The Latest Ocular Oncology Journal Articles

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Keep up to date with the latest in ocular oncology. Check out the latest ocular oncology articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily

  • Genetic associations of central serous chorioretinopathy: a systematic review and meta-analysis.
    To identify single-nucleotide polymorphisms (SNPs) associated with central serous chorioretinopathy (CSCR) by a systematic review and meta-analysis, and to compare the association profiles between CSCR, neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV).We searched the EMBASE, PubMed and Web of Science for genetic studies of CSCR from the starting dates of the databases […]
  • Development and validation of a nomogram to predict cancer-specific survival of uveal melanoma.
    Uveal melanoma (UM) is a rare but aggressive cancer, which is the most common primary intraocular malignancy in adults. We aimed to develop and validate a competing risk nomogram to predict cancer-specific survival (CSS) of patients with UM, as well as compare its prognostic value with that of the American Joint Committee on Cancer (AJCC) […]
  • Evaluation of intravitreal topotecan dose levels, toxicity and efficacy for retinoblastoma vitreous seeds: a preclinical and clinical study.
    Current melphalan-based intravitreal regimens for retinoblastoma (RB) vitreous seeds cause retinal toxicity. We assessed the efficacy and toxicity of topotecan monotherapy compared with melphalan in our rabbit model and patient cohort.Rabbit experiments: empiric pharmacokinetics were determined following topotecan injection. For topotecan (15 μg or 30 µg), melphalan (12.5 µg) or saline, toxicity was evaluated by serial electroretinography […]
  • Partial lamellar sclerouvectomy surgery for anteriorly located uveal tumour resection: a 20-year experience.
    To investigate the results of partial lamellar sclerouvectomy (PLSU) for anteriorly located uveal tumours.We reviewed the tumour features, histopathologic findings, complications, visual acuity outcomes, eye preservation, metastasis, and mortality data of 56 cases with uveal tumours who underwent PLSU between February 1999 and February 2019.The mean largest tumour base diameters were 5.8 × 3.4 mm and the mean […]
  • Clinical Utility of Antiretinal Antibody Testing.
    The clinical utility of most antiretinal antibodies (retina antibodies) currently available for testing remains unclear and unproven. Despite this, the presence of retinal antibodies is included in current diagnostic autoimmune retinopathy criteria.To evaluate the clinical significance of comprehensive retinal antibody evaluations currently offered in North America.In this cross-sectional study, 14 patients without autoimmune retinopathy were […]
  • Long term outcomes of transcutaneous non-image guided bleomycin sclerotherapy in orbital/adnexal lymphatic malformations: a protocol-based management in 69 eyes.
    To study the efficacy and the long-term outcomes of treating micro and macrocystic orbital and/or adnexal lymphatic malformations (OA-LM) with protocol-based bleomycin sclerotherapy.A retrospective interventional study of 69 eyes having OA-LM treated with non-image guided transcutaneous or transconjunctival bleomycin sclerotherapy (1IU/ml aqueous solution) between December 2014 and December 2018. Based on clinical regression, the outcomes […]
  • Risk factors leading to trabeculectomy surgery of glaucoma patient using Japanese nationwide administrative claims data: a retrospective non-interventional cohort study.
    Early recognition and management of baseline risk factors may play an important role in reducing glaucoma surgery burdens. However, no studies have investigated them using real-world data in Japan or other countries. This study aimed to clarify the risk factors leading to trabeculectomy surgery, which is the most common procedure of glaucoma surgery, of glaucoma […]
  • Conjunctival melanoma: outcomes based on tumour origin in 629 patients at a single ocular oncology centre.
    To investigate clinical features and outcomes of conjunctival melanoma classified by tumour origin.Retrospective review of conjunctival melanoma patients at a single ocular oncology centre between April 18, 1974 and September 9, 2019. Lesions were divided into three tumour origin groups (primary acquired melanosis [PAM], nevus, and de novo) and clinical features and outcomes were compared.There […]
  • Epidemiological characteristics and clinical course of eyelid squamous cell carcinoma patients from a large tertiary centre between 2009 and 2020.
    To assess epidemiological tumour features, risk factors, clinical management and outcome of eyelid squamous cell carcinoma (SCC) and changes thereof. Furthermore, we searched for validating predictors of the American Joint Committee on Cancer (AJCC) 8 classification system.We evaluated data of 117 patients with histologically proven eyelid SCC at a large tertiary German university centre between […]
  • Survival in small choroidal melanocytic lesions with risk factors managed by initial observation until detection of tumour growth.
    Main objective was to describe metastatic and survival rates in patients with small choroidal melanocytic lesions initially managed by observation.Retrospective, observational study of consecutive cases recruited from 2001 through 2018, followed for a median (mean, range) of 81.0 (89.3, 10-204) months in a tertiary referral centre for ocular oncology. 75 consecutive patients diagnosed with small […]
  • Orbital exenteration for conjunctival melanoma: comparison of long-term outcome between individualised and conventional techniques.
    Growing evidence supports an individualised approach rather than radical surgery for conjunctival melanoma (CM). This study aimed to compare the long-term outcome between individualised and conventional exenteration techniques.Our study retrospectively recruited advanced CM (clinical T3 stage) patients treated with individualised (13 cases) or conventional (18 cases) exenteration from June 2014 to April 2019. The individualised […]
  • Uveal melanoma: laboratory advances and new frontiers in patient care.
    To review recent advancements in the genetic understanding, diagnosis, prognosis, and treatment of uveal melanoma (UM).UM is a molecularly distinct melanocytic malignancy driven by mutations in GNAQ or GNA11, with mitogen-activated protein kinase pathway upregulation. Earlier diagnosis and treatment are important factors for improving life prognosis. These goals can be aided by more objective multimodal […]
  • Optimising prediction of early metastasis-free survival in uveal melanoma using a four-category model incorporating gene expression profile and tumour size.
    Largest basal diameter (LBD) appears to have independent prognostic value in uveal melanoma (UM).All patients undergoing plaque brachytherapy or enucleation for UM involving the choroid and/or ciliary body between 2012 and 2019.A total of 348 patients with a mean age of 60±14 years were included and followed for a mean of 40±26 months (3.3±2.2 years). […]
  • Robotic assisted CyberKnife radiosurgery for the treatment of choroidal metastasis.
    Choroidal metastases occur in many patients with systemic cancer and limit quality of life due to visual deterioration or pain. The limited prognosis of these patients demand treatment approaches that aim at a quick response and easy application. We evaluated a robotic assisted radiosurgery device, the CyberKnife, in the treatment of choroidal metastasis.Following retrobulbar anaesthesia, […]
  • Orbital aspergillosis: a case report and review of the literature.
    Orbital aspergillosis is a rare sight- and life-threatening fungal infection affecting immunocompromised or otherwise healthy patients. It is often misdiagnosed due to its unspecific clinical and radiologic appearance. Therapeutic delay can have dramatic consequences. However, progress in microbiological diagnostic techniques and therapeutic experience from case series help improve the management of this disease.A 78-year-old immunocompetent […]
  • Population-based frequency of ophthalmic adverse events in melanoma, other cancers, and after immune checkpoint inhibitor treatment.
    To examine the frequency of ophthalmic immune-related adverse events (OirAEs) in melanoma, other cancers, and following immune checkpoint inhibitor (ICI) treatment.Retrospective clinical cohort study METHODS: This study identified patients diagnosed with OirAEs between January 1, 2011 and December 31, 2018 in the Kaiser Permanente Southern California electronic health records. The primary exposures of interest were […]
  • Proton beam irradiation of uveal melanoma involving the iris, ciliary body and anterior choroid without surgical localisation (light field).
    To assess treatment outcomes after proton beam irradiation (PBI) without surgical localisation of uveal melanomas involving the iris, ciliary body and anterior choroid.Retrospective chart review of 125 patients evaluated at Massachusetts Eye and Ear and treated with PBI using a light field set-up without localisation surgery between November 1975 and April 2017. The tumours were […]
  • Cascade screening for glaucoma in high-risk family members of African-Caribbean glaucoma patients in an urban population in London.
    Cascade screening has been used successfully in relatives of patients with inherited cancers and other genetic diseases to identify presymptomatic disease. This study was designed to examine if this approach would be successful in a high-risk group: first-degree relatives (FDR) of African-Caribbean glaucoma patients resident in London.African-Caribbean patients (probands) with glaucoma from an inner London […]
  • Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults.
    To examine associations between birth defects and cancer from birth into adulthood.Population based nested case-control study.Nationwide health registries in Denmark, Finland, Norway, and Sweden.62 295 cancer cases (0-46 years) and 724 542 frequency matched controls (matched on country and birth year), born between 1967 and 2014.Relative risk of cancer in relation to major birth defects, estimated as […]
  • Risk Factors and Disease Course for Blood-Brain Barrier Disruption-Associated Maculopathy.
    Blood-brain barrier disruption (BBBD) is a systemic therapy for malignant central nervous system (CNS) tumors that has been linked to poorly understood pigmentary maculopathy.To examine the rate of and risk factors for the development of BBBD-associated maculopathy and to assess whether there can be visually significant progression after completion of systemic therapy.In this retrospective case […]
  • Neoadjuvant vismodegib in the management of locally advanced periocular basal cell carcinoma.
    Vismodegib, a hedgehog pathway inhibitor, has been used in the management of locally advanced basal cell carcinoma (BCC) not suitable for surgery or radiation therapy. We report our experience using neoadjuvant vismodegib for locally advanced periocular BCC, followed by surgical excision. Our aim was to assess the effect on the extent of surgical excision and […]
  • Clinical outcomes of Modified Collaborative Ocular Melanoma Study IRIS plaques for treatment of iris, iridociliary, and ciliary body melanoma.
    To report clinical outcomes of modified Collaborative Ocular Melanoma Study IRIS (COMS IRIS) plaques for treatment of iris, iridociliary, and ciliary body melanoma.Retrospective, single-centre cohort study of iris melanoma treated with COMS IRIS plaque radiotherapy from July 26, 2010 to October 15, 2018. Medical records were reviewed for demographics, tumour features, treatment parameters, and clinical […]
  • Single B-cell Genomic Analyses Differentiates Vitreoretinal Lymphoma from Chronic Inflammation.
    To test whether analyzing DEPArrayTM-isolated single B cells from the vitreous fluid can reveal crucial genomic and clinicopathological features to distinguish patients with VRL from those with chronic inflammation using immunoglobulin heavy chain (IGH), disease biomarker MYD88L265P mutation, and copy number profiling.A single center, retrospective study.Remnant vitreous biopsies from seven patients with vitreoretinal lymphoma (VRL) […]
  • The natural history of conjunctival naevi in children and adolescents.
    The objective of this study is to characterise the natural history of conjunctival naevi in a paediatric and adolescent population.All children and adolescents referred to Moorfields Ocular Oncology Service for evaluation between January 2015 and 2020 were included. Exclusion criteria included age >20 years old and lack of anterior segment photographs. A total of 77 […]
  • Bilateral idiopathic orbital pseudotumour in a child: a case report.
    Idiopathic orbital pseudotumour is rare in children. We report a case of bilateral paediatric idiopathic orbital pseudotumour and review the characteristics of this case.A 14-year-old female patient presented at our Department of Pulmonary and Critical Care Medicine (PCCM) with complaints of recurrent severe cold and cough for 3 weeks, which had been treated with an intravenous […]
  • Unilateral retinoblastoma; natural history and an age-based protocol in 248 patients.
    We aimed to study the clinical state and prognosis of patients with unilateral retinoblastoma who were being treated at a paediatric comprehensive cancer centre in a limited-resource country, to assess the different phases of treatment and the success of different, more complex real-life models.In this retrospective study, we created a snapshot of our retinoblastoma database […]
  • Malignant acanthosis nigricans: a case report.
    To report a case of malignant acanthosis nigricans with two unusual aspects, including the patient’s young age and the development of filiform papillomas on the eyelid margins.A 30-year-old woman presented with dry eye symptoms. Examination revealed filiform papillomas on the eyelid margins, gums, lips, hands, and axillae and excessive pigmentation localized to the neck, axillae, […]
  • Postoperative severe visual impairment: surgical outcome of 165 patients with orbital tumours in the muscle cone.
    This study aimed to evaluate the risk factors of postoperative severe vision impairment (PSVI) for a primary orbital tumour in the muscle cone.A retrospective analysis of the patients who underwent orbitotomy for primary intraconal tumours at the Tianjin Medical University Eye Hospital from January 2010 to December 2015.A total of 165 cases of orbitotomy for […]
  • Association of Retinal Vascular Occlusion With Women Filling a Prescription for Female Hormone Therapy.
    Oral contraceptives have been associated with cardiovascular disease, ischemic stroke, venous thromboembolic disease, and breast cancer. Retinal vascular occlusions share the same risk factors as cardiovascular and cerebrovascular disease.To determine whether filling a prescription of female hormone therapy (FHT) is associated with an increased risk of retinal artery occlusion (RAO) or retinal vein occlusions (RVO).A […]
  • Optical coherence tomography angiography characteristics of choroidal melanoma.
    The purpose of this study is to evaluate tumour vasculature with optical coherence tomography angiography (OCTA) in malignant choroidal melanoma (CM).Patients with unilateral CM were included in this cross-sectional observational clinical study. Applying OCTA systems operating at 840-nm wavelengths, eyes with CM were imaged. The primary main outcome measures were OCTA images, qualitative evaluation of […]
  • Ophthalmic immune-related adverse events following anti-CTLA-4 or PD-1 therapy recorded in the American Academy of Ophthalmology IRIS® Registry.
    Detailed study of ophthalmic immune-related adverse events (OirAEs), including determination of incidence and recurrence rates, is of integral importance in the evolving field of cancer immunotherapy to inform management and treatment guidelines.Retrospective registry study SUBJECTS, PARTICIPANTS, AND/OR CONTROLS: Patients newly diagnosed with OirAEs between January 1, 2013 and December 31, 2017 in the American Academy […]
  • Optic nerve Hemangioblastoma with bilateral frontal lobe Oedema: a case report.
    Hemangioblastomas are rare benign tumours that are most commonly detected in the subtentorium or spinal cord. Optic nerve hemangioblastoma is very rare and is most commonly associated with Von Hippel-Lindau (VHL) syndrome.Here, we report a case of hemangioblastoma of the optic nerve with bilateral frontal lobe oedema without VHL syndrome, which has not yet been […]
    To describe the incidence of subretinal deposits that are similar in structure and stage on OCT imaging to subretinal drusenoid deposits (SDD) in AMD, in patients with hypertensive choroidopathy secondary to severe preeclampsia (PE) and malignant hypertension (MHT), and the implications of this ischemic choroidopathy for the pathophysiology of SDD in AMD.Retrospective cross-sectional study.33 PE […]
  • Prognostic value of TERT promoter mutations in conjunctival melanomas in addition to clinicopathological features.
    To evaluate the prognostic value of clinical, histopathological and molecular features and to relate different treatment modalities to clinical outcome in conjunctival melanomas (CM).Retrospective review of clinical, histopathological and BRAF V600E and telomerase reverse transcriptase (TERT) promoter mutation status and treatment modalities, correlated to recurrence and metastasis in 79 patients with CM, diagnosed between 1987 […]
  • Effect of Vitamin D and ω-3 Fatty Acid Supplementation on Risk of Age-Related Macular Degeneration: An Ancillary Study of the VITAL Randomized Clinical Trial.
    Observational studies suggest that higher intake or blood levels of vitamin D and marine ω-3 fatty acids may be associated with lower risks of age-related macular degeneration (AMD). However, evidence from randomized trials is limited.To evaluate whether daily supplementation with vitamin D3, marine ω-3 fatty acids, or both prevents the development or progression of AMD.This […]
  • Association of Vision Impairment With Preventive Care Use Among Older Adults in the United States.
    Preventive care is associated with decreased morbidity and mortality among older adults. Vision impairment may be a barrier to accessing care and health promotion information and therefore may contribute to decreased preventive care uptake.To examine the association between self-reported vision impairment and uptake of preventive care services (ie, breast and colon cancer screenings and influenza […]
  • Optical coherence tomography angiography characteristics of optic disc melanocytoma.
    Optic disc melanocytoma (ODMC) was a benign pigmented intraocular tumor with the rare potential malignant transformation. This study was designed to evaluate tumor vasculature with optical coherence tomography angiography (OCTA) in ODMC.Eyes of healthy individuals in a control group and of patients with ODMC were imaged by OCTA systems operating at 840 nm wavelengths and examined. […]
  • Primary orbital extraskeletal osteosarcoma and review of literature.
    Extraskeletal osteosarcoma is a malignant tumour composed of an osteoid and/or cartilaginous matrix; it arises in soft tissues without connection to the skeleton, and to our knowledge, this type of tumour is extremely rare.The present study reports a 57-year-old man with primary orbital extraskeletal osteosarcoma who presented with a history of painful swelling in the […]
  • Outcomes of intravitreal methotrexate to salvage eyes with relapsed primary intraocular lymphoma.
    To report the outcomes of intravitreal methotrexate (MTX) injections to rescue eyes with relapsed primary intraocular lymphoma (PIOL).Retrospective case series of patients with ocular relapse of PIOL who had initially received systemic chemotherapy (all five cases) and external beam radiotherapy (EBRT) to brain and orbits (two cases). Injections of MTX (400 µg/0.1 mL) were given one […]
  • Subclinical subretinal fluid detectable only by optical coherence tomography in choroidal naevi-the SON study.
    Subretinal fluid is a risk factor for growth and malignant transformation of choroidal naevi, however it is unclear if this applies to subclinical fluid that is only detectable by optical coherence tomography (OCT). The objective of this study was to determine the prevalence and associations of subclinical but OCT-detectable subretinal fluid over choroidal naevi.Cross-sectional study […]
  • Diagnostic and treatment challenges of a case of primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid.
    Primary cutaneous signet-ring cell/histiocytoid carcinoma of the eyelid is an extremely rare but aggressive neoplasm diagnosed primarily in elderly men. Until now there are 32 published cases of signet-ring cell carcinoma or histiocytoid carcinoma of the eyelid. We report the clinical, radiographic and histological features of the 33rd reported case of PCSRCC in the eyelid […]
  • Dual Sensory Impairment and Perceived Everyday Discrimination in the United States.
    Perceived everyday discrimination is a psychosocial stressor linked to adverse health outcomes, including mortality.To assess the association of vision impairment (VI), hearing impairment (HI), and dual sensory impairments (DSI) with everyday discrimination.Cross-sectional analysis of the Health and Retirement Study 2006 and 2008 surveys, a US population-based survey that included noninstitutionalized adults 51 years and older. […]
  • Limbal stem cell deficiency secondary to systemic paclitaxel (Taxol) for breast cancer: a case report.
    Paclitaxel (PTX) is an antineoplastic drug widely used in treatments for ovarian, breast, and small-cell lung cancer. Although ocular effects associated with PTX have been previously described, very few studies have specifically reported systemic PTX as a contributing factor for limbal stem cell deficiency (LSCD), which is characterized by the loss of stem cell and […]
  • Utility of PAX8 immunohistochemistry in adult intraocular tumor diagnosis.
    To evaluate the distribution of the PAX8 transcription factor protein in ocular tissues and to investigate if immunohistochemical stains for this biomarker are useful in the diagnosis of intraocular tumors DESIGN: Observational case series.Excisions and cytology specimens of 6 ciliary body epithelial neoplasms, 2 iris epithelial neoplasms, 3 retinal pigment epithelial neoplasms, 3 intraocular medulloepitheliomas, […]
  • Increased risk of cancer in patients with retinal vein occlusion: a 12-year nationwide cohort study.
    To investigate the association between incident retinal vein occlusion (RVO) and the subsequent development of cancer.In this nationwide population-based retrospective study using 2002-2013 National Health Insurance Service database which covers the entire South Korean population, 186 701 incident RVO patients and their 1:1 propensity-score matched controls were included. We defined the fixed cohort from January 1st, […]
  • Clinical spectrum of uveal metastasis in Korean patients based on primary tumor origin.
    To describe the clinical features and prognosis of patients with uveal metastasis in Korea.Retrospective observational case series.Patients diagnosed at two tertiary high-volume centers between November 2005 and November 2019.Evaluation of multimodal imaging and electronic records.The clinical features and outcomes were assessed based on the primary cancer site.A total of 134 uveal metastases (128 choroidal, 3 […]
  • Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries.
    The travel distance from home to a treatment centre, which may impact the stage at diagnosis, has not been investigated for retinoblastoma, the most common childhood eye cancer. We aimed to investigate the travel burden and its impact on clinical presentation in a large sample of patients with retinoblastoma from Africa and Europe.A cross-sectional analysis […]
  • Adjuvant use of laser in eyes with macular retinoblastoma treated with primary intravenous chemotherapy.
    Adjuvant use of laser with systemic chemotherapy for treatment of retinoblastoma may reduce recurrence rates while also causing local side effects. Information is lacking on the effect of laser on visual outcomes.A retrospective review of two retinoblastoma centres in the United Kingdom was conducted. Patients were included if there was a macular tumour in at […]
  • Anterior Segment OCTA of Melanocytic Lesions of the Conjunctiva and Iris.
    To study the feasibility and diagnostic value of vascular imaging using OCT-Angiography (OCTA) of melanocytic lesions of the conjunctiva and iris. Design; Cross-sectional study.Twenty-five patients with an untreated conjunctival lesion (5 melanoma, 13 nevus, 7 primary acquired melanosis (PAM) and 52 patients with an untreated iris lesion (10 melanoma, 42 nevus) were included. Patients were […]
  • Orbital disease in neuro-ophthalmology.
    Orbital disease represents a diverse spectrum of pathology and can result in a variety of neuro-ophthalmic manifestations. The aim of this review is to provide updates on recent advances in our understanding of orbital disease secondary to thyroid eye disease, myositis, IgG4-related disease, sarcoidosis, granulomatosis with polyangiitis and various tumours.With regards to thyroid eye disease, […]
  • Conjunctival melanoma treatment outcomes in 288 patients: a multicentre international data-sharing study.
    To relate conjunctival melanoma characteristics to local control.Retrospective, registry-based interventional study with data gathered from 10 ophthalmic oncology centres from 9 countries on 4 continents. Conjunctival melanoma patients diagnosed between January 2001 and December 2013 were enrolled in the study. Primary treatments included local excision, excision with cryotherapy and exenteration. Adjuvant treatments included topical chemotherapy, […]
  • Long term outcomes of small pigmented choroidal melanoma treated with primary photodynamic therapy.
    To report the long-term outcomes of patients with small, pigmented posteriorly located choroidal melanoma undergoing primary treatment using photodynamic therapy (PDT) with verteporfin at the London Ocular Oncology Service.Retrospective interventional consecutive case series SUBJECTS: All patients undergoing primary treatment using PDT with verteporfin from April 2014 and December 2015 and followed until December 2019.This is […]
  • Small choroidal melanoma: outcomes following apical height dose brachytherapy.
    To assess the outcomes of small choroidal melanoma following iodine-125 episcleral brachytherapy (apical height dose of 85 Gy).Patients with small choroidal melanoma that underwent iodine-125 episcleral brachytherapy between January 2004 and December 2017 were reviewed. Inclusion criterion for this study was the COMS small tumour size (tumour apical height of 1.0-2.5 mm and largest basal diameter […]
  • Nationwide trends in the incidence of orbital lymphoma from 1999 to 2016 in South Korea.
    Lymphomas are the most frequent neoplasm of the orbit. However, the epidemiology of orbital lymphomas is not well reported. This study aimed to provide a population-based report on the epidemiology of orbital lymphomas and measure the trends in the incidence of orbital lymphoma cancer in South Korea.Nationwide cancer incidence data from 1999 to 2016 were […]
  • Gene fusions in ocular adnexal tumors.
    To highlight the increasing importance of gene fusions in the diagnosis, prognosis, and therapy of ocular adnexal tumors.A perspective.A focused review of gene fusions, their pathogenic mechanism, and gene fusion detection methods in lacrimal gland and primary orbital and ocular adnexal soft tissue tumors; reappraisal of diagnostic, prognostic, and therapeutic approach to ocular adnexal tumors […]
  • Focal choroidal excavation: review of literature.
    Focal choroidal excavation (FCE) is defined as an area of concavity in choroid detected on optical coherence tomography. These are mostly present in macular region without evidence of accompanying scleral ectasia or posterior staphyloma. Though initially considered to be congenital, increasing number of cases have been identified in association with other choroidal pathologies such as […]
  • Retinal vasculometry associations with glaucoma; findings from the European Prospective Investigation of Cancer-Norfolk Eye study.
    To examine retinal vasculometry associations with different glaucomas in older British people.Cross-sectional study METHODS: 8,623 European Prospective Investigation into Cancer-Norfolk Eye study participants were examined, who underwent retinal imaging, ocular biometry assessment, and clinical ascertainment of ocular hypertensive or glaucoma status (including glaucoma suspect [GS], high tension open-angle glaucoma [HTG], and normal tension glaucoma [NTG]). […]
  • Power to see: Drivers of aerobic glycolysis in the mammalian retina – A review.
    The mammalian retina converts most glucose to lactate rather than catabolising it completely to carbon dioxide via oxidative phosphorylation, despite the availability of oxygen. This unusual metabolism is known as aerobic glycolysis or the Warburg effect. Molecules and pathways that drive aerobic glycolysis have been identified and thoroughly studied in the context of cancer but […]
  • Bacillary Layer Detachment in Bilateral Diffuse Uveal Melanocytic Proliferation Masquerading as Neovascular AMD.
    Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare and unusual paraneoplastic ocular syndrome with generally poor prognosis. The authors present a case of BDUMP in a patient with bladder cancer, examined with current multimodal imaging. In the clinical setting with drusen and exudative macular detachments, the fundus simulated neovascular age-related macular degeneration, warranting standard-of-care […]
  • Reduction in Mammography Screening for Breast Cancer Among Visually Impaired Women.
    Timely receipt of mammograms to screen for breast cancer in accordance with the United States Preventive Services Task Force (USPSTF) recommendations can substantially reduce morbidity and mortality. The purpose of this study is to assess whether odds of receiving screening mammograms are similar for women with and without visual impairment.Retrospective longitudinal cohort study.1044 females, 65-72 […]