To describe a surgical approach that involves anterior segment reconstruction with CustomFlex Artificial Iris (CAI; HumanOptics, Erlangen, Germany) followed by Descemet membrane endothelial keratoplasty (DMEK) in complex eyes with corneal decompensation.Restrospective case series of eyes that underwent anterior segment restoration involving (1) synechiolysis of peripheral anterior synechiae and excision of iris remnants, (2) securing a […]
To compare the recurrence rate and surgical complications of retinopathy of prematurity (ROP) between patients treated with intravitreal injection of conbercept (IVC) and intravitreal injection of ranibizumab (IVR) within 6 months.A multicentral prospective, randomised controlled trial was applied from May 2017 to February 2019 for the infants diagnosed as aggressive posterior-ROP, zone I or posterior […]
To determine the cost-effectiveness of preloaded Descemet membrane endothelial keratoplasty (pDMEK) versus non-preloaded DMEK (n-pDMEK) for the treatment of Fuchs endothelial corneal dystrophy (FECD).From a societal and healthcare perspective, this retrospective cost-effectiveness analysis analysed a cohort of 58 patients with FECD receiving pDMEK (n=38) or n-pDMEK (n=30) from 2016 to 2018 in the Department of […]
It has been suggested that ocular antihypertensives are associated with an increased risk of nasolacrimal duct obstruction. This study aims to assess the effect of topical antihypertensive treatment on surgical outcomes for patients undergoing Dacryocystorhinostomy (DCR) with intubation.Single centre, retrospective analysis of 170 operations carried out on 144 patients between January 2014 and January 2019. […]
Orbital inflammatory disease (OID) encompasses a wide range of pathology including thyroid-associated orbitopathy (TAO), granulomatosis with polyangiitis (GPA), sarcoidosis and non-specific orbital inflammation (NSOI), accounting for up to 6% of orbital diseases. Understanding the underlying pathophysiology of OID can improve diagnosis and help target therapy.To test the hypothesis that shared signalling pathways are activated in […]
We examined the associations between the 6-year incidence of age-related macular degeneration (AMD) and vision-related quality of life (VRQoL), and the contribution of presenting visual acuity (VA), in an Asian population.Fundus images from the Singapore Chinese Eye Study, a population-based cohort study (baseline: 2009-2011; follow-up: 2015-2017), were graded using a modified Wisconsin age-related maculopathy grading […]
Narrowly focused surgical practice has become increasingly common in ophthalmology and may have an effect on surgical outcomes. Previous research evaluating the influence of surgical focus on cataract surgical outcomes has been lacking. This study aimed to evaluate whether surgeons’ exclusive surgical focus on cataract surgery influences the risk of cataract surgical adverse events.Population-based cohort […]
To evaluate the changes of retinal nerve fibre layer (RNFL) and ganglion cell layer/inner plexiform layer (GCL/IPL) with the severity of thyroid eye disease (TED).One hundred and forty-five eyes of 75 patients with TED and 70 eyes of 35 healthy controls were included. The eyes with TED were divided into mild group (35 eyes), moderate-to-severe […]
Un-operated cataract is the leading cause of vision loss worldwide, responsible for 33% of visual impairment, and half of global blindness. The study aimed to build a fast evaluation method utilizing Andersen’s utilization framework and identify predictors of cataract surgical rate in sub-Saharan Africa and China.The study was a cross-over ecological epidemiology study with a […]
To review the current published literature on the use of OCT angiography (OCTA) to help detect changes associated with the diagnosis of primary open-angle glaucoma.Searches of the peer-reviewed literature were conducted in March 2018, June 2018, April 2019, December 2019, and June 2020 in the PubMed and Cochrane Library databases. Abstracts of 459 articles were […]
Cogan’s anterior internuclear ophthalmoplegia (INO) is characterized by INO with inability to converge and commonly thought to be due to rostral midbrain lesion. A lesion outside midbrain that causes unilateral Cogan’s anterior INO combined with upgaze palsy and ataxia are rarely described.A 67-year old male presented with left Cogan’s anterior internuclear ophthalmoplegia (INO), left appendicular […]
The purpose of this study is to report the safety and efficacy of pars plana glaucoma drainage devices with pars plana vitrectomy using one of the vitrectomy sclerotomy sites for tube placement in patients with refractory glaucoma.Retrospective case series of 28 eyes of 28 patients who underwent combined pars plana glaucoma drainage device and pars […]
Hyperoxia-mediated inhibition of vascular endothelial growth factor (VEGF) in the retina is the main cause of impeded angiogenesis during phase I retinopathy of prematurity (ROP). Human retinal angiogenesis involves the proliferation, migration and vessel-forming ability of microvascular endothelial cells. Previous studies have confirmed that BTB and CNC homology l (BACH1) can inhibit VEGF and angiogenesis, […]
The dacryoendoscope is the only instrument that can observe the luminal side of the lacrimal passage with minimal invasiveness. It was developed to treat lacrimal passage obstructions by inserting a bicanalicular nasal stent with sheath-guided bicanalicular intubation (SG-BCI). The purpose of this study was to determine the outcomes of SG-BCI to treat lacrimal passage obstructions. […]
Main objective was to describe metastatic and survival rates in patients with small choroidal melanocytic lesions initially managed by observation.Retrospective, observational study of consecutive cases recruited from 2001 through 2018, followed for a median (mean, range) of 81.0 (89.3, 10-204) months in a tertiary referral centre for ocular oncology. 75 consecutive patients diagnosed with small […]
Numerous studies have confirmed the association of ambient temperature and air pollution with a higher risk of morbidities, yet few have addressed their effect on the ocular system. The purpose of this study was to assess the association between temperature, air pollution, and emergency room visits for conjunctivitis.In this case-crossover study, the records of all […]
To observe the characteristics of binocular integration and stereopsis in children with television torticollis.A retrospective study was carried out, where data were collected from 25 children with television torticollis as the disease group after refractive error correction and 25 normal children as the control group. A virtual reality system was used to assess and analyze […]
The corneal epithelium is a crucial barrier against pathogens, and when disrupted in the setting of certain underlying risk factors such as neurotrophic keratopathy (NK), may result in persistent epithelial defects (PEDs) of the cornea. Management is challenging and may require a variety of different approaches ranging from conservative medical therapy to surgical intervention. The […]
Outcome data are limited regarding early experience with brolucizumab, the most recently approved anti-vascular endothelial growth factor (VEGF) agent for the treatment of neovascular age-related macular degeneration (nAMD).To report clinical outcomes after intravitreous injection (IVI) of brolucizumab, 6 mg, for nAMD.This retrospective case series conducted at 15 private or academic ophthalmological centers in the United […]
This review describes therapeutic research programs for geographic atrophy (GA) due to age-related macular degeneration (AMD). We highlight clinical trial data from phase I, II, and III studies.There are currently no treatments for GA, a form of advanced AMD that causes significant visual morbidity. Currently, therapeutic candidates are being developed to delay further progression of […]
To evaluate the longitudinal course of consecutive esotropia following surgery for basic-type intermittent exotropia.Patients who underwent surgery (bilateral lateral rectus muscle recession [BLR] or unilateral lateral rectus muscle recession-medial rectus muscle resection [RR]) for the treatment of intermittent exotropia between 2011 and 2017 with a minimum follow-up period of 2 years were retrospectively reviewed. When […]
This review explores metabolic syndrome (MetS) as a risk factor that accelerates aging in retinal neurons and may contribute to the neurodegeneration seen in glaucomatous optic neuropathy (GON) and age-related macular degeneration (AMD).Both animal model experiments and epidemiologic studies suggest that metabolic stress may lead to aberrant regulation of a number of cellular pathways that […]
After removing the native vitreous during vitreoretinal surgery, an adequate substitute is required to ensure homeostasis of the eye. Current clinically used endotamponades (silicone oil, gases, semifluorinated alkanes) are effective in promoting retinal reattachment, but lead to complications such as emulsification, prolonged inflammation, blurred vision, raised intraocular pressure, cataract formation or the need for revision […]
Streptococcus is a common cause of post-traumatic endophthalmitis in children. This study aimed to analyse the clinical features, antibiotic susceptibilities and outcomes of traumatic endophthalmitis caused by streptococcus in preschool children.Patients aged ≤6 years with traumatic streptococcal endophthalmitis seen at Zhongshan Ophthalmic Center between January 2013 and December 2018 were included in this retrospective study.In […]
The natural course of a vortex vein varix, though not well understood, has been known to remain stable. However, here we report a novel case of a vortex vein varix that resolved after an extended period of monitoring.An asymptomatic 96-year-old Caucasian man was found to have a vortex vein varix. At his previous examination 13 […]
To evaluate biometric changes throughout the anterior chamber during accommodation and presbyopia using single image acquisition swept-source anterior-segment optical coherence tomography (AS-OCT).Anterior-segment images were obtained using a new swept-source AS-OCT device (ANTERION, Heidelberg Engineering) from healthy volunteers (n = 71) across two centers in this prospective observational case series. In one image acquisition, cornea through posterior lens, […]
To evaluate the surgical outcomes of patients with hereditary transthyretin amyloidosis (TTR-FAP) who underwent Ahmed glaucoma valve (AGV) implantation.A retrospective cohort study was performed on patients with a diagnosis of TTR-FAP secondary glaucoma, who underwent AGV implantation in our department, between November 2010 and July 2019. The cumulative probability of treatment success was measured with […]
To elucidate the influence of age and myopic shift on retinal development.This 1-year longitudinal study included 769 participants aged 6-17 years. Cycloplegic refraction, axial length and swept-source optical coherence tomography were examined at baseline and follow-up. The thickness changes in the retina, ganglion cell complex (GCC) and outer retinal layers (ORL) in the macular region […]
To determine the potential impact on visual outcomes of delayed treatment initiation in patients with neovascular age-related macular degeneration (nAMD).Post hoc analysis of anti-vascular endothelial growth factor treatment-naïve patients with nAMD from HARBOR. Time to treatment was defined as first ranibizumab injection date minus screening date. Comparisons were made between the prompt (≤ 6 days) […]
The purpose of this research was to evaluate the incidence, risk factors and complications of ocular graft-versus-host disease (GVHD) in a large single center study.Retrospective observational case series.This study included 283 patients who underwent hematopoietic stem cell transplantation (HSCT) between 2005 and 2020. Ocular GVHD was diagnosed according to the International Chronic Ocular GVHD Consensus […]
To compare long-term outcomes of primary versus secondary (postgraft failure) Boston keratoprosthesis type 1 (KPro) implantation.Medical records of patients at the Centre hospitalier de l’Université de Montréal having undergone KPro implantation between 2008 and 2017 were reviewed and included if they had a preoperative Snellen best-corrected visual acuity (BCVA) of 20/100 or worse and a […]
[Ophthalmic Surg Lasers Imaging Retina. 2021;52:110.]. View the full article @ Ophthalmic surgery, lasers & imaging retina Get PDF with LibKey Authors: João Pedro Marques
Sarcoidosis is a chronic multisystemic disease of unknown aetiology, characterised by non-caseating granulomas. Ocular involvement rate ranges from 30% to 60% among individuals with sarcoidosis, and can vary widely, making the diagnosis a challenge to the ophthalmologist. Cutaneous manifestations occur in about 22% of sarcoidosis cases, but eyelid involvement is rare. Eyelid swelling and nodules […]
To identify factors associated with successful treatment discontinuation in eyes with retinal vein occlusions (RVOs) and macular edema (ME) in real-world settings.Retrospective study of 214 eyes with RVO and ME with 24-month follow-up at five academic centers. Regression analyses identified factors associated with (1) successful treatment discontinuation for at least 6 months without fluid recurrence […]
To examine whether glaucomatous central visual field abnormalities can be more effectively detected using a qualitative, expert evaluation of the 10-2 test compared to the topographically corresponding central 12 locations of the 24-2 test (C24-2).Cross-sectional study.Eyes with a glaucomatous optic nerve appearance or ocular hypertension (n = 523) and healthy eyes (n = 107) were included as cases and […]
Flanged intrascleral haptic fixation (FISHF) is a useful method to secure intraocular lenses (IOLs) in eyes without capsular support. Biomechanical studies were conducted to support the use of this technique.Laboratory investigation METHODS: Haptics of 3-piece IOLs were passed through cadaveric human sclera using 30-gauge and 27-gauge needles. Flanges were created by melting 1.0 mm from […]
To determine the relationship between glaucoma severity and rate of falls, fear of falling, and avoidance of activities at-risk for falls.Cross-sectional study.Glaucoma patients (n=138), ages 55-90 years, with mild (n=61), moderate (n=54), and advanced (n=23) glaucoma in the better-eye based on the Glaucoma Staging System, and age-matched controls (n=50) were recruited from the Eye Clinics […]
To assess the in vivo physiology of retinal reattachment in humans using swept-source optical coherence tomography (SS-OCT) in real-time.Prospective case series.Fifteen consecutive patients with fovea-involving rhegmatogenous retinal detachment undergoing pneumatic retinopexy (PnR). SS-OCT was performed at presentation and frequent intervals immediately following PnR. Primary outcome was longitudinal assessment of early post-operative SS-OCT to establish stages […]
Obesity is a well-known risk factor for diabetes, but its association with diabetic retinopathy (DR) is inconclusive, in particular in Asians. We aimed to assess whether body mass index (BMI) is associated with the presence and severity of DR in Asian populations with diabetes.Pooled analysis of individual-level cross-sectional data from 10 010 adults with diabetes who […]
To report the clinical outcomes of the use of a novel, specially designed, scleral-fixated intraocular lens (IOL) for the correction of aphakia in the absence of capsular support of variable etiology in children.This is a retrospective, noncomparative, interventional case series of five eyes of five consecutive patients who underwent three-port pars plana vitrectomy and scleral […]
This study aimed to identify patient and appointment characteristics associated with no-shows to new patient appointments at a US academic ophthalmology department.Cross-sectional study.This was a study of all adult patients with new patient appointments scheduled with an attending ophthalmologist at Penn State Eye Center between January 1st and December 31st of 2019. A multiple logistic […]
Jeune syndrome is a rare skeletal dysplasia with an associated retinal dystrophy. The authors describe a case of progressive bilateral macular atrophy (with multimodal imaging) in a patient with Jeune syndrome who was followed over 13 years. This case, confirmed with genetic testing, highlights the importance of characterizing the relationship between phenotype and genotype in […]
The authors describe the case of a 25-year-old male who presented with a cilioretinal artery occlusion secondary to posterior scleritis. The patient had a history of juvenile spondyloarthritis that evolved into ankylosing spondylitis. Cilioretinal artery occlusion is a rare complication of posterior scleritis, having only been described once previously in the literature. This is the […]
To assess the incidence of unplanned return to the operating room (ROR) at ≤45 days or ≥46 days after primary retinal detachment (RD) surgery and correlate ROR with preoperative risk factors and visual outcomes.Retrospective Cohort Study METHODS: : A retrospective review of patients with primary retinal detachment surgery to assess for unplanned ROR between January […]
To characterize and compare patient-reported recovery of function after cataract or glaucoma surgery using a novel visual analog scale.Prospective observational cohort study METHODS: : Daily for two weeks and weekly thereafter, patients recovering from trabeculectomy, tube shunt implantation, or cataract extraction (CE) completed a diary-style questionnaire including visual analog scales (VAS; scored 0-100) grading pain […]
Torpedo maculopathy (TM) is a rare macular lesion involving the retinal pigment epithelium (RPE). This paper describes a retrospective case report of TM. In addition, the authors present a comprehensive systematic review of 110 cases found in the literature.A search for the term “torpedo maculopathy” was conducted on PubMed, Embase, and Web of Science databases […]
Most surgeons now utilize small-gauge (23- or 25-gauge) pars plana vitrectomy (PPV) with or without scleral buckling for repair of rhegmatogenous retinal detachments (RRD), in addition to primary scleral buckle (SB), but comparative data between the two gauges are limited.This study is an analysis of primary RRD repairs comparing 23- versus 25-gauge vitrectomy for PPV […]
Exfoliation syndrome is a systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates manifesting clinically in the anterior chamber of the eye. This disorder is the most commonly known cause of glaucoma and a major cause of irreversible blindness.To determine if exfoliation syndrome is associated with rare, protein-changing variants predicted to impair protein […]
The prevalence of age-related macular degeneration (AMD) varies from 6.8 to 18.3% for all forms of AMD and from 0.6 to 2.6% for late AMD according to race, suggesting the existence of genetic differences among races. The purpose of this study was to determine the genetic causes of differences in the prevalence of AMD among […]
Unhealthy alcohol use can lead to agitation in the intensive care unit (ICU).To assess whether high-dose baclofen reduces agitation-related events compared with placebo in patients with unhealthy alcohol use receiving mechanical ventilation.This phase 3, double-blind, placebo-controlled, randomized clinical trial conducted in 18 ICUs in France recruited adults receiving mechanical ventilation who met criteria for unhealthy […]
Photodynamic therapy (PDT) is known to occlude choroidal neovascularisation selectively, and there have been several reports on its adverse effects on the normal choroid and retinal pigment epithelium, resulting in decreased vision.This retrospective interventional case series aimed to investigate the changes in visual acuity and retinal thickness in the immediate post-treatment period after half-fluence PDT, […]
The use of a tissue patch graft is common practice with a glaucoma drainage device (GDD). Patch grafts can be visible in the palpebral fissure and may be cosmetically displeasing for some patients. The aim of this study was to report the cosmetic satisfaction of pericardial, scleral, and corneal patch grafts related to superior GDD […]
To determine whether eyes with pathologic myopia can be identified and whether each type of myopic maculopathy lesion in fundus photographs can be diagnosed by deep learning (DL) algorithms.A DL algorithm was developed to recognize myopic maculopathy features and to automatically categorize the myopic maculopathy.We examined 7020 fundus images from 4432 highly myopic eyes obtained […]
We describe an experience of a large-scale self-initiated recruitment of patients to a self-monitoring initiative for macular pathology over the COVID-19 pandemic.observational study with retrospective analysis.A total of 2272 patients from the Singapore National Eye Centre (SNEC) whose visits were rescheduled over lockdown (13 April to 1 June 2020) were offered participation in a self-monitoring […]
The presence of persistent choroidal hyper-transmission defects on custom en face OCT images can be used as a stand-alone precursor for the progression of drusen to geographic atrophy in age-related macular degeneration. View the full article @ Ophthalmology. Retina Get PDF with LibKey Authors: Yingying Shi, Jin Yang, William Feuer, Giovanni Gregori, Philip J Rosenfeld
To evaluate whether baseline demographic, clinical and optical coherence tomography (OCT) characteristics predict visual acuity outcomes in patients receiving anti-VEGF therapy for ME (macular edema) due to CRVO (central retinal vein occlusion).Post-hoc analysis of the randomized noninferiority trial (Lucentis, Eylea, Avastin in CRVO) – LEAVO Study from December 12, 2014, through December 16, 2016 carried […]
To introduce a novel method for assessment of retinal vasculitis using Swept Source OCT Angiography (SS-OCTA).Retrospective case series SUBJECTS: Patients with retinal vasculitis METHODS: The subjects were identified among the clinic population and imaged with 12 x 12 mm SS-OCTA scans centered on the fovea. A custom retina segmentation superimposed the color retinal thickness map […]
To analyze whether corneal refractive surgery (CRS) is associated with the distribution of different accommodative dysfunctions (ADs) and binocular dysfunctions (BDs) in civilian pilots. A further aim was to analyze the percentages and visual symptoms associated with ADs and/or BDs in this population.One hundred and eight civilian pilots who underwent CRS from January 2001 to […]
To evaluate longitudinal endothelial cell characteristics of children with posterior polymorphous corneal dystrophy (PPCD).In this prospective case-control study, children with PPCD were followed with slit-lamp photography and non-contact specular microscopy. Patient’s eyes were subdivided according to the clinical subtypes of PPCD (vesicular, band, diffuse, and unaffected) and the number of lesions present on the posterior […]
Globally, visual impairment affects about 285 million (4.25%) people, of those, 266.4 million were adults aged 18 years and above. Ethiopia is one of developing countries estimated to have high prevalence of visual impairment which have an enormous socio-economic impact. Also there is limited available information regarding with the magnitude of visual impairment among adults in […]
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