The Latest Gynaecological Cancer
Keep up to date with the latest in gynaecological cancer. Check out the latest gynaecological cancer articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily
- Treatment of epithelial ovarian cancer.Ovarian cancer is the third most common gynecologic malignancy worldwide but accounts for the highest mortality rate among these cancers. A stepwise approach to assessment, diagnosis, and treatment is vital to appropriate management of this disease process. An integrated approach with gynecologic oncologists as well as medical oncologists, pathologists, and radiologists is of paramount importance […]
- Adherence to Oral Anticancer Therapeutics in the Gynecologic Oncology Population.To gain a better understanding of gynecologic oncology patient adherence to oral anticancer agents through both a cross-sectional survey of adherence and qualitative interviews with patients and clinicians regarding their experience with these medications.Eligible participants completed a survey for this cross-sectional study that included an assessment of adherence, distress, quality of life, and health literacy. […]
- Fertility-Sparing Treatment for Early-Stage Cervical, Ovarian, and Endometrial Malignancies.Approximately 20% of gynecologic malignancies are diagnosed in reproductive-aged women, and standard-of-care surgical treatment often precludes future fertility. In early-stage disease, shared decision making about fertility-sparing medical and surgical approaches may give well-selected patients the opportunity to pursue their family-building goals without compromising long-term survival. Although future fertility is an important consideration for young women […]
- Determinants of p16/Ki-67 adequacy and positivity in HPV-positive women from a screening population.The objective of this study was to describe the determinants of adequacy and positivity of the p16/Ki-67 assay in a human papillomavirus (HPV)-positive screening population enrolled within the New Technologies for Cervical Cancer 2 (NTCC2) study.ThinPrep slides were immunostained for p16/Ki-67; each slide had 3 reports from different laboratories. The authors included population-related, sampling-related/staining-related, and […]
- An Ecological Evaluation of the Increasing Incidence of Endometrial Cancer and the Obesity Epidemic.The prevalence of obesity has increased significantly in recent decades, particularly among younger women, and is a known risk factor for endometrial cancer.The objective of this study was to evaluate the trend in the prevalence of obesity and the incidence of type I endometrial cancer over time in various age categories to determine if an […]
- New-Onset myocardial injury in COVID-19 Pregnant Patients: A Case Series of 15 Patients.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the new coronavirus responsible for the coronavirus disease (COVID-19), characterized by acute respiratory distress syndrome and atypical pneumonia. In non-pregnant women, studies have shown that SARS-CoV-2 causes cardiac injury, which can result in myocardial inflammation and damage. Despite many studies investigating the extent of cardiac compromise in […]
- A meta-analysis of reversion mutations in BRCA genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistance.Germline mutations in the BRCA1 or BRCA2 (BRCA) genes predispose to hereditary breast and ovarian cancer and, mostly in the case of BRCA2, are also prevalent in cases of pancreatic and prostate malignancies. Tumours from these patients tend to lose both copies of the wild type BRCA gene, which makes them exquisitely sensitive to platinum […]
- An evolution in sentinel node mapping for cervical cancer.The technique of sentinel lymph node (SLN) biopsy has emerged as an alternative to complete pelvic lymphadenectomy to establish lymph node status in early stage cervical cancers. Traditional lymph node stripping techniques are associated with high rates of patient morbidity, such as lymphedema. For the majority of patients who are free of lymph node metastases […]
- Camrelizumab Plus Apatinib in Patients With Advanced Cervical Cancer (CLAP): A Multicenter, Open-Label, Single-Arm, Phase II Trial.Camrelizumab is an antibody against programmed death protein 1. We assessed the activity and safety of camrelizumab plus apatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor-2, in patients with advanced cervical cancer.This multicenter, open-label, single-arm, phase II study enrolled patients with advanced cervical cancer who progressed after at least one line of […]
- Effect of Length of Surgery on the Incidence of Venous Thromboembolism after Benign Hysterectomy.Venous thromboembolism is a leading cause of morbidity and mortality postoperatively. Current venous thromboembolism risk assessment tools have not been validated in gynecologic patients. Most patients undergoing hysterectomy for benign indications will receive mechanical or pharmacological prophylaxis based on preoperative risk assessment. However, current guidelines do not incorporate newer data that indicate additional risk of […]
- Mismatch repair status influences response to fertility-sparing treatment of endometrial cancer.Patients younger than 40 years usually present with early-stage endometrial cancer with favorable prognosis. However, such patients are usually in their childbearing age and may desire fertility-sparing options. The identification of biomarkers may improve the clinical outcomes in these patients and aid in fertility-sparing management; however, there has been no reports on biomarker analysis so […]
- Risk of Cervical Precancer and Cancer Among Uninsured and Underserved Women 2009-2017.New guidelines for managing cervical precancer among US women directly use risk to guide clinical actions for individuals who are being screened. These risk-based management guidelines have previously only been based on risks from a large, integrated, health care system. However, for the first time, data representative of low-income women without continuous insurance coverage were […]
- Distinct microRNA profiles for complete hydatidiform moles at risk for malignant progression.MicroRNAs (miRNAs) are small non-coding RNAs with important regulatory functions. While well-studied in cancer, less is known about the role of miRNAs in premalignant disease. Complete hydatidiform moles are benign forms of gestational trophoblastic disease that progress to gestational trophoblastic neoplasia in up to 20% of cases; however, there is no well-established biomarker that can […]
- HPV Vaccination and the Risk of Invasive Cervical Cancer.The efficacy and effectiveness of the quadrivalent human papillomavirus (HPV) vaccine in preventing high-grade cervical lesions have been shown. However, data to inform the relationship between quadrivalent HPV vaccination and the subsequent risk of invasive cervical cancer are lacking.We used nationwide Swedish demographic and health registers to follow an open population of 1,672,983 girls and […]
- Salpingectomy versus tubal ligation for sterilization: a systematic review and meta-analysis.Following strong evidence and major organizations recommending salpingectomy over tubal ligation, we sought to perform a systematic review and meta-analysis comparing the intraoperative attributes and complication rates associated with these two procedures.We searched PubMed, the Cochrane Library, EMBASE and clinical trials registries without time or language restrictions. The search was carried out in February 2020. […]
- Role of carbon nanoparticle suspension in sentinel lymph node biopsy for early-stage cervical cancer: a prospective study.To evaluate the clinical diagnostic validity of carbon nanoparticle suspension (CNS) in sentinel lymph node biopsy (SLNB) for assessing lymphatic spread of early-stage cervical cancer.A prospective study.356 cases.We enrolled 356 stage Ia2-IIa2 cervical cancer patients to undergo SLNB using CNS, followed by systematic pelvic lymphadenectomy. All lymph node specimens were assessed using conventional histopathologic ± […]
- Cervical cancer prevention in transgender men: a review.There is increased awareness of transgender physical and mental health widely and in academic research. A significant proportion of transgender men will retain their cervix with an increased risk of cervical cancer. In this review of cervical cancer screening among transgender men, we try to estimate how many transgender men still have a cervix, understand […]
- Outcomes after the regionalization of care for high-grade endometrial cancers: a population-based study.In June 2013, Ontario Health – Cancer Care Ontario (CCO), the agency responsible for advancing cancer care in Ontario, Canada, published practice guidelines recommending that Gynaecologic Oncologists (GOs) at tertiary care centers manage the treatment of patients with high-grade endometrial cancers. This study examines the effects of this regionalization of care on patient outcomes.In this […]
- Occupational Exposure to Human Papillomavirus and Vaccination for Health Care Workers.Multiple studies suggest that health care workers treating human papillomavirus (HPV)-associated conditions may experience occupational exposure to the virus. Case reports describe the development of cancer and other disease in health care professionals at low risk for such conditions except for their work. Despite limited data, vaccination can be a safe and effective method to […]
- Occupational Exposure to Human Papillomavirus and Vaccination for Health Care Workers.Multiple studies suggest that health care workers treating human papillomavirus (HPV)-associated conditions may experience occupational exposure to the virus. Case reports describe the development of cancer and other disease in health care professionals at low risk for such conditions except for their work. Despite limited data, vaccination can be a safe and effective method to […]
- The impact of surgical learning curve on survival – reopening the door for minimally invasive surgery in the management of cervical cancer?Minimally invasive surgery has been widely adopted in gynaecologic oncology with a significant surge the past decade associated with the introduction of robot-assisted surgery. Up until 2018, virtually all testimonials of minimally invasive surgery for cervical cancer indicated equal oncologic outcomes compared to laparotomy. The unexpected results from the only randomised controlled trial (Ramirez PT […]
- The impact of surgical learning curve on survival – reopening the door for minimally invasive surgery in the management of cervical cancer?Minimally invasive surgery has been widely adopted in gynaecologic oncology with a significant surge the past decade associated with the introduction of robot-assisted surgery. Up until 2018, virtually all testimonials of minimally invasive surgery for cervical cancer indicated equal oncologic outcomes compared to laparotomy. The unexpected results from the only randomised controlled trial (Ramirez PT […]
- Ovarian cancer risk in Lynch syndrome: It’s time to individualize.Our understanding of cancer risks associated with Lynch syndrome (LS) has evolved since Dr. Warthin first identified family G in 1913. The current study by Ryan et al provides insight into provider and patient knowledge about gynecologic cancer care options in LS and found that counseling, surveillance, and risk reduction (RR) for these patients vary […]
- Ovarian cancer risk in Lynch syndrome: It’s time to individualize.Our understanding of cancer risks associated with Lynch syndrome (LS) has evolved since Dr. Warthin first identified family G in 1913. The current study by Ryan et al provides insight into provider and patient knowledge about gynecologic cancer care options in LS and found that counseling, surveillance, and risk reduction (RR) for these patients vary […]
- Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: A report from the ESMO Precision Medicine Working Group.Next-generation sequencing (NGS) allows sequencing a high number of nucleotides in a short time frame at an affordable cost. While this technology has been widely implemented, there are no recommendations from scientific societies about their use in oncology practice. The European Society for Medical Oncology (ESMO) is proposing three levels of recommendations for the use […]
- Ovarian cancer prognosis in women with endometriosis. A retrospective nationwide cohort study of 32,419 women.Contradicting results regarding ovarian cancer prognosis in women with endometriosis have been reported in the literature. Due to the small sample size of previous studies, larger studies are required to elucidate the role of endometriosis on ovarian cancer prognosis.To evaluate the survival rate in women with ovarian cancer with or without histological proven endometriosis in […]
- A combination of cytokeratin 5/6, p63, p40 and MUC5AC are useful for distinguishing squamous cell carcinoma from adenocarcinoma of the cervix.Squamous cell carcinomas and adenocarcinomas are the most common types of cervical cancer. Compared to squamous cell carcinomas, adenocarcinomas are more common in younger women and have a poorer prognosis. Yet, so far, no useful biomarkers have been developed for these two types of cancer. In the following study, we examined the combination of cytokeratin […]
- Report of NCI and NICHD-Sponsored Workshop: Gynecology and Women’s Health-Benign Conditions and Cancer.The Division of Cancer Prevention and the Division of Cancer Biology at the National Cancer Institute, and the Gynecologic Health and Disease Branch in the National Institute of Child Health and Human Development, organized a workshop in April 2019 to explore current insights into the progression of gynecologic cancers from benign conditions. Working groups were […]
- Endometrial biomarkers in premenopausal obese women: an at-risk cohort.Obesity is a well-known risk factor for endometrial cancer, yet mechanisms of obesity-related carcinogenesis are not well-defined, particularly for premenopausal women. With the continuing obesity epidemic, increases in endometrial cancer incidence and younger age of diagnosis are often attributed to a hyper-estrogenic state created by hormone production in adipose tissue, but significant knowledge gaps remain. […]
- Anorectal Disorders: Clinical Updates in Women’s Health Care Primary and Preventive Care Review.Anorectal disorders can have overlapping symptoms, which sometimes can make it difficult to establish a diagnosis. Obtaining a detailed history and performing a physical examination are vital to establish the correct diagnosis and to outline appropriate treatment for anorectal disorders. Obstetrician-gynecologists often are the primary care providers and may be the only medical professional a […]
- Robot-Assisted Surgery for Noncancerous Gynecologic Conditions: ACOG COMMITTEE OPINION SUMMARY, Number 810.For noncancerous conditions, such as hysterectomy, a minimally invasive approach to gynecologic surgery has well-documented advantages-including faster return to normal activities, decreased length of stay, and better quality of life-compared with an abdominal approach. Although the quality of data for robot-assisted surgery is still low to moderate, the use of robot-assisted surgery has rapidly increased […]
- Robot-Assisted Surgery for Noncancerous Gynecologic Conditions: ACOG COMMITTEE OPINION, Number 810.For noncancerous conditions, such as hysterectomy, a minimally invasive approach to gynecologic surgery has well-documented advantages-including faster return to normal activities, decreased length of stay, and better quality of life-compared with an abdominal approach. Although the quality of data for robot-assisted surgery is still low to moderate, the use of robot-assisted surgery has rapidly increased […]
- MILO/ENGOT-ov11: Binimetinib Versus Physician’s Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum.Low-grade serous ovarian carcinomas (LGSOCs) have historically low chemotherapy responses. Alterations affecting the MAPK pathway, most commonly KRAS/BRAF, are present in 30%-60% of LGSOCs. The purpose of this study was to evaluate binimetinib, a potent MEK1/2 inhibitor with demonstrated activity across multiple cancers, in LGSOC.This was a 2:1 randomized study of binimetinib (45 mg twice […]
- CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma.Uterine leiomyosarcoma is a rare and aggressive gynecologic malignancy originating in the myometrium of the uterine corpus that tends to recur even after complete surgical excision. Current therapeutic agents have only modest effects on uterine leiomyosarcoma. Although antibodies and antibody-drug conjugates (ADCs) have been recognized as useful targeted therapies for other cancers, no study has […]
- Cost of Care for the Initial Management of Cervical Cancer in Women with Commercial Insurance.Women with newly diagnosed cervical cancer are often treated with extensive, multimodal therapy that may include a combination of surgery, radiation, and chemotherapy. Little is known about the cost of treatment or how costs are passed on to patients.The objectives of the study were to examine the cost of care during the first year after […]
- Benefit and burden in the Dutch cytology-based versus high-risk human papillomavirus-based cervical cancer screening program.In 2017, the Dutch cervical cancer screening program has replaced primary cytology-based screening by primary high-risk human papillomavirus based screening, including the opportunity to participate through self-sampling. Evaluation and balancing benefit (detection of high-grade cervical intraepithelial neoplasia) and burden (unnecessary referrals, invasive diagnostics and overtreatment) of screening is needed.To compare referral rates, detection of high-grade […]
- Prospective Phase II Trial of Levonorgestrel Intrauterine Device: Non-Surgical Approach for Complex Atypical Hyperplasia and Early Endometrial Cancer.The incidence of complex atypical hyperplasia and early stage endometrioid endometrial cancer is increasing, in part due to the epidemic of obesity, a risk factor tightly linked to development of endometrial hyperplasia and cancer. The standard upfront treatment for complex atypical hyperplasia and early stage endometrial cancer is hysterectomy. However, non-surgical treatment of early endometrial […]
- Attitudes towards risk-reducing early salpingectomy with delayed oophorectomy for ovarian cancer prevention: a cohort study.To determine risk-reducing early salpingectomy and delayed oophorectomy (RRESDO) acceptability and effect of surgical prevention on menopausal sequelae/satisfaction/regret in women at increased ovarian cancer (OC) risk.Multicentre, cohort, questionnaire study (IRSCTN:12310993).United Kingdom (UK).UK women without OC ≥18 years, at increased OC risk, with/without previous RRSO, ascertained through specialist familial cancer/genetic clinics and BRCA support groups.Participants completed […]
- PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.To provide recommendations on the use of poly(ADP-ribose) polymerase inhibitors (PARPis) for management of epithelial ovarian, tubal, or primary peritoneal cancer (EOC).Randomized, controlled, and open-labeled trials published from 2011 through 2020 were identified in a literature search. Guideline recommendations were based on the review of the evidence, US Food and Drug Administration approvals, and consensus […]
- Impact of Medicaid expansion on women with gynecologic cancer: A difference-in-difference analysis.Women with gynecologic cancer face socioeconomic disparities in care that impact survival outcomes. The Affordable Care Act offered states the option to expand Medicaid enrollment eligibility criteria as a means of improving timely and affordable access to care for the most vulnerable. Variable uptake of expansion by states created a natural experiment, allowing for quasi-experimental […]
- Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study.Poly (ADP-ribose) polymerase inhibitors combined with immunotherapy have shown antitumour activity in preclinical studies. We aimed to assess the safety and activity of olaparib in combination with the PD-L1-inhibitor, durvalumab, in patients with germline BRCA1-mutated or BRCA2-mutated metastatic breast cancer.The MEDIOLA trial is a multicentre, open-label, phase 1/2, basket trial of durvalumab and olaparib in […]
- Human papillomavirus vaccine effectiveness within a cervical cancer screening programme: cohort study.To assess the effectiveness of an HPV vaccination programme in reducing the risk of cervical abnormalities identified at subsequent screening.Retrospective cohort study using administrative health data.General population of Ferrara Province, Italy.Female residents born in 1986-1993 and participating in the organized cervical screening programme in 2011-2018, who were eligible for HPV vaccination in catch-up cohorts.Logistic regression […]
- Front-line ovarian cancer maintenance therapy: PARP inhibitors for all?Poly (ADP-ribose) polymerase inhibitors (PARPi) have enjoyed enormous recent success in the treatment of ovarian cancer, a deadly and difficult to treat disease. In recent years, PARPi have gained approvals as monotherapy in BRCA mutated ovarian cancer, as maintenance treatment after platinum-sensitive recurrence, and most recently as maintenance therapy after successful front-line treatment. These benefits […]
- Radical Trachelectomy for the Treatment of Early-Stage Cervical Cancer: A Systematic Review.To assess surgical, oncologic, and pregnancy outcomes in patients undergoing radical vaginal, abdominal, or laparoscopic trachelectomy for the treatment of early-stage cervical cancer, using a methodic review of published literature.PubMed, EMBASE, and Cochrane Library sources, including ClinicalTrials.gov, were searched from 1990-2019 with terms “cervical cancer” and “(vaginal, abdominal, open, minimally invasive, or laparoscopic) radical trachelectomy.” […]
- Insurance-Associated Disparities in Opioid Use and Misuse Among Patients Undergoing Gynecologic Surgery for Benign Indications.To compare perioperative use and persistent postoperative opioid use among Medicaid-insured women and commercially insured women who underwent gynecologic surgery for benign indications.The Truven Health MarketScan database, a nationwide data source collecting commercial insurance claims across all states and Medicaid insurance claims from 12 states, was used to identify opioid-naïve women without cancer aged 18-64 […]
- Gynecologic Care in Women With Down Syndrome: Findings From a National Registry.To estimate receipt of recommended gynecologic care, including cancer screening and menstrual care, among women with Down syndrome in the United States.We conducted a retrospective cohort study of women participating in DS-Connect, the National Institute of Health’s registry of women with Down syndrome. Using 2013-2019 survey data, we estimated the proportion of women receiving recommended […]
- The role and contribution of treatment and imaging modalities in global cervical cancer management: survival estimates from a simulation-based analysis.Cervical cancer is the fourth most common cancer among women worldwide, causing more than 300 000 deaths globally each year. In addition to screening and prevention, effective cancer treatment is needed to reduce cervical cancer mortality. We discuss the role of imaging in cervical cancer management and estimate the potential survival effect of scaling up imaging […]
- Efficacy of Maintenance Olaparib for Patients With Newly Diagnosed Advanced Ovarian Cancer With a BRCA Mutation: Subgroup Analysis Findings From the SOLO1 Trial.In SOLO1, maintenance olaparib (300 mg twice daily) significantly improved progression-free survival (PFS) for patients with newly diagnosed BRCA1- and/or BRCA2-mutated advanced ovarian cancer compared with placebo (hazard ratio [HR], 0.30; 95% CI, 0.23 to 0.41; median not reached v 13.8 months). We investigated PFS in SOLO1 for subgroups of patients based on preselected baseline […]
- Human Papillomavirus Vaccination: ACOG Committee Opinion Summary, Number 809.Human papillomavirus (HPV) causes significant morbidity and mortality in women and men. The HPV vaccine significantly reduces the incidence of anogenital cancer and genital warts in women and in men. Human papillomavirus vaccines are among the most effective vaccines available worldwide, with unequivocal data demonstrating greater than 99% efficacy when administered to women who have […]
- Human Papillomavirus Vaccination: ACOG Committee Opinion, Number 809.Human papillomavirus (HPV) causes significant morbidity and mortality in women and men. The HPV vaccine significantly reduces the incidence of anogenital cancer and genital warts in women and in men. Human papillomavirus vaccines are among the most effective vaccines available worldwide, with unequivocal data demonstrating greater than 99% efficacy when administered to women who have […]
- Validation of models to diagnose ovarian cancer in patients managed surgically or conservatively: multicentre cohort study.To evaluate the performance of diagnostic prediction models for ovarian malignancy in all patients with an ovarian mass managed surgically or conservatively.Multicentre cohort study.36 oncology referral centres (tertiary centres with a specific gynaecological oncology unit) or other types of centre.Consecutive adult patients presenting with an adnexal mass between January 2012 and March 2015 and managed […]
- A mismatch in care: results of a United Kingdom-wide patient and clinician survey of gynaecological services for women with Lynch syndrome.To describe the current testing practice, referral pathways and gynaecological services available to women with Lynch syndrome (LS) in the United Kingdom.Cross sectional nationwide survey of gynaecological oncologists and women with LS.United Kingdom METHODS: Gynaecological oncologists were contacted directly. Women with LS were identified from national and regional clinical databases and the patient support group, […]
- Association of Menopausal Hormone Therapy With Breast Cancer Incidence and Mortality During Long-term Follow-up of the Women’s Health Initiative Randomized Clinical Trials.The influence of menopausal hormone therapy on breast cancer remains unsettled with discordant findings from observational studies and randomized clinical trials.To assess the association of prior randomized use of estrogen plus progestin or prior randomized use of estrogen alone with breast cancer incidence and mortality in the Women’s Health Initiative clinical trials.Long-term follow-up of 2 […]
- Atypical squamous cells of undetermined significance cervical cytology in the Chinese population: Age-stratified reporting rates, high-risk HPV testing, and immediate histologic correlation results.The US American Society of Colposcopy and Cervical Pathology guidelines for cervical cancer screening have been largely adopted worldwide. Pooled high-risk human papillomavirus (hrHPV) testing has been routinely used to risk-stratify women who have atypical squamous cells of undetermined significance (ASC-US) cytology. However, it has been reported that there are distinguished differences in the distribution […]
- Impact of uterine manipulator on oncological outcome in endometrial cancer surgery.There is limited data available to indicate whether oncologic outcomes might be influenced by the uterine manipulator, which is used at the time of hysterectomy for minimally invasive surgery in patients with endometrial cancer. The current evidence derives from retrospective studies with limited sample sizes. Without substantial evidence to support its use, surgeons are required […]
- Implementation of Human Papillomavirus Video Education for Women Participating in Mass Cervical Cancer Screening in Tanzania.Because the global disease burden of cervical cancer is greatest in Africa, the WHO has endorsed visual inspection with acetic acid (VIA) screening with cryotherapy triage for screen-and-treat. With the lowest doctor-to-patient ratio in the world (1:50,000), Tanzania has nearly 10,000 new cases of cervical cancer and 7,000 deaths annually.We report on feasibility of VIA […]
- A Prospective Randomized Trial Comparing Liposomal Bupivacaine vs. Standard Bupivacaine Wound Infiltration in Open Gynecologic Surgery On An Enhanced Recovery Pathway.Value in healthcare is reflected by patient-centered outcomes of care per health dollar expended. Although more expensive, liposomal bupivacaine has been shown to provide prolonged analgesia (72 hours).To evaluate whether the addition of liposomal bupivacaine to standard bupivacaine could decrease opioid intake and improve pain control after laparotomy for gynecologic surgery compared to standard bupivacaine […]
- Ovarian cancer: diagnostic accuracy and tumor types distribution in East Africa compared to North America.Ovarian cancer is a spectrum of several histologically distinct tumor types that differ in etiology, response to therapy, and prognosis. In resource-limited settings, the diagnosis of ovarian cancer can be challenging. This study describes the distribution of ovarian cancer tumor types in East Africa as well as assessing the diagnostic accuracy by using contemporary methods.Data […]
- PARP inhibitors as maintenance therapy in newly diagnosed advanced ovarian cancer: A meta-analysis.Up to 70% of the patients with advanced ovarian cancer have a relapse after primary therapy. New agents and approaches are urgently needed to avoid or slow down the reccurence.To investigate the efficacy of PARP inhibitors (PARPis) as maintenance treatment in patients with newly diagnosed advanced ovarian cancer.PubMed, Medline, Embase, Cochrane Library and Web of […]
- Validation of an enhanced recovery after surgery protocol in gynecological surgery: an Italian randomized study.The study aims to validate an enhanced recovery after surgery (ERAS) protocol in gynecological surgery both for benign and malignant disease (endometrial cancer and advanced ovarian cancer) and to measure the adherence to ERAS items in a randomized trial setting.In this trial (NCT03347409), we randomly assigned patients to undergo standard perioperative care or ERAS protocol. […]