The Latest Osteoarthritis Journal Articles

Keep up to date with the latest in osteoarthritis. Check out the latest osteoarthritis articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily

• Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis.27th April 2021
  To determine how gene expression profiles in osteoarthritis joint tissues relate to patient phenotypes and whether molecular subtypes can be reproducibly captured by a molecular classification algorithm.We analysed RNA sequencing data from cartilage and synovium in 113 osteoarthritis patients, applying unsupervised clustering and Multi-Omics Factor Analysis to characterise transcriptional profiles. We tested the association of […]
• Towards sex-specific osteoarthritis risk models: evaluation of risk factors for knee osteoarthritis in males and females.25th April 2021
  The aim of this study was to identify sex-specific prevalence and strength of risk factors for the incidence of radiographic knee osteoarthritis (incRKOA).Our study population consisted of 10,958 Rotterdam Study participants free of knee OA in one/both knees at baseline. 1064 participants developed RKOA after a median follow-up time of 9.6 years. We estimated the […]
• The impact of comorbidities on health-related quality of life of people with osteoarthritis over ten years.19th April 2021
  To investigate the impact of total number and patterns of comorbidities on health-related quality of life (HRQoL) and identify the most prevalent and influential comorbidity patterns in people with osteoarthritis (OA) over ten years.Participants from the Tasmanian Older Adult Cohort aged 50-80 years, with self-reported OA and data on comorbidities and HRQoL were included. Participants […]
• Reduction of Smad2 caused by oxidative stress leads to necrotic death of hypertrophic chondrocytes associated with an endemic osteoarthritis.26th March 2021
  The occurrence and development of an endemic osteoarthritis Kashin-Beck Disease (KBD) is closely related to oxidative stress induced by free radicals. The aim of the study was to find the key signalling molecules or pathogenic factors as a potential treatment strategy for KBD.Real-time PCR and western blotting were performed to detect the mRNA and protein […]
• Multifocal Calcific Periarthritis with Distinctive Clinical and Radiological Features in Patients with CD73 Deficiency.21st March 2021
  Arterial calcification due to deficiency of CD73 (ACDC) is a hereditary autosomal recessive ectopic mineralization syndrome caused by loss-of-function mutations in the 5′-nucleotidase Ecto (NT5E) gene. Periarticular calcification has been reported but the clinical characterization of arthritis as well as the microstructure and chemical composition of periarticular calcifications and synovial fluid crystals has not been […]
• β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study.12th March 2021
  To examine the association between β-blocker prescription and first primary-care consultation for knee osteoarthritis (OA), hip OA, knee pain and hip pain.Data source: Clinical Practice Research Datalink. Participants aged ≥40 years in receipt of new oral β-blocker prescriptions were propensity score (PS) matched to an unexposed control. Cox proportional hazard ratios (HRs) and 95% confidence intervals […]
• Factors associated with longitudinal change of meniscal extrusion in overweight women without clinical signs of osteoarthritis.11th March 2021
  To identify variables associated with longitudinal change in meniscal extrusion, which might be used as possible targets for knee osteoarthritis (KOA) prevention.In a high-risk population of middle-aged overweight women, meniscal extrusion was assessed with magnetic resonance imaging (1.5 T, coronal proton density, in-plane resolution 0.5 mm2, Sante DICOM Editor) at baseline and after 30 months. Outcomes were the […]
• Relationship between the dynamics of telomere loss in peripheral blood leukocytes from osteoarthritis patients and mitochondrial DNA haplogroup.2nd March 2021
  The evaluation of the evolution of telomere length from peripheral blood leukocytes (PBL) in subjects from the Osteoarthritis Initiative (OAI) cohort in relation to the incidence of osteoarthritis (OA) and explore its possible interactive influence with the mitochondrial DNA (mtDNA) haplogroup.Dynamics of telomere sequence loss was quantified in PBL from initially healthy individuals, without symptoms […]
• The circadian clock: a central mediator of cartilage maintenance and osteoarthritis development?25th February 2021
  The circadian clock is a specialised cell signalling pathway present in all cells. Loss of clock function leads to tissue degeneration and premature aging in animal models demonstrating the fundamental importance of clocks for cell, tissue and organism health There is now considerable evidence that the chondrocyte circadian clock is altered in osteoarthritis (OA). The […]
• Osteoarthritis and risk of hospitalization for ambulatory care sensitive conditions: A general population-based cohort study.16th February 2021
  To determine the association between osteoarthritis (OA) and risk of hospitalization for ambulatory care sensitive conditions (HACSCs).We included all individuals aged 40-85 years who resided in Skåne, Sweden on 31st December 2005 with at least one healthcare consultation during 1998-2005 (n = 515 256). We identified those with a main diagnosis of OA between January 1, 1998 and December […]
• Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial.16th February 2021
  Thigh muscle weakness is associated with knee discomfort and osteoarthritis disease progression. Little is known about the efficacy of high-intensity strength training in patients with knee osteoarthritis or whether it may worsen knee symptoms.To determine whether high-intensity strength training reduces knee pain and knee joint compressive forces more than low-intensity strength training and more than […]
• Associations of blood pressure and arterial stiffness with knee cartilage volume in patients with knee osteoarthritis.12th February 2021
  To describe the associations of blood pressure and arterial stiffness with knee cartilage volume in patients with knee osteoarthritis (OA).A secondary analysis was performed on the data from participants of a randomized controlled trial, which identified the effects of vitamin D supplementation on knee structures and symptoms among patients with symptomatic knee OA. Brachial and […]
• Characteristics associated between the incidence of hip osteoarthritis and early hip complaints (CHECK study) within 10 years.12th February 2021
  To determine which baseline characteristics, especially clinically variables like pain, stiffness, physical functioning and disease variables, are associated with incident hip osteoarthritis (OA) within 10-years in first presenters with hip complaints.Data were obtained from the nationwide prospective Cohort Hip and Cohort Knee (CHECK) study (n = 1002). Incident hip OA was defined as fulfilling the clinical ACR […]
• Diagnostic criteria for early hip osteoarthritis; first steps, based on the CHECK study.12th February 2021
  Although there is a general focus on early diagnosis and treatment of hip osteoarthritis, there are no validated diagnostic criteria for early-stage hip OA. The current study aimed to take the first steps in developing diagnostic criteria for early-stage hip OA, using factors obtained through history taking, physical examination, radiography and blood testing at the […]
• Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review.9th February 2021
  Osteoarthritis (OA) is the most common joint disease, affecting an estimated more than 240 million people worldwide, including an estimated more than 32 million in the US. Osteoarthritis is the most frequent reason for activity limitation in adults. This Review focuses on hip and knee OA.Osteoarthritis can involve almost any joint but typically affects the […]
• The role of inflammation in mesenchymal stromal cell therapy in osteoarthritis, perspectives for post-traumatic osteoarthritis: a review.7th January 2021
  Osteoarthritis (OA) is a complex and highly prevalent degenerative disease affecting the whole joint, in which factors like genetic predisposition, gender, age, obesity and traumas contribute to joint destruction. ∼50-80% of OA patients develop synovitis. OA-associated risk-factors contribute to joint instability and the release of cartilage matrix fragments, activating the synovium to release pro-inflammatory factors […]
• Low rate of subsequent surgery and serious complications following intra-articular steroid injection for base of thumb osteoarthritis: national cohort analysis.7th January 2021
  Intra-articular steroid injection is commonly used to treat base of thumb osteoarthritis (BTOA), despite a lack of large scale data on safety and effectiveness. We estimate the incidence of serious complications and further procedures following BTOA injection, including the risk of post-operative serious surgical site infection for subsequent operative intervention.Hospital Episode Statistics data linked to […]
• Base of thumb osteoarthritis (BTOA) in UK interface services-a cohort and survey based study to assess current practice.28th December 2020
  Base of thumb osteoarthritis (BTOA) is a common age-related disease which has a significant negative impact upon quality of life, while little is known about structure and pathways of interface services. Our aim was to assess disease burden, referral pathways, service structure and management pathways in UK interface services.A structured questionnaire was carried out with […]
• Relationship between motion, using the GaitSmartTM system, and radiographic knee osteoarthritis: an explorative analysis in the IMI-APPROACH cohort.28th December 2020
  To assess underlying domains measured by GaitSmartTMparameters and whether these are additional to established OA markers including patient reported outcome measures (PROMs) and radiographic parameters, and to evaluate if GaitSmart analysis is related to the presence and severity of radiographic knee OA.GaitSmart analysis was performed during baseline visits of participants of the APPROACH cohort (n = 297). […]
• Mediation of the association between obesity and osteoarthritis by blood pressure, vessel wall stiffness and subclinical atherosclerosis.21st December 2020
  We investigated the role of blood pressure, vessel wall stiffness [pulse wave velocity (PWV)] and subclinical atherosclerosis markers [carotid intima-media thickness (cIMT), popliteal vessel wall thickness (pVWT)] as mediators of the association of obesity with OA.We used cross-sectional data from a subset of the population-based NEO study (n = 6334). We classified clinical hand and knee OA […]
• Does the 1-year Decline in Walking Speed Predict Mortality Risk Beyond Current Walking Speed in Adults With Knee Osteoarthritis?2nd December 2020
  To investigate whether walking speed at 1 timepoint, decline over the past 12 months, or both predict mortality risk over 11 years in adults with, or at risk of, knee osteoarthritis (OA).Using the data from the Osteoarthritis Initiative, we defined slow versus adequate walking speed as walking < 1.22 versus ≥ 1.22 m/s on a […]
• The clinical and cost effectiveness of splints for thumb base osteoarthritis: a randomized controlled clinical trial.30th November 2020
  To investigate the clinical effectiveness, efficacy and cost effectiveness of splints (orthoses) in people with symptomatic basal thumb joint OA (BTOA).A pragmatic, multicentre parallel group randomized controlled trial at 17 National Health Service (NHS) hospital departments recruited adults with symptomatic BTOA and at least moderate hand pain and dysfunction. We randomized participants (1:1:1) using a […]
• Prognostic factors for finger interphalangeal joint osteoarthritis: a systematic review.30th November 2020
  Radiographic hand OA affects one in five adults. Symptomatic hand OA can result in functional impairment, pain and reduced quality of life. A prevalent form of hand OA is IP joint OA, however prognostic factors for IP joint OA remain poorly understood. This systematic review aimed to identify prognostic factors for IP joint OA, and […]
• The association between change in bone marrow lesion size and change in tibiofemoral cartilage volume and knee symptoms.30th November 2020
  To describe the association between change in subchondral bone marrow lesions (BMLs) and change in tibiofemoral cartilage volume and knee symptoms in patients with symptomatic knee OA.In total, 251 participants (mean 61.7 years, 51% female) were included. Tibiofemoral cartilage volume was measured at baseline and 24 months, and BML size at baseline, 6 and 24 months. Knee pain […]
• Potential efficacy of dendritic cell immunomodulation in the treatment of osteoarthritis.29th November 2020
  Dendritic cells (DCs) are a cluster of heterogeneous antigen-presenting cells that play a pivotal role in both innate and adaptive immune responses. Rare reports have discussed their role in OA immunopathogenesis. Recently, DCs derived from the synovial fluid of OA mice were shown to have increased expression of toll-like receptors. Moreover, from in vitro studies […]
• Towards developing diagnostic criteria for early knee osteoarthritis: data from the CHECK study.27th November 2020
  There is a general consensus that a shift in focus towards early diagnosis and treatment of knee OA is warranted. However, there are no validated and widely accepted diagnostic criteria for early knee OA available. The current study aimed to take the first steps towards developing diagnostic criteria for early knee OA.Data of 761 individuals […]
• Constitutional morphological features and risk of hip osteoarthritis: a case-control study using standard radiographs.24th November 2020
  To evaluate the risk of association with hip osteoarthritis (OA) of 14 morphological features measured on standard antero-posterior pelvis radiographs.A case-control study of 566 symptomatic unilateral hip OA cases and 1108 controls without hip OA, using the Genetics of OA and Lifestyle database. Unaffected hips of cases were assumed to reflect pre-OA morphology of the […]
• Causal association of adipokines with osteoarthritis: a Mendelian randomization study.22nd November 2020
  This two-sample Mendelian randomization study aimed to delve into the effects of genetically predicted adipokine levels on OA.Summary statistic data for OA originated from a meta-analysis of a genome-wide association study with an overall 50 508 subjects of European ancestry. Publicly available summary data from four genome-wide association studies were exploited to respectively identify instrumental variables […]
• Efficacy and safety of fasinumab in patients with chronic low back pain: a phase II/III randomised clinical trial.17th November 2020
  To study the efficacy and safety of fasinumab in moderate-to-severe, chronic low back pain (CLBP).In this phase II/III, double-blind, placebo-controlled study, patients with CLBP aged ≥35 years with inadequate pain relief/intolerance to acetaminophen, non-steroidal anti-inflammatory drugs and opioids were randomised to fasinumab 6 or 9 mg subcutaneous every 4 weeks (Q4W), 9 mg intravenous every 8 weeks […]
• Risk of osteoarthritis in an incident cohort of people with psoriatic arthritis: a population-based cohort study.16th November 2020
  To determine the risk of a diagnosis of osteoarthritis (OA) in psoriatic arthritis (PsA) patients compared to patients with psoriasis and a general population cohort.Incident PsA patients aged 18-89 years at diagnosis were identified from the UK Clinical Practice Research Datalink between 1998 and 2014. All PsA patients were matched to two cohorts of patients […]
• Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials.16th November 2020
  To determine individual responses to ibuprofen gel or capsaicin cream for painful, radiographic knee OA using a series of n-of-1 trials.Twenty-two participants were allocated 5% ibuprofen gel (A) and 0.025% capsaicin cream (B) in random sequence (AB or BA). Patients underwent up to 3 treatment cycles, each comprising one treatment for 4 weeks, an individualized washout […]
• Machine-learning, MRI bone shape and important clinical outcomes in osteoarthritis: data from the Osteoarthritis Initiative.14th November 2020
  Osteoarthritis (OA) structural status is imperfectly classified using radiographic assessment. Statistical shape modelling (SSM), a form of machine-learning, provides precise quantification of a characteristic 3D OA bone shape. We aimed to determine the benefits of this novel measure of OA status for assessing risks of clinically important outcomes.The study used 4796 individuals from the Osteoarthritis […]
• Antidepressant and anticonvulsant prescription rates in patients with osteoarthritis: a population-based cohort study.11th November 2020
  There are signs that antidepressants and anticonvulsants are being prescribed more often for OA patients, despite limited evidence. Our objectives were to examine prescription rates and time trends for antidepressants and anticonvulsants in OA patients, to assess the percentage of long-term prescriptions, and to determine patient characteristics associated with antidepressant or anticonvulsant prescription.A population-based cohort […]
• Causal relationship of serum nutritional factors with osteoarthritis: a Mendelian randomization study.9th November 2020
  OA is the most common form of arthritis worldwide and has a major impact on the quality of life among the older population. This study aimed at determining the potential causal effects of several serum nutritional factors on OA.A total of seven serum nutritional factors were identified from genome-wide association studies. Summary statistics for OA […]
• Endotypes of primary osteoarthritis identified by plasma metabolomics analysis.7th November 2020
  To identify endotypes of osteoarthritis (OA) by a metabolomics analysis.Study participants included hip/knee OA patients and controls. Fasting plasma samples were metabolomically profiled. Common factor analysis and K-means clustering were applied to the metabolomics data to identify the endotypes of OA patients. Logistic regression was utilized to identify the most significant metabolites contributing to the […]
• Co-prescription of gabapentinoids and opioids among adults with and without osteoarthritis in the United Kingdom between 1995 and 2017.7th November 2020
  To produce national and regional estimates and trends for gabapentinoid-opioid co-prescribing rates in patients with OA, both in absolute terms and relative to matched controls without OA.Using the UK Clinical Practice Research Datalink database we first constructed age-sex-practice-date 1:1 matched cohorts of patients aged ≥40 years with and without a new diagnosis of OA between 1995-2017 […]
• Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis.7th November 2020
  Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been considered as primarily a disease of the articular cartilage, the participation of subchondral bone in the pathogenesis of OA has attracted increasing attention. This review summarises the microstructural and histopathological changes in subchondral bone during OA progression that are due, at […]
• Vitamin D receptor gene polymorphisms and osteoarthritis: a meta-analysis.4th November 2020
  To investigate the association of vitamin D receptor (VDR) gene polymorphisms with OA susceptibility.Meta-analyses were performed using allelic contrast, contrast of homozygotes, and recessive and dominant models to clarify the association between OA and VDR ApaI, BsmI, TaqI and FokI polymorphisms. Odds ratio (OR) and the corresponding 95% CI were obtained, and subgroup analyses were […]
• Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis.3rd November 2020
  Synovial fibroblasts (SFs) are one of the major components of the inflamed synovium in rheumatoid arthritis (RA). We aimed to gain insight into the pathogenic mechanisms of SFs through elucidating the genetic contribution to molecular regulatory networks under inflammatory condition.SFs from RA and osteoarthritis (OA) patients (n=30 each) were stimulated with eight different cytokines (interferon (IFN)-α, […]
• Precise targeting of miR-141/200c cluster in chondrocytes attenuates osteoarthritis development.28th October 2020
  Despite preclinical studies involving miRNA therapeutics conducted in osteoarthritis (OA) over the years, none of these miRNAs have yet translated to clinical applications, owing largely to the lack of efficient intra-articular (IA) delivery systems. Here, we investigated therapeutic efficacy of the chondrocyte-specific aptamer-decorated PEGylated polyamidoamine nanoparticles (NPs)-based miRNAs delivery for OA.The role of miR-141/200c cluster […]
• Quantitative and semi-quantitative assessment of synovitis on MRI and the relationship with symptoms in symptomatic knee osteoarthritis.24th October 2020
  Synovitis in symptomatic knee OA (KOA) is common and is associated with joint symptoms. Optimal synovial measurement on MRI is, however, unclear. Our aims were to examine the relationship between MRI measures of synovitis and knee symptoms in symptomatic KOA.Data from a randomized, multicentre, placebo-controlled trial (UK-VIDEO) of vitamin-D therapy in symptomatic KOA were utilized. […]
• OATargets: a knowledge base of genes associated with osteoarthritis joint damage in animals.20th October 2020
  To collate the genes experimentally modulated in animal models of osteoarthritis (OA) and compare these data with OA transcriptomics data to identify potential therapeutic targets.PubMed searches were conducted to identify publications describing gene modulations in animal models. Analysed gene expression data were retrieved from the SkeletalVis database of analysed skeletal microarray and RNA-Seq expression data. […]
• Expression of mitochondrial TSPO and FAM173B is associated with inflammation and symptoms in patients with painful knee osteoarthritis.17th October 2020
  To characterize the expression profiles of two nuclear-encoded mitochondrial genes previously associated with chronic pain, the translocator protein (TSPO) and family with sequence similarity 173B (FAM173B), in different knee compartments from patients with painful knee OA. Also, to examine their association with the joint expression of inflammatory cytokines/chemokines and clinical symptoms.The study was performed on […]
• A narrative review on measurement properties of fixed-distance walk tests up to 40 meters for adults with knee osteoarthritis.16th October 2020
  Knee osteoarthritis (OA) is a serious disease and has no cure to date. Knee OA is a leading cause of functional limitation, e.g., difficulty walking. Walking speed is one method of quantifying difficulty with walking, and should be assessed in clinical practice for adults with knee OA because it has prognostic value and is modifiable. […]
• (Ethic)Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial.15th October 2020
  To evaluate the efficacy of tocilizumab, an antibody against IL-6 receptor, in patients with hand osteoarthritis.This was a multicentre, 12-week, randomised, double-blind, placebo-controlled study from November 2015 to October 2018. Patients with symptomatic hand osteoarthritis (pain ≥40 on a 0-100 mm visual analogue scale (VAS) despite analgesics and non-steroidal anti-inflammatory drugs; at least three painful joints, […]
• Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene.15th October 2020
  Despite recent advances in the understanding of the genetic architecture of osteoarthritis (OA), only two genetic loci have been identified for OA of the hand, in part explained by the complexity of the different hand joints and heterogeneity of OA pathology.We used data from the Rotterdam Study (RSI, RSII and RSIII) to create three hand […]
• Targeting rehabilitation to improve outcomes after total knee arthroplasty in patients at risk of poor outcomes: randomised controlled trial.13th October 2020
  To evaluate whether a progressive course of outpatient physiotherapy offers superior outcomes to a single physiotherapy review and home exercise based intervention when targeted at patients with a predicted poor outcome after total knee arthroplasty.Parallel group randomised controlled trial.13 secondary and tertiary care centres in the UK providing postoperative physiotherapy.334 participants with knee osteoarthritis who […]
• Mendelian randomization provides evidence for a causal effect of higher serum IGF-1 concentration on risk of hip and knee osteoarthritis.7th October 2020
  How insulin-like growth factor-1 (IGF-1) is related to OA is not well understood. We determined relationships between IGF-1 and hospital-diagnosed hand, hip and knee OA in UK Biobank, using Mendelian randomization (MR) to determine causality.Serum IGF-1 was assessed by chemiluminescent immunoassay. OA was determined using Hospital Episode Statistics. One-sample MR (1SMR) was performed using two-stage […]
• Sustained-release diclofenac conjugated to hyaluronate (diclofenac etalhyaluronate) for knee osteoarthritis: a randomized phase 2 study.2nd October 2020
  To evaluate the efficacy and safety of diclofenac etalhyaluronate (DF-HA) (ONO-5704/SI-613), a novel DF-conjugated hyaluronate, in patients with knee OA in Japan.In this randomized, double-blind, placebo-controlled phase 2 study, patients were randomly assigned (1:1) to receive either 30 mg of DF-HA or placebo intra-articularly at weeks 0, 4 and 8 and were followed up for 24 weeks. […]
• Time-trends in Opioid Use Disorder Hospitalizations in Gout, Rheumatoid arthritis, Fibromyalgia, Osteoarthritis, and Low Back Pain.2nd October 2020
  To examine opioid use disorder (OUD)-related hospitalizations and associated healthcare utilization outcomes in people with five common musculoskeletal diseases.We used the U.S. National Inpatient Sample (NIS) data from 1998-2014 to examine the rates of OUD-hospitalizations (per 100,000 NIS claims overall), time-trends and outcomes in five, common rheumatic diseases, gout, rheumatoid arthritis (RA), fibromyalgia, osteoarthritis (OA), […]
• Effect of stem cell injections on osteoarthritis-related structural outcomes – a systematic review.2nd October 2020
  To systematically review the evidence for the efficacy of mesenchymal stem cell (MSC) injections in improving osteoarthritis-related structural outcomes.Ovid Medline and EMBASE were searched from their inception to April 2020 using MeSH terms and key words. Independent reviewers extracted data and assessed methodological quality. Qualitative evidence synthesis was performed due to the heterogeneity in interventions […]
• Criterion validity of ultrasound in the identification of calcium pyrophosphate crystal deposits at the knee: an OMERACT ultrasound study.29th September 2020
  To evaluate the discriminatory ability of ultrasound in calcium pyrophosphate deposition disease (CPPD), using microscopic analysis of menisci and knee hyaline cartilage (HC) as reference standard.Consecutive patients scheduled for knee replacement surgery, due to osteoarthritis (OA), were enrolled. Each patient underwent ultrasound examination of the menisci and HC of the knee, scoring each site for […]
• Association between meniscal volume and development of knee osteoarthritis.25th September 2020
  To assess the association between meniscal volume, its change over time and the development of knee OA after 30 months in overweight/obese women.Data from the PRevention of knee Osteoarthritis in Overweight Females study were used. This cohort included 407 women with a BMI ≥ 27 kg/m2, free of OA-related symptoms. The primary outcome measure was incident OA after 30 months, […]
• Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis.23rd September 2020
  Osteophytes are highly prevalent in osteoarthritis (OA) and are associated with pain and functional disability. These pathological outgrowths of cartilage and bone typically form at the junction of articular cartilage, periosteum and synovium. The aim of this study was to identify the cells forming osteophytes in OA.Fluorescent genetic cell-labelling and tracing mouse models were induced […]
• The association between psychological factors and pain exacerbations in hip osteoarthritis.17th September 2020
  To evaluate the association between psychological factors and pain exacerbations in people with hip OA.Eligible participants with symptomatic hip OA were instructed to complete online questionnaires every 10 days over a 90-day follow-up period. In addition, they were required to complete the questionnaire whenever they perceived they were experiencing a hip pain exacerbation. Hip pain exacerbation […]
• Risk of venous thromboembolism in knee, hip and hand osteoarthritis: a general population-based cohort study.17th September 2020
  Osteoarthritis is a leading cause of immobility and joint replacement, two strong risk factors for venous thromboembolism (VTE). We aimed to examine the relation of knee, hip and hand osteoarthritis to the risk of VTE and investigate joint replacement as a potential mediator.We conducted three cohort studies using data from The Health Improvement Network. Up […]
• TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis.8th September 2020
  Recently, necroptosis has attracted increasing attention in arthritis research; however, it remains unclear whether its regulation is involved in osteoarthritis (OA) pathogenesis. Since receptor-interacting protein kinase-3 (RIP3) plays a pivotal role in necroptosis and its dysregulation is involved in various pathological processes, we investigated the role of the RIP3 axis in OA pathogenesis.Experimental OA was […]
• Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration.5th September 2020
  To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics.This study includes n = 66 primary OA patients (41 knees and 25 hips), who underwent a joint replacement surgery, from which macroscopically unaffected (preserved, n = 56) and lesioned (n = 45) OA articular cartilage were collected [Research Arthritis […]
• Hospitalized Infections in People with Osteoarthritis: A National U.S. Study.3rd August 2020
  To study the incidence, time-trends and outcomes of serious infections in people with osteoarthritis.We used the 1998-2016 U.S. National Inpatient Sample data. We examined the epidemiology of five hospitalized, i.e., serious infections (opportunistic infections (OI), skin and soft tissue infections (SSTI), urinary tract infection (UTI), pneumonia, and sepsis/bacteremia) in people with osteoarthritis, using recommended weights. […]
• A roadmap to target interleukin-6 in osteoarthritis.22nd July 2020
  Joint inflammation is present in the majority of OA patients and pro-inflammatory mediators, such as IL-6, are actively involved in disease progression. Increased levels of IL-6 in serum or synovial fluid from OA patients correlate with disease incidence and severity, with IL-6 playing a pivotal role in the development of cartilage pathology, e.g. via induction […]