Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration. 14th July 2020 Glucocorticoids are considered first-line therapy in a variety of eosinophilic disorders. They […]
Whole blood viscosity and red blood cell adhesion: Potential biomarkers for targeted and curative therapies in sickle cell disease. 14th July 2020 Sickle cell disease (SCD) is a recessive genetic blood disorder exhibiting abnormal […]
NCOA4 is Regulated by HIF and Mediates Mobilization of Murine Hepatic Iron Stores After Blood Loss. 14th July 2020 The mechanisms by which phlebotomy promotes the mobilization of hepatic iron stores […]
Impact of Total Body Irradiation- Versus Chemotherapy-Based Myeloablative Conditioning on Outcomes of Haploidentical Hematopoietic Cell Transplantation for Acute Myelogenous Leukemia. 14th July 2020 The optimal myeloablative conditioning (MAC) for patients undergoing haploidentical hematopoietic cell transplantation […]
Survival of patients with newly diagnosed high-grade myeloid neoplasms who do not meet standard trial eligibility. 11th July 2020 Few patients with cancer, including those with acute myeloid leukemia and high-grade […]
DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch. 11th July 2020 Recently, we described B-cell precursor acute lymphoblastic leukemia (BCP-ALL) subtype with early […]
HIV antiretroviral therapy and prevention use in US blood donors: A new blood safety concern. 10th July 2020 Antiretroviral therapy (ART) to treat and pre-exposure prophylaxis (PrEP) to prevent HIV […]
Cancer immunoediting and immune dysregulation in multiple myeloma. 10th July 2020 Avoiding immune destruction is a hallmark of cancer. Over the past few […]
Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism. 10th July 2020 Growth differentiation factor 15 (GDF-15), a marker of inflammation and oxidative stress, […]
Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs. 9th July 2020 Platelets engage cues of pending vascular injury through coordinated adhesion, secretion and […]
Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms. 9th July 2020 Large-scale sequencing studies of hematologic malignancies have revealed notable epistasis among high-frequency […]
Expression of NrasQ61R and MYC transgene in germinal center B cells induces a highly malignant multiple myeloma in mice. 9th July 2020 NRAS Q61 mutations are prevalent in advanced/relapsed multiple myeloma (MM) and correlate […]
Venetoclax and hypomethylating agents in FLT3-mutated acute myeloid leukemia. 7th July 2020 FMS-like tyrosine kinase 3 (FLT3) mutations are prevalent in acute myeloid leukemia […]
CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity. 4th July 2020 Adhesive properties of leukemia cells shape the degree of organ infiltration and […]
Chronic lymphocytic leukemia: from molecular pathogenesis to novel therapeutic strategies. 4th July 2020 Chronic lymphocytic leukemia is a well-defined lymphoid neoplasm with very heterogeneous biological […]
Fatigue in chronic myeloid leukemia patients on tyrosine kinase inhibitor therapy: predictors and the relationship with physical activity. 4th July 2020 Fatigue is a common side effect of tyrosine kinase inhibitor (TKI) therapy […]
Haploidentical Transplants for Patients with Relapse After the First Allograft. 4th July 2020 Relapse after allogeneic stem-cell transplantation (AHSCT) is associated with very poor outcomes. […]
Characterization of the Rate, Predictors, and Thrombotic Complications of Thrombocytosis in Iron Deficiency Anemia. 4th July 2020 The association of thrombocytosis with iron deficiency anemia (IDA) is well-recognized, but […]
Robust Expansion of HIV CAR T Cells Following Antigen Boosting in ART-Suppressed Nonhuman Primates. 3rd July 2020 CAR T cells targeting CD19+ hematologic malignancies have rapidly emerged as a […]
Haematopoietic Cell Transplantation in Chronic Granulomatous Disease: a Study on 712 Children and Adults. 3rd July 2020 Chronic Granulomatous Disease (CGD) is a primary immunodeficiency resulting in life-threatening infections […]
Single cell analyses and machine learning define hematopoietic progenitor and HSC-like cells derived from human PSCs. 3rd July 2020 Haematopoietic stem and progenitor cells (HSPCs) develop through distinct waves at various […]
CAR-modified memory-like NK cells exhibit potent responses to NK-resistant lymphomas. 3rd July 2020 NK cells are a promising cellular immunotherapy for cancer. Cytokine-induced memory-like (ML) […]
vWF maturation and release are controlled by two regulators of Weibel-Palade body biogenesis: exocyst and BLOC-2. 3rd July 2020 von Willebrand factor (vWF) is an essential hemostatic protein that is synthesized […]
NPM1-mutated acute myeloid leukemia: from bench to bedside. 2nd July 2020 The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent nucleolar […]
Procoagulant Activities of Skeletal and Cardiac Muscle Myosin depend on contaminating phospholipid. 1st July 2020 Recent reports indicate that suspended skeletal and cardiac myosin, such as might […]
Sirolimus with CSP and MMF as GVHD prophylaxis for allogeneic transplantation with HLA antigen mismatched donors. 1st July 2020 This trial aimed to evaluate the efficacy of sirolimus in addition to […]
Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency. 1st July 2020 Biallelic mutations in the genes encoding CD27 or its ligand CD70 underlie […]
Changes in Bcl-2 members in response to ibrutinib or venetoclax uncover functional hierarchy in determining resistance to venetoclax in CLL. 1st July 2020 Chronic lymphocytic leukemia (CLL) cells cycle between lymph node (LN) and peripheral […]
Outcome of Primary Mediastinal Large B-cell Lymphoma Using R-CHOP: Impact of a PET Adapted Approach. 1st July 2020 Cure rates for primary mediastinal large B-cell lymphoma (PMBCL) have improved with […]
Localized immunoglobulin light chain amyloidosis: novel insights including prognostic factors for local progression. 1st July 2020 In localized light chain amyloidosis (locAL), amyloidogenic light chains (aLC) are produced […]
CD38 deletion of human primary NK cells eliminates daratumumab-induced fratricide and boosts their effector activity. 1st July 2020 Multiple myeloma (MM) is a plasma cell neoplasm that commonly expresses CD38. […]
Sensitive and broadly applicable residual disease detection in acute myeloid leukemia using flow cytometry-based leukemic cell enrichment followed by mutational profiling. 1st July 2020 Persistent measurable residual disease (MRD) is an increasingly important prognostic marker in […]
The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes. 30th June 2020 Although cytokine-mediated expansion of human hematopoietic stem cells (HSCs) can result in […]
Key diagnostic markers for Autoimmune Lymphoproliferative Syndrome with molecular genetic diagnosis. 30th June 2020 Autoimmune lymphoproliferative syndrome (ALPS) is a rare immunodeficiency caused by mutations in […]
MYC-induced human acute myeloid leukemia requires a continuing IL3/GM-CSF co-stimulus. 30th June 2020 Hematopoietic clones with leukemogenic mutations arise in healthy people as they age, […]
Activation of the receptor tyrosine kinase, RET, improves long-term hematopoietic stem cell outgrowth and potency. 27th June 2020 Expansion of Human Hematopoietic Stem Cells (HSCs) is a rapidly advancing field […]
Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation. 27th June 2020 Hemophagocytic Lymphohistiocytosis (HLH) and Macrophage Activation Syndrome (MAS) are life-threatening hyperinflammatory syndromes […]
miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis. 27th June 2020 Neutrophil extracellular traps (NETs) induce a procoagulant response linking inflammation and thrombosis. […]
In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor. 27th June 2020 Pharmacological induction of fetal hemoglobin (HbF) expression is an effective therapeutic strategy […]
Plasmodium falciparum sexual parasites develop in human erythroblasts and affect erythropoiesis. 27th June 2020 Plasmodium falciparum gametocytes, the sexual stages responsible for malaria parasites transmission from […]
How I Treat Relapsed Acute Lymphoblastic Leukemia in the Pediatric Population. 27th June 2020 Relapsed acute lymphoblastic leukemia (ALL) has remained challenging to treat in children […]
Synergistic Targeting of FLT3 Mutations in AML via Combined Menin-MLL and FLT3 Inhibition. 27th June 2020 The interaction of Menin (MEN1) and MLL (MLL1, KMT2A) is a dependency […]
Rosetting T cells in Hodgkin lymphoma are activated by immunological synapse components HLA class II and CD58. 27th June 2020 A unique feature of Hodgkin lymphoma (HL) is the presence of CD4+ […]
A new gene associated with a beta-thalassemia phenotype: the observation of variants in SUPT5H. 27th June 2020 Click here to read the full article @ Blood
Sialic Acid Bearing Paraproteins Are Implicated In Heparin-Like Coagulopathy In Myeloma Patients. 27th June 2020 Click here to read the full article @ Blood
Chronic lymphocytic leukaemia and prolymphocytic leukaemia. Two coins or two sides of the same coin? 27th June 2020 Click here to read the full article @ Haematologica
Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma. 27th June 2020 Click here to read the full article @ Haematologica
Infrequent “chronic lymphocytic leukemia-specific” immunoglobulin stereotypes in aged individuals with or without low count monoclonal B cell lymphocytosis. 27th June 2020 Click here to read the full article @ Haematologica
Anemia and hemodilution: analysis of a single center cohort based on 2858 Red Cell Mass measurements. 27th June 2020 Click here to read the full article @ Haematologica
Isatuximab plus pomalidomide and dexamethasone in elderly patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis. 27th June 2020 Click here to read the full article @ Haematologica
Membrane protein CAR promotes hematopoietic regeneration upon stress. 27th June 2020 Adult hematopoietic stem cells (HSCs) are quiescent most of the time, and […]
HOW I TREAT GASTRO-INTESTINAL BLEEDING IN CONGENITAL AND ACQUIRED VON WILLEBRAND DISEASE. 26th June 2020 Gastro-intestinal (GI) bleeding is distinctive of severe von Willebrand disease (VWD). It […]
Maternal Hepcidin Determines Embryo Iron Homeostasis. 26th June 2020 Iron disorders are associated with adverse pregnancy outcomes, yet iron homeostatic mechanisms […]
Genomic and epigenomic insights into the origin, pathogenesis and clinical behavior of mantle cell lymphoma subtypes. 26th June 2020 Mantle cell lymphoma (MCL) is a mature B-cell neoplasm initially driven by […]
How I treat unexplained arterial thrombosis. 26th June 2020 Most arterial thrombotic events have a clear atherosclerotic or cardioembolic etiology, but […]
MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma. 26th June 2020 Multiple myeloma (MM) remains largely incurable despite significant advances in bio- and […]
14-3-3ζ-c-Src-integrin-β3 complex is vital for platelet activation. 26th June 2020 Several adaptor molecules bind to cytoplasmic tails of β-integrins and facilitate bidirectional […]
Prediction and prevention of central nervous system relapse in patients with extranodal natural killer/T-cell lymphoma. 26th June 2020 Since non-anthracycline-based chemotherapy with L-asparaginase has improved survival outcomes in patients with […]
Genetics in the era of targeted CLL therapy. 26th June 2020 Click here to read the full article @ Blood
CML: new tools to answer old questions. 26th June 2020 Click here to read the full article @ Blood
