The latest haematology articles

ClinOwl brings you the latest haematology articles from the leading medical journals in a single view.

Haematology latest

• CXCR4 mutational status does not impact outcomes in patients with Waldenstrom macroglobulinemia treated with proteasome inhibitors.17th January 2020
  Click here to read the full article @ American journal of hematology
• Increased activation of PI3 kinase-δ predisposes to B cell lymphoma.17th January 2020
  Activated PI3-kinase-δ syndrome (APDS) is a rare primary combined immunodeficiency caused by either dominant gain-of-function mutations in the PIK3CD gene encoding the catalytic subunit p110δ of phosphoinositide 3-kinase-δ … Read more
• A heavy metal baseline score predicts outcome in AML.17th January 2020
  Despite abundant epidemiological data linking metals to leukemia and other cancers, baseline values of toxic and essential metals in patients with leukemia and the clinical impact of these … Read more
• Primary immunodeficiencies reveal the molecular requirements for effective host defense against EBV infection.17th January 2020
  Epstein-Barr virus (EBV) is an enigma – on one hand, it infects and persists in latent form in the vast majority of the global population, causing relatively benign … Read more
• Wdr26 regulates nuclear condensation in developing erythroblasts.17th January 2020
  Mammalian red blood cells lack nuclei. The molecular mechanisms underlying erythroblast nuclear condensation and enucleation, however, remain poorly understood. Here we show that Wdr26, a gene upregulated during … Read more

Anticoagulation

• Coagulation mixing studies: utility, algorithmic strategies and limitations for lupus anticoagulant testing or follow up of abnormal coagulation tests.2nd November 2019
  Coagulation testing underpins the investigation of hemostasis and/or monitoring of anticoagulation therapy for prevention and/or treatment of thrombosis related pathology. Assessment of coagulation results requires comparison against a … Read more
• Association of Surgical Hematoma Evacuation vs Conservative Treatment With Functional Outcome in Patients With Cerebellar Intracerebral Hemorrhage.9th October 2019
  Abstract: The association of surgical hematoma evacuation with clinical outcomes in patients with cerebellar intracerebral hemorrhage (ICH) has not been established.To determine the association of surgical hematoma evacuation … Read more
• Safety of using direct oral anticoagulants in the diagnostic workup of outpatients with suspicion of acute venous thromboembolism.5th October 2019
  Abstract: Click here to read full article on original source website
• Circulating Levels of Biomarkers of Cerebral Injury in Patients with Atrial Fibrillation.3rd October 2019
  Abstract: Atrial fibrillation (AF) is a source of altered brain perfusion and ischemia, potentially leading to cerebral injury and blood brain barrier (BBB) disruption, which may result in … Read more
• Evaluation of Time to Therapeutic Anticoagulation and Associated Outcomes in Critically Ill, Obese Patients With Pulmonary Embolism Receiving Unfractionated Heparin.29th September 2019
  Abstract: Delays in time to therapeutic activated partial thromboplastin time (aPTT) have been associated with poor outcomes in patients with acute pulmonary embolism (PE).To investigate the relationship between … Read more

Haemato-oncology

• Integrated drug profiling and CRISPR screening identify essential pathways for CAR T cell cytotoxicity.13th December 2019
  Chimeric antigen receptor (CAR) T cell therapy has proven effective in relapsed and refractory B cell malignancies, but resistance and relapses still occur. Better understanding of mechanisms influencing … Read more
• Outcome in Children With Standard-Risk B-Cell Acute Lymphoblastic Leukemia: Results of Children’s Oncology Group Trial AALL0331.12th December 2019
  Children's Oncology Group (COG) AALL0331 tested whether intensified postinduction therapy that improves survival in children with high-risk B-cell acute lymphoblastic leukemia (ALL) would also improve outcomes for those … Read more
• Impact of NPM1/FLT3-ITD genotypes defined by the2017 European LeukemiaNet in patients with acute myeloid leukemia.12th December 2019
  Patients with AML harboring FLT3 internal tandem duplications (ITD) have poor outcomes, in particular AML with a high ({greater than or equal to}0.5) mutant-to-wildtype allelic ratio (AR). The … Read more
• Lack of the multidrug transporter MRP4/ABCC4 defines the PEL-negative blood group and impairs platelet aggregation.12th December 2019
  The rare PEL-negative phenotype is one of the last blood groups with an unknown genetic basis. By combining whole-exome sequencing and comparative global proteomic investigations, we found a … Read more
• Association Between Fertility Treatment and Cancer Risk in Children.11th December 2019
  An increasing number of children worldwide are born after the use of fertility treatment, although it remains unclear whether the treatment affects the risk of childhood cancer and … Read more