The Latest Paediatric Dermatology Journal Articles
Keep up to date with the latest in paediatric dermatology. Check out the latest paediatric dermatology articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily.
- The use of direct oral challenge to confirm allergies to penicillin class antibiotics in Danish children.A high number of children are referred to pediatric departments with a suspected allergic reaction to antibiotics. The prevalence of true allergy is considered to be significantly lower than shown from clinical history and symptoms alone. This study investigated the historical use of direct oral challenges at three specialist pediatric departments in Denmark.In this retrospective […]
- Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting.The Harmonising Outcome Measures for Eczema (HOME) initiative has established a core outcome set of domains for atopic eczema clinical trials. Previous consensus meetings have agreed upon preferred instruments for clinician-reported signs (Eczema Area and Severity Index – EASI) and patient-reported symptoms (Patient-Oriented Eczema Measure – POEM). This paper reports consensus decisions from the HOME […]
- Neuroimaging in infants and children in select neurocutaneous disorders.The role of neuroimaging in neurocutaneous disorders is an evolving field. Research can be inconsistent and inconclusive, leading to divergent practice for some disorders. This study provides an overview of the current role of magnetic resonance imaging (MRI) of the brain in select neurocutaneous disorders, namely Sturge-Weber syndrome, congenital melanocytic naevus syndrome, neurofibromatosis type 1, […]
- Mean core to peripheral temperature difference and mean lactate levels in first 6 hours of hospitalisation as two indicators of prognosis: an observational cohort study.To study mean core to peripheral temperature difference (CPTD) and the mean lactate levels over the first 6 h of admission to hospital, as indicators of prognosis in critically ill children.A prospective observational study in a tertiary level Pediatrics ICU in Delhi, India. Seventy eight paediatric patients from 1 month to 12 years were studied. Children with physical […]
- Trichoscopic signs of tinea capitis: a guide for selection of appropriate antifungal.Tinea capitis is the most common pediatric dermatophyte infection. Optimal treatment regimen differs according to the type of the dermatophyte involved.The aim of this work was to study the trichoscopic signs in relation to isolated organism in a sample of Egyptian patients with tinea capitis and the possibility of using them as a guide for […]
- Association between Air Pollution and Atopic Dermatitis in Guangzhou, China: Modification by Age and Season.The short-term effect of ambient air pollution on atopic dermatitis (AD), along with its effect modifiers, has not been fully addressed in previous studies.To examine the short-term associations between air pollution and AD, and identify effect modifications by age and season.We used the Generalized Additive Model to evaluate the short-term effect of ambient air pollution […]
- Laugier-Hunziker syndrome: a case report of the pediatric patient and review of the literature.Laugier-Hunziker syndrome (LHS) is a rare, idiopathic pigmentary disorder especially affecting the lips and oral mucosa. At present, no more than 200 cases of patients diagnosed with LHS syndrome have been described worldwide. To date, three patients under the age of 20 have been described, including the youngest patient who is a 12-year-old child. The […]
- Chronic Ulcers and Malnutrition in an African Patient.An 11-year-old girl with a congenitally malformed left hand, sickle cell trait, asthma, and history of appendicitis was transferred from Zambia for evaluation and treatment of widespread suppurative and ulcerative skin lesions that typically appeared after trauma to her skin. The ulcers first presented 3 years earlier but had markedly worsened in the 9 months before […]
- Classic Ehlers-Dalnos syndrome presenting as atypical chronic haematoma: a case report with novel frameshift mutation in COL5A1.Ehlers-Danlos syndrome (EDS) is a group of inherited connective tissue disorders characterized by skin hyperextensibility, joint hypermobility and soft tissue vulnerable to blunt injury. Early recognition and diagnosis are crucial to patients to provide appropriate treatment, as well as to screen for life-threatening conditions such as aortic dissection and hollow organ perforation. The diagnosis of […]
- Study protocol: parents as pain management in Swedish neonatal care – SWEpap, a multi-center randomized controlled trial.During the first period of life, critically ill as well as healthy newborn infants experience recurrent painful procedures. Parents are a valuable but often overlooked resource in procedural pain management in newborns. Interventions to improve parents’ knowledge and involvement in infants’ pain management are essential to implement in the care of the newborn infant. Neonatal […]
- Systematic Review of Mohs Micrographic Surgery in Children: Identifying Challenges and Practical Considerations for Successful Application.Few data exist to guide the application of Mohs micrographic surgery (MMS) in the pediatric population.To summarize the clinical characteristics of children undergoing MMS, identify challenges that limit the use of MMS in this population, and examine how these challenges can be overcome.A systematic review of PubMed and EMBASE, from inception of databases to November […]
- The global burden of atopic dermatitis: lessons from the GBD Study – 1990 to 2017.The Global Burden of Disease (GBD) Study provides an annually updated resource to study disease-related morbidity and mortality worldwide. Here we present the burden estimates for atopic dermatitis (AD), including data from inception of the GBD project in 1990 until 2017. Atopic dermatitis (AD) ranks 15th among all non-fatal diseases and has the highest disease […]
- Randomised controlled trial of topical corticosteroid and home-based narrowband UVB for active and limited vitiligo – results of the HI-Light Vitiligo trial.Evidence for the effectiveness of vitiligo treatments is limited.To determine effectiveness of (a) hand-held narrowband-UVB (NB-UVB) and (b) combination of potent topical corticosteroid (TCS) and NB-UVB compared to TCS, for localised vitiligo.Pragmatic, 3-arm, placebo-controlled RCT (9 months’ treatment; 12 months’ follow-up). Adults and children, recruited from secondary care and community, aged ≥5 years with active […]
- Pressure Urticaria in an Infant Appearing Similar to Physical Abuse.A healthy Hispanic boy was born via cesarean delivery after an uncomplicated pregnancy. At 4 weeks old , his parents brought him to the emergency department for bruising on both soles of the feet. At 6 weeks old, his parents brought him to primary care for new bruises on his arms and back. After evaluation, primary […]
- Interferon-γ Release Assays for Tuberculosis Infection Diagnosis in Refugees <5 Years Old.New guidelines support using interferon-γ release assays (IGRAs) in children ≥2 years for diagnosis of latent tuberculosis infection (LTBI). However, lack of experience in young children and concern that IGRAs are less sensitive than tuberculin skin tests (TSTs) limit their use. Our aim was to identify active tuberculosis (TB) cases among high risk children <5 […]
- Establishment of a pediatric trigger tool based on Global Trigger Tool to identify adverse drug events of children: experience in a Chinese hospital.The Global Trigger Tool (GTT),which is a method using “triggers” to review medical record retrospectively to identify possible adverse events. Several studies showed that the GTT was effective. However, there were only a few localized trigger tools that had been established to detect pediatric adverse drug events (ADEs) in China. This study aimed to establish […]
- Dupilumab provides favourable long-term safety and efficacy in children aged ≥ 6 to < 12 years with uncontrolled, severe atopic dermatitis: results from an open-label phase IIa study and subsequent phase III open-label extension study.Children aged ≥6 to <12 years with severe atopic dermatitis (AD) have limited treatment options. In a 16-week, randomized, placebo-controlled, phase III trial in children, dupilumab, a monoclonal antibody inhibiting interleukin (IL)-4/IL-13 signaling, significantly improved signs and symptoms with acceptable safety; longer-term safety and efficacy data are lacking.To report the pharmacokinetic profile and long-term safety […]
- Children of the Sun: a historical look at how pediatric light therapy shaped attitudes and behaviors toward sunbathing.Today, parents are warned to protect their children from the sun’s ultraviolet (UV) rays, the most preventable and leading cause of skin cancer. Yet, during the first half of the 20th century, the medical community widely extolled the health benefits of daily sunbaths for babies and children. What initially had begun as evidence-based medical therapies […]
- What are the best endpoints for Eczema Area and Severity Index and Scoring Atopic Dermatitis in clinical practice? A prospective observational study.Multiple strategies have been used to evaluate the minimal important change (MIC) of the Eczema Area and Severity Index (EASI) and Scoring Atopic Dermatitis (SCORAD). The meaningfulness of these MICs is not well established across all severities of atopic dermatitis (AD).To determine the MIC of percentage and absolute improvement of EASI and SCORAD scores in […]
- Symptom burden of atopic dermatitis in early childhood assessed from daily monitoring of symptoms and topical steroid usage.Disease burden of atopic dermatitis (AD) as number of days with symptoms and medical treatment has never been studied as measure of severity.To investigate risk factors for AD burden in the first 3 years of life.The Copenhagen Prospective Studies on Asthma in Childhood2010 included 700 children. AD burden was assessed by daily diary entries with […]
- Long-term sequelae secondary to snakebite envenoming: a single centre retrospective study in a Costa Rican paediatric hospital.Although devastating acute effects associated with snake envenoming are well described, the long-term sequelae resulting from these envenomings have not been adequately addressed, especially in the paediatric population. The aim of our study is to describe the clinical characteristics among paediatric patients in Costa Rica who developed long-term sequelae secondary to snakebite envenoming.Retrospective descriptive study […]
- An economic evaluation of the randomised controlled trial of topical corticosteroid and home-based narrowband UVB for active and limited vitiligo (The HI-Light Trial).Economic evidence for vitiligo treatments is absent.To determine the cost-effectiveness of (a) hand-held narrowband-UVB (NB-UVB) and (b) combination of topical corticosteroid (TCS) and NB-UVB compared to TCS for localised vitiligo.Cost-effectiveness analysis alongside a pragmatic, 3-arm, placebo-controlled RCT with 9 months’ treatment. 517 Adults and children (aged ≥5 years) with active vitiligo affecting <10% of skin […]
- Characteristics and Impacts of Itch in Children with Inflammatory Skin Disorders.Itch is a cardinal feature of pediatric disorders and can impair quality of life. However, few studies have addressed symptoms and impacts of itch in pediatric patients.We focused on understanding the child’s experience of itch and impact of itch specifically on affected children, including by comparison with the adult experience.Semi-structured interviews (9 parents/15 children with […]
- Characteristics and Impacts of Itch in Children with Inflammatory Skin Disorders.Itch is a cardinal feature of pediatric disorders and can impair quality of life. However, few studies have addressed symptoms and impacts of itch in pediatric patients.We focused on understanding the child’s experience of itch and impact of itch specifically on affected children, including by comparison with the adult experience.Semi-structured interviews (9 parents/15 children with […]
- Household Food Security and Infant Adiposity.Food insecurity has been associated with obesity, but previous studies are inconsistent and few included infants. We examined associations between household food security and infant adiposity and assessed the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) and Supplemental Nutrition Assistance Program (SNAP) as effect modifiers. We hypothesized that infants from food-insecure households […]
- What’s new in atopic eczema? An analysis of systematic reviews published in 2018. Part 1: prevention and topical therapies.This review is part of a series of annual updates that summarize the evidence base for atopic eczema (AE). The aim is to provide a succinct guide for clinicians on the key findings from 14 systematic reviews on the prevention and topical treatment of AE published or indexed in 2018. Various supplements, including long-chain polyunsaturated […]
- Adolescents exposed to discrimination: are they more prone to excessive internet use?The Internet may serve as a suitable environment for discriminated adolescents as they may consider the online space as the place where they have possibility to build social ties they are missing in their offline life or manage their self-presentation. Therefore, our aim was to explore the association between different types of discrimination by peers […]
- Capillary malformation-arteriovenous malformation syndrome. A multicenter study.Capillary malformation-arteriovenous malformation (CM-AVM) syndrome is a rare syndrome that associates characteristic skin lesions with fast-flow vascular malformations (FFVM) in one-third of patients. Few case series have been described, and none in Spain.We conducted an observational study of patients with CM-AVM syndrome diagnosed in 15 Spanish hospitals over 3 years. The main clinical, radiological, genetic findings […]
- Hidradenitis Suppurativa in Pediatric Patients.Interest and research in Hidradenitis Suppurativa (HS) has grown over the decade, resulting in expanded knowledge on the associated comorbidities and treatment efficacy. Knowledge on pediatric onset HS is still limited, based upon case studies, small case series, and extrapolation from adult studies. With increasing prevalence of childhood obesity, lowering pubertal age and increasing awareness […]
- Prospective study of 5-day challenge with penicillins in children.To examine if a 5-day challenge with penicillin improves the diagnostic sensitivity compared with a single full dose in children with mild skin reactions.Subjects referred with suspected allergy to penicillin were consecutively included. Irrespectively of the morphology of the index reaction and the result of specific IgE, all subjects underwent a two-step titrated drug provocation […]
- Autosomal recessive hypotrichosis with loose anagen hairs associated with TKFC mutations.Loose anagen hair is a rare form of impaired hair anchorage in which anagen hairs that lack inner and outer root sheaths can be gently and painlessly plucked from the scalp. Usually occurring in children and often self-limiting, a genetic basis to the disorder has been suggested but not proven. A better understanding the aetiology […]
- International recommendations for an effective control of head louse infestations.Head louse infestations continue to be a concern of public health in most countries, including the most developed ones. The present recommendations are intended to inform and stress the role and impact of the different authorities, institutions, industry, and the public in the control of head lice in order to reduce the prevalence of this […]
- Diagnosis of Mycoplasma aetiology in Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.We were pleased that the first national guidelines for paediatric Stevens-Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN) were published in your journal last year1 . They highlighted the higher rate of infectious triggers in children compared to adults. This message is especially important for us, as author SW’s son had SJS/TEN triggered by Mycoplasma […]
- Water hardness and a possible genetic link with eczema in children.Previous studies have found a possible link between the risk of children developing atopic eczema, and hardness of the water used at home. The harder the water (containing more calcium), the more children seemed to develop eczema. Yet a study in children with eczema using water softeners to reduce water hardness had shown no difference […]
- Serum level and clinical significance of vitamin E in children with allergic rhinitis.Allergic rhinitis (AR) is one of the most prevalent allergic diseases in children. This study aimed to investigate the association between serum concentrations of vitamin E and AR to determine if the vitamin E level is correlated with the occurrence and severity of AR.A total of 113 children were enrolled in this cross-sectional study. Sixty-five […]
- Management of nail psoriasis.Nail involvement is estimated to affect 80-90% of patients with psoriasis at some point in their lives and is often associated with severe disease. Patients with nail involvement experience pain, functional impairment and social stigma, with significant restriction of daily activities and quality of life. Nail psoriasis is also considered a risk factor for the […]
- Shades of grey: what is paediatric psoriasiform dermatitis and what does it have in common with childhood psoriasis?While the majority of children with a chronic itchy rash suffer from atopic dermatitis (AD) and other forms of dermatitis, psoriasis is in the differential diagnosis. Certain patterns such as guttate and napkin psoriasis are accepted as classic paediatric psoriasis (PP), however there are many patients who do not fit these classic forms of OO […]
- Development of locally relevant clinical guidelines for procedure-related neonatal analgesic practice in Kenya: a systematic review and meta-analysis.Background Increasing numbers of neonates are undergoing painful procedures in low-income and middle-income countries, with adequate analgesia seldom used. In collaboration with a multi-disciplinary team in Kenya, we aimed to establish the first evidence-based guidelines for the management of routine procedure-related neonatal pain that consider low-resource hospital settings.We did a systematic review by searching MEDLINE, […]
- Development of locally relevant clinical guidelines for procedure-related neonatal analgesic practice in Kenya: a systematic review and meta-analysis.Background Increasing numbers of neonates are undergoing painful procedures in low-income and middle-income countries, with adequate analgesia seldom used. In collaboration with a multi-disciplinary team in Kenya, we aimed to establish the first evidence-based guidelines for the management of routine procedure-related neonatal pain that consider low-resource hospital settings.We did a systematic review by searching MEDLINE, […]
- Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study.The risk of vertical and perinatal transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, which causes COVID-19), the most appropriate management, and the neonate’s risk of developing COVID-19 during the perinatal period are unknown. Therefore, we aimed to elucidate best practices regarding infection control in mother-newborn dyads, and identify potential risk factors associated with […]
- Prostaglandin D2 metabolite is not a useful clinical indicator for assessing atopic dermatitis.Prostaglandin D2 (PGD2 ) plays an important role in atopic dermatitis (AD) and 11, 15-dioxo-9α-hydroxy-, 2, 3, 4, 5-tetranorprostan-1, 20-dioicacid (PGDM) is a major metabolite of PGD2 . We investigated the relationship between the urinary-PGDM levels and the severity of pediatric AD. Thirty-one AD and 21 non-AD subjects were recruited, and urinary-PGDM levels were measured. […]
- Clinical presentation, sonographic features and treatment options of segmental stiff skin syndrome: a case series.Segmental stiff skin syndrome (SSSS) is a rare genetic connective tissue disease, which is often misdiagnosed. High-frequency ultrasonography can represent a useful clinical adjunct in the differential diagnosis of this condition, in conjunction with the clinical and histopathological findings. Treatment options are limited and evidence is scarce. We present the clinical, sonographic and histological features […]
- Intensive care needs and long-term outcome of pediatric toxic epidermal necrolysis – A 10-year experience.Toxic epidermal necrolysis (TEN) is a life-threatening severe cutaneous adverse reaction. Data on pediatric TEN is limited.Case records of 44 children, 1 month-12 years with a diagnosis of TEN (>30% body surface area [%BSA] detachment) admitted to a tertiary pediatric intensive care unit (PICU) between 2009 and 2018 were analyzed retrospectively. The primary outcome was mortality, and […]
- Cutaneous Reactions in Children Treated with MEK Inhibitors, BRAF Inhibitors, or Combination Therapy: A Multi-Center Study.Treatment with BRAFI and MEKI causes cutaneous reactions in children limiting dosing or resulting in treatment cessation. The spectrum and severity of theses reactions is not defined.To determine the frequency and spectrum of cutaneous reactions in children on BRAFI and MEKI and their effects on continued therapy.A multi-center, retrospective study was conducted at 11 clinical […]
- Transcutaneous bilirubinometry during and after phototherapy in preterm infants: a prospective observational study.To examine the accuracy of transcutaneous bilirubinometry (TCB) measurements during and after phototherapy (PT) in preterm infants.Prospective observational cohort study.Level III neonatal centre.Preterm infants (from 23+0 to 36+6 weeks of gestation) born between June 2017 and May 2018 requiring PT.TCB was measured from an exposed area of the skin (the sternum; TCBU) and the covered […]
- The efficacy and safety of treatments for infantile hemangiomas: a Bayesian network meta-analysis.Whether infantile hemangiomas (IHs) need to be treated and which treatment should be preferred are still controversial. We aimed to compare and rank the treatments and identify the optimal treatment for IHs. We searched PubMed, EMBASE, the Cochrane Library, Web of Science, and other sources for randomized controlled trials up to August 2019. We included […]
- Scabies coexisting with other dermatoses: the importance of recognizing multiple pathologies in resource-poor settings.Background Skin Neglected Tropical Diseases (NTDs) are a group of ten diseases often co-endemic in African rural communities and characterized by primary skin involvement. If not diagnosed and treated promptly, they can lead to long-term disfigurement, disability, stigmatization, and socioeconomic loss. Scabies is a parasitic disease and it was added in 2017 to the World […]
- A Retrospective Multicenter Study of Fatal Pediatric Melanoma.Pediatric melanoma is rare and diagnostically challenging.Characterize clinical and histopathological features of fatal pediatric melanomas.Multi-center retrospective study of fatal melanoma cases in patients under 20 years diagnosed between 1994-2017.Of 38 cases of fatal pediatric melanoma identified, 57% presented in Caucasian patients and 19% in Hispanic patients. Average age at diagnosis was 12.7 years (range 0.0-19.9) […]
- No evidence of SARS-Cov-2 infection by PCR or serology in children with pseudochilblain.Despite its aggressive clinical course, leading to 6.4% fatality rate as of May 25, 2020 (https://qap.ecdc.europa.eu/public/extensions/COVID-19/COVID-19.html), COVID-19 turned out to be only marginally aggressive in children. In a report from Lombardy, 18/88 COVID-19 hospitalized adults (20%) had developed cutaneous manifestations: erythematous rash, widespread urticarial, and chickenpox-like vesicles. Trunk was the main involved region. Itching was […]
- Multisystem Inflammatory Syndrome in Children in New York State.A multisystem inflammatory syndrome in children (MIS-C) is associated with coronavirus disease 2019. The New York State Department of Health (NYSDOH) established active, statewide surveillance to describe hospitalized patients with the syndrome.Hospitals in New York State reported cases of Kawasaki’s disease, toxic shock syndrome, myocarditis, and potential MIS-C in hospitalized patients younger than 21 years […]
- The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review.Early antibiotic exposure may be contributing to the onset of childhood allergies. The main objective of this study was to conduct a systematic review on the relationship between early life antibiotic exposure and childhood asthma, eczema and hay fever.Pubmed and Embase were searched for studies published between 01-01-2008 and 01-08-2018, examining the effects of (1) […]
- Review of Transition of Care Literature: Epidermolysis Bullosa, A Paradigm for Patients with Complex Dermatologic Conditions.Transition from pediatric to adult care is a critical component of healthcare for children with chronic needs. The characteristics of epidermolysis bullosa (EB) demand higher than average levels of provider support. There is consensus among health care professionals regarding the importance of transition, however, there is a scarcity of practical information regarding models for patients […]
- Malnutrition in children with ichthyosis: recommendations for monitoring from a multidisciplinary clinic experience.Short stature has been reported in congenital ichthyoses (CI) but little data exist on patients’ nutritional status.To describe the nutritional status at the first evaluation of children and young adults with CI.Prospective observational study of patients assessed at a multidisciplinary clinic. Clinical variables and ichthyosis severity were collected. Anthropometric assessment was made measuring weight and […]
- What’s new in atopic eczema? An analysis of systematic reviews published in 2018. Part 2: systemic therapies.This review forms part of an annual update series on atopic eczema (AE), where systematic reviews (SRs) are gathered and appraised to provide a summary of key recent research findings. The focus of this article is systemic therapies used in AE, while a review on prevention and topical therapies is provided in Part 1. In […]
- Pros and cons of pre-emptive screening programmes before peanut introduction in infancy.Peanut allergy is an important public health concern and causes substantial psychosocial comorbidity. Although fatal anaphylaxis is rare (occurring at 0·03-0·3 per million person-years in the general population), peanuts are one of the most frequent causes of food allergy mortality. The Learning Early About Peanut study transformed prevention of peanut allergy by showing that early […]
- Cross-Sectional Evaluation of the Pediatric Baseline Series in Detection of Contact Sensitization in Children.Click here to read the full article @ Journal of the American Academy of Dermatology
- Psychosocial and psychiatric comorbidities and health-related quality of life in alopecia areata: a systematic review.Alopecia areata (AA) is an immune-mediated disease resulting in non-scarring hair loss. Systematic reviews on the psychosocial and psychiatric comorbidities, health-related quality of life, and interventions targeting psychosocial well-being are limited.To conduct a systematic review of the psychosocial comorbidities, health-related quality of life, and treatment options targeting psychosocial well-being in adult and pediatric AA patients.A […]
- Views and experiences of managing eczema: systematic review and thematic synthesis of qualitative studies.The number of qualitative studies on eczema has increased rapidly in recent years. Systematically reviewing these can provide greater understandings of people’s perceptions of eczema and eczema treatments.We sought to systematically review and thematically synthesise qualitative studies exploring views and experiences of people with eczema and parents/carers of children with eczema.We searched MEDLINE, PsycINFO, CINAHL […]
- In-Hospital Formula Feeding and Breastfeeding Duration.In-hospital formula feeding (IHFF) of breastfed infants is associated with shorter duration of breastfeeding. Despite evidence-based guidelines on when IHFF is appropriate, many infants are given formula unnecessarily during the postpartum hospital stay. To account for selection bias inherent in observational data, in this study, we estimate liberal and conservative bounds for the association between […]
- A 8- year Bangladeshi girl with disseminated histoplasmosis, presented as chronic liver disease with portal hypertension: a rare case report.Histoplasmosis is a rare infectious condition with mainly pulmonary involvement. Disseminated histoplasmosis may occur in immunocompromised condition. It can present in different ways but jaundice and ascites is very uncommon.A 8- year old girl visited to department of pediatric gastroenterology & nutrition, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Child presented with fever, jaundice and […]