Pre-existing and treatment-emergent autoimmune cytopenias in patients with CLL treated with targeted drugs. 2nd March 2021 Autoimmune cytopenias (AIC) affect 5-9% of patients with chronic lymphocytic leukemia (CLL). […]
Retinoids in haematology : a timely revival? 2nd March 2021 The retinoic acid receptors (RARA, RARB, RARG) are ligand-regulated nuclear receptors which […]
The molecular bases for the association of FHR-1 with atypical hemolytic uremic syndrome and other diseases. 2nd March 2021 Factor H-related proteins (FHRs) are a group of partly characterized complement proteins […]
The pathobiology of thrombosis, microvascular disease, and hemorrhage in the myeloproliferative neoplasms. 2nd March 2021 Thrombotic, vascular, and bleeding complications are the most common causes of morbidity […]
Venetoclax sensitivity in multiple myeloma is associated with B cell gene expression. 2nd March 2021 Venetoclax is a highly potent, selective BCL2 inhibitor capable of inducing apoptosis […]
Weekly Carfilzomib plus Cyclophosphamide and Dexamethasone in the Treatment of Relapsed/Refractory Multiple Myeloma: Final results from the MCRN-003/MYX.1 single arm phase II trial. 2nd March 2021 The MCRN-003/CCTGMYX.1 is a single arm phase II trial of weekly carfilzomib, […]
AID overexpression leads to aggressive murine CLL and non-Ig mutations that mirror human neoplasms. 2nd March 2021 Most cancers become more dangerous by the outgrowth of malignant subclones with […]
Annual Incidence and Severity of Acute Episodes in Hereditary Thrombotic Thrombocytopenic Purpura. 2nd March 2021 Hereditary thrombotic thrombocytopenic purpura (hTTP) is a rare thrombotic microangiopathy characterized by […]
Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. 2nd March 2021 Blinatumomab is a CD3/CD19-directed bispecific T-cell engager molecule with efficacy in children […]
Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. 2nd March 2021 Standard chemotherapy for first relapse of B-cell acute lymphoblastic leukemia (B-ALL) in […]
Impacts of ABO Incompatible Platelet Transfusions on Platelet Recovery and Outcomes after Intracerebral Hemorrhage. 2nd March 2021 Acute platelet transfusion after intracerebral hemorrhage (ICH) given in efforts to reverse […]
Outcome of T-cell Acute Lymphoblastic Leukemia/Lymphoma: Focus on Near-ETP Phenotype & Differential Impact of Nelarabine. 27th February 2021 Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) is characterized by a distinct […]
Chronic organ injuries in children with sickle cell disease. 25th February 2021 Median life expectancy of patients with sickle cell disease has increased to […]
Clinical spectrum, outcome and management of immune thrombocytopenia associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. 25th February 2021 Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) are associated with systemic […]
Dual cytoplasmic and nuclear localization of HTLV-1-encoded HBZ protein is a unique feature of adult T cell leukemia. 25th February 2021 Adult T-cell leukemia-lymphoma (ATL), is a highly malignant T-cell neoplasm caused by […]
Immune thrombocytopenia in myeloid and lymphoid clonal disorders: an intriguing association. 25th February 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
Is it NICE (nuclear import as a carcinogenic mechanism) to restrict HBZ in the cytoplasm? 25th February 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
Rationale for the combination of venetoclax and ibrutinib in Tprolymphocytic leukemia. 25th February 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
The EBF1-PDGFRB T681I mutation is highly resistant to imatinib and dasatinib in vitro and detectable in clinical samples prior to treatment. 25th February 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
Unique ethnic features of DDX41 mutations in patients with idiopathic cytopenia of undetermined significance, myelodysplastic syndrome, or acute myeloid leukemia. 25th February 2021 DDX41 mutations are associated with hematologic malignancies including myelodysplastic syndrome (MDS) and […]
Enhanced Homology-directed Repair for Highly Efficient Gene Editing in Hematopoietic Stem/Progenitor Cells. 24th February 2021 Lentivector gene therapy for X-linked chronic granulomatous disease (X-CGD) has proven to […]
The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia. 24th February 2021 Molecular classification of acute myeloid leukemia (AML) aids prognostic stratification and clinical […]
Differentiation Syndrome with Lower-intensity Treatments for Acute Myeloid Leukemia. 24th February 2021 Differentiation Syndrome (DS) has been identified in a subset of patients undergoing […]
EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene. 23rd February 2021 Genes encoding B lineage restricted transcription factors are frequently mutated in B-lymphoid […]
Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin. 23rd February 2021 During early embryonic development in mammals, including humans and mice, megakaryocytes first […]
HIF2α is a Direct Regulator of Neutrophil Motility. 23rd February 2021 Orchestrated recruitment of neutrophils to inflamed tissue is essential during initiation of […]
P-selectin deficiency promotes liver senescence in sickle cell disease mice. 23rd February 2021 Sickle cell disease (SCD) is caused by a homozygous mutation in the […]
STING and Transplantation: Can targeting this pathway improve outcomes? 23rd February 2021 Stimulator of Interferon Genes (STING) is an innate immune sensor of cytoplasmic […]
TWIST1 preserves hematopoietic stem cell function via CACNA1B/Ca2+/mitochondria axis. 23rd February 2021 Mitochondria of hematopoietic stem cells (HSCs) play crucial roles in regulating cell […]
ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia. 23rd February 2021 The expression of ZAP-70 in a subset of CLL patients strongly correlates […]
Haplo-identical or mismatched unrelated donor hematopoietic cell transplantation for Fanconi anemia: results from the Severe Aplastic Anemia Working Party of the EBMT. 19th February 2021 Allogeneic hematopoietic cell transplantation (HCT) is the only curative option for bone […]
Prediction of postpartum hemorrhage in pregnant women with immune thrombocytopenia: development and validation of the MONITOR model in a nationwide multicenter study. 19th February 2021 Globally, postpartum hemorrhage (PPH) is the leading cause of maternal death. Women […]
Upgrading the evidence for the use of ambroxol in Gaucher disease and GBA related Parkinson: Investigator initiated registry based on real life data. 19th February 2021 Ambroxol hydrochloride is an oral mucolytic drug available over-the-counter for many years […]
Identification of a novel genetic locus associated with immune mediated thrombotic thrombocytopenic purpura. 18th February 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
Light chain proteinuria revealing mu-heavy chain disease: an atypical presentation of Waldenström macroglobulinemia in two cases. 18th February 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma. 18th February 2021 Multiple myeloma is a malignancy of plasma cells (PC) initiated and driven […]
The miR-200c/141-ZEB2-TGFβ axis is aberrant in human T-cell prolymphocytic leukemia. 18th February 2021 T cell prolymphocytic leukemia (T-PLL) is mostly characterized by aberrant expansion of […]
The TRPV2 channel mediates Ca2+ influx and the Δ9-THC-dependent decrease in osmotic fragility in red blood cells. 18th February 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
A mutation in the iron-responsive element of ALAS2 is a modifier of disease severity in a patient suffering from CLPX associated erythropoietic protoporphyria. 18th February 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
ATG5 promotes eosinopoiesis, but inhibits eosinophil effector functions. 18th February 2021 Eosinophils are white blood cells contributing to the regulation of immunity and […]
BH3 profiling identifies ruxolitinib as a promising partner for venetoclax to treat T-cell prolymphocytic leukemia. 18th February 2021 Conventional therapies for patients with T-cell prolymphocytic leukemia (T-PLL) such as cytotoxic […]
Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin. 18th February 2021 In the international randomized phase III RATIFY trial, the multi-kinase inhibitor midostaurin […]
Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus. 18th February 2021 Activation of coagulation factor (F) XI promotes multi-organ failure in rodent models […]
Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy. 17th February 2021 Uterine fibroids are a common cause of heavy menstrual bleeding and pain. […]
Intravenous ferric derisomaltose for the treatment of iron deficiency anemia. 13th February 2021 Intravenous (IV) iron is the therapy of choice when oral iron is […]
Factor XIII cross-links fibrin(ogen) independent of fibrin polymerization in experimental acute liver injury. 11th February 2021 Intravascular fibrin clot formation follows a well-ordered series of reactions catalyzed by […]
JAK out of the box: MPN-associated JAK2 V617F mutations contribute to aortic aneurysms. 11th February 2021 Not available. View the full article @ Haematologica Get PDF with LibKey
Loss of interleukin-10 activates innate immunity to eradicate adult T cell leukemia initiating cells. 11th February 2021 Adult T cell leukemia/lymphoma (ATL) is associated to chronic human T cell […]
Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia. 11th February 2021 Symptomatic methotrexate-related central neurotoxicity, ‘MTX neurotoxicity’, is a severe toxicity experienced during […]
Molecular determinants of the factor VIII/von Willebrand factor complex revealed by BIVV001 cryo-electron microscopy. 11th February 2021 Interaction of factor VIII (FVIII) with von Willebrand factor (VWF) is mediated […]
Reduced frequencies and functional impairment of dendritic cell subsets and non-classical monocytes in myelodysplastic syndromes. 11th February 2021 In myelodysplastic syndromes (MDS) the immune system is involved in pathogenesis as […]
RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells. 11th February 2021 Patients with familial platelet disorder with a predisposition to myeloid malignancy (FPDMM) […]
Sequence-specific 2′-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of plateletleukocyte aggregates. 11th February 2021 Antisense oligonucleotides (ASOs) are DNA-based, disease-modifying drugs. Clinical trials with 2′-O-methoxyethyl (2’MOE) […]
Sulfated non-anticoagulant heparin derivative modifies intracellular hemoglobin, inhibits cell sickling in vitro, and prolongs survival of sickle cell mice under hypoxia. 11th February 2021 Sickle cell disease (SCD) is an autosomal recessive genetic disease caused by […]
Crucial role of hematopoietic JAK2V617F in the development of aortic aneurysms. 11th February 2021 JAK2V617F is the most frequent driver mutation in myeloproliferative neoplasms (MPNs) and […]
Early detection of T-cell lymphoma with T follicular helper phenotype by RHOA mutation analysis. 11th February 2021 Angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma with T follicular helper […]
Impaired adhesion of neutrophils expressing Slc44a2/HNA-3b to VWF protects against NETosis under venous shear rate. 8th February 2021 Genome wide association studies linked expression of the human neutrophil antigen 3b […]
VWF antigen levels are associated with burden of rare nonsynonymous variants in the VWF gene. 8th February 2021 Approximately 35% of patients with Type 1 von Willebrand Disease (VWD) do […]
A combination of cyclophosphamide, interleukin-2 allow CD4+ T cells converted to Tregs to control scurfy syndrome. 5th February 2021 Immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome is caused by mutations in FOXP3, […]
N-glycan mediated shielding of ADAMTS13 prevents binding of pathogenic autoantibodies in immune-mediated TTP. 5th February 2021 Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is an autoimmune disorder caused by the […]
