Vemurafenib plus Rituximab in Refractory or Relapsed Hairy-Cell Leukemia. 12th May 2021 Hairy-cell leukemia (HCL) is a CD20+ indolent B-cell cancer in which a […]
Long-term Outcomes after Gene Therapy for Adenosine Deaminase Severe Combined Immune Deficiency (ADA SCID). 11th May 2021 Patients lacking functional adenosine deaminase activity suffer from severe combined immunodeficiency (ADA […]
GlcNAc is a mast-cell chromatin-remodeling oncometabolite that promotes systemic mastocytosis aggressiveness. 11th May 2021 Systemic mastocytosis (SM) is a KIT-driven hematopoietic neoplasm characterized by the excessive […]
Investigation of product derived lymphoma following infusion of piggyBac modified CD19 chimeric antigen receptor T-cells. 11th May 2021 We performed a Phase I clinical trial of donor derived CD19-specific chimeric […]
Anthracycline Treatment, Cardiovascular Risk Factors and the Cumulative Incidence of Cardiovascular Disease in a Cohort of Newly Diagnosed Lymphoma Patients from the Modern Treatment Era. 10th May 2021 The development of cardiovascular disease (CVD) in long-term survivors of lymphoma is […]
Imaging the dynamics and microstructure of fibrin clot polymerization in cardiac surgical patients using spectrally encoded confocal microscopy. 10th May 2021 During cardiac surgery with cardiopulmonary bypass (CPB), altered hemostatic balance may disrupt […]
Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML. 10th May 2021 The mechanism underlying cell type-specific gene induction conferred by ubiquitous transcription factors […]
Overexpression of wild type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma. 10th May 2021 Tight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα […]
Transcranial color-coded duplex sonography reliably identifies intracranial vasculopathy in adults patients with sickle cell disease. 10th May 2021 In order to prevent stroke, screening for disease-related intracranial vasculopathy using Doppler […]
VEXAS Syndrome. 10th May 2021 VEXAS syndrome is a monogenic disease of adulthood caused by somatic mutations […]
DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome. 6th May 2021 DIS3 gene mutations (DIS3mts) occur in roughly 10% of multiple myeloma (MM) […]
IL4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation. 6th May 2021 Cytokines are key regulators of tumor immune surveillance by controlling immune cell […]
Improved outcomes of high-risk relapsed Hodgkin lymphoma patients after high-dose chemotherapy: a 15-year analysis. 6th May 2021 High-dose chemotherapy and autologous stem-cell transplant (HDC/ASCT) is standard treatment of chemosensitive […]
MAP-kinase and JAK-STAT pathways dysregulation in plasmablastic lymphoma. 6th May 2021 Plasmablastic lymphoma (PBL) is an aggressive B-cell lymphoma with an immunoblastic/large cell […]
CEBPA bZip Mutations are Associated with Favorable Prognosis in de novo AML: A Report from the Children’s Oncology Group. 5th May 2021 Bi-allelic CEBPA mutations are associated with favorable outcomes in AML. We evaluated […]
IFNλ Therapy Prevents Severe Gastrointestinal Graft-versus-Host Disease. 5th May 2021 Immunopathology and intestinal stem cell (ISC) loss in the gastrointestinal (GI) tract […]
GADD45g acts as a novel tumor suppressor and its activation confers new combination regimens for the treatment of AML. 4th May 2021 Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy for which there […]
Low-burden TP53 mutations in CLL: Clinical impact and clonal evolution within the context of different treatment options. 4th May 2021 Chronic lymphocytic leukemia (CLL) patients with TP53 mutations experience chemo-refractory disease and […]
A Flow cytometric assay to detect platelet activating antibodies in VITT after ChAdOx1 nCov-19 vaccination. 4th May 2021 Vaccination is crucial in combatting the SARS-CoV-2 pandemic. The rare complication of […]
A PSGL-1 Glycomimetic Reduces Thrombus Burden Without Affecting Hemostasis. 4th May 2021 Events mediated by the P-selectin/PSGL-1 pathway play a critical role in the […]
BCOR gene alterations in hematological diseases. 4th May 2021 The BCL6 co-repressor (BCOR) is a transcription factor involved in the control […]
Aspirin and anti-platelet treatments in cancer. 3rd May 2021 Platelets have been hypothesized to promote certain neoplastic malignancies, however, antiplatelet drugs […]
Lessons to learn from tumor-educated platelets. 3rd May 2021 Platelets have long been known to play important roles beyond hemostasis and […]
Platelets and extracellular vesicles and their cross-talk with cancer. 3rd May 2021 Platelets play significant and varied roles in cancer progression, as detailed throughout […]
Platelets and tumor-associated RNA transfer. 3rd May 2021 Until recently the nucleic acid content of platelets was considered to be […]
Diagnostic Value of D-dimers for Limb Deep Vein Thrombosis in Children: A Prospective Study. 30th April 2021 The present study sought to evaluate the discriminative and predictive ability of […]
Tranexamic Acid for the Prevention of Blood Loss after Cesarean Delivery. 29th April 2021 Prophylactic administration of tranexamic acid has been associated with reduced postpartum blood […]
Adding eltrombopag to immunosuppression: the importance of predicting outcome. 29th April 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
Carfilzomib or bortezomib in combination with cyclophosphamide and dexamethasone followed by carfilzomib maintenance for patients with multiple myeloma after one prior therapy: results from a multi-centre, phase II, randomized, controlled trial (MUKfive). 29th April 2021 The proteasome inhibitors (PIs), carfilzomib and bortezomib, are widely used to treat […]
LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for Mixed Lineage Leukemia-Rearranged acute leukemia. 29th April 2021 Although great advances have been made in understanding the pathobiology of MLL-rearranged […]
Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag. 29th April 2021 Pretreatment blood counts, particularly the absolute reticulocyte count (ARC) ≥25×109/L, correlate with […]
Synergistic interaction between HDAC and MCL-1 inhibitors through downregulation of BCL-XL in multiple myeloma. 29th April 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
Prolonged in-hospital stay and higher mortality after Covid-19 among patients with non-Hodgkin lymphoma treated with B-cell depleting immunotherapy. 28th April 2021 Prolonged Covid-19 is an emerging issue for patients with lymphoma or immune […]
Prothrombotic immune thrombocytopenia after COVID-19 vaccine. 28th April 2021 We report five cases of prothrombotic immune thrombocytopenia after exposure to the […]
Assessment of Fixed-Duration Therapies for Treatment-Naïve Waldenström Macroglobulinemia. 28th April 2021 Comparative data guiding initial therapy for Waldenström macroglobulinemia (WM), an infrequently encountered […]
MondoA Drives B-ALL Malignancy through Enhanced Adaptation to Metabolic Stress. 28th April 2021 Cancer cells are in most instances characterized by rapid proliferation and uncontrolled […]
Multi-Site 11-Year Experience of Less-Intensive versus Intensive Therapies in Acute Myeloid Leukemia. 28th April 2021 Less-intensive induction therapies are increasingly used in older patients with acute myeloid […]
Screening for Hypertension in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. 27th April 2021 Hypertension is a major risk factor for cardiovascular disease and can be […]
B Cell Receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter Transformation. 26th April 2021 B cell receptor (BCR) signals play a critical role in the pathogenesis […]
Long-term Results of Low-intensity Chemotherapy with Clofarabine or Cladribine Combined with Low-Dose Cytarabine Alternating with Decitabine in Older Patients with Newly Diagnosed Acute Myeloid Leukemia. 26th April 2021 The treatment of older patients with newly diagnosed acute myeloid leukemia (AML) […]
Low dose venetoclax as a single agent treatment of plasma cell malignancies harboring t(11;14). 26th April 2021 Approximately 20% of newly diagnosed multiple myeloma (NDMM) patients harbor t(11;14), a […]
How I treat dysfibrinogenemia. 25th April 2021 Congenital dysfibrinogenemia (CD) is caused by structural changes in fibrinogen that modify […]
Molecular Classification Improves Risk Assessment in Adult BCR-ABL1-negative B-ALL. 25th April 2021 Genomic classification has improved risk assignment of pediatric but not adult B-lineage […]
Platelet MHC Class I Mediates CD8+ T Cell Suppression During Sepsis. 25th April 2021 Circulating platelets interact with leukocytes to modulate host immune and thrombotic responses. […]
Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C. 25th April 2021 Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) […]
RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation. 25th April 2021 Ferroportin (FPN), the body’s sole iron exporter, is essential for maintaining systemic […]
The Cost-effectiveness of Gene Therapy for Severe Hemophilia B: Microsimulation Study from the United States Perspective. 25th April 2021 Adeno-associated virus (AAV)-mediated gene therapy is a novel treatment promising to reduce […]
Real-world use of thrombopoietin receptor agonists in elderly patients with primary immune thrombocytopenia. 23rd April 2021 The efficacy and safety of thrombopoietin-receptor agonists (TRAs) in elderly patients with […]
Reduced global cerebral oxygen metabolic rate in sickle cell disease and chronic anemias. 23rd April 2021 Anemia is the most common blood disorder in the world. In patients […]
How we incorporate novel agents into the treatment of classic Hodgkin lymphoma. 23rd April 2021 The introduction of targeted immunotherapies specifically, brentuximab vedotin (BV) and programmed death-1 […]
Targeting the tumor microenvironment in chronic lymphocytic leukemia. 22nd April 2021 The tumor microenvironment (TME) plays an essential role in the development, growth, […]
The post-hematopoietic cell transplantation microbiome: relationships with transplant outcome and potential therapeutic targets. 22nd April 2021 Microbiota injury occurs in many patients undergoing allogeneic hematopoietic cell transplantation, likely […]
Brain injury pathophysiology study by a multimodal approach in children with sickle cell anemia with no intra or extra cranial arteriopathy. 22nd April 2021 Despite its high prevalence in children with sickle cell anemia (SCA), the […]
Clinical diagnostic value of telomere length measurement in inherited bone marrow failure syndromes. 22nd April 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
Dual intracellular targeting by ruxolitinib and Mcl-1 inhibitor S63845 in IL-6 dependent myeloma cells blocks in vivo tumor growth. 22nd April 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
Evolutionary clonal trajectories in nodular lymphocyte predominant Hodgkin lymphoma with high transformation risk. 22nd April 2021 The B cell architecture of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is […]
Progress in understanding the biology of nodular lymphocyte predominant Hodgkin lymphoma. 22nd April 2021 Not available. View the full article @ Haematologica Get PDF with LibKey […]
Extracellular vesicles shed by follicular lymphoma B cells promote the polarization of bone marrow stromal cell niche. 21st April 2021 Follicular Lymphoma (FL) originates in the lymph nodes (LN) and infiltrates bone […]
Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke. 21st April 2021 Intracerebral hemorrhage associated with thrombolytic therapy with tissue plasminogen activator (tPA) in […]
Prognostic significance of concurrent gene mutations in intensively treated patients with IDH-mutated AML, an ALFA study. 21st April 2021 IDH inhibitors are effective in AML, and trials evaluating frontline combinations with […]
