Factors associated with outcomes after a second CD19-targeted CAR T-cell infusion for refractory B cell malignancies. 23rd September 2020 CD19-targeted chimeric antigen receptor-engineered (CD19 CAR) T cell therapy has shown significant […]
piRNA-30473 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in DLBCL. 23rd September 2020 The initiation and progression of diffuse large B-cell lymphoma (DLBCL) is governed […]
Once-Weekly Insulin for Type 2 Diabetes without Previous Insulin Treatment. 22nd September 2020 It is thought that a reduction in the frequency of basal insulin […]
Neutrophils promote clearance of nuclear debris following acid-induced lung injury. 22nd September 2020 Neutrophils are critical mediators of host defense in pathogen-induced and sterile inflammation. […]
CANOMAD: a neurological monoclonal gammopathy of clinical significance that benefits from B-cell targeted therapies. 22nd September 2020 CANOMAD (chronic ataxic neuropathy, ophthalmoplegia, IgM paraprotein, cold agglutinins and disialosyl antibodies) […]
A phase II study of venetoclax plus R-CHOP as first-line treatment for patients with diffuse large B-cell lymphoma. 22nd September 2020 The phase II CAVALLI (NCT02055820) study assessed efficacy and safety of venetoclax, […]
Heat Shock Factor 1 (HSF1-pSer326) Predicts Response to Bortezomib-Containing Chemotherapy in Pediatric AML: A COG Study. 22nd September 2020 Bortezomib (BTZ) was recently evaluated in a randomized Phase 3 clinical trial […]
Non-canonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling. 22nd September 2020 T-cell prolymphocytic leukemia (T-PLL) is a poor-prognostic neoplasm. Differentiation stage and immune-effector […]
Contribution of Clonal Hematopoiesis to Adult-Onset Hemophagocytic Lymphohistiocytosis. 22nd September 2020 Adult-onset hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disease of immune hyperactivation. […]
Mutational Landscape of Grey Zone Lymphoma. 22nd September 2020 The mutational landscape of grey zone lymphoma (GZL) has not yet been […]
Machine learning demonstrates that somatic mutations imprint invariant morphologic features in myelodysplastic syndromes. 22nd September 2020 Morphological interpretation is the standard in diagnosing myelodysplastic syndrome (MDS), but it […]
The impact of cytogenetic risk on the outcomes of Allogeneic Hematopoietic Cell Transplantation in patients with relapsed/refractory acute myeloid leukemia: on behalf of the Acute Leukemia Working Party (ALWP) of the EBMT. 18th September 2020 Karyotypic analysis at time of diagnosis has an important value in determining […]
Cell-type-specific insights into iron regulatory processes. 18th September 2020 Despite its essential role in many biological processes, iron is toxic when […]
Tricuspid regurgitant jet velocity and myocardial tissue doppler parameters predict mortality in a cohort of patients with sickle cell disease spanning from pediatric to adult age groups – revisiting this controversial concept after sixteen years of additional evidence. 18th September 2020 Sickle cell disease (SCD) is a monogenic hemoglobinopathy associated with significant morbidity […]
Comparative evaluation of involved free light chain and monoclonal spike as markers for progression from MGUS to MM. 16th September 2020 Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant clonal plasma cell […]
The prognostic value of additional copies of 1q21 in multiple myeloma depends on the primary genetic event. 16th September 2020 Hyperdiploidy (HRD) and specific IGH translocations are primary chromosomal abnormalities (CA) in […]
Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma. 15th September 2020 Hematopoietic stem and progenitor cells (HSPC) fate is tightly regulated by their […]
RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia development. 15th September 2020 Inversion of chromosome 16 is a consistent finding in patients with acute […]
Flotetuzumab as Salvage Immunotherapy for Refractory Acute Myeloid Leukemia. 15th September 2020 Despite recent advancements, approximately 50% of patients with acute myeloid leukemia (AML) […]
The dangers of déjà vu: Memory B-cells as the cell-of-origin of ABC-DLBCLs. 15th September 2020 Activated B-cell (ABC)-Diffuse large B-cell lymphomas (DLBCLs) are clinically aggressive and phenotypically […]
Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate. 15th September 2020 Polyphosphate is a procoagulant inorganic polymer of linear linked orthophosphate residues. Multiple […]
Specialized regulatory T cells control venous blood clot resolution through SPARC. 15th September 2020 The cells and mechanisms involved in blood clot resorption are only partially […]
Outcomes of lenalidomide- or bortezomib-based regimens in older patients with plasma cell myeloma. 12th September 2020 The “triplet” regimen of lenalidomide, bortezomib, and dexamethasone (RVD) showed survival advantage […]
A multicenter study evaluating the effectiveness and safety of single-dose low molecular weight iron dextran vs single-dose ferumoxytol for the treatment of iron deficiency. 12th September 2020 There are multiple intravenous (IV) iron formulations available, of which several may […]
Activity of Transgene-Produced B-Domain Deleted Factor VIII in Human Plasma Following AAV5 Gene Therapy. 11th September 2020 Adeno-associated virus (AAV)-based gene therapies can restore endogenous factor VIII (FVIII) expression […]
BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells. 10th September 2020 BCL6 is a transcription repressor and proto-oncogene that plays a crucial role […]
An intact gut microbiome protects genetically predisposed mice against leukemia. 10th September 2020 The majority of childhood leukemias are precursor B cell-acute lymphoblastic leukemias (pB-ALL) […]
Anticoagulant therapy for splanchnic vein thrombosis: A systematic review and meta-analysis. 10th September 2020 Treatment of splanchnic vein thrombosis (SVT) is challenging and evidence to guide […]
Trends in Blood Pressure Control Among US Adults With Hypertension, 1999-2000 to 2017-2018. 9th September 2020 Controlling blood pressure (BP) reduces the risk for cardiovascular disease.To determine whether […]
Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells. 9th September 2020 Immune checkpoint therapy has resulted in remarkable improvements in the outcome for […]
Absent B cells, agammaglobulinemia, and hypertrophic cardiomyopathy in Folliculin Interacting Protein 1 deficiency. 9th September 2020 Agammaglobulinemia is the most profound primary antibody deficiency that can occur due […]
Retinoic acid-responsive CD8 effector T-cells are selectively increased in IL-23-rich tissue in gastrointestinal GvHD. 9th September 2020 Gastrointestinal (GI) graft-versus-host disease (GvHD) is a major barrier in allogeneic hematopoietic […]
Haploidentical versus matched unrelated donor transplantation for acute myeloid leukemia in remission: a prospective comparative study. 9th September 2020 Despite comparable outcomes of haploidentical transplants (Haplo-HSCT) with HLA-matched unrelated transplants (MUD-HSCT) […]
How I treat anticoagulant-refractory thrombotic antiphospholipid syndrome. 8th September 2020 The standard treatment of thrombotic antiphospholipid syndrome (APS) is lifelong oral anticoagulation […]
Concomitant use of a dual ABL/Src kinase inhibitor eliminates the in vitroefficacy of blinatumomab against Ph+ ALL. 8th September 2020 Blinatumomab is currently approved for use as a single agent in relapsed […]
A prospective, blinded study of a PF4-dependent assay for HIT diagnosis. 8th September 2020 Heparin-induced thrombocytopenia (HIT) is a life-threatening, pro-thrombotic, antibody-mediated disorder. To maximize the […]
Chromosome 20 loss is characteristic for Breast implant-Associated Anaplastic Large Cell Lymphoma. 8th September 2020 Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a very rare type […]
Identification of functional cooperative mutations of GNAO1 in human acute lymphoblastic leukemia. 8th September 2020 Leukemogenesis is characterized by chromosomal rearrangements with additional molecular disruptions, yet the […]
Insufficient evidence exists to use histopathologic subtype to guide treatment of idiopathic multicentric Castleman disease. 7th September 2020 Idiopathic multicentric Castleman disease (iMCD) is a rare immunologic disorder characterized by […]
Insufficient evidence exists to use histopathologic subtype to guide treatment of idiopathic multicentric Castleman disease. 7th September 2020 Idiopathic multicentric Castleman disease (iMCD) is a rare immunologic disorder characterized by […]
The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells. 4th September 2020 Hematopoietic and nervous systems are linked via innervation of bone marrow (BM) […]
Thrombospondin-1 promotes haemostasis through modulation of cAMP signalling in blood platelets. 4th September 2020 Thrombospondin-1 (TSP-1) is released by platelets upon activation and can promote platelet […]
Tumor intrinsic and extrinsic determinants of response to blinatumomab in adults with B-ALL. 4th September 2020 Blinatumomab, a bispecific antibody that directs CD3+ T cells to CD19+ tumor […]
Effect of Multilevel Upper Airway Surgery vs Medical Management on the Apnea-Hypopnea Index and Patient-Reported Daytime Sleepiness Among Patients With Moderate or Severe Obstructive Sleep Apnea: The SAMS Randomized Clinical Trial. 4th September 2020 Many adults with obstructive sleep apnea (OSA) use device treatments inadequately and […]
Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis. 3rd September 2020 Sodium phenylbutyrate and taurursodiol have been found to reduce neuronal death in […]
Optimizing Therapy in the Modern Age: Differences in Length of Maintenance Therapy in Acute Lymphoblastic Leukemia. 3rd September 2020 The majority of children and young adults with acute lymphoblastic leukemia (ALL) […]
Recombinant VWF Fragments Improve Bioavailability of Subcutaneous Factor VIII in Hemophilia A Mice. 3rd September 2020 Conventional treatment of hemophilia A (HA) requires repetitive intravenous (IV) injection of […]
How I treat nodular lymphocyte-predominant Hodgkin Lymphoma. 3rd September 2020 Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma entity with distinct […]
Association of New-Onset Atrial Fibrillation After Noncardiac Surgery With Subsequent Stroke and Transient Ischemic Attack. 2nd September 2020 Outcomes of postoperative atrial fibrillation (AF) after noncardiac surgery are not well […]
Double unrelated umbilical cord blood versus HLA-haploidentical bone marrow transplantation (BMT CTN 1101). 2nd September 2020 Results of two parallel phase II trials of transplantation of unrelated umbilical […]
Results of a Phase 2 Trial of an Oral CXCR4 Antagonist Mavorixafor for Treatment of WHIM Syndrome. 2nd September 2020 Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare primary immunodeficiency […]
Placental thrombo-inflammation impairs embryonic survival by reducing placental thrombomodulin expression. 2nd September 2020 Excess platelet-activation by extracellular vesicles (EVs) results in trophoblast inflammasome activation, IL-1β […]
Efficacy and safety results from CheckMate 140, a phase 2 study of nivolumab for relapsed/refractory follicular lymphoma. 2nd September 2020 Nivolumab, an anti-programmed death-1 (PD-1) monoclonal antibody, showed promising activity in relapsed […]
Spatial Signatures Identify Immune Escape via PD-1 as a Defining Feature of T-cell/Histiocyte-rich Large B-cell Lymphoma. 2nd September 2020 T-cell/histiocyte-rich large B cell lymphoma (TCRLBCL) is an aggressive variant of diffuse […]
A Personalized Approach to Guide Allogeneic Stem Cell Transplantation in Younger Adults with Acute Myeloid Leukemia. 2nd September 2020 A multistage model instructed by a large dataset (knowledge bank [KB] algorithm) […]
Long-Term Results of PET-Guided Radiation in Advanced-Stage Diffuse Large B-Cell Lymphoma Patients Treated with R-CHOP. 2nd September 2020 Consolidative radiation therapy (RT) for advanced-stage diffuse large B-cell lymphoma (DLBCL) remains […]
Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1 mutated acute myeloid leukemia. 2nd September 2020 Plasmacytoid dendritic cells (pDC) are the principal natural type I interferon producing […]
Early BCR-ABL1 kinetics are predictive of subsequent achievement of treatment-free remission in chronic myeloid leukemia. 2nd September 2020 With treatment-free remission (TFR) rapidly becoming the ultimate goal of therapy in […]
Aspirin with or without Clopidogrel after Transcatheter Aortic-Valve Implantation. 1st September 2020 The effect of single as compared with dual antiplatelet treatment on bleeding […]
High-dose dexamethasone plus recombinant human thrombopoietin versus high-dose dexamethasone alone as frontline treatment for newly diagnosed adult primary immune thrombocytopenia:a prospective, multicenter, randomized trial. 1st September 2020 We conducted a prospective, multicenter, randomized, controlled clinical trial to compare the […]
