bioavailability and stability.The bioavailability of conventional eye drops is very low due to different […]
- Double-dose cefuroxime concentrations in bone, synovial fluid of the knee joint and subcutaneous adipose tissue-A randomised porcine microdialysis study.This study evaluated target tissue concentrations of double dose cefuroxime administered intravenously […]
- Short peptide sequence enhances epithelial permeability through interaction with protein kinase C.We have identified a short peptide sequence (L-R5) acting as partial inhibitor […]
- Chemical synthesis, molecular docking and MepA efflux pump inhibitory effect by 1,8-naphthyridines sulfonamides.This study aimed to evaluate the antibacterial activity and to verify, in […]
- Evaluating the impact of acid-reducing agents on drug absorption using biorelevant in vitro tools and PBPK modeling – Case example dipyridamole.in vitro and in silico methods have become an essential tool in […]
- Pharmacokinetics and safety evaluation of oral Palonosetron in Chinese healthy volunteers: A phase 1, open-label, randomized, cross-over study.Palonosetron hydrochloride is a specific 5-HT3 receptor antagonist, used to prevent chemotherapy-induced […]
- Combating multidrug-resistant bacteria by integrating a novel target site penetration and receptor binding assay platform into translational modeling.Multidrug-resistant bacteria are causing a serious global health crisis. A dramatic decline […]
- A1C Reduction in Patients Who Declined Pharmacist-Led Diabetes Management Services.The purpose of this research is to assess the mean change in […]
- Key challenges in providing effective antibiotic therapy for critically ill patients with bacterial sepsis and septic shock.Early initiation of effective antibiotic therapy is vitally important for saving the […]
- Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1.Acid-sensing ion channels (ASICs) are proton-gated cation channels critical for neuronal functions. […]
- Priming as a strategy to overcome detrimental pH effects on cells for intervertebral disc regeneration.Disc disease is characterised by degeneration of the nucleus pulposus (NP), the […]
- A Steep-Slope MoS2/Graphene Dirac-Source Field-Effect Transistor with a Large Drive Current.In the continuous transistor feature size scaling down, the scaling of the […]
- From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotics.Therapeutic drug monitoring (TDM) and model-informed precision dosing (MIPD) have evolved as […]
- Implementation of a Leeches + Antimicrobial Prophylaxis Order Panel to Optimize Medicinal Leech Use at a Tertiary Care Academic Medical Center.Medicinal leech therapy promotes vascular flow and can be used to salvage […]
- Latanoprost-Loaded Phytantriol Cubosomes for the Treatment of Glaucoma.Glaucoma is a degenerative optic neuropathy characterized by increased intraocular pressure that […]
- Minireview: Antimicrobial Dose Selection under the Animal Rule.The Food and Drug Administration’s (FDA’s) ”Animal Rule” provides a unique regulatory […]
- Biomarker-guided individualization of antibiotic therapy.Treatment failure of antibiotic therapy due to insufficient efficacy or occurrence of […]
- Population-based signals of antidepressant drug interactions associated with unintentional traumatic injury.Antidepressants are very widely used and associated with traumatic injury, yet little […]
- DMSO as new, counterintuitive excipient for freeze-drying human keratinocytes.DMSO is widely used as powerful cryoprotectant for the storage and transport […]
- Model-Informed Drug Development for Anti-Infectives: State of the Art and Future.Model-informed drug development (MIDD) has a long and rich history in infectious […]
- Novel multiplex capacitive sensor based on molecularly imprinted polymers: A promising tool for tracing specific amphetamine synthesis markers in sewage water.The development of a sensing system for amphetamine (AMP), N-formyl amphetamine (NFA), […]
- Role of Intracellular complement activation in kidney fibrosis.Increased expression of C1r, C1s and C3 in kidney cells play an […]
- Sodium rutin extends lifespan and health span in mice including positive impacts on liver health.Aging is associated with progressive metabolic dysregulation. Rutin has reported as a […]
- Therapeutic effect of kaempferol on atopic dermatitis by attenuation of T cell activity via interaction with Multidrug resistance-associated protein 1.Kaempferol is a natural flavonoid widely investigated in various fields due to […]
- TRV130 partial agonism and capacity to induce antinociceptive tolerance revealed through reducing available μ opioid receptor number.β-arrestin2 recruitment to μ receptors may contribute to the development opioid analgesics […]
- Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain.Acid-sensing ion channels (ASICs) are Na+-permeable ion channels activated by protons and […]
- KV 1.3 channels are novel determinants of macrophage-dependent endothelial dysfunction in a mouse model with angiotensin II-induced hypertension.KV 1.3 potassium channels are expressed in vascular smooth muscle cells (VSMCs), […]
- Preparation, characterization and biological evaluation of β-cyclodextrin-biotin conjugate based podophyllotoxin complex.Podophyllotoxin is a natural occurring aryltetralin lignin with pronounced cytotoxic activity. However, […]
- Evaluation of meropenem-ciprofloxacin combination dosage regimens for the pharmacokinetics of critically ill patients with augmented renal clearance.Augmented renal clearance (ARC, creatinine clearance >130mL/min) makes difficult achievement of effective […]
- Novel method for the prediction of drug-drug Interaction based on Gene Expression profiles.The accurate prediction of new interactions between drugs is important for avoiding […]
- Anti-infective Dosing in Special Populations: Pregnancy.Substantial anatomical and physiological changes occur during pregnancy and labour, which impact […]
- Neglecting plasma protein binding in COVID-19 patients leads to a wrong interpretation of lopinavir overexposure.Boffito et al. recalled the critical importance to correctly interpret protein binding. […]
- Antigen mass may influence trastuzumab concentrations in cerebrospinal fluid after intrathecal administration.Intravenous administration of monoclonal antibodies leads to low concentrations in the central […]
- Evaluation Strategies for Triple-Drug Combinations against Carbapenemase-Producing Klebsiella pneumoniae in an In Vitro Hollow-fiber Infection Model.Mounting antimicrobial resistance to carbapenemase-producing Klebsiella pneumoniae (CPKP) highlights the need to […]
- Rostral cuneiform nucleus and the defense reaction: Direct and indirect midbrain-medullary serotonin mechanisms in baroreflex inhibition.The activation of the defense reaction inhibits the baroreflex response through the […]
- Fabrication of 1D Te/2D ReS2 Mixed-Dimensional van der Waals p-n Heterojunction for High-Performance Phototransistor.The superior optical and electronic properties of the two-dimensional (2D) rhenium disulfide […]
- Modulation of Local Overactive Inflammation via Injectable Hydrogel Microspheres.Although injectable hydrogel microsphere has demonstrated tremendous promise in clinical applications, local […]
- Symmetrical and un-symmetrical curcumin analogues as selective COX-1 and COX-2 inhibitor.Curcumin, a popular herbal medicine derived from turmeric, blocks the synthesis of […]
- Evaluation of local bioavailability of metronidazole from topical formulations using dermal microdialysis: preliminary study in a Yucatan mini-pig model.Dermal microdialysis (dMD) can measure the rate and extent to which a […]
- Pharmacology of HIV Cure: Site of Action.Despite significant advances in HIV treatment over the past 30 years, critical […]
Toxicology
- Short peptide sequence enhances epithelial permeability through interaction with protein kinase C.We have identified a short peptide sequence (L-R5) acting as partial inhibitor of intracellular protein kinase C, capable of tight junction modulation in terms of reversible and non-toxic […]
- Untapped potential: Therapeutically targeting eicosanoids and endocannabinoids in the lung.Inflammation of the airway involves the recruitment of highly active immune cells to combat and clear microbes and toxic factors, however this inflammatory response can result in unintended […]
- Size-shrinkable and protein kinase Cα-recognizable nanoparticles for deep tumor penetration and cellular internalization.In the present study, the three functions, including enhanced permeability and retention (EPR) effect, deep penetration within tumor, and receptor-mediated endocytosis, were integrated into a single platform in […]
- FKBP-CaN-NFAT pathway polymorphisms selected by in silico biological function prediction are associated with tacrolimus efficacy in renal transplant patients.The aim of the present study was to investigate the potential effects of genetic variations in the FKBP-CaN-NFAT pathway on clinical events associated with tacrolimus efficacy in Chinese […]
- Exploring precipitation inhibitors to improve in vivo absorption of cinnarizine from supersaturated lipid-based drug delivery systems.Supersaturated lipid-based drug delivery systems are increasingly being explored as a bio-enabling formulation approach, particularly in preclinical evaluation of poorly-water soluble drugs. While increasing the drug load through […]
- A potential anticancer dihydropyrimidine derivative and its protein binding mechanism by multispectroscopic, molecular docking and molecular dynamic simulation along with its in-silico toxicity and metabolic profile.Human serum albumin (HSA) is the core protein in the systemic circulation and has a fundamental role in transportation and distribution of ligands in-vivo. In this study, a […]
- Comparison of the effects of the intestinal permeation enhancers, SNAC and sodium caprate (C10): isolated rat intestinal mucosae and sacs.SNAC and C10 are intestinal permeation enhancers (PEs) used in formulations of peptides for oral delivery in clinical trials. The aims were to compare their: (i) mechanism of […]
- Quercetin Induces p53-independent Cancer Cell Death via TFEB-mediated Lysosome Activation and ROS-dependent Ferroptosis.Cancer cells exhibit more dependence on iron and enhanced sensitivity to ferroptosis than normal cells. Quercetin is known to possess anti-cancer effects, but the molecular mechanism is largely […]