The latest pharmacology articles
- The Global Bioequivalence Harmonisation Initiative: Report of EUFEPS/AAPS Third Conference.The European Federation of Pharmaceutical Sciences (EUFEPS) and American Association of Pharmaceutical […]
- Gellan gum-based hydrogel containing nanocapsules for vaginal indole-3-carbinol delivery in trichomoniasis treatment.Trichomonas vaginalis infection is the STI most common worldwide. Indole-3-carbinol (I3C) is […]
- Discovery of 2-aryl and 2-pyridinylbenzothiazoles endowed with antimicrobial and aryl hydrocarbon receptor agonistic activities.Benzothiazole is a privileged scaffold in medicinal chemistry present in diverse bioactive […]
- Nanoporous microneedle arrays seamlessly connected to a drug reservoir for tunable transdermal delivery of memantine.Conventional transdermal drug patches have been on the market since 1997 but […]
- Targeting TDP-43 proteinopathy with drugs and drug-like small molecules.Following the discovery of TDP-43 involvement in Amyotrophic Lateral Sclerosis (ALS) and […]
- NANOEMULSION COMPOSED OF 10-(4,5-DIHYDROTHIAZOL-2-YL)THIO)DECAN-1-OL), A SYNTHETIC ANALOG OF 3-ALKYLPIRIDINE MARINE ALKALOID: DEVELOPMENT, CHARACTERIZATION, AND ANTIMALARIAL ACTIVITY.Malaria treatment is based on a reduced number of antimalarial drugs, and […]
- BK channel subunits promote breast cancer development and modulate endocrine treatment response in pre-clinical models.Pore-forming α subunits of the voltage- and Ca2+ -activated K+ channel of […]
- Pharmacokinetic and bioequivalence study of new S-1 capsule in Chinese cancer patients.S-1 is a multicomponent capsule containing tegafur, gimeracil, and oteracil potassium that […]
- Genome-wide association study of platelet reactivity and cardiovascular response in patients treated with clopidogrel: a study by the International Clopidogrel Pharmacogenomics Consortium (ICPC).Antiplatelet response to clopidogrel shows wide variation, and poor response is correlated […]
- Metformin mitigates gastrointestinal radiotoxicity and radiosensitises P53 mutation colorectal tumours via optimising autophagy.There is an urgent but unmet need for mitigating radiation-induced intestinal toxicity […]
- Converting a batch based high-shear granulation process to a continuous dry granulation process; a demonstration with ketoprofen tablets.When one wishes to convert a batch based manufacturing process of an […]
- 6-hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the substantia nigra pars reticulata.Abnormal involuntary movements known as L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) are considered a […]
- Commentary on “Morphine-induced respiratory depression is independent of β-arrestin2 signalling”.Click here to read the full article @ British journal of pharmacology
- Hypoxia-induced pulmonary hypertension – utilising experiments of nature.An increase in pulmonary artery pressure is a common observation in adult […]
- The effect of reduced gastric acid secretion on the gastrointestinal disposition of a ritonavir amorphous solid dispersion in fasted healthy volunteers: an in vivo – in vitro investigation.This paper summarizes efforts to (i) better understand the behavior of amorphous […]
- How to Transition from Single Gene Pharmacogenetic Testing to Preemptive Panel-Based Testing: A Tutorial.There have been significant advancements in precision medicine and approaches to medication […]
- Intestinal P-gp and Putative Hepatic OATP1B Induction: ITC Perspective on Drug Development Implications.There is an increasing interest in transporter induction (i.e., decreased systemic drug […]
- Prediction of drug exposure in critically ill encephalopathic neonates treated with therapeutic hypothermia based on a pooled population pharmacokinetic analysis of seven drugs and five metabolites.Drug dosing in encephalopathic neonates treated with therapeutic hypothermia is challenging; exposure […]
- Interpretation of Cytochrome P-450 Inhibition and Induction Effects from Clinical Data: Current Standards and Recommendations for Implementation.Agents that modify cytochrome P-450 (CYP) enzyme activity are characterized as strong, […]
- Genetic association of co-trimoxazole-induced severe cutaneous adverse reactions is phenotype-specific: HLA class I genotypes and haplotypes.Co-trimoxazole (CTX) causes various forms of severe cutaneous adverse reactions (SCARs). This […]
- Drug Dosing Recommendations for All Patients: A Roadmap for Change.Most drug labels do not contain dosing recommendations for a significant portion […]
- Population pharmacokinetic/pharmacodynamic modelling of nifekalant in healthy Chinese volunteers.Nifekalant is a class III antiarrhythmic drug, and its major adverse effect […]
- Rac1: A Potential Radiosensitization Target of Human Nasopharyngeal Carcinoma CNE2 Cells.Radiotherapy has a high cure rate for early nasopharyngeal carcinoma(NPC). However, the […]
- Safety and Effectiveness of Sedation With Adjunctive Ketamine Versus Nonketamine Sedation in the Medical Intensive Care Unit.Ketamine, an N-methyl-d-aspartate receptor antagonist with sedative and analgesic properties, is becoming […]
- Evaluation of a Pharmacist-Managed Hypertension Clinic in a Rural Primary Care Setting.To describe clinical pharmacy services provided in a rural North Carolina primary […]
- Exercise Training as Prophylactic Strategy in the Management of Neutropenia during Chemotherapy.Chemotherapy induced immune-suppression is a common, but potential detrimental, adverse reaction in […]
- Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons.Acids can disturb the ecosystem of wild animals through altering their olfaction […]
- Mucoadhesive emulgel systems containing curcumin for oral squamous cell carcinoma treatment: from pre-formulation to cytotoxicity in tissue-engineering oral mucosa.Current oral squamous cell carcinoma chemotherapies demonstrate off-target toxicity, which could be […]
- Exploring MicroRNAs in Diabetic Chronic Cutaneous Ulcers: Regulatory Mechanisms and Therapeutic Potentials.Diabetic chronic cutaneous ulcers (DCU) is one of the serious complications of […]
- Improved surface adhesion and wound healing effect of madecassoside liposomes modified by temperature-responsive PEG-PCL-PEG copolymers.Madecassoside (MA) exhibits excellent therapeutic effects in wound healing and scar management. […]
- REGULATION OF GENE EXPRESSION BY MF63, A SELECTIVE INHIBITOR OF INDUCIBLE PROSTAGLANDIN E SYNTHASE-1 (mPGES-1) IN HUMAN OSTEOARTHRITIC CHONDROCYTES.mPGES-1 catalyzes the production of prostaglandin E2 (PGE2 ), the most abundant […]
- Pyridine and quinoline molecules as crucial protagonists in the never-stopping discovery of new agents against tuberculosis.Tuberculosis (TB) disease remains to be an alarming infection worldwide with nearly […]
- Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: The effect of supersaturation and silica geometry.Silica-lipid hybrid (SLH) microparticles are a solidified lipid-based drug delivery system under […]
- From real-world patient data to individualized treatment effects using machine learning: Current and future methods to address underlying challenges.Clinical decision making needs to be supported by evidence that treatments are […]
- Ion Channels of Nociception.The special issue “Ion Channels of Nociception” contains 13 articles published by […]
- Physiologically based pharmacokinetic model outputs depend on dissolution data and their input: case examples glibenclamide and dipyridamole.A plethora of dissolution tests exists for oral dosage forms, with variations […]
- Transgenic LQT2, LQT5 and LQT2-5 rabbit models with decreased repolarisation reserve for prediction of drug-induced ventricular arrhythmias.The reliable prediction of pro-arrhythmic side-effects of novel drug candidates represents a […]
- Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit.The sites and actions of ethanol in the central nervous system have […]
- Open-channel blocking action of volatile anesthetics desflurane and sevoflurane on human voltage-gated Kv1.5 channel.Volatile anesthetics have been shown to differentially modulate mammalian Shaker-related voltage-gated potassium […]
- The novel TRPA1 antagonist BI01305834 inhibits ovalbumin-induced bronchoconstriction in guinea pigs.We hypothesized that TRPA1 channels contribute to airway hyperresponsiveness (AHR) and inflammation […]
- Astaxanthin attenuates hepatic damages and mitochondrial dysfunction in nonalcoholic fatty liver disease by up-regulating the FGF21/PGC-1α pathway.Non-alcoholic fatty liver disease (NAFLD) is considered to be one of the […]
- High glucose-mediated PICALM and mTORC1 modulate processing of amyloid precursor protein via endosomal abnormalities.Although diabetes mellitus (DM) is an important risk factor for Alzheimer’s disease […]
- Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide.Amino acid substitutions at the N-termini of glucagon-like peptide-1 receptor agonist (GLP-1RA) […]
- Heterogeneous expression of GABA receptor-like subunits LCCH3 and GRD reveals functional diversity of Apis mellifera GABA receptors.Despite a growing awareness, the annual losses of honeybee colonies worldwide continue […]
- Effect of Selective IK,ACh Inhibition by XAF-1407 in an Equine Model of Tachypacing-induced Persistent Atrial Fibrillation (AF).Inhibition of the G-protein gated acetylcholine-activated inward rectifier potassium (K+ ) current, […]
- N-benzhydryl quinuclidine (NBQN) compounds are a potent and Src kinase-independent inhibitor of NALCN channels.NALCN is a Na+ leak, G-protein-coupled receptor (GPCR)-activated channel that regulates the […]
- A physiologically based pharmacokinetic – pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug-drug interactions of paclitaxel in cancer patients.Paclitaxel is the backbone of standard chemotherapeutic regimens used in a number […]
- CIGB-552, a promising candidate to cancer therapy.Peptide-based cancer therapy has been of great interest due to the unique […]
- Role of Guidance and Policy in Enhancing the Impact of Clinical Pharmacology in Drug Development, Regulation, and Use.Click here to read the full article @ Clinical pharmacology and therapeutics
- Dissolving Microneedle Arrays with Optimized Needle Geometry for Transcutaneous Immunization.In this study, the feasibility of transcutaneous immunization using different needle-geometries dissolving […]
- Pharmaceutical company payments to Japanese government drug regulation committee members.Little is known about the characteristics and distribution of financial conflicts of […]
- High throughput and comprehensive approach to develop multiepitope vaccine against minacious COVID-19.The ongoing enigmatic COVID-19 outbreak, first reported from Wuhan, China, on last […]
- A2A adenosine receptor antagonists: From caffeine to selective non-xanthines.A long evolution of knowledge of the psychostimulant caffeine, led in the […]
- Propranolol suppresses the growth of colorectal cancer through simultaneously activating autologous CD8+ T cells and inhibiting tumor AKT/MAPK pathway.Propranolol suppresses tumor growth in a variety of preclinical solid tumor models, […]
- Biomarkers of disease activity and other factors as predictors of adalimumab pharmacokinetics in inflammatory bowel disease.Inflammatory bowel disease (IBD) is commonly treated with adalimumab. The main objective […]
- Kinetic and thermodynamic study of c-Met interaction with single chain fragment variable (scFv) antibodies using phage based surface plasmon resonance.Mesenchymal epithelial transition factor (c-Met) has been recently regarded as an attractive […]
- Integrated Circuit Design for Radiation-Hardened Charge-Sensitive Amplifier Survived up to 2 Mrad.According to the continuous development of metal-oxide semiconductor (MOS) fabrication technology, transistors […]
- Characterization of the Uniformity of High-Flux CdZnTe Material.Since the late 2000s, the availability of high-quality cadmium zinc telluride (CdZnTe) […]
- Population pharmacokinetics and pharmacodynamics of chloroquine in a Plasmodium vivax volunteer infection study.Chloroquine has been used for the treatment of malaria for more than […]
- Thalidomide suppresses breast cancer tumor growth by inhibiting tumor-associated macrophage accumulation in breast tumor-bearing mice.we aimed to explore the role of thalidomide in breast cancer by […]
Toxicology
- P-glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Cancer Patients.Paclitaxel-induced peripheral neuropathy (PIPN) is a common and dose-limiting adverse event. The role of P-glycoprotein (P-gp) in the neuronal efflux of paclitaxel was assessed using a translational approach. […]
- Activation of the Met receptor attenuates doxorubicin-induced cardiotoxicity in vivo and in vitro.Doxorubicin anti-cancer therapy is associated with cardiotoxicity, resulting from DNA damage response (DDR). Hepatocyte growth factor (HGF) protects cardiomyocytes from injury, but its administration is hampered by low […]
- Cannabidiol protects against high glucose-induced oxidative stress and cytotoxicity in cardiac voltage-gated sodium channels.Cardiovascular complications are the major cause of mortality in diabetic patients. However, the molecular mechanisms underlying diabetes-associated arrhythmias are unclear. We hypothesized that high glucose, could adversely affect […]
- Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice.Neonatal hyperbilirubinemia is a common clinical condition that can lead to brain encephalopathy, particularly when concurrent with acidosis due to infection, ischemia, and hypoxia. The prevailing view is […]
- Protective effect of cilastatin against diclofenac-induced nephrotoxicity in mice through interaction with diclofenac acyl glucuronide via OATs.Diclofenac is a widely used nonsteroidal anti-inflammatory drug. However, adverse effects in the kidney limit the clinical application of diclofenac. The present study was aimed to evaluate the […]
- An application of machine learning in pharmacovigilance: estimating likely patient genotype from phenotypical manifestations of fluoropyrimidine toxicity.Dihydropyrimidine dehydrogenase (DPD) deficient patients might only become aware of their genotype after exposure to dihydropyrimidines, if testing is performed. Case reports to pharmacovigilance databases might only contain […]
- ALPHA-TOCOPHERYL SUCCINATE IMPROVES ENCAPSULATION, pH-SENSITIVITY, ANTITUMOR ACTIVITY AND REDUCES TOXICITY OF DOXORUBICIN-LOADED LIPOSOMES.Doxorubicin (DOX) plays an important role in cancer treatment; however, high cardiotoxicity and low penetration in solid tumors are the main limitations of its use. Liposomal formulations have […]
- Proposed therapeutic range of treosulfan in reduced toxicity pediatric allogeneic hematopoietic stem cell transplant conditioning: results from a prospective trial.Treosulfan is given off-label in pediatric allogeneic hematopoietic stem cell transplant. This study investigated treosulfan’s pharmacokinetics (PK), efficacy and safety in a prospective trial. Pediatric patients (n=87) receiving […]