The latest pharmacology articles
- Identification of Glycochenodeoxycholate 3-O-Glucuronide and Glycodeoxycholate 3-O-Glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers.The aim of this study was to investigate the sensitivity and specificity […]
- Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity.The TRPV4 cation channel participates in multiple physiological processes and is also […]
- Structural basis of AMPA receptor inhibition by 4-BCCA.AMPA receptors, which shape excitatory postsynaptic currents and are directly involved in […]
- Discovery and characterization of ORM-11372, a unique and positively inotropic sodium-calcium exchanger/inhibitor.The lack of selective sodium-calcium exchanger (NCX) inhibitors has hampered the exploration […]
- Methnaridine is an orally bioavailable, fast-killing and long-acting antimalarial agent that cures Plasmodium infections in mice.Malaria is one of the deadliest diseases in the world. Novel chemotherapeutic […]
- Nervous system regulated by POK family transcription repressor RP58.The POZ domain Krüppel-like zinc finger transcription repressor (POK family) contains many […]
- Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic acetylcholine receptors.Mucociliary clearance is an innate immune process of the airways, essential for […]
- Effects of mavacamten on Ca2+ -sensitivity of contraction as sarcomere length varied in human myocardium.Heart failure can reflect impaired contractile function at the myofilament level. In […]
- Evaluating the Risk of Developing Thrombocytopenia Within Five Days of Continuous Renal Replacement Therapy Initiation in Septic Patients.The differential diagnosis for thrombocytopenia in critical illness is often extensive. This […]
- Towards chirality control of graphene nanoribbons embedded in hexagonal boron nitride.The integrated in-plane growth of graphene nanoribbons (GNRs) and hexagonal boron nitride […]
- How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?In response to the current pandemic situation, we present the development of […]
- Guided bone regeneration by the development of alendronate sodium loaded in-situ gel and membrane formulations.Biocompatible materials applied in guided bone regeneration are needed to prevent leakage […]
- Formyl peptide receptor type 2 agonists to kick-start resolution pharmacology.One way to develop innovative approaches for the treatment of chronic diseases […]
- Three-dimensional (3D)-printed devices composed of hydrophilic cap and hydrophobic body for improving buoyancy and gastric retention of domperidone tablets.The aim of this study was to produce capsule-shaped floating devices (CFD) […]
- Laser-assisted skin delivery of immunocontraceptive rabies nanoparticulate vaccine in poloxamer gel.A painless skin delivery of vaccine for disease prevention is of great […]
- Tumor Supernatant Derived from Hepatocellular Carcinoma Cells Treated with Vincristine Sulfate have Therapeutic Activity.Vincristine sulfate (VCR), a commonly used chemotherapeutic agent, kills cancer cells as […]
- The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of itraconazole-HPMCAS spray dried dispersions.Spray dried dispersions (SDDs) have the potential to dramatically improve the oral […]
- Development of Immediate Release (IR) 3D-printed oral dosage forms with focus on industrial relevance.Pharmaceutical 3D-printing represents a potentially new dosing and manufacturing approach for the […]
- EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES: Albumin fusion at the N-terminus or C-terminus of human lactoferrin leads to improved pharmacokinetics and anti-proliferative effects on cancer cell lines.Human lactoferrin (hLF), a soluble factor of the innate immune system, exhibits […]
- Prediction of Fasted and Fed Bioequivalence for Immediate Release Drug Products using Physiologically based Biopharmaceutics Modeling (PBBM).Bioequivalence studies are an integral part of clinical pharmacology strategy for drug […]
- Topical ocular pharmacokinetics and bioavailability for a cocktail of atenolol, timolol and betaxolol in rabbits.Ocular bioavailability after eye drops administration is an important, but rarely determined, […]
- Pharmacist Transition-of-Care Services Improve Patient Satisfaction and Decrease Hospital Readmissions.Pharmacists ability to directly impact patient satisfaction through increases in the Hospital […]
- Impact of a Pharmacist-Driven Protocol to Improve Guideline-Concordant Prescribing of Diabetes Medications in Patients With Atherosclerotic Cardiovascular Disease: A Pilot Study.To determine whether a pharmacist-driven protocol improves guideline-concordant prescribing of diabetes medications […]
- Flexible Ultrathin Single-Crystalline Perovskite Photodetector.Flexible optoelectronic devices attract considerable attention due to their prominent role in […]
- BCS-based biowaivers: extension to paediatrics.A BCS-based biowaiver allows extrapolation of drug product bioequivalence (when applicable) based […]
- Applications of Adaptive Designs in Generic Drug Development.The possibilities of stopping a clinical study earlier based on interim study […]
- Human Papillomavirus, Herpes Zoster, and Hepatitis B Vaccinations in Immunocompromised Patients: An Update for Pharmacists.Current evidence regarding efficacy and safety of human papillomavirus 9-valent (9vHPV), recombinant […]
- Recent advances in inflammatory bowel disease therapy.Inflammatory bowel disease (IBD) is a group of chronic, relapsing disorders of […]
- Preparation and In Vitro / In Vivo Evaluation of Flurbiprofen Nanosuspension-Based Gel for Dermal Application.Flurbiprofen (FB) is an analgesic and anti-inflammatory drug, but its low water […]
- A combined in vitro in-silico approach to predict the oral bioavailability of borderline BCS Class II/IV weak base Albendazole and its main metabolite Albendazole Sulfoxide.The aim of this study was to use a combined in vitro-in […]
- Linked Pharmacometric-Pharmacoeconomic Modelling and Simulation in Clinical Drug Development.Market access and pricing of pharmaceuticals are increasingly contingent on the ability […]
- Safety of Nebulized Colistin Solution as Adjunctive Treatment of Lower Respiratory Tract Infections.Systemic colistin is often utilized for management of drug resistant lower respiratory […]
- ABC’s of Vitamin Supplementation in Critical Illness.Critical illness commonly presents as a systemic inflammatory process. Through this inflammation, […]
- Significant Publications on Infectious Diseases Pharmacotherapy in 2019.To provide a summary of the most prominent peer-reviewed infectious diseases (ID) […]
- Ultrasensitive detection of Cr(VI) (Cr2O72-/CrO42-) ions in water environment with a fluorescent sensor based on metal-organic frameworks combined with sulfur quantum dots.Accurate, simple and quick detection methods for Cr(VI) detection are urgently needed […]
- Optimizing pharmacology studies in pregnant and lactating women using lessons from HIV: a consensus statement.Information on the extent of drug exposure to mothers and infants during […]
- Preclinical studies to dissect the neural mechanism for the comorbidity of migraine and temporomandibular disorders (TMD): the role of CGRP.Temporomandibular disorders (TMD) and migraine can be co-morbid. This can be a […]
- Metabolic Effects of Carvedilol Through β-Arrestin Proteins: Investigations in Streptozotocin-Induced Diabetes Rat Model and C2C12 Myoblasts.Carvedilol is a 3rd generation β-blocker that also stimulates β-arrestins (βarr). βarrs […]
- Effects of Advanced Pharmacy Practice Experience Characteristics on Postgraduate Year 1 Residency Match Rates.Mentors often provide advice to students regarding selection of Advanced Pharmacy Practice […]
- Mechanistic Insights on Clearance and Inhibition Discordance between Liver Microsomes and Hepatocytes When Clearance in Liver Microsomes Is Higher than in Hepatocytes.Human liver microsomes (HLM) and human hepatocytes (HHEP) are two common in […]
- Patient Case Report Daptomycin Holiday-A Daptomycin Dosing Strategy for Asymptomatic Increases in Creatine Phosphokinase Levels.Daptomycin possesses excellent activity against many multidrug-resistant gram positive organisms. However, a […]
- Biliverdin and bilirubin sulfonate inhibit monosodium urate induced sterile inflammation in the rat.Biliverdin, a by-product of haem catabolism, possesses potent endogenous antioxidant and anti-inflammatory […]
- Prolonged Intra-Sinus Alteplase Infusion in Severe Case of CVST.Cerebral venous sinus thrombosis (CVST) is an uncommon condition accounting for 0.5-1% […]
- Prediction of negative food effect induced by bile micelle binding on oral absorption of hydrophilic cationic drugs.The purpose of the present study was to quantitatively predict the negative […]
- Stain Associated Autoimmune Myopathy: Case Report With Delayed Onset and Treatment Challenges.A case of delayed statin associated autoimmune myopathy (SAAM) is presented along […]
- A New Drug Testing Platform Based on 3D Tri-culture in Lab-on-a-chip Devices.Drug discovery has a 90% rate of failure because preclinical platforms for […]
- Etomidate Induced Seizure: Adverse Drug Event Case Report.To report a case of etomidate induced seizure in a patient that […]
- Patient Case Report Daptomycin Holiday-A Daptomycin Dosing Strategy for Asymptomatic Increases in Creatine Phosphokinase Levels.Daptomycin possesses excellent activity against many multidrug-resistant gram positive organisms. However, a […]
- Prolonged Intra-Sinus Alteplase Infusion in Severe Case of CVST.Cerebral venous sinus thrombosis (CVST) is an uncommon condition accounting for 0.5-1% […]
- Stain Associated Autoimmune Myopathy: Case Report With Delayed Onset and Treatment Challenges.A case of delayed statin associated autoimmune myopathy (SAAM) is presented along […]
- The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives.We report an in vitro phase I metabolism study on COR659 (1), […]
- Enhanced cellular uptake of platinum by a tetracationic Pt(II) nanocapsule and its implications to cancer treatment.Despite the known limitations of cisplatin chemotherapy, the treatment of cancer by […]
- Biocompatibility and mechanical properties evaluation of chitosan films containing an N-acylhydrazonic derivative.The N-acylhydrazone subunit is considered a privileged structure in medicinal chemistry for […]
- Mechanistic Insights on Clearance and Inhibition Discordance between Liver Microsomes and Hepatocytes When Clearance in Liver Microsomes Is Higher than in Hepatocytes.Human liver microsomes (HLM) and human hepatocytes (HHEP) are two common in […]
- Biliverdin and bilirubin sulfonate inhibit monosodium urate induced sterile inflammation in the rat.Biliverdin, a by-product of haem catabolism, possesses potent endogenous antioxidant and anti-inflammatory […]
- The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives.We report an in vitro phase I metabolism study on COR659 (1), […]
- Prediction of negative food effect induced by bile micelle binding on oral absorption of hydrophilic cationic drugs.The purpose of the present study was to quantitatively predict the negative […]
- Enhanced cellular uptake of platinum by a tetracationic Pt(II) nanocapsule and its implications to cancer treatment.Despite the known limitations of cisplatin chemotherapy, the treatment of cancer by […]
- A New Drug Testing Platform Based on 3D Tri-culture in Lab-on-a-chip Devices.Drug discovery has a 90% rate of failure because preclinical platforms for […]
- Biocompatibility and mechanical properties evaluation of chitosan films containing an N-acylhydrazonic derivative.The N-acylhydrazone subunit is considered a privileged structure in medicinal chemistry for […]
Toxicology
- Tumor Supernatant Derived from Hepatocellular Carcinoma Cells Treated with Vincristine Sulfate have Therapeutic Activity.Vincristine sulfate (VCR), a commonly used chemotherapeutic agent, kills cancer cells as well as the normal cells for its cytotoxicity. But it is still unclear whether it can […]
- Safety of Nebulized Colistin Solution as Adjunctive Treatment of Lower Respiratory Tract Infections.Systemic colistin is often utilized for management of drug resistant lower respiratory tract infections (LRTI). Nebulized administration of colistin allows direct instillation of active agent to maximize concentrations […]
- Optimizing pharmacology studies in pregnant and lactating women using lessons from HIV: a consensus statement.Information on the extent of drug exposure to mothers and infants during pregnancy and lactation normally becomes available years after regulatory approval of a drug. Clinicians face knowledge […]
- The GABAB receptor positive allosteric modulator COR659: in vitro metabolism, in vivo pharmacokinetics in rats, synthesis and pharmacological characterization of metabolically protected derivatives.We report an in vitro phase I metabolism study on COR659 (1), a 2-acylaminothiophene derivative able to suppress alcohol and chocolate self-administration in rats, likely via positive allosteric […]
- Enhanced cellular uptake of platinum by a tetracationic Pt(II) nanocapsule and its implications to cancer treatment.Despite the known limitations of cisplatin chemotherapy, the treatment of cancer by platinum-based drugs remains the method of choice for many oncologists. The advancement in drug delivery formulations […]
- Biocompatibility and mechanical properties evaluation of chitosan films containing an N-acylhydrazonic derivative.The N-acylhydrazone subunit is considered a privileged structure in medicinal chemistry for its importance in pharmaceutical research. Also, alternative methods to deliver these molecules have a great pharmaceutical […]
- A New Drug Testing Platform Based on 3D Tri-culture in Lab-on-a-chip Devices.Drug discovery has a 90% rate of failure because preclinical platforms for drug testing do not mimic the in vivo conditions. Doxorubicin (DOX) is a commonly used drug […]
- Stain Associated Autoimmune Myopathy: Case Report With Delayed Onset and Treatment Challenges.A case of delayed statin associated autoimmune myopathy (SAAM) is presented along with review of clinical findings and treatment strategies.A 54 year old male presented with proximal extremity […]