The double-edged sword of AlloHCT for SCD. 4th April 2020 Click here to read the full article @ Blood
Genotype-phenotype association and variant characterization in Diamond-Blackfan anemia caused by pathogenic variants in RPL35A. 4th April 2020 Diamond Blackfan anemia (DBA) is predominantly an autosomal dominant inherited red cell […]
Stem cell engraftment within our G(P)RASP. 4th April 2020 Click here to read the full article @ Blood
Endothelial injury, F-actin and vitamin-D binding protein after hematopoietic stem cell transplant and association with clinical outcomes. 4th April 2020 Endothelial injury after hematopoietic stem cell transplant is an important initiating factor […]
TRIF turns the switch for DIC in sepsis. 4th April 2020 Click here to read the full article @ Blood
BTK inhibitor therapy is effective in patients with CLL resistant to venetoclax. 4th April 2020 Highly active BTK inhibitors (BTKi) and the BCL2 inhibitor venetoclax have transformed […]
Diagnosing HIT: the need for speed. 4th April 2020 Click here to read the full article @ Blood
Tricuspid Regurgitation Velocity and Other Biomarkers of Mortality in Children, Adolescents and Young Adults with Sickle Cell Disease in the United States: the PUSH Study. 4th April 2020 In the US, mortality in sickle cell disease (SCD) increases after age […]
Structured assessment of frailty in multiple myeloma as a paradigm of individualized treatment algorithms in cancer patients at advanced age. 4th April 2020 Click here to read the full article @ Haematologica
Risk of Invasive Fungal Infections in Patients with High-Risk MDS and AML Receiving Hypomethylating Agents. 4th April 2020 Invasive fungal infections (IFI) are a significant source of morbidity and mortality […]
A case of Epstein-Barr virus-related lymphoproliferative disorder after haploidentical allogeneic stem cell transplantation using post-transplantation cyclophosphamide. 4th April 2020 Click here to read the full article @ Haematologica
Excellent proliferation and persistence of allogeneic donor-derived 41-BB based CAR-T cells despite immunosuppression with cyclosporine A. 4th April 2020 Click here to read the full article @ Haematologica
Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid leukemia. 4th April 2020 Mutant IDH1 (mIDH1) inhibitors have shown single-agent activity in relapsed/refractory AML, though […]
Validated single-tube multiparameter flow cytometry approach for the assessment of minimal residual disease in multiple myeloma. 4th April 2020 Click here to read the full article @ Haematologica
Diagnosis and prognosis are comforted by integrated assessment of next-generation sequencing in chronic myeloid malignancies. A real-life study. 4th April 2020 Next generation sequencing (NGS) investigates for somatic mutations. The utility of incorporating […]
Primary therapy and survival in patients aged over 70-years-old with primary central nervous system lymphoma: a contemporary, nationwide, population-based study in the Netherlands. 4th April 2020 Click here to read the full article @ Haematologica
Patient-Reported Outcomes in Survivors of Childhood Hematologic Malignancies with Hematopoietic Stem Cell Transplant. 4th April 2020 Patient-reported outcomes among survivors of pediatric hematopoietic stem cell transplant (HSCT) are […]
B-cell lymphoblastic lymphoma with cutaneous involvement and a KMT2A gene rearrangement. 4th April 2020 Click here to read the full article @ American journal of hematology
Immunoglobulin variable domain high-throughput sequencing reveals specific novel mutational patterns in POEMS syndrome. 4th April 2020 POEMS syndrome is a rare multisystem disease due to an underlying plasma […]
A case of aleukemic mast cell leukemia with an underlying myeloproliferative neoplasm: morphological and molecular characteristics of a highly aggressive disease. 4th April 2020 Click here to read the full article @ American journal of hematology
A Phase II Trial Evaluating The Efficacy of High-Dose Radioiodinated Tositumomab (Anti-CD20) Antibody, Etoposide and Cyclophosphamide followed by Autologous Transplantation, for High-Risk Relapsed or Refractory Non-Hodgkin’s Lymphoma. 4th April 2020 Radiation is the most effective treatment for localized lymphoma, but treatment of […]
Genome editing of donor-derived T-cells to generate allogenic chimeric antigen receptor-modified T cells: Optimizing αβ T cell-depleted haploidentical hematopoietic stem cell transplantation. 4th April 2020 Allogeneic hematopoietic stem cell transplantation is an effective therapy for high-risk leukemias. […]
Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity. 4th April 2020 Red blood cell storage in the blood bank promotes the progressive accumulation […]
Daratumumab Plus CyBorD for Patients With Newly Diagnosed AL Amyloidosis: Safety Run-in Results of ANDROMEDA. 4th April 2020 Although no therapies are currently approved for light chain (AL) amyloidosis, cyclophosphamide, […]
Clinical practice recommendation on hematopoietic stem cell transplantation for acute myeloid leukemia patients with FLT3 internal tandem duplication: a position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. 4th April 2020 The FMS-like tyrosine kinase 3 (FLT3) gene is mutated in 25-30% of […]
Verruconis gallopava in a patient with myelofibrosis on ruxolitinib. 4th April 2020 Click here to read the full article @ Blood
Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals. 4th April 2020 Anemia is a major and currently poorly understood clinical manifestation of hematopoietic […]
Bone marrow niche dysregulation in myeloproliferative neoplasms. 4th April 2020 The specific role of the bone marrow niche, a complex and dynamic […]
Extracavitary primary effusion lymphoma presenting as a thalamic mass in a patient with multicentric Castleman disease. 4th April 2020 Click here to read the full article @ Blood
Transplant eligibility in elderly Multiple Myeloma patients: prospective external validation of the International Myeloma Working Group (IMWG) frailty score and comparison with clinical judgment and other comorbidity scores in unselected patients aged 65-75 years. 4th April 2020 Autologous stem cell transplantation (ASCT) is feasible and effective in selected older […]
The benefits of iron supplementation following blood donation vary with baseline iron status. 4th April 2020 Whole blood donation rapidly removes approximately 10% of a donor’s blood volume […]
Does clonal hematopoiesis explain unexplained anemia? 4th April 2020 Click here to read the full article @ Blood
Immunophenotypic characterization of reactive and neoplastic plasmacytoid dendritic cells permits establishment of a 10-color flow cytometric panel for initial workup and residual disease evaluation of blastic plasmacytoid dendritic cell neoplasm. 4th April 2020 Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematopoietic neoplasm whose […]
Lenalidomide in follicular lymphoma. 3rd April 2020 Lenalidomide is an immunomodulatory drug approved in the United States for use […]
Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients. 3rd April 2020 Click here to read the full article @ Haematologica
Chronic Myeloid Leukemia: 2020 Update on Diagnosis, Therapy and Monitoring. 3rd April 2020 Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm with an incidence of […]
Efficacy of venetoclax in high risk relapsed mantle cell lymphoma (MCL) – outcomes and mutation profile from venetoclax resistant MCL patients. 3rd April 2020 Venetoclax is effective in relapsed patients with mantle cell lymphoma (MCL). Mechanisms […]
Novel BCL2 mutations in venetoclax-resistant, ibrutinib-resistant CLL patients with BTK/PLCG2 mutations. 2nd April 2020 Click here to read the full article @ Blood
Prognostic Value of Interim FDG-PET in Diffuse Large Cell Lymphoma: Results from the CALGB 50303 Clinical Trial. 2nd April 2020 As part of a randomized, prospective clinical trial in large cell lymphoma, […]
AML Displays Increased CTCF Occupancy Associated to Aberrant Gene Expression and Transcription Factor Binding. 2nd April 2020 CTCF is a key regulator of gene expression through organization of the […]
Clonal Hematopoiesis and Measurable Residual Disease Assessment in Acute Myeloid Leukemia. 2nd April 2020 Current objectives regarding treatment for acute myeloid leukemia (AML) include achieving complete […]
International prognostic indices in diffuse large B-cell lymphoma (DLBCL): a comparison of IPI, R-IPI and NCCN-IPI. 2nd April 2020 Great heterogeneity in survival exists for patients newly diagnosed with DLBCL. Three […]
An Intestinal Organoid-Based Platform That Recreates Susceptibility to T Cell-Mediated Tissue Injury. 2nd April 2020 A goal in precision medicine is to use patient-derived material to predict […]
Initial Invasive or Conservative Strategy for Stable Coronary Disease. 1st April 2020 Among patients with stable coronary disease and moderate or severe ischemia, whether […]
Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease. 1st April 2020 In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization […]
FDA Trials Find Sunscreen Ingredients in Blood, but Risk Is Uncertain. 1st April 2020 Click here to read the full article @ JAMA
Management of Coronary Disease in Patients with Advanced Kidney Disease. 1st April 2020 Clinical trials that have assessed the effect of revascularization in patients with […]
Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease. 1st April 2020 In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in […]
Impact of the type of anthracycline and of stem cell transplantation in younger patients with acute myeloid leukaemia: long-term follow up of a phase III study. 31st March 2020 We provide a long-term evaluation of patients enrolled in the EORTC/GIMEMA AML-10 […]
Compliments to complement blockade for TA-TMA. 29th March 2020 Click here to read the full article @ Blood
Hemoglobin, altitude, and sensitive Swiss men. 29th March 2020 Click here to read the full article @ Blood
Are all splicing mutations the same? 29th March 2020 Click here to read the full article @ Blood
MYC needs MNT to drive B cells over the edge. 29th March 2020 Click here to read the full article @ Blood
Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia. 29th March 2020 Acute myeloid leukemia (AML) with inv(3)/t(3;3)(q21q26) is a distinct WHO recognized entity, […]
Venetoclax plus LDAC for patients with untreated AML ineligible for intensive chemotherapy: phase 3 randomized placebo-controlled trial. 29th March 2020 Effective treatment options are limited for patients with acute myeloid leukemia (AML) […]
Aromatase is a novel neo-substrate of cereblon responsible for immunomodulatory drugs-induced thrombocytopenia. 29th March 2020 Immunomodulatory drugs (IMiDs) are key agents for the treatment of multiple myeloma […]
Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms. 29th March 2020 Mutations in JAK2, MPL, or CALR are detected in more than 80% […]
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. 29th March 2020 Oncogenic RAS mutations pose substantial challenges for rational drug discovery. Sequence variations […]
Integrin α6 mediates drug resistance of acute lymphoblastic B-cell leukemia. 29th March 2020 Resistance to multimodal chemotherapy continues to limit the prognosis of acute lymphoblastic […]
Effect of Dapagliflozin on Worsening Heart Failure and Cardiovascular Death in Patients With Heart Failure With and Without Diabetes. 29th March 2020 Additional treatments are needed for heart failure with reduced ejection fraction (HFrEF). […]
