The latest pharmacology articles
- AMPK ACTIVATION AMELIORATES KIDNEY VASCULAR DYSFUNCTION, OXIDATIVE STRESS AND INFLAMMATION IN OBESITY.Obesity is a risk factor for the development of chronic kidney disease […]
- Honokiol inhibits proliferation of colorectal cancer cells by targeting Anoctamin 1/TMEM16A Ca2+ -activated Cl- channels.Anoctamin 1 (Ano1, also named TMEM16A) Ca2+ -activated Cl- channels contribute to […]
- A Broadband Photoelectronic Detector in a Silicon Nanopillar Array with High Detectivity Enhanced by a Monolayer Graphene.To meet the fast-growing need for broad applications in remote sensing, novel […]
- Haplogroup Prediction Using Y-Chromosomal Short Tandem Repeats in the General Population of Bosnia and Herzegovina.Human Y-chromosomal haplogroups are an important tool used in population genetics and […]
- Effect of Oral Ranitidine on Urinary Excretion of N-Nitrosodimethylamine (NDMA): A Randomized Clinical Trial.In 2019, the US Food and Drug Administration (FDA) received a citizen […]
- A mean-field approach for modeling the propagation of perturbations in biochemical reaction networks.Often, the time evolution of a biochemical reaction network is crucial for […]
- Pharmacokinetic and tissue distribution study of ZCY-15, a novel compound against Alzheimer’s disease, in rats byliquid chromatography-tandem mass spectrometry.ZCY-15, N-(3,5-dimethyladamatan-1-yl)-N-(3-methylphenyl) urea, is a candidate compound synthesized from the memantine structure […]
- Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion – formulation development and in vivo pharmacokinetics.Phenytoin is a low aqueous solubility antiepileptic drug, but its phosphate ester […]
- Scalable, highly stable Si-based metal-insulator-semiconductor photoanodes for water oxidation fabricated using thin-film reactions and electrodeposition.Metal-insulator-semiconductor (MIS) structures are widely used in Si-based solar water-splitting photoelectrodes to […]
- Case Report: Delayed Alemtuzumab-Induced Concurrent Neutropenia and Thrombocytopenia in Relapsing-Remitting Multiple Sclerosis.Alemtuzumab is an anti-CD52 monoclonal antibody used to treat relapsing-remitting multiple sclerosis […]
- Impact of Anticipatory Batching of Pharmacy Compounded Sterile Products on Time to Nurse Administration.Timely medication administration is integral to patient care, and operational delays can […]
- In-Furnace Control of Arsenic Vapor Emissions Using Fe2O3 Microspheres with Good Sintering Resistance.The addition of Fe2O3 into furnaces is a promising method for arsenic […]
- Multi-organ Targeting of HIV-1 Viral Reservoirs with Etravirine Loaded Nanostructured Lipid Carrier: An In-vivo Proof of Concept.The inadequate bioavailability and toxicity potential of antiretroviral therapy limit their effectiveness […]
- Pharmacotherapy Considerations in Heart Failure with Mildly-Reduced Ejection Fraction.Heart failure with mildly reduced ejection fraction (HFmrEF) has been classified using […]
- The Role of Pharmacogenetics in Smoking.Smoking continues to be the leading preventable contributor to death worldwide. Twin […]
- Uncontrolled Extensions of Clinical Trials and the Use of External Controls – scoping opportunities and methods.Increased interest in real-world evidence (RWE) for clinical and regulatory decision making […]
- Asystole in 2 Pediatric Patients During Dexmedetomidine Infusion.Bradycardia is a known side effect of dexmedetomidine. Reports of sinus pauses […]
- Crystalline Sponge Affinity Screening: A Fast Tool for Soaking Condition Optimization without the Need of X-ray Diffraction Analysis.Structural elucidation of small molecules only available in low quantity (nanogram) is […]
- A Retrospective Review of Hospitalized Patients Receiving a Higher than Maximum Dose of Acetaminophen.Although the 3 to 4 gram per 24 hours dose recommended for […]
- Doing More With Less: Pragmatic Implementation of Vancomycin Area-Under-the-Curve (AUC) Monitoring.Universal area-under-the-curve (AUC) guided vancomycin therapeutic drug monitoring (TDM) is resource-intensive, cost-prohibitive, […]
- Medicines Related Problems (MRPs) Originating in Primary Care Settings in Older Adults – A Systematic Review.As people age, they become increasingly vulnerable to the untoward effects of […]
- Electronic Cigarettes: Their Role in the Lives of College Students.Electronic cigarettes have increased in popularity amongst college-aged adults. Although often advertised […]
- Patient-Specific Risk Factors Associated With the Development of Hyperchloremia in a Neurocritical Care Intensive Care Unit.Hypertonic sodium chloride (HTS) is used in intensive care unit (ICU) settings […]
- Remimazolam: A Novel Option for Procedural Sedation in High Risk Patients.The purpose of this drug review was to explore the safety and […]
- Synthesis of multi-color fluorine and nitrogen co-doped graphene quantum dots for use in tetracycline detection, colorful solid fluorescent ink, and film.Fluorine-doped graphene quantum dots have unique chemical bonds and charge distribution, which […]
- Contemporary Management and Prevention of Vaso-Occlusive Crises (VOCs) in Adults With Sickle Cell Disease.Sickle cell disease (SCD) is a hematological disorder that primarily affects individuals […]
- A semi-mechanistic pharmacokinetic model for depot medroxyprogesterone acetate and drug-drug interactions with antiretroviral and antituberculosis treatment.Depot medroxyprogesterone acetate (DMPA) is an injectable hormonal contraceptive, widely used by […]
- Development and verification of an endogenous PBPK model to inform hydrocortisone replacement dosing in children and adults with cortisol deficiency.The goal of hormone replacement is to mirror physiology. Hydrocortisone granules and […]
- Development of Gliclazide ionic liquid and the transdermal patches: an effective and noninvasive sustained release formulation to achieve hypoglycemic effects.Ionic liquids (IL) technology provides a useful platform to achieve the topical […]
- Electrospun gold nanorods/graphene oxide loaded-core-shell nanofibers for local delivery of paclitaxel against lung cancer during photo-chemotherapy method.The combinations of photothermal therapy (PTT) and chemotherapy (CHT) have attracted increasing […]
- Cost to Medicare of Delayed Adalimumab Biosimilar Availability.Launched in 2002, adalimumab (Humira) is the top revenue-generating drug in the […]
- Immunopharmacogenomics: Mechanisms of HLA-associated drug reactions.The human leukocyte antigen (HLA) system is the most polymorphic in the […]
- ULECGNet: An Ultra-Lightweight End-to-End ECG Classification Neural Network.ECG classification is a key technology in intelligent ECG monitoring. In the […]
- Benefit- risk assessment of off-label drug use in children: the bravo framework.A drug is granted a license for use after a thorough assessment […]
- A model-based approach to assess unstable creatinine clearance in critically ill patients.Creatinine clearance is an important tool to describe the renal elimination of […]
- Improved efficacy and safety of low doses of benznidazole-loaded multiparticulate delivery systems in experimental Chagas disease therapy.Benznidazole (BZ) is a first-line drug for the treatment of Chagas disease; […]
- Interface-sensitized prodrug nanoaggregate as an effective in situ antitumor vaccine.In situ antitumor vaccines have been widely explored as an effective strategy […]
- Flow Structure and Particle Deposition Analyses for Optimization of a Pressurized Metered Dose Inhaler (pMDI) in a Model of Tracheobronchial Airway.Inhalation therapy plays an important role in management or treatment of respiratory […]
- Hospital Pharmacy Response to Covid-19 Pandemic in Italy: What We Learned From the First Outbreak Wave.When COVID-19 pandemic started, Italian hospital pharmacists faced multiple challenges and change […]
- Insights into the mechanisms underlying opioid use disorder and potential treatment strategies.Opioid use disorder is a worldwide societal problem and public health burden. […]
- PERSPECTIVES FOR THERAPY OF TREATMENT-RESISTANT DEPRESSION.A high proportion of depressed patients fail to respond to antidepressant drug […]
- Pharmacogenetics-guided advances in antipsychotic treatment.Pharmacogenetics (PGx) research over the past two decades has produced extensive evidence […]
- Thromboinflammation in COVID-19: The Clot Thickens.Since the start of the coronavirus SARS-Cov-2 pandemic, a disease that has […]
- QbD-driven development of dissolving microneedle patch loaded with Ultradeformable liposomes encapsulated Noopept: Exploring a patient friendly, once-daily option to manage Dementia.Noopept (NPT), a potent neuroprotective agent, suffers the problem of poor oral […]
- Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared and Raman spectroscopy.Electrospinning is a technology for manufacture of nano- and micro-sized fibers, which […]
- Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches.The aim of this work was the formulation and the comprehensive evaluation […]
- Medication errors during treatment with new oral anticancer agents: consequences for clinical practice based on the AMBORA study.Patients treated with oral anticancer agents (e.g. kinase inhibitors) are a high-risk […]
- Nondestructive Investigation of the Agglomeration Process for Nanosuspensions via NMR Relaxation of Water Molecules.This study investigated an agglomeration of nanoparticles in a suspension using nuclear […]
- A Case-Report of Drug-Induced Mixed Liver Injury Resulting From Cefepime Exposure.A 99-year-old African-American male presented to the hospital with severe sepsis secondary […]
- A Portable Wireless Urine Detection System with Power-Efficient Electrochemical Readout ASIC and ABTS-CNT Biosensor for UACR Detection.This work presents a portable wireless urine detection system which consists of […]
- An in-memory computing architecture based on two-dimensional semiconductors for multiply-accumulate operations.In-memory computing may enable multiply-accumulate (MAC) operations, which are the primary calculations […]
- Characterization of Prophylactic Antimicrobial Therapy Practices for Patients With Marine-Associated Injuries in the Emergency Department.Centers for Disease Control and Prevention (CDC) recommendations for the treatment of […]
- Evaluation of Weight-Based Dose During Transition From Immediate-Release to Extended-Release Tacrolimus in Kidney Transplant Recipients.Manufacturer recommendations for conversion from immediate-release to extended-release tacrolimus, Envarsus XR®, suggests […]
- Moving Pharmacogenetics into Practice: It’s All About the Evidence!The evidence for pharmacogenetics has grown rapidly in recent decades. However, the […]
- Non-Sterile to Sterile Compounding: An Unconventional Response During the COVID-19 Pandemic.The drug supply chain has suffered many interruptions over the past decade. […]
- Use of Intravenous Vitamin C in Critically Ill Patients With COVID-19 Infection.The pathophysiology for Coronavirus Disease 2019 (COVID-19) infection is characterized by cytokine […]
- How does pressure affect the molecular dynamics, intramolecular interactions, and the relationship between structural (α) and secondary (JG-β) relaxation above and below the glass transition temperature in binary mixtures of H-bonded API – probucol and acetylated saccharides?In this paper, the molecular dynamics as well as inter- and intramolecular […]
- Ultrafast non-volatile flash memory based on van der Waals heterostructures.Flash memory has become a ubiquitous solid-state memory device widely used in […]
- Physiologically based modelling of tranexamic acid pharmacokinetics following intravenous, intramuscular, sub-cutaneous and oral administration in healthy volunteers.Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood loss […]
- Recent advances of dendrimers as multifunctional nano-carriers to combat breast cancer.Breast cancer (BC) is a highly heterogeneous malignant carcinoma that is the […]
Toxicology
- Atypical kinetics of cytochrome P450 2J2: epoxidation of arachidonic acid and reversible inhibition by xenobiotic inhibitors.Extrahepatic CYP2J2 metabolism of arachidonic acid (AA) to bioactive regioisomeric epoxyeicosatrienoic acids (EETs) is implicated in both physiological and pathological conditions. Here, we aimed to characterize atypical substrate […]
- Population pharmacokinetics and individual analysis of daptomycin in kidney transplant recipients.Little is known about the population pharmacokinetics (PPK) of daptomycin in kidney transplant patients. The present study established a pharmacokinetic model for daptomycin in kidney transplant patients in […]
- Sex-specific classification of drug-induced Torsade de Pointes susceptibility using cardiac simulations and machine learning.Torsade de Pointes (TdP), a rare but lethal ventricular arrhythmia, is a toxic side effect of many drugs. To assess TdP risk, safety regulatory guidelines require quantification of […]
- Searching for new anxiolytic agents among derivatives of 11-dialkylaminoethyl-2,3,4,5-tetrahydrodiazepino[1,2-a]benzimidazole.A study on the anxiolytic activity of the new derivatives of 11-dialkylaminoethyl-2,3,4,5-tetrahydrodiazepino[1,2-a]benzimidazole, containing privileged scaffolds of benzodiazepine and benzimidazole in their structure, was conducted. The cytotoxic properties of […]
- Antibody Conjugated Lipid Nanoparticles as a Targeted Drug Delivery System for Hydrophobic Pharmaceuticals.Cancer remains a significant health issue worldwide. The most common group of chemotherapeutic agents are small-molecule drugs, which often are associated with toxic side-effects and non-specific delivery, leading […]
- Chitosan nanoparticles for enhancing drugs and cosmetic components penetration through the skin.Chitosan nanoparticles (CT NPs) have attractive biomedical applications due to their unique properties. This present research aimed at development of chitosan nanoparticles to be used as skin delivery […]
- Short peptide sequence enhances epithelial permeability through interaction with protein kinase C.We have identified a short peptide sequence (L-R5) acting as partial inhibitor of intracellular protein kinase C, capable of tight junction modulation in terms of reversible and non-toxic […]
- Untapped potential: Therapeutically targeting eicosanoids and endocannabinoids in the lung.Inflammation of the airway involves the recruitment of highly active immune cells to combat and clear microbes and toxic factors, however this inflammatory response can result in unintended […]