The Latest Paediatric Dermatology Journal Articles
Keep up to date with the latest in paediatric dermatology. Check out the latest paediatric dermatology articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily.
- Paternal and maternal use of dupilumab in patients with atopic dermatitis: a case series.Dupilumab is a relatively new treatment option for patients with moderate-to-severe atopic dermatitis. There is a lack of knowledge about treatment with dupilumab during conception in both males and females, as well as during pregnancy and lactation. We report four patients who expressed a wish to conceive during treatment with dupilumab in daily practice. Two […]
- Single-parenthood and health conditions among children receiving public assistance in Japan: a cohort study.Children’s healthy development is important. While governmental public assistance benefits financially troubled families, it cannot compensate for a lack of social support. Single-parenthood is a health risk factor for children owing to low-income-associated food insecurity and stress. No study has investigated the association between single-parenthood and health status in children from families receiving public assistance. […]
- Treatment of Pediatric Alopecia Areata: A Systematic Review.Alopecia areata (AA) is an autoimmune, non-scarring hair loss disorder with slightly greater prevalence in children than adults. Various treatment modalities exist; however, their evidence in pediatric AA patients is lacking.We conducted a systematic review on the PubMed database in October 2019 for all published articles involving patients <18 years old. Articles discussing AA treatment […]
- Natural evolution in pediatric cutaneous mastocytosis: 10-year follow-up.Mastocytosis is a heterogeneous group of myeloproliferative disorders characterized by accumulation of clonal mast cells in various tissues. The aim of this study was to determine the symptoms evolution and outcome after 10 years observation.Fifty-five children with mastocytosis were included in the study group and monitored concerning mast cell mediator-related symptoms (MC MRSs) and clinical course […]
- Onychoscopy in a Colombian population with toenail onychomycosis diagnosis: an evaluating diagnostic test study.Onychomycosis is defined as the infection of nails caused by dermatophytes, yeasts, and non-dermatophyte molds. Fungal infections of the nail represent about 30% of all mycotic cutaneous infections1 and approximately 50% of all nail diseases. Onychomycosis affects between 2% 1 to 13% 3 of the worldwide population, with a high prevalence in adults over 70 […]
- Atopic diseases in children and adolescents are associated with behavioural difficulties.Atopic diseases and behavioural difficulties in children have both been on the rise in recent decades. This study seeks to assess associations between atopic diseases and behavioural difficulties, examining the differences considering child age and how behavioural difficulties were reported (via self-report or parent-report).Data on behavioural difficulties, assessed through the Strengths and Difficulties Questionnaire (SDQ), […]
- Intrapartum Group B Streptococcal Prophylaxis and Childhood Allergic Disorders.To determine if maternal intrapartum group B Streptococcus (GBS) antibiotic prophylaxis is associated with increased risk of childhood asthma, eczema, food allergy, or allergic rhinitis.Retrospective cohort study of 14 046 children. GBS prophylaxis was defined as administration of intravenous penicillin, ampicillin, cefazolin, clindamycin, or vancomycin to the mother, ≥4 hours before delivery. Composite primary outcome was […]
- Neonatal systemic juvenile Xanthogranuloma with Hydrops diagnosed by Purpura skin biopsy: a case report and literature review.Systemic juvenile xanthogranuloma is a very rare disease typically presents as skin lesions with yellow papules or nodules and is sometimes fatal. We report a case of congenital neonatal systemic juvenile xanthogranuloma with atypical skin appearance that made the diagnosis difficult.A preterm Japanese female neonate with prenatally diagnosed fetal hydrops in-utero was born with purpuric […]
- Mucocutaneous Manifestations in Hospitalized Children with COVID-19.The cutaneous manifestations in hospitalized children infected with SARS-CoV-2 have not been studied systematically.To describe the mucocutaneous involvement in pediatric patients with COVID-19 admitted in a pediatric institution in Madrid (Spain), a most prevalent COVID-19 zone in Europe.A descriptive, analytical study of a series of 50 hospitalized children with COVID-19 from March 1 to November […]
- Diagnosis and management of morphoea in children: an overview.Paediatric morphoea (localized scleroderma) is an inflammatory sclerosing disorder of the skin and subcutis associated with tissue atrophy. It is thought that the disease develops on the background of genetic predisposition (e.g. mosaicism for the common linear variant) initiated by various trigger factors, and that detected autoantibodies and inflammatory cytokines represent secondary epiphenomena. In contrast […]
- United Kingdom Psychodermatology Services in 2019: service provision has improved but is still very poor nationally.Psychodermatology is an emerging sub-specialty of dermatology. Psychodermatology clinics use a multidisciplinary approach to deal with psychological or psychiatric elements related to skin disease. Two previous studies in 2004 and 2012 highlighted the deficiency of psychodermatology services in the UK, despite the evidence that these services are highly in demand and cost-efficient.To re-assess psychodermatology service […]
- Novel ERCC2 variant in trichothiodystrophy infant: the first case report in China.Trichothiodystrophy (TTD) is a rare, autosomal recessive, multisystem disorder most commonly caused by variants in ERCC2.Here, we describe the first Chinese patient with a novel variant in ERCC2. A male infant, who was born to a healthy non-consanguineous couple, exhibited brittle hair, hair loss ichthyosis, eczema, retinal pigmentation and hypospadias. He carried a novel heterozygous […]
- Body Site Distribution of Pediatric-Onset Morphea and Association with Extracutaneous Manifestations.The distribution of pediatric-onset morphea and site-based likelihood for extracutaneous complications has not been well-characterized.Characterize lesional distribution of pediatric-onset morphea and determine sites with the highest association with extracutaneous manifestations.A retrospective cross-sectional study was performed. Using clinical photographs, morphea lesions were mapped onto body diagrams using customized software.There were 823 patients with 2522 lesions included. […]
- Real-world comorbidities of atopic dermatitis in the pediatric ambulatory population in the United States.Increasing evidence points to the systemic nature of atopic dermatitis (AD), a common inflammatory skin condition in children. However, comprehensive analyses of real-world comorbidities in pediatric AD are limited.To characterize the comorbidity burden in patients <18 years old with AD.The MarketScan Commercial Claims database was queried from January 1, 2017 to December 31, 2017. Age- […]
- Association of pediatric atopic dermatitis and psoriasis with school absenteeism and parental work absenteeism: a cross-sectional United States population-based study.The impact of childhood atopic dermatitis (AD) and psoriasis on school absenteeism are not fully elucidated.To determine the burden and predictors of chronic school absenteeism in children with AD and psoriasis.Data were analyzed from the 1999-2015 Medical Expenditure Panel Surveys, a cross-sectional, population-based study of US health status and function.Among 3132 and 200 children with […]
- Supportive care in the acute phase of Stevens-Johnson syndrome and toxic epidermal necrolysis: an international, multidisciplinary DELPHI-based consensus.Supportive care is the cornerstone of adult and pediatric management of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). However, consensus on the modalities of supportive care is lacking.Our aim in this international multicentric Delphi exercise was to establish a multidisciplinary expert consensus to standardize recommendations regarding supportive care in the acute phase of SJS/TEN.Participants […]
- Severe epidermolysis bullosa/Kindler syndrome-like phenotype of an autoinflammatory syndrome in a child.A 5-year-old boy presented with generalized cutaneous erosions, severe scarring, depigmentation and contractures affecting major joints. The lesions had initially affected his ears, nose, feet, and the genital and ocular mucosa, leading to significant depigmentation, scarring, contractures and mutilation. The whole of the trunk and limbs were involved at the time of presentation, with the […]
- Diagnosis of latent tuberculosis infection among pediatric household contacts of Iranian tuberculosis cases using tuberculin skin test, IFN- γ release assay and IFN-γ-induced protein-10.Although the World Health Organization has recommended the diagnosis and prophylactic treatment of latent tuberculous infection (LTBI) in child household contacts of tuberculosis (TB) cases, the national programs in high-burden TB regions rarely implement adequate screening of this high-risk group, mainly because of resource limitations. We aimed to evaluate the prevalence of LTBI among pediatric household […]
- Subcutaneous abscess caused by Streptococcus pneumoniae serotype 28F in an infant: a case report.Invasive pneumococcal disease (IPD) is defined by the detection of Streptococcus pneumoniae on culture from samples obtained from a normally sterile site. Pneumococcal conjugate vaccines (PCV) have been developed for the prevention of IPD that is caused by highly virulent serotypes. Despite the effective reduction of IPD caused by vaccine serotypes after the introduction of […]
- Scabies involving palms in older children and adults: a changing scenario.Scabies is a highly contagious, intensely pruritic skin infestation caused by Sarcoptes scabiei var hominis. It has high prevalence in many tropical countries where crowded people live in resource-poor settings. The rash is distributed differently in adults and children. Adults manifest lesions primarily on the interdigital web spaces of the hands, flexor aspects of the […]
- Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting.The Harmonising Outcome Measures for Eczema (HOME) initiative has established a core outcome set of domains for atopic eczema (AE) clinical trials. Previous consensus meetings have agreed on preferred instruments for clinician-reported signs (Eczema Area and Severity Index, EASI) and patient-reported symptoms (Patient-Oriented Eczema Measure, POEM). This paper reports consensus decisions from the HOME VII […]
- Rare Genetic Variants in Immune Genes and Neonatal Herpes Simplex Viral Infections.Neonatal herpes simplex virus (HSV) infection is a devastating disease with high mortality, particularly when disseminated. Studies in adults and children suggest that susceptibility to herpes simplex encephalitis (HSE) may represent phenotypes for inborn errors in toll-like receptor 3 (TLR3) signaling. However, the genetic basis of susceptibility to neonatal HSV including disseminated disease remains unknown. […]
- Skin Disease is More Recalcitrant Than Muscle Disease: A Long-Term Prospective Study of 184 Children with Juvenile Dermatomyositis.Persistent skin manifestations, especially calcinoses, contribute to morbidity in children with juvenile dermatomyositis (JDM).To compare the course of skin and muscle involvement and document frequency of calcinosis in JDM.Prospective cohort study of 184 untreated children with JDM (July 1971-May 2019) at a single children’s hospital RESULTS: Disease activity scores (DAS) were persistently higher for skin […]
- Efficacy and safety of fumaric acid esters in young patients aged 10 to 17 years with moderate-to-severe plaque psoriasis – A randomised, double-blinded, placebo-controlled trial.Apart from three biologics, no systemic drugs are approved in Europe for children with moderate-to-severe psoriasis. Retrospective observational studies showed promising results for fumaric acid esters (FAE) in this setting.To show superiority of FAE over placebo in terms of treatment response after 20 weeks in children and adolescents aged 10-17 years.In a multicentre, randomised, double-blind, […]
- Pathologically oriented descriptive study of male genital circumcisions across medical and surgical specialties.Circumcision is one of the most frequently performed procedure by clinicians, yet its role and indication in clinical practice lacks consensus and remains unclear. We sought to evaluate a collection of male circumcisions to determine the range of indications, histopathological diagnoses, and type of clinicians associated with circumcision.We performed a retrospective descriptive cohort study of […]
- Infantile infection and antibiotic exposure in association with pediatric psoriasis development: a nationwide nested case-control study.Microbiol dysbiosis and antibiotic exposure have been implicated in the pathogenesis of pediatric inflammatory diseases.To investigate the impacts of infantile infection and antibiotic exposure on pediatric psoriasis development METHODS: This is a nationwide nested case control study. From the National Health Insurance Research Database of Taiwan, a total of 1,527 patients with pediatric psoriasis were […]
- Juvenile xanthogranuloma: retrospective analysis of 44 pediatric cases (single tertiary care center experience).Juvenile xanthogranuloma (JXG) is a rarely encountered skin disorder, which is characterized by the proliferation of non-Langerhans cell histiocytes. As JXG primarily affects infants and young children, this study aims to describe the epidemiologic, clinical, and histopathologic characteristics of 44 children diagnosed with JXG at a tertiary health care center.Fourty-four children with a histopathologic diagnosis […]
- Screening for infantile hepatic hemangioma in patients with cutaneous infantile hemangioma: a multicenter prospective study.Abdominal ultrasonography has been proposed for screen infantile hepatic hemangioma (IHH) in patients with multiple cutaneous infantile hemangiomas (IHs).The aim of this study was to establish the optimal cutoff point for the number of cutaneous IHs needed to screen for IHH.We performed a prospective, multicenter study to screen for IHH in patients younger than 9 […]
- Co-occurrence of Aicardi-Goutières syndrome type 6 and dyschromatosis symmetrica hereditaria due to compound heterozygous pathogenic variants in ADAR1: a case series from India.Aicardi-Goutières syndrome type 6 (AGS6) and dyschromatosis symmetrica hereditaria (DSH) are allelic disorders due to homozygous/ compound heterozygous and heterozygous mutations in ADAR1 respectively. We report three unrelated children presenting with features of both AGS6 and DSH, two of whom had pathogenic variants in ADAR1. We also allude to the novel genetic variants in our […]
- A study of medication errors during the prescription stage in the pediatric critical care services of a secondary-tertiary level public hospital.Medication Errors (MEs) are considered the most common type of error in pediatric critical care services. Moreover, the ME rate in pediatric patients is up to three times higher than the rate for adults. Nevertheless, information in pediatric population is still limited, particularly in emergency/critical care practice. The purpose of this study was to describe […]
- News on infantile haemangioma. Part 1: clinical course and pathomechanism.Currently, there is no doubt that the first choice of treatment for alarming infantile haemangiomas (IHs) is oral beta-blockers. However, research in this field remains active, as the pathogenesis of IH is still not completely elucidated. Furthermore, there are different approaches to the management of IHs with beta-blockers. In Part 1 of this review we […]
- Topical Corticosteroids Normalize both Skin and Systemic Inflammatory Markers in Infant Atopic Dermatitis.Atopic dermatitis (AD) is the most common inflammatory skin disease. It is highly heterogeneous in clinical presentation, treatment response, disease trajectory and associated atopic comorbidities. Immune biomarkers are dysregulated in skin and peripheral blood.We used non-invasive skin and peripheral biomarkers to observe the effects of real-world topical corticosteroid treatment (TCS) in infants with AD, by […]
- Ecthyma gangrenosum due to Pseudomonas aeruginosa sepsis as initial manifestation of X-linked agammaglobulinemia: a case report.X-linked agammaglobulinemia (XLA, OMIM#300,300), caused by mutations in the Bruton tyrosine kinase (BTK) gene, is a rare monogenic inheritable immunodeficiency disorder. Ecthyma gangrenosum is a cutaneous lesion caused by Pseudomonas aeruginosa that typically occurs in patients with XLA and other immunodeficiencies.We report the case of a 20-month-old boy who presented with fever, vomiting, diarrhea, and […]
- Differences between Stevens-Johnson syndrome versus toxic epidermal necrolysis.To retrospectively review the outcomes of two rare cutaneous diseases, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), and to question the practice of averaging the mortality rate on the assumption that they are one disease.A retrospective chart review of all patients diagnosed with SJS and TEN by a dermatologist between January 1, 2000, and […]
- Morphea patients with mucocutaneous involvement: A cross sectional study from the Morphea in Adults and Children (MAC) cohort.Demographic and clinical findings of patients with mucocutaneous morphea have not been well characterized.To determine the demographic and clinical characteristics of morphea patients with mucocutaneous lesions enrolled in the Morphea in Adults and Children Cohort (MAC).Cross-sectional study of 735 patients in the MAC Cohort from 2007 to 2018.4.6% of linear morphea patients had oral involvement […]
- Hemiscrotal agenesis: a novel phenotype of a rare malformation.Hemiscrotal agenesis (HSA) is an exceedingly rare congenital anomaly in scrotal development. It is characterized by unilateral absence of scrotal skin with intact midline raphe. In the English literature, only seven patients were diagnosed with HSA. Herein, we report a 14-month-old boy with HSA, unilateral cryptorchidism and a perineal skin tag. Additionally, the patient had […]
- Burden, risk factors and infectious complications of cellulitis and erysipelas in United States adults and children in the emergency department setting.Little is known about the utilization and burden of emergency department (ED) visits for cellulitis/erysipelas in the United States.To determine the prevalence, risk factors, complications and cost of emergency care for cellulitis/erysipelas in the US.Cross-sectional study of the 2006-2016 National Emergency Department Sample, including a 20% sample of US ED visits (n=320,080,467).The mean annual incidence […]
- Acceptability, safety, and patterns of use of oral tenofovir disoproxil fumarate and emtricitabine for HIV pre-exposure prophylaxis in South African adolescents: an open-label single-arm phase 2 trial.HIV incidence among adolescents in southern Africa remains unacceptably high. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention intervention but there are few data on its implementation among adolescents. We aimed to investigate the safety, feasibility, and acceptability of PrEP with oral tenofovir disoproxil fumarate and emtricitabine as part of a comprehensive HIV prevention package […]
- Childhood rosacea and related disorders.Rosacea is a chronic inflammatory condition that affects the skin and the eyes. The pathogenesis of rosacea is complex and includes the interaction between genetic and environmental factors, dysregulation of the innate immune system, neurovascular modifications and the interaction with skin commensals. Clinical manifestations in children include the telangiectatic form, papulopustular rosacea, ocular rosacea, periorificial […]
- Pediatric Allergic Contact Dermatitis. Part II. Patch Testing Series, Procedure, and Unique Scenarios.Patch testing is the gold standard for diagnosing allergic contact dermatitis. Causative allergens differ between children and adults, necessitating the development of pediatric-specific patch test series. The Pediatric Baseline Series was developed in 2018 through expert-consensus and includes relevant pediatric allergens of which dermatologists can use in practice. Obstacles in patch testing, such as the […]
- Pediatric Allergic Contact Dermatitis. Part I. Clinical Features and Common Contact Allergens in Children.Allergic contact dermatitis (ACD), a delayed hypersensitivity skin reaction to environmental allergens, has a prevalence that is similar in children and adults. However, diagnostic testing for ACD in pediatric populations accounts for less than one-tenth of all patch tests. The relative infrequency of pediatric patch testing may be attributed to the difficulty in testing in […]
- The use of direct oral challenge to confirm allergies to penicillin class antibiotics in Danish children.A high number of children are referred to pediatric departments with a suspected allergic reaction to antibiotics. The prevalence of true allergy is considered to be significantly lower than shown from clinical history and symptoms alone. This study investigated the historical use of direct oral challenges at three specialist pediatric departments in Denmark.In this retrospective […]
- Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting.The Harmonising Outcome Measures for Eczema (HOME) initiative has established a core outcome set of domains for atopic eczema clinical trials. Previous consensus meetings have agreed upon preferred instruments for clinician-reported signs (Eczema Area and Severity Index – EASI) and patient-reported symptoms (Patient-Oriented Eczema Measure – POEM). This paper reports consensus decisions from the HOME […]
- Neuroimaging in infants and children in select neurocutaneous disorders.The role of neuroimaging in neurocutaneous disorders is an evolving field. Research can be inconsistent and inconclusive, leading to divergent practice for some disorders. This study provides an overview of the current role of magnetic resonance imaging (MRI) of the brain in select neurocutaneous disorders, namely Sturge-Weber syndrome, congenital melanocytic naevus syndrome, neurofibromatosis type 1, […]
- Mean core to peripheral temperature difference and mean lactate levels in first 6 hours of hospitalisation as two indicators of prognosis: an observational cohort study.To study mean core to peripheral temperature difference (CPTD) and the mean lactate levels over the first 6 h of admission to hospital, as indicators of prognosis in critically ill children.A prospective observational study in a tertiary level Pediatrics ICU in Delhi, India. Seventy eight paediatric patients from 1 month to 12 years were studied. Children with physical […]
- Trichoscopic signs of tinea capitis: a guide for selection of appropriate antifungal.Tinea capitis is the most common pediatric dermatophyte infection. Optimal treatment regimen differs according to the type of the dermatophyte involved.The aim of this work was to study the trichoscopic signs in relation to isolated organism in a sample of Egyptian patients with tinea capitis and the possibility of using them as a guide for […]
- Association between Air Pollution and Atopic Dermatitis in Guangzhou, China: Modification by Age and Season.The short-term effect of ambient air pollution on atopic dermatitis (AD), along with its effect modifiers, has not been fully addressed in previous studies.To examine the short-term associations between air pollution and AD, and identify effect modifications by age and season.We used the Generalized Additive Model to evaluate the short-term effect of ambient air pollution […]
- Laugier-Hunziker syndrome: a case report of the pediatric patient and review of the literature.Laugier-Hunziker syndrome (LHS) is a rare, idiopathic pigmentary disorder especially affecting the lips and oral mucosa. At present, no more than 200 cases of patients diagnosed with LHS syndrome have been described worldwide. To date, three patients under the age of 20 have been described, including the youngest patient who is a 12-year-old child. The […]
- Chronic Ulcers and Malnutrition in an African Patient.An 11-year-old girl with a congenitally malformed left hand, sickle cell trait, asthma, and history of appendicitis was transferred from Zambia for evaluation and treatment of widespread suppurative and ulcerative skin lesions that typically appeared after trauma to her skin. The ulcers first presented 3 years earlier but had markedly worsened in the 9 months before […]
- Classic Ehlers-Dalnos syndrome presenting as atypical chronic haematoma: a case report with novel frameshift mutation in COL5A1.Ehlers-Danlos syndrome (EDS) is a group of inherited connective tissue disorders characterized by skin hyperextensibility, joint hypermobility and soft tissue vulnerable to blunt injury. Early recognition and diagnosis are crucial to patients to provide appropriate treatment, as well as to screen for life-threatening conditions such as aortic dissection and hollow organ perforation. The diagnosis of […]
- Study protocol: parents as pain management in Swedish neonatal care – SWEpap, a multi-center randomized controlled trial.During the first period of life, critically ill as well as healthy newborn infants experience recurrent painful procedures. Parents are a valuable but often overlooked resource in procedural pain management in newborns. Interventions to improve parents’ knowledge and involvement in infants’ pain management are essential to implement in the care of the newborn infant. Neonatal […]
- Systematic Review of Mohs Micrographic Surgery in Children: Identifying Challenges and Practical Considerations for Successful Application.Few data exist to guide the application of Mohs micrographic surgery (MMS) in the pediatric population.To summarize the clinical characteristics of children undergoing MMS, identify challenges that limit the use of MMS in this population, and examine how these challenges can be overcome.A systematic review of PubMed and EMBASE, from inception of databases to November […]
- The global burden of atopic dermatitis: lessons from the GBD Study – 1990 to 2017.The Global Burden of Disease (GBD) Study provides an annually updated resource to study disease-related morbidity and mortality worldwide. Here we present the burden estimates for atopic dermatitis (AD), including data from inception of the GBD project in 1990 until 2017. Atopic dermatitis (AD) ranks 15th among all non-fatal diseases and has the highest disease […]
- Randomised controlled trial of topical corticosteroid and home-based narrowband UVB for active and limited vitiligo – results of the HI-Light Vitiligo trial.Evidence for the effectiveness of vitiligo treatments is limited.To determine effectiveness of (a) hand-held narrowband-UVB (NB-UVB) and (b) combination of potent topical corticosteroid (TCS) and NB-UVB compared to TCS, for localised vitiligo.Pragmatic, 3-arm, placebo-controlled RCT (9 months’ treatment; 12 months’ follow-up). Adults and children, recruited from secondary care and community, aged ≥5 years with active […]
- Pressure Urticaria in an Infant Appearing Similar to Physical Abuse.A healthy Hispanic boy was born via cesarean delivery after an uncomplicated pregnancy. At 4 weeks old , his parents brought him to the emergency department for bruising on both soles of the feet. At 6 weeks old, his parents brought him to primary care for new bruises on his arms and back. After evaluation, primary […]
- Interferon-γ Release Assays for Tuberculosis Infection Diagnosis in Refugees <5 Years Old.New guidelines support using interferon-γ release assays (IGRAs) in children ≥2 years for diagnosis of latent tuberculosis infection (LTBI). However, lack of experience in young children and concern that IGRAs are less sensitive than tuberculin skin tests (TSTs) limit their use. Our aim was to identify active tuberculosis (TB) cases among high risk children <5 […]
- Establishment of a pediatric trigger tool based on Global Trigger Tool to identify adverse drug events of children: experience in a Chinese hospital.The Global Trigger Tool (GTT),which is a method using “triggers” to review medical record retrospectively to identify possible adverse events. Several studies showed that the GTT was effective. However, there were only a few localized trigger tools that had been established to detect pediatric adverse drug events (ADEs) in China. This study aimed to establish […]
- Response to ‘No evidence of SARS-CoV-2 infection by polymerase chain reaction or serology in children with pseudo-chilblain’. Reply from the authors.Dear Editor, Recalcati et al. conclude that chilblain-like lesions (CLLs) are part of the spectrum of COVID-19 based on reports of SARS-CoV-2 in endothelial cells of skin biopsies assessed by immunohistochemistry and electron microscopy (EM).1 Nevertheless, the conclusion does not seem to be adequately supported by the data. Recalcati et al. expand their previously reported […]
- Dupilumab provides favourable long-term safety and efficacy in children aged ≥ 6 to < 12 years with uncontrolled, severe atopic dermatitis: results from an open-label phase IIa study and subsequent phase III open-label extension study.Children aged ≥6 to <12 years with severe atopic dermatitis (AD) have limited treatment options. In a 16-week, randomized, placebo-controlled, phase III trial in children, dupilumab, a monoclonal antibody inhibiting interleukin (IL)-4/IL-13 signaling, significantly improved signs and symptoms with acceptable safety; longer-term safety and efficacy data are lacking.To report the pharmacokinetic profile and long-term safety […]
- Children of the Sun: a historical look at how pediatric light therapy shaped attitudes and behaviors toward sunbathing.Today, parents are warned to protect their children from the sun’s ultraviolet (UV) rays, the most preventable and leading cause of skin cancer. Yet, during the first half of the 20th century, the medical community widely extolled the health benefits of daily sunbaths for babies and children. What initially had begun as evidence-based medical therapies […]