The Latest Osteoarthritis Journal Articles

Keep up to date with the latest in osteoarthritis. Check out the latest osteoarthritis articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily

• The association between psychological factors and pain exacerbations in hip osteoarthritis.17th September 2020
  To evaluate the association between psychological factors and pain exacerbations in people with hip OA.Eligible participants with symptomatic hip OA were instructed to complete online questionnaires every 10 days over a 90-day follow-up period. In addition, they were required to complete the questionnaire whenever they perceived they were experiencing a hip pain exacerbation. Hip pain exacerbation […]
• TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis.8th September 2020
  Recently, necroptosis has attracted increasing attention in arthritis research; however, it remains unclear whether its regulation is involved in osteoarthritis (OA) pathogenesis. Since receptor-interacting protein kinase-3 (RIP3) plays a pivotal role in necroptosis and its dysregulation is involved in various pathological processes, we investigated the role of the RIP3 axis in OA pathogenesis.Experimental OA was […]
• Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration.5th September 2020
  To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics.This study includes n = 66 primary OA patients (41 knees and 25 hips), who underwent a joint replacement surgery, from which macroscopically unaffected (preserved, n = 56) and lesioned (n = 45) OA articular cartilage were collected [Research Arthritis […]
• Hospitalized Infections in People with Osteoarthritis: A National U.S. Study.3rd August 2020
  To study the incidence, time-trends and outcomes of serious infections in people with osteoarthritis.We used the 1998-2016 U.S. National Inpatient Sample data. We examined the epidemiology of five hospitalized, i.e., serious infections (opportunistic infections (OI), skin and soft tissue infections (SSTI), urinary tract infection (UTI), pneumonia, and sepsis/bacteremia) in people with osteoarthritis, using recommended weights. […]
• A roadmap to target interleukin-6 in osteoarthritis.22nd July 2020
  Joint inflammation is present in the majority of OA patients and pro-inflammatory mediators, such as IL-6, are actively involved in disease progression. Increased levels of IL-6 in serum or synovial fluid from OA patients correlate with disease incidence and severity, with IL-6 playing a pivotal role in the development of cartilage pathology, e.g. via induction […]
• Multicenter validation of the DETAIL questionnaire for the screening of spondyloarthritis in patients with inflammatory bowel diseases.17th July 2020
  Spondyloarthritis (SpA) is among the most frequent extra-intestinal manifestations in inflammatory bowel diseases (IBD). In this study, we aimed to validate the DETection of Arthritis in Inflammatory bowel diseases (DETAIL) questionnaire in a multicenter cohort of IBD patients enrolled at eleven Gastroenterology Units.From October 2018 to March 2019, consecutive adult patients with IBD, either Crohn’s […]
• Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence.16th July 2020
  Previous work has established that the deacetylase sirtuin-1 (SIRT1) is cleaved by cathepsin B in chondrocytes subjected to proinflammatory stress, yielding a stable but inactive N-terminal (NT) polypeptide (75SIRT1) and a C-terminal (CT) fragment. The present work examined if chondrocyte-derived NT-SIRT1 is detected in serum and may serve as an investigative and exploratory biomarker of […]
• Effect of laser moxibustion for knee osteoarthritis: a multi-site double-blind randomized controlled trial.3rd July 2020
  To examine the effects of laser moxibustion on pain and function in patients with knee osteoarthritis.A double-blind randomized clinical trial (4-week treatment, 20-week follow-up) was conducted. A total of 392 symptomatic knee osteoarthritis patients with moderate or greater clinically significant knee pain were randomly assigned to laser treatment or sham laser control group (1:1). Twelve […]
• Initial analgesic prescriptions for osteoarthritis in the United Kingdom, 2000-2016.29th June 2020
  To examine trends in the initial prescription of commonly-prescribed analgesics and patient- as well as practice-level factors related to their selection in incident OA.Patients consulting with incident clinical OA between 2000-2016 were identified within The Health Improvement Network in the United Kingdom (UK) general practice. Excluded were patients who had history of cancer or were […]
• Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study.20th June 2020
  Click here to read the full article @ Rheumatology (Oxford, England)
• A Decline in Walking Speed is Associated with Incident Knee Replacement in Adults with and at Risk for Knee Osteoarthritis.17th June 2020
  To determine if a one-year change in walking speed is associated with receiving an incident knee replacement during the following year in adults with and at risk for knee osteoarthritis (OA).Using data from the Osteoarthritis Initiative, we determined a one-year change in 20- meter walk speed from three observation periods (i.e., 0-12, 12-24, and 24-36 […]
• The inverse OARSI-OMERACT criteria is a valid indicator of the clinical worsening of knee osteoarthritis: data from the Osteoarthritis Initiative.17th June 2020
  We assessed if the inverse OARSI-OMERACT criteria relate to concurrent radiographic knee osteoarthritis (KOA) progression and decline in walking speed as well as future knee replacement.We conducted knee-based analyses of data from the Osteoarthritis Initiative. All knees had symptomatic osteoarthritis: at least doubtful radiographic KOA (Kellgren-Lawrence Grade≥1) and knee pain≥10/100 (WOMAC pain) at the 12-month […]
• To what extent is severe osteoarthritis preventable? Occupational and non-occupational risk factors for knee and hip osteoarthritis.14th June 2020
  To explore the relative contribution of cumulative physical workload, sociodemographic and lifestyle factors, as well as prior injury to hospitalization due to knee and hip OA.We examined a nationally representative sample of persons aged 30-59 years, who participated in a comprehensive health examination (the Health 2000 Study). A total of 4642 participants were followed from mid-2000 […]
• An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis.11th June 2020
  The objective of this study was to investigate whether diacerein has comparable efficacy with celecoxib in pain reduction for treatment in symptomatic knee OA patients.This randomized double-blind multicentre non-inferiority trial evaluated diacerein vs celecoxib treatment in patients with Kellgren-Lawrence grade 2-3 and pain scoring ≥4 (10-cm VAS). Patients were randomized to 6 months of treatment with […]
• Risks of solid cancers in elderly persons with osteoarthritis or ankylosing spondylitis.23rd May 2020
  Patients with osteoarthritis and ankylosing spondylitis have lower cancer-related mortality than the general population. We examined risks of solid cancers at 16 sites in elderly patients with knee or hip osteoarthritis (KHOA) or ankylosing spondylitis.In this population-based retrospective cohort study, we used US Medicare data from 1999 to 2010 to identify cohorts of persons with […]
• Incidence trend of five common musculoskeletal disorders from 1990 to 2017 at the global, regional and national level: results from the global burden of disease study 2017.17th May 2020
  To assess cause-specific incidence and its trend of musculoskeletal (MSK) disorders at global, regional and national levels.Data on MSK disorders were downloaded from the Global Burden of Disease 2017 study website. Estimated annual percentage change (EAPC) was calculated to quantify the temporal trend in age-standardised incidence rate (ASR) of MSK disorders, by age, sex, region […]
• Are OMERACT knee osteoarthritis ultrasound scores associated with pain severity, other symptoms, radiographic and MRI findings?17th May 2020
  To investigate the associations of Outcome Measures in Rheumatology (OMERACT) ultrasound scores for knee osteoarthritis (OA) with pain severity, other symptoms, and OA severity on radiographs and magnetic resonance imaging (MRI).Participants with symptomatic and mild-moderate radiographic knee OA underwent baseline dynamic ultrasound assessment according to standardized OMERACT scanning protocol. Using the published ultrasound image atlas, […]
• TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.16th May 2020
  FBXO6, a component of the ubiquitin E3 ligases, has been shown to bind high mannose N-linked glycoproteins and act as ubiquitin ligase subunits. Most proteins in the secretory pathway, such as matrix metalloproteinases, are modified with N-glycans and play important roles in the development of osteoarthritis (OA). However, whether FBXO6 exerts regulatory effects on the […]
• Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017.14th May 2020
  To report the level and trends of prevalence, incidence and years lived with disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by age, sex and Socio-demographic index (SDI; a composite of sociodemographic factors).Publicly available modelled data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 […]
• Effect of Biomechanical Footwear on Knee Pain in People With Knee Osteoarthritis: The BIOTOK Randomized Clinical Trial.13th May 2020
  Individually calibrated biomechanical footwear therapy may improve pain and physical function in people with symptomatic knee osteoarthritis, but the benefits of this therapy are unclear.To assess the effect of a biomechanical footwear therapy vs control footwear over 24 weeks of follow-up.Randomized clinical trial conducted at a Swiss university hospital. Participants (N = 220) with symptomatic, radiologically confirmed […]
• Does cartilage loss cause pain in osteoarthritis and if so, how much?9th May 2020
  Although treatment development in osteoarthritis (OA) focuses on chondroprotection, it is unclear how much preventing cartilage loss reduces joint pain. It is also unclear how nociceptive tissues may be involved.Using data from the Osteoarthritis Initiative, we quantified the relation between cartilage loss and worsening knee pain after adjusting for bone marrow lesions (BMLs) and synovitis, […]
• Trajectory analysis combining pain and physical function in individuals with knee and hip osteoarthritis: results from the French KHOALA cohort.7th May 2020
  The aims of this study were to identify homogeneous subgroups of knee and/or hip OA patients with distinct trajectories of the combination of pain and physical function (PF) over time and to determine the baseline factors associated with these trajectories.We used data from the Knee and Hip Osteoarthritis Long-term Assessment (KHOALA) cohort, a French population-based […]
• BCP crystals promote chondrocyte hypertrophic differentiation in OA cartilage by sequestering Wnt3a.7th May 2020
  Calcification of cartilage with basic calcium phosphate (BCP) crystals is a common phenomenon during osteoarthritis (OA). It is directly linked to the severity of the disease and known to be associated to hypertrophic differentiation of chondrocytes. One morphogen regulating hypertrophic chondrocyte differentiation is Wnt3a.Calcification and sulfation of extracellular matrix of the cartilage was analysed over […]
• Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain.5th May 2020
  The crosstalk between the immune and nervous system in the regulation of OA pain is increasingly becoming evident. GM-CSF signals in both systems and might be a new treatment target to control OA pain. Anti GM-CSF treatment has analgesic effects in OA without affecting synovitis scores, suggesting that treatment effects are not caused by local […]
• Phenylalanine is a novel marker for radiographic knee osteoarthritis progression: the MOST study.3rd May 2020
  To identify plasma markers associated with an increased risk of radiographic knee osteoarthritis (OA) progression using a metabolomics approach.Study participants were from the Multicenter Osteoarthritis Study (MOST) and were categorized into two groups based on the presence of baseline radiographic OA. Subjects in group 1 had unilateral knee OA and subjects in group 2 had […]
• Association between disease progression and depression onset in persons with radiographic knee osteoarthritis.26th April 2020
  Osteoarthritis (OA) disease progression may lead to deteriorating psychosocial function, but it is unclear what aspects of disease severity are related to the onset of depression. This study assessed which components of OA disease progression cumulatively contribute to depression onset in persons with radiographic knee OA.Osteoarthritis Initiative participants (n = 1651) with radiographic disease (Kellgren-Lawrence grade ≥2) […]
• Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions: A Randomized Clinical Trial.22nd April 2020
  A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with knee osteoarthritis, but data from large trials are lacking.To determine the effects of intravenous zoledronic acid on knee cartilage volume loss in patients with symptomatic knee osteoarthritis and bone marrow lesions.A 24-month multicenter, […]
• The contribution of age and obesity to the number of painful joint sites in individuals reporting osteoarthritis: a population-based study.20th April 2020
  To investigate the association of OA risk factors with number of painful joint sites in a representative population sample.Analysis of the 2009 Survey on Living with Chronic Diseases in Canada – Arthritis Component (n = 1614) for respondents reporting symptomatic OA. Variables: painful joints sites (hands, wrists, elbows, shoulders, hips, knees, ankles, feet, back, neck), joint symptom […]
• Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials.11th April 2020
  To identify predictors of the specific (difference between treatment and placebo) and overall (change from baseline in treatment arm) treatment effects of topical NSAIDs in OA.Randomized controlled trials (RCTs) of topical NSAIDs in OA were identified through systematic literature searching and inquiry to pharmaceutical companies. The raw, de-identified data were analysed in one-stage individual patient […]
• Horizontal fissuring at the osteochondral interface: a novel and unique pathological feature in patients with obesity-related osteoarthritis.10th April 2020
  Obesity is a well-recognised risk factor for osteoarthritis (OA). Our aim is to characterise body mass index (BMI)-associated pathological changes in the osteochondral unit and determine if obesity is the major causal antecedent of early joint replacement in patients with OA.We analysed the correlation between BMI and the age at which patients undergo total knee […]
• Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee.9th April 2020
  Both physical therapy and intraarticular injections of glucocorticoids have been shown to confer clinical benefit with respect to osteoarthritis of the knee. Whether the short-term and long-term effectiveness for relieving pain and improving physical function differ between these two therapies is uncertain.We conducted a randomized trial to compare physical therapy with glucocorticoid injection in the […]
• Diagnostic value of optical spectral transmission in rheumatoid arthritis: associations with clinical characteristics and comparison with joint ultrasonography.3rd April 2020
  To examine the value of optical spectral transmission (OST) in detecting joint inflammation in patients with rheumatoid arthritis (RA) and to evaluate whether OST correlates with certain patient characteristics.OST measurements were performed in the metacarpophalangeal, proximal intraphalangeal and wrist joints of 168 RA patients and 114 controls. OST difference between the two groups was statistically […]
• Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period.3rd April 2020
  Tanezumab, a nerve growth factor inhibitor, was investigated for osteoarthritis (OA) of the hip or knee in a study with 24-week treatment and 24-week safety follow-up.This double-blind, randomised, phase III study enrolled adults in Europe and Japan with moderate-to-severe OA who had not responded to or could not tolerate standard-of-care analgesics. Patients were randomised to […]
• Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice.25th March 2020
  Emerging evidence suggests that the microbiome plays an important role in the pathogenesis of osteoarthritis (OA). We aimed to test the two-hit model of OA pathogenesis and potentiation in which one ‘hit’ is provided by an adverse gut microbiome that activates innate immunity; the other ‘hit’ is underlying joint damage.Medical history, faecal and blood samples […]
• Association Between Surgical Approach and Major Surgical Complications in Patients Undergoing Total Hip Arthroplasty.18th March 2020
  Controversy exists about the preferred surgical approach for total hip arthroplasty (THA).To determine whether an anterior approach is associated with lower risk of complications than either a lateral or posterior approach.Population-based retrospective cohort study of all adults in Ontario, Canada, who had undergone primary THA for osteoarthritis between April 1, 2015, and March 31, 2018. […]
• Five-year evolution patterns of physical activity and sedentary behavior in patients with lower-limb osteoarthritis and their sociodemographic and clinical correlates.17th March 2020
  The present study aimed to identify trajectories of physical activity (PA) components (frequency, duration, intensity, type) and screen-based sedentary behavior (SB) as well as baseline predictors of each trajectory in patients with hip and/or knee OA.We included 878 patients with a 5-year follow-up from the KHOALA cohort. PA and SB were measured by the Modifiable […]
• The Association of an Increasing Waist Circumference and Risk of Incident Low Physical Function in Adults with Knee Osteoarthritis.17th March 2020
  To investigate an eight-year change in waist circumference (WC) with the risk of incident low physical function over one-year in adults with or at risk of knee osteoarthritis (OA).Data from the Osteoarthritis Initiative (OAI) were used. Change in WC was measured from study enrollment (0-month) to the 96-month visit and classified as Increase (≥ 5cm […]
• Metformin limits osteoarthritis development and progression through activation of AMPK signalling.12th March 2020
  In this study, we aim to determine the effect of metformin on osteoarthritis (OA) development and progression.Destabilisation of the medial meniscus (DMM) surgery was performed in 10-week-old wild type and AMP-activated protein kinase (AMPK)α1 knockout (KO) mice. Metformin (4 mg/day in drinking water) was given, commencing either 2 weeks before or 2 weeks after DMM surgery. […]
• Psychological and pain sensitisation characteristics are associated with patellofemoral osteoarthritis symptoms: The Multicenter Osteoarthritis Study.3rd March 2020
  Determine the relation of symptomatic and structural features of patellofemoral osteoarthritis (PFOA) to psychological characteristics and measures of pain sensitisation, in older adults with or at risk of knee OA.1112 participants from the Multicenter Osteoarthritis Study were included (713 females; mean±SD age 66.8±7.6 years, body mass index 29.5±4.8 kg/m2). Participants were grouped based on presence […]
• Intra-articular sprifermin reduces cartilage loss in addition to increasing cartilage gain independent of location in the femorotibial joint: post-hoc analysis of a randomised, placebo-controlled phase II clinical trial.27th February 2020
  In the phase II FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses (FORWARD) study, sprifermin demonstrated cartilage modification in the total femorotibial joint and in both femorotibial compartments by MRI in patients with knee osteoarthritis. Here, we evaluate whether sprifermin reduces cartilage loss and increases cartilage thickness, independent of location.Patients were randomised 1:1:1:1:1 to […]
• Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study.26th February 2020
  Statins are reported to have a potential benefit on progression of OA and on disease activity in RA, but existing evidence is conflicting. Our objective was to examine whether statins associate with reduction in the risk for joint replacement due to OA and RA.This was a propensity score-matched cohort study. Electronic health records from the […]
• Effects of Comorbid Cardiovascular Disease and Diabetes Mellitus on Hand Osteoarthritis, Pain, and Functional State Transitions.17th February 2020
  The purpose of this study is to examine the course of hand osteoarthritis (HOA) and its relationship with cardiovascular disease (CVD) and diabetes (DM).Data were collected at 3 time points from 845 Johnston County Osteoarthritis Project participants (2/3 women, 1/3 African-Americans, mean age 60 years) with and without HOA, CVD, or DM. A diagnosis of […]
• Opioid prescriptions in patients with osteoarthritis: a population-based cohort study.22nd January 2020
  To examine the incidence, prevalence and trends for opioid prescriptions in patients with OA. Furthermore, types of opioids prescribed and long-term prescription rates were examined. Finally, the patient characteristics associated with the prescription of opioids were assessed.A population-based cohort study was conducted using the Integrated Primary Care Information database. Incidence and prevalence of opioid prescriptions […]
• Statistical shape modelling provides a responsive measure of morphological change in knee osteoarthritis over 12 months.17th January 2020
  Responsive biomarkers are needed to assess the progression of OA and their lack has hampered previous clinical trials. Statistical shape modelling (SSM) from radiographic images identifies those at greatest risk of fast-progression or joint replacement, but its sensitivity to change has not previously been measured. This study evaluates the responsiveness of SSM in knee OA […]
• The burden of osteoarthritis: self-reported severity in the KHOALA population-based cohort.1st January 2020
  Lay descriptions of mild, moderate and severe disease states have been utilized in Global Burden of Disease studies in the calculation of years lived with disability, and may be a useful brief starting point for clinical care. The primary aims of this study were to estimate the proportion of an OA cohort within each severity […]
• Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease.20th December 2019
  In these studies, we examined the association of single nucleotide polymorphisms (SNPs) of the IL1RN gene with radiographic severity of symptomatic knee osteoarthritis (SKOA) and the risk of incident OA. We also explored these genetic polymorphisms in patients with new onset rheumatoid arthritis (RA).Over 1000 subjects who met American College of Rheumatology criteria for tibiofemoral […]
• Does This Patient Have Hip Osteoarthritis?: The Rational Clinical Examination Systematic Review.18th December 2019
  Hip osteoarthritis (OA) is a common cause of pain and disability.To identify the clinical findings that are most strongly associated with hip OA.Systematic search of MEDLINE, PubMed, EMBASE, and CINAHL from inception until November 2019.Included studies (1) quantified the accuracy of clinical findings (history, physical examination, or simple tests) and (2) used plain radiographs as […]
• Health-related quality of life in patients with hand osteoarthritis from the general population and the outpatient clinic.3rd December 2019
  To investigate the association of hand osteoarthritis and concurrent hand and knee osteoarthritis with health-related quality of life (HRQoL) in the general population, and in patients consulting a rheumatology outpatient clinic.In the population-based NEO study, participants were recruited from the greater area of Leiden. In the HOSTAS study, patients with a rheumatologist’s diagnosis of hand […]
• When has a knee or hip replacement failed? A patient perspective.3rd December 2019
  To perform a qualitative study to define the patient perspective of what constitutes a failure of total joint replacement (TJR).We used the nominal group technique (NGT) with participants who had undergone elective total hip replacements (THR) and/or total knee replacements (TKR) to answer the question “When would you consider a knee or hip replacement to […]
• Use of recommended non-surgical knee osteoarthritis management in patients prior to totalv knee arthroplasty: a cross-sectional study.17th November 2019
  Our aim was to assess prior use of core recommended non-surgical treatment among patients with knee osteoarthritis (OA) scheduled for total knee arthroplasty (TKA); and, to assess potential patient-level correlates of underuse, if found.This was a cross-sectional study of patients undergoing TKA for primary knee OA at two provincial central intake hip and knee clinics […]
• Sleep quality is related to worsening knee pain in those with widespread pain: The Multicenter Osteoarthritis Study.17th November 2019
  We examined the association between sleep and odds of developing knee pain, and whether this relationship varied by status of widespread pain (WSP).At the 60-month visit of the Multicenter Osteoarthritis Study, sleep quality and restless sleep were each assessed by using a single item from two validated questionnaires; each sleep measure was categorized into three […]
• Correction: Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study.14th November 2019
  Click here to read the full article @ Annals of the rheumatic diseases
• FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice.31st October 2019
  This study aims to investigate the role and mechanism of FGFR3 in macrophages and their biological effects on the pathology of arthritis.Mice with conditional knockout of FGFR3 in myeloid cells (R3cKO) were generated. Gait behaviours of the mice were monitored at different ages. Spontaneous synovial joint destruction was evaluated by digital radiographic imaging and μCT […]
• Exosomes in intercellular communication and implications for osteoarthritis.20th October 2019
  Abstract: Osteoarthritis (OA) is the most prevalent of the musculoskeletal conditions and represents a significant public health burden. While degeneration of articular cartilage is a key feature, it is now increasingly recognized as a complex condition affecting the whole joint, with synovial inflammation present in a significant proportion of patients. As a secretory tissue, the […]
• Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial.9th October 2019
  Abstract: Sprifermin is under investigation as a disease-modifying osteoarthritis drug.To evaluate the effects of sprifermin on changes in total femorotibial joint cartilage thickness in the more symptomatic knee of patients with osteoarthritis.FORWARD (FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses) was a 5-year, dose-finding, multicenter randomized clinical trial conducted at 10 sites. Eligible participants […]
• The bulge sign – a simple physical examination for identifying progressive knee osteoarthritis: data from the Osteoarthritis Initiative.4th October 2019
  Abstract: To examine whether the presence of bulge sign or patellar tap was associated with frequent knee pain, progression of radiographic OA (ROA) and total knee replacement (TKR).This study included 4344 Osteoarthritis Initiative participants examined at baseline for bulge sign and/or patellar tap. The clinical signs were categorized as no (none at baseline and 2 […]
• Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture.27th September 2019
  Abstract: Globally, hip fractures are among the top 10 causes of disability in adults. For displaced femoral neck fractures, there remains uncertainty regarding the effect of a total hip arthroplasty as compared with hemiarthroplasty.We randomly assigned 1495 patients who were 50 years of age or older and had a displaced femoral neck fracture to undergo […]
• Self-reported painful joint count and assessor-reported tender joint count as instruments to assess pain in hand osteoarthritis.20th September 2019
  Abstract: To evaluate self-reported and assessor-reported joint counts for pain and their value in measuring pain and joint activity in hand OA patients.A total of 524 patients marked painful joints on hand diagrams. Nurses assessed tenderness upon palpation. Pain was measured with a visual analogue scale pain and the Australian/Canadian hand OA index subscale pain. […]
• Knee osteoarthritis risk in non-industrial societies undergoing an energy balance transition: evidence from the indigenous Tarahumara of Mexico.15th September 2019
  Abstract: Here, we propose that knee osteoarthritis is one such disease for which susceptibility is amplified by this energy balance transition.Support for our hypothesis comes from comparisons of knee radiographs, knee pain and anthropometry among men aged ?40 years in two populations: Tarahumara subsistence farmers in Mexico undergoing the energy balance transition and urban Americans […]
• Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative.1st September 2019
  Abstract: To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA).A Nucleic-acid Programmable Protein Arrays (NAPPA) platform was used to screen AAbs against 2125 human proteins in sera at baseline from participants free of radiographic KOA belonging to the incidence and non-exposed subcohorts of the Osteoarthritis Initiative […]