Loss of alpha-globin genes in human subjects is associated with improved nitric oxide-mediated vascular perfusion. 28th November 2020 Alpha thalassemia is a hemoglobinopathy due to decreased production of the α-globin […]
Identifying potential germline variants from sequencing hematopoietic malignancies. 26th November 2020 Next-generation sequencing (NGS) of bone marrow and peripheral blood increasingly guides clinical […]
How to manage CML patients with comorbidities. 26th November 2020 Patients with chronic myeloid leukemia (CML) often have comorbidities, at an incidence […]
Endogenous and combination retinoids are active in myelomonocytic leukemias. 26th November 2020 Retinoid therapy transformed response and survival outcomes in acute promyelocytic leukemia (APL), […]
The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion. 26th November 2020 The gene CXXC5, encoding a Retinoid-Inducible Nuclear Factor (RINF), is located within […]
Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis. 26th November 2020 BH3-mimetics inhibiting anti-apoptotic BCL-2 proteins represent a novel and promising class of […]
The clinical role of the gut microbiome and fecal microbiota transplantation in allogeneic stem cell transplantation. 26th November 2020 Outcomes of allogeneic hematopoietic stem cell transplantation (allo- HSCT) have improved in […]
Increased β4GALT1 expression associates with platelet surface galactosylation and thrombopoietin plasma levels in MPNs. 25th November 2020 Aberrant megakaryopoiesis is a hallmark of the myeloproliferative neoplasms (MPNs), a group […]
Clinical Insights into the Origins of Thrombosis in Myeloproliferative Neoplasms. 25th November 2020 The Philadelphia chromosome negative myeloproliferative neoplasms (MPNs), polycythemia vera, essential thrombocythemia, and […]
Persistent Challenges with Treating Multiple Myeloma Early. 25th November 2020 Over the last decade, two strategies have advanced the treatment of patients […]
Behavioral Counseling to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults With Cardiovascular Risk Factors: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. 24th November 2020 Cardiovascular disease is the leading cause of death in the US, and […]
Platelet Extracellular Vesicles mediate Transfusion-related Acute Lung Injury by imbalancing the Sphingolipid Rheostat. 24th November 2020 Transfusion-related acute lung injury (TRALI) is a hazardous transfusion complication with an […]
Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas. 24th November 2020 Aberrant B-cell receptor (BCR)/NF-kB signaling is a hallmark feature of B-cell non-Hodgkin […]
Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults With Cardiovascular Risk Factors: US Preventive Services Task Force Recommendation Statement. 24th November 2020 Cardiovascular disease (CVD) is a leading cause of death in the US. […]
Platelet Extracellular Vesicles mediate Transfusion-related Acute Lung Injury by imbalancing the Sphingolipid Rheostat. 24th November 2020 Transfusion-related acute lung injury (TRALI) is a hazardous transfusion complication with an […]
Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas. 24th November 2020 Aberrant B-cell receptor (BCR)/NF-kB signaling is a hallmark feature of B-cell non-Hodgkin […]
Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults With Cardiovascular Risk Factors: US Preventive Services Task Force Recommendation Statement. 24th November 2020 Cardiovascular disease (CVD) is a leading cause of death in the US. […]
A natural DNMT1 mutation elevates the fetal hemoglobin via epigenetic de-repression of γ-globin gene in β-thalassemia. 23rd November 2020 DNA methyltransferase 1 (DNMT1) is a major epigenetic regulator of the formation […]
Single cell RNA-seq reveals developmental plasticity with coexisting oncogenic and immune evasion programs in ETP-ALL. 23rd November 2020 Lineage plasticity and stemness have been invoked as the cause of therapy […]
SRP54 mutations induce Congenital Neutropenia via dominant-negative effects on XBP1 splicing. 23rd November 2020 Heterozygous de novo missense variants of SRP54 were recently identified in patients […]
Final Results of a Phase 1 Study of Loncastuximab Tesirine in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma. 19th November 2020 The prognosis for patients with relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma […]
IGLV3-21R110 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigenetics. 19th November 2020 B-cell receptor (BCR) signaling is crucial for chronic lymphocytic leukemia (CLL) biology. […]
Obinutuzumab versus Rituximab in young patients with advanced DLBCL, a PET-guided and randomized phase 3 study by LYSA. 19th November 2020 Rituximab plus polychemotherapy is standard of care in diffuse large B-cell lymphoma […]
Lineage-Independent Tumors in Bilateral Neuroblastoma. 19th November 2020 Childhood tumors that occur synchronously in different anatomical sites usually represent metastatic […]
Harnessing lymphoma epigenetics to improve therapies. 18th November 2020 Affinity maturation and terminal differentiation of B-cells via the germinal center reaction […]
A validated pediatric disease risk index for allogeneic hematopoietic cell transplantation. 18th November 2020 A disease risk index (DRI) that was developed for adults with hematologic […]
Genomic and transcriptomic correlates of Richter’s transformation in Chronic Lymphocytic Leukemia. 18th November 2020 The transformation of chronic lymphocytic leukemia (CLL) to high-grade B-cell lymphoma is […]
Ciraparantag, an Anticoagulant Reversal Drug: Mechanism of Action, Pharmacokinetics and Reversal of Anticoagulants. 18th November 2020 Ciraparantag, an anticoagulant reversal agent, is a small molecule specifically designed to […]
EBV-tissue positive primary CNS lymphoma occurring after immunosuppression is a distinct immunobiological entity. 17th November 2020 Primary central nervous system lymphoma (PCNSL) is confined to the brain, eyes, […]
Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor. 17th November 2020 Somatic mutations of calreticulin (CALR)have been identified as one of the main […]
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management. 16th November 2020 Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by stem cell-derived […]
CC-90009, a novel cereblon E3 ligase modulator targets acute myeloid leukemia blasts and leukemia stem cells. 16th November 2020 A number of clinically validated drugs have been developed by repurposing the […]
How I Manage cyclic thrombocytopenia. 16th November 2020 Cyclic thrombocytopenia (CTP) is a rare disease, which is characterized by periodic […]
Halting the FGF/FGFR axis leads to anti-tumor activity in Waldenström’s Macroglobulinemia by silencing MYD88. 16th November 2020 The human fibroblast growth factor/fibroblast growth factor-receptor (FGF/FGFR) axis deregulation is largely […]
Polypill with or without Aspirin in Persons without Cardiovascular Disease. 13th November 2020 A polypill comprising statins, multiple blood-pressure-lowering drugs, and aspirin has been proposed […]
Structure of the platelet glycoprotein Ib receptor in complex with a novel antithrombotic agent Agkisacucetin. 12th November 2020 Agkisacucetin is a snake C-type lectin-like protein (snaclec) isolated from the venom […]
Ibrutinib, Obinutuzumab And Venetoclax In Relapsed and Untreated Patients with Mantle-Cell Lymphoma, a phase I/II trial. 12th November 2020 Ibrutinib, obinutuzumab plus venetoclax demonstrate synergy in pre-clinical models of mantle-cell lymphoma […]
IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias. 12th November 2020 Previous reports indicate IL18 is a novel candidate gene for diastolic dysfunction […]
Enhanced IL-9 secretion by p66Shc-deficient CLL cells modulates the chemokine landscape of the stromal microenvironment. 12th November 2020 The stromal microenvironment is central to chronic lymphocytic leukemia (CLL) pathogenesis. How […]
Networking for advanced molecular diagnosis in acute myeloid leukemia patients is possible: the PETHEMA NGS-AML project. 12th November 2020 Next-Generation Sequencing has recently been introduced to efficiently and simultaneously detect genetic […]
A prognostic index predicting survival in transformed Waldenström macroglobulinemia. 12th November 2020 Histological transformation into diffuse large B-cell lymphoma is a rare complication in […]
Structural aberrations are associated with poor survival in patients with clonal cytopenia of undetermined significance. 12th November 2020 Not available. View the full article @ Haematologica Get PDF with LibKey
Rapid decline in estimated glomerular filtration rate in sickle cell anemia: results of a multicenter pooled analysis. 12th November 2020 Not available. View the full article @ Haematologica Get PDF with LibKey
Homozygous Southeast Asian Ovalocytosis in five live-born neonates. 12th November 2020 Not available. View the full article @ Haematologica Get PDF with LibKey
The LEukemia Artificial Intelligence Program (LEAP) in Chronic Myeloid Leukemia in Chronic Phase: A Model to Improve Patient Outcomes. 12th November 2020 Extreme gradient boosting methods outperform conventional machine-learning models. Here, we have developed […]
Global loss of Tfr2 with concomitant induced iron deficiency greatly ameliorates the phenotype of a murine thalassemia intermedia model. 12th November 2020 β-thalassemias result from mutations in β-globin, causing ineffective erythropoiesis and secondary iron […]
When Non-Whiteness Becomes a Condition. 12th November 2020 The term “benign ethnic neutropenia” describes the phenotype of having an ANC […]
UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes. 11th November 2020 Epigenetic regulation is essential for the maintenance of the hematopoietic system, and […]
Minimal Residual Disease Quantification in Ovarian Tissue Collected in Patients in Complete Remission of Acute Leukemia. 10th November 2020 Ovarian tissue cryopreservation (OTC) is offered to women treated for acute leukemia […]
How I diagnose and treat NPM1-mutated AML. 10th November 2020 Mutations of the nucleophosmin (NPM1) gene, encoding for a nucleolar multifunctional protein, […]
Combined Oral 5-Azacytidine and Romidepsin are Highly Effective in Patients with PTCL: A Multicenter Phase 2 Study. 10th November 2020 Peripheral T-cell lymphomas (PTCL) are uniquely vulnerable to epigenetic modifiers. We demonstrated […]
Hereditary Hemorrhagic Telangiectasia: Systemic Therapies, Guidelines, and an Evolving Standard of Care. 10th November 2020 Hereditary hemorrhagic telangiectasia (HHT) management is evolving due to the emergence and […]
The treatment of Burkitt lymphoma in adults. 10th November 2020 Burkitt lymphoma (BL) is a highly aggressive, B-cell, non-Hodgkin lymphoma (NHL) categorized […]
miR-29 Modulates CD40 Signaling in Chronic Lymphocytic Leukemia by Targeting TRAF4: an Axis Affected by BCR inhibitors. 10th November 2020 B cell receptor (BCR) signaling and T cell interactions play a pivotal […]
Venous thromboembolism in cancer patients: a population-based cohort study. 10th November 2020 The incidence of venous thromboembolism in cancer patients may have changed in […]
Immune thrombocytopenia (ITP) World Impact Survey (I-WISh): patient and physician perceptions of diagnosis, signs and symptoms, and treatment. 10th November 2020 Immune thrombocytopenia (ITP) is now well-known to reduce patients’ health-related-quality-of-life. However, data […]
Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial. 10th November 2020 The benefits of vitamin D, omega-3 fatty acids, and exercise in disease […]
A fixed-duration, measurable residual disease-guided approach in CLL: follow-up data from the phase 2 ICLL-07 FILO trial. 9th November 2020 Trials assessing first-line, fixed-duration approaches in chronic lymphocytic leukemia (CLL) are yielding […]
FBXO11-Mediated Proteolysis of BAHD1 Relieves PRC2-dependent Transcriptional Repression in Erythropoiesis. 6th November 2020 The histone mark H3K27me3 and its reader/writer Polycomb repressive complex 2 (PRC2) […]
Expression of the chemokine receptor CCR1 promotes the dissemination of multiple myeloma plasma cells in vivo . 5th November 2020 Multiple myeloma (MM) disease progression is dependent on the ability of MM […]
