The Latest Gynaecological Cancer
Keep up to date with the latest in gynaecological cancer. Check out the latest gynaecological cancer articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily
- Association of Infertility and All-Cause Mortality: Analysis of US Claims Data.The consequences of an infertility diagnosis extend beyond the pursuit of family building, as infertile women also face increased risks of severe maternal morbidity, cancer, and chronic disease.To examine the association between female infertility and all-cause mortality.Retrospective analysis of 72,786 infertile women identified in the Optum Clinformatics Datamart from 2003-2019 by infertility diagnosis, testing and […]
- Five-year retrospective review in gynecologic cytopathology: is it time to amend?According to the Clinical Laboratory Improvement Amendments 1988 regulations, 5-year retrospective review (5YRR) of normal Papanicolaou tests in patients with a newly diagnosed high grade squamous intraepithelial lesion or above (HSIL+) is mandatory. Since this mandate has been in place, a multitude of changes have taken place in the screening and management guidelines of cervical […]
- Ovarian conservation for young women with early-stage low-grade endometrial cancer: A proposal for a two-step approach.In 2020, endometrial cancer continues to be the most common gynecologic malignancy in the United States. The majority of endometrial cancer is low-grade, and nearly one out of every eight low-grade endometrial cancer diagnoses occurs in women younger than 50 with early-stage disease. The incidence of early-stage, low-grade endometrial cancer is increasing in particular among […]
- Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants.Two cases of pediatric lung cancer (in 23-month-old and 6-year-old boys) resulting from mother-to-infant transmission of uterine cervical tumors were incidentally detected during routine next-generation sequencing of paired samples of tumor and normal tissue. Spontaneous regression of some lesions in the first child and slow growth of the tumor mass in the second child suggested […]
- Options for Prevention and Management of Menstrual Bleeding in Adolescent Patients Undergoing Cancer Treatment: ACOG Committee Opinion, Number 817.Obstetrician-gynecologists frequently are consulted either before the initiation of cancer treatment to request menstrual suppression or during an episode of severe heavy bleeding to stop bleeding emergently. Adolescents presenting emergently with severe uterine bleeding usually require only medical management; surgical management rarely is required. Surgical management should be considered for patients who are not clinically […]
- Options for Prevention and Management of Menstrual Bleeding in Adolescent Patients Undergoing Cancer Treatment: ACOG Committee Opinion Summary, Number 817.Obstetrician-gynecologists frequently are consulted either before the initiation of cancer treatment to request menstrual suppression or during an episode of severe heavy bleeding to stop bleeding emergently. Adolescents presenting emergently with severe uterine bleeding usually require only medical management; surgical management rarely is required. Surgical management should be considered for patients who are not clinically […]
- Objective responses to first-line neoadjuvant carboplatin-paclitaxel regimens for ovarian, fallopian tube, or primary peritoneal carcinoma (ICON8): post-hoc exploratory analysis of a randomised, phase 3 trial.Platinum-based neoadjuvant chemotherapy followed by delayed primary surgery (DPS) is an established strategy for women with newly diagnosed, advanced-stage epithelial ovarian cancer. Although this therapeutic approach has been validated in randomised, phase 3 trials, evaluation of response to neoadjuvant chemotherapy using Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST), and cancer antigen 125 (CA125) […]
- Low incidence of pulmonary metastases in vulvar cancer patients; limited value of routine chest imaging based on a cohort study.To evaluate the incidence of pulmonary metastases in the preoperative work-up of patients with primary vulvar squamous cell carcinoma (SCC).Retrospective cohort study SETTING: Tertiary referral center POPULATION: Patients treated for primary vulvar SCC from 2000-2018 METHODS: The preoperative chest imaging of 452 consecutively treated patients was documented with a minimal follow-up period of two years […]
- Cancer in pregnancy increases the risk of venous thromboembolism: A nationwide cohort study.To investigate if cancer in pregnancy causes a higher risk of venous thromboembolism (VTE) during pregnancy and postpartum compared to pregnant patients without cancer.A historical prospective cohort study using data from nationwide registries.We assessed all pregnancies in Denmark between January 1, 1977 to December 31, 2017.We linked information concerning cancer diagnosis, pregnancy and VTE diagnosis […]
- Cervical cancer risk and screening among women seeking assistance with basic needs.In the United States more than half of cervical cancers occur in women who are inadequately screened. Interventions to improve access to cervical cancer preventive care is critical to reduce health inequities.We aimed to evaluate need for cervical cancer screening among women seeking assistance with basic needs and to assess best approaches to facilitate Papanicolaou […]
- Less-radical Surgery for Early Stage Cervical Cancer: A Systematic Review.A systematic review was performed to examine the outcomes of simple hysterectomy for women with low-risk, early-stage cervical cancer.MEDLINE, Embase, Web of Science, and ClinicalTrials.gov were searched from inception until November 4, 2020.Original research reporting recurrence and/or survival outcomes among women with early stage (defined as IA2-IB1) cervical cancer who were treated with simple hysterectomy.Data […]
- Impact of socioeconomic deprivation on endometrial cancer survival in the North West of England: a prospective database analysis.To assess the impact of socioeconomic deprivation on endometrial cancer survival.Single centre prospective database study.North West England.Women with endometrial cancer treated between 2010 and 2015 METHODS: Areal-level socioeconomic status, using English Indices of Multiple Deprivation from residential postcodes, was analysed in relation to survival using Kaplan-Meier estimation and multivariable Cox-regression.Overall survival, cancer-specific survival, patterns and […]
- Updates and New Options in Advanced Epithelial Ovarian Cancer Treatment.The medical and surgical treatment strategies for women with epithelial ovarian cancer continue to evolve. In the past several years, there has been significant progress backed by landmark clinical trials. Although primary epithelial ovarian cancer is still treated with a combination of surgery and systemic therapy, more complex surgical procedures and novel therapeutics have emerged […]
- Gemogenovatucel-T (Vigil) immunotherapy as maintenance in frontline stage III/IV ovarian cancer (VITAL): a randomised, double-blind, placebo-controlled, phase 2b trial.Gemogenovatucel-T is an autologous tumour cell vaccine manufactured from harvested tumour tissue, which specifically reduces expression of furin and downstream TGF-β1 and TGF-β2. The aim of this study was to determine the safety and efficacy of gemogenovatucel-T in front-line ovarian cancer maintenance.This randomised, double-blind, placebo-controlled, phase 2b trial involved 25 hospitals in the USA. Women […]
- Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm, phase 2 trial.Survival outcomes for patients with recurrent or advanced cervical cancer are poor. Pembrolizumab has been approved for the treatment of recurrent or metastatic cervical cancer, with an overall response rate of 14·3%. GX-188E vaccination has been shown to induce human papillomavirus (HPV) E6-specific and E7-specific T-cell responses and cervical lesion regression in patients with cervical […]
- Efficacy of the bivalent HPV vaccine against HPV 16/18-associated precancer: long-term follow-up results from the Costa Rica Vaccine Trial.Oncogenic human papillomavirus (HPV) infections cause most cases of cervical cancer. Here, we report long-term follow-up results for the Costa Rica Vaccine Trial (publicly funded and initiated before licensure of the HPV vaccines), with the aim of assessing the efficacy of the bivalent HPV vaccine for preventing HPV 16/18-associated cervical intraepithelial neoplasia grade 2 or […]
- Assessing novel therapies for vulval neoplasia.Vulval cancer is a potential outcome of two separate pathological processes. Human Papilloma Virus (HPV) infection and subsequent clearance is so common as to be normal, but it can sometimes persist and ultimately lead to invasive disease. Lichen sclerosus is a vulval dermatosis that is estimated to progress to vulval cancer in less than 5% […]
- Quantitative and Qualitative Assessment of an All-Inclusive Postpartum Human Papillomavirus Vaccination Program.A postpartum human papillomavirus (HPV) vaccination program was locally implemented to address low initiation rates among young adults. Within 20 months, the program achieved high vaccine initiation and series completion rates. Based on the program’s success, it was expanded to all 36 counties served by a public hospital.To conduct a quantitative and qualitative evaluation to […]
- Pelvic Organ Prolapse after Three Modes of Hysterectomy: Long-Term Follow Up.There are various indications and approaches for hysterectomy; yet, the difference in long-term risk of subsequent prolapse after surgery is not well studied.To assess the risk of prolapse after abdominal, vaginal and laparoscopic/robotic hysterectomy for up to 17 years from surgery.A retrospective chart review study of women undergoing hysterectomy across all indications (benign and malignant) […]
- Treatment of epithelial ovarian cancer.Ovarian cancer is the third most common gynecologic malignancy worldwide but accounts for the highest mortality rate among these cancers. A stepwise approach to assessment, diagnosis, and treatment is vital to appropriate management of this disease process. An integrated approach with gynecologic oncologists as well as medical oncologists, pathologists, and radiologists is of paramount importance […]
- Adherence to Oral Anticancer Therapeutics in the Gynecologic Oncology Population.To gain a better understanding of gynecologic oncology patient adherence to oral anticancer agents through both a cross-sectional survey of adherence and qualitative interviews with patients and clinicians regarding their experience with these medications.Eligible participants completed a survey for this cross-sectional study that included an assessment of adherence, distress, quality of life, and health literacy. […]
- Fertility-Sparing Treatment for Early-Stage Cervical, Ovarian, and Endometrial Malignancies.Approximately 20% of gynecologic malignancies are diagnosed in reproductive-aged women, and standard-of-care surgical treatment often precludes future fertility. In early-stage disease, shared decision making about fertility-sparing medical and surgical approaches may give well-selected patients the opportunity to pursue their family-building goals without compromising long-term survival. Although future fertility is an important consideration for young women […]
- Determinants of p16/Ki-67 adequacy and positivity in HPV-positive women from a screening population.The objective of this study was to describe the determinants of adequacy and positivity of the p16/Ki-67 assay in a human papillomavirus (HPV)-positive screening population enrolled within the New Technologies for Cervical Cancer 2 (NTCC2) study.ThinPrep slides were immunostained for p16/Ki-67; each slide had 3 reports from different laboratories. The authors included population-related, sampling-related/staining-related, and […]
- An Ecological Evaluation of the Increasing Incidence of Endometrial Cancer and the Obesity Epidemic.The prevalence of obesity has increased significantly in recent decades, particularly among younger women, and is a known risk factor for endometrial cancer.The objective of this study was to evaluate the trend in the prevalence of obesity and the incidence of type I endometrial cancer over time in various age categories to determine if an […]
- New-Onset myocardial injury in COVID-19 Pregnant Patients: A Case Series of 15 Patients.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the new coronavirus responsible for the coronavirus disease (COVID-19), characterized by acute respiratory distress syndrome and atypical pneumonia. In non-pregnant women, studies have shown that SARS-CoV-2 causes cardiac injury, which can result in myocardial inflammation and damage. Despite many studies investigating the extent of cardiac compromise in […]
- A meta-analysis of reversion mutations in BRCA genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistance.Germline mutations in the BRCA1 or BRCA2 (BRCA) genes predispose to hereditary breast and ovarian cancer and, mostly in the case of BRCA2, are also prevalent in cases of pancreatic and prostate malignancies. Tumours from these patients tend to lose both copies of the wild type BRCA gene, which makes them exquisitely sensitive to platinum […]
- An evolution in sentinel node mapping for cervical cancer.The technique of sentinel lymph node (SLN) biopsy has emerged as an alternative to complete pelvic lymphadenectomy to establish lymph node status in early stage cervical cancers. Traditional lymph node stripping techniques are associated with high rates of patient morbidity, such as lymphedema. For the majority of patients who are free of lymph node metastases […]
- Camrelizumab Plus Apatinib in Patients With Advanced Cervical Cancer (CLAP): A Multicenter, Open-Label, Single-Arm, Phase II Trial.Camrelizumab is an antibody against programmed death protein 1. We assessed the activity and safety of camrelizumab plus apatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor-2, in patients with advanced cervical cancer.This multicenter, open-label, single-arm, phase II study enrolled patients with advanced cervical cancer who progressed after at least one line of […]
- Effect of Length of Surgery on the Incidence of Venous Thromboembolism after Benign Hysterectomy.Venous thromboembolism is a leading cause of morbidity and mortality postoperatively. Current venous thromboembolism risk assessment tools have not been validated in gynecologic patients. Most patients undergoing hysterectomy for benign indications will receive mechanical or pharmacological prophylaxis based on preoperative risk assessment. However, current guidelines do not incorporate newer data that indicate additional risk of […]
- Mismatch repair status influences response to fertility-sparing treatment of endometrial cancer.Patients younger than 40 years usually present with early-stage endometrial cancer with favorable prognosis. However, such patients are usually in their childbearing age and may desire fertility-sparing options. The identification of biomarkers may improve the clinical outcomes in these patients and aid in fertility-sparing management; however, there has been no reports on biomarker analysis so […]
- Risk of Cervical Precancer and Cancer Among Uninsured and Underserved Women 2009-2017.New guidelines for managing cervical precancer among US women directly use risk to guide clinical actions for individuals who are being screened. These risk-based management guidelines have previously only been based on risks from a large, integrated, health care system. However, for the first time, data representative of low-income women without continuous insurance coverage were […]
- Distinct microRNA profiles for complete hydatidiform moles at risk for malignant progression.MicroRNAs (miRNAs) are small non-coding RNAs with important regulatory functions. While well-studied in cancer, less is known about the role of miRNAs in premalignant disease. Complete hydatidiform moles are benign forms of gestational trophoblastic disease that progress to gestational trophoblastic neoplasia in up to 20% of cases; however, there is no well-established biomarker that can […]
- HPV Vaccination and the Risk of Invasive Cervical Cancer.The efficacy and effectiveness of the quadrivalent human papillomavirus (HPV) vaccine in preventing high-grade cervical lesions have been shown. However, data to inform the relationship between quadrivalent HPV vaccination and the subsequent risk of invasive cervical cancer are lacking.We used nationwide Swedish demographic and health registers to follow an open population of 1,672,983 girls and […]
- Salpingectomy versus tubal ligation for sterilization: a systematic review and meta-analysis.Following strong evidence and major organizations recommending salpingectomy over tubal ligation, we sought to perform a systematic review and meta-analysis comparing the intraoperative attributes and complication rates associated with these two procedures.We searched PubMed, the Cochrane Library, EMBASE and clinical trials registries without time or language restrictions. The search was carried out in February 2020. […]
- Role of carbon nanoparticle suspension in sentinel lymph node biopsy for early-stage cervical cancer: a prospective study.To evaluate the clinical diagnostic validity of carbon nanoparticle suspension (CNS) in sentinel lymph node biopsy (SLNB) for assessing lymphatic spread of early-stage cervical cancer.A prospective study.356 cases.We enrolled 356 stage Ia2-IIa2 cervical cancer patients to undergo SLNB using CNS, followed by systematic pelvic lymphadenectomy. All lymph node specimens were assessed using conventional histopathologic ± […]
- Cervical cancer prevention in transgender men: a review.There is increased awareness of transgender physical and mental health widely and in academic research. A significant proportion of transgender men will retain their cervix with an increased risk of cervical cancer. In this review of cervical cancer screening among transgender men, we try to estimate how many transgender men still have a cervix, understand […]
- Outcomes after the regionalization of care for high-grade endometrial cancers: a population-based study.In June 2013, Ontario Health – Cancer Care Ontario (CCO), the agency responsible for advancing cancer care in Ontario, Canada, published practice guidelines recommending that Gynaecologic Oncologists (GOs) at tertiary care centers manage the treatment of patients with high-grade endometrial cancers. This study examines the effects of this regionalization of care on patient outcomes.In this […]
- Occupational Exposure to Human Papillomavirus and Vaccination for Health Care Workers.Multiple studies suggest that health care workers treating human papillomavirus (HPV)-associated conditions may experience occupational exposure to the virus. Case reports describe the development of cancer and other disease in health care professionals at low risk for such conditions except for their work. Despite limited data, vaccination can be a safe and effective method to […]
- Occupational Exposure to Human Papillomavirus and Vaccination for Health Care Workers.Multiple studies suggest that health care workers treating human papillomavirus (HPV)-associated conditions may experience occupational exposure to the virus. Case reports describe the development of cancer and other disease in health care professionals at low risk for such conditions except for their work. Despite limited data, vaccination can be a safe and effective method to […]
- The impact of surgical learning curve on survival – reopening the door for minimally invasive surgery in the management of cervical cancer?Minimally invasive surgery has been widely adopted in gynaecologic oncology with a significant surge the past decade associated with the introduction of robot-assisted surgery. Up until 2018, virtually all testimonials of minimally invasive surgery for cervical cancer indicated equal oncologic outcomes compared to laparotomy. The unexpected results from the only randomised controlled trial (Ramirez PT […]
- The impact of surgical learning curve on survival – reopening the door for minimally invasive surgery in the management of cervical cancer?Minimally invasive surgery has been widely adopted in gynaecologic oncology with a significant surge the past decade associated with the introduction of robot-assisted surgery. Up until 2018, virtually all testimonials of minimally invasive surgery for cervical cancer indicated equal oncologic outcomes compared to laparotomy. The unexpected results from the only randomised controlled trial (Ramirez PT […]
- Ovarian cancer risk in Lynch syndrome: It’s time to individualize.Our understanding of cancer risks associated with Lynch syndrome (LS) has evolved since Dr. Warthin first identified family G in 1913. The current study by Ryan et al provides insight into provider and patient knowledge about gynecologic cancer care options in LS and found that counseling, surveillance, and risk reduction (RR) for these patients vary […]
- Ovarian cancer risk in Lynch syndrome: It’s time to individualize.Our understanding of cancer risks associated with Lynch syndrome (LS) has evolved since Dr. Warthin first identified family G in 1913. The current study by Ryan et al provides insight into provider and patient knowledge about gynecologic cancer care options in LS and found that counseling, surveillance, and risk reduction (RR) for these patients vary […]
- Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: A report from the ESMO Precision Medicine Working Group.Next-generation sequencing (NGS) allows sequencing a high number of nucleotides in a short time frame at an affordable cost. While this technology has been widely implemented, there are no recommendations from scientific societies about their use in oncology practice. The European Society for Medical Oncology (ESMO) is proposing three levels of recommendations for the use […]
- Ovarian cancer prognosis in women with endometriosis. A retrospective nationwide cohort study of 32,419 women.Contradicting results regarding ovarian cancer prognosis in women with endometriosis have been reported in the literature. Due to the small sample size of previous studies, larger studies are required to elucidate the role of endometriosis on ovarian cancer prognosis.To evaluate the survival rate in women with ovarian cancer with or without histological proven endometriosis in […]
- A combination of cytokeratin 5/6, p63, p40 and MUC5AC are useful for distinguishing squamous cell carcinoma from adenocarcinoma of the cervix.Squamous cell carcinomas and adenocarcinomas are the most common types of cervical cancer. Compared to squamous cell carcinomas, adenocarcinomas are more common in younger women and have a poorer prognosis. Yet, so far, no useful biomarkers have been developed for these two types of cancer. In the following study, we examined the combination of cytokeratin […]
- Report of NCI and NICHD-Sponsored Workshop: Gynecology and Women’s Health-Benign Conditions and Cancer.The Division of Cancer Prevention and the Division of Cancer Biology at the National Cancer Institute, and the Gynecologic Health and Disease Branch in the National Institute of Child Health and Human Development, organized a workshop in April 2019 to explore current insights into the progression of gynecologic cancers from benign conditions. Working groups were […]
- Endometrial biomarkers in premenopausal obese women: an at-risk cohort.Obesity is a well-known risk factor for endometrial cancer, yet mechanisms of obesity-related carcinogenesis are not well-defined, particularly for premenopausal women. With the continuing obesity epidemic, increases in endometrial cancer incidence and younger age of diagnosis are often attributed to a hyper-estrogenic state created by hormone production in adipose tissue, but significant knowledge gaps remain. […]
- Anorectal Disorders: Clinical Updates in Women’s Health Care Primary and Preventive Care Review.Anorectal disorders can have overlapping symptoms, which sometimes can make it difficult to establish a diagnosis. Obtaining a detailed history and performing a physical examination are vital to establish the correct diagnosis and to outline appropriate treatment for anorectal disorders. Obstetrician-gynecologists often are the primary care providers and may be the only medical professional a […]
- Robot-Assisted Surgery for Noncancerous Gynecologic Conditions: ACOG COMMITTEE OPINION SUMMARY, Number 810.For noncancerous conditions, such as hysterectomy, a minimally invasive approach to gynecologic surgery has well-documented advantages-including faster return to normal activities, decreased length of stay, and better quality of life-compared with an abdominal approach. Although the quality of data for robot-assisted surgery is still low to moderate, the use of robot-assisted surgery has rapidly increased […]
- Robot-Assisted Surgery for Noncancerous Gynecologic Conditions: ACOG COMMITTEE OPINION, Number 810.For noncancerous conditions, such as hysterectomy, a minimally invasive approach to gynecologic surgery has well-documented advantages-including faster return to normal activities, decreased length of stay, and better quality of life-compared with an abdominal approach. Although the quality of data for robot-assisted surgery is still low to moderate, the use of robot-assisted surgery has rapidly increased […]
- MILO/ENGOT-ov11: Binimetinib Versus Physician’s Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum.Low-grade serous ovarian carcinomas (LGSOCs) have historically low chemotherapy responses. Alterations affecting the MAPK pathway, most commonly KRAS/BRAF, are present in 30%-60% of LGSOCs. The purpose of this study was to evaluate binimetinib, a potent MEK1/2 inhibitor with demonstrated activity across multiple cancers, in LGSOC.This was a 2:1 randomized study of binimetinib (45 mg twice […]
- CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma.Uterine leiomyosarcoma is a rare and aggressive gynecologic malignancy originating in the myometrium of the uterine corpus that tends to recur even after complete surgical excision. Current therapeutic agents have only modest effects on uterine leiomyosarcoma. Although antibodies and antibody-drug conjugates (ADCs) have been recognized as useful targeted therapies for other cancers, no study has […]
- Cost of Care for the Initial Management of Cervical Cancer in Women with Commercial Insurance.Women with newly diagnosed cervical cancer are often treated with extensive, multimodal therapy that may include a combination of surgery, radiation, and chemotherapy. Little is known about the cost of treatment or how costs are passed on to patients.The objectives of the study were to examine the cost of care during the first year after […]
- Benefit and burden in the Dutch cytology-based versus high-risk human papillomavirus-based cervical cancer screening program.In 2017, the Dutch cervical cancer screening program has replaced primary cytology-based screening by primary high-risk human papillomavirus based screening, including the opportunity to participate through self-sampling. Evaluation and balancing benefit (detection of high-grade cervical intraepithelial neoplasia) and burden (unnecessary referrals, invasive diagnostics and overtreatment) of screening is needed.To compare referral rates, detection of high-grade […]
- Prospective Phase II Trial of Levonorgestrel Intrauterine Device: Non-Surgical Approach for Complex Atypical Hyperplasia and Early Endometrial Cancer.The incidence of complex atypical hyperplasia and early stage endometrioid endometrial cancer is increasing, in part due to the epidemic of obesity, a risk factor tightly linked to development of endometrial hyperplasia and cancer. The standard upfront treatment for complex atypical hyperplasia and early stage endometrial cancer is hysterectomy. However, non-surgical treatment of early endometrial […]
- Attitudes towards risk-reducing early salpingectomy with delayed oophorectomy for ovarian cancer prevention: a cohort study.To determine risk-reducing early salpingectomy and delayed oophorectomy (RRESDO) acceptability and effect of surgical prevention on menopausal sequelae/satisfaction/regret in women at increased ovarian cancer (OC) risk.Multicentre, cohort, questionnaire study (IRSCTN:12310993).United Kingdom (UK).UK women without OC ≥18 years, at increased OC risk, with/without previous RRSO, ascertained through specialist familial cancer/genetic clinics and BRCA support groups.Participants completed […]
- PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.To provide recommendations on the use of poly(ADP-ribose) polymerase inhibitors (PARPis) for management of epithelial ovarian, tubal, or primary peritoneal cancer (EOC).Randomized, controlled, and open-labeled trials published from 2011 through 2020 were identified in a literature search. Guideline recommendations were based on the review of the evidence, US Food and Drug Administration approvals, and consensus […]
- Impact of Medicaid expansion on women with gynecologic cancer: A difference-in-difference analysis.Women with gynecologic cancer face socioeconomic disparities in care that impact survival outcomes. The Affordable Care Act offered states the option to expand Medicaid enrollment eligibility criteria as a means of improving timely and affordable access to care for the most vulnerable. Variable uptake of expansion by states created a natural experiment, allowing for quasi-experimental […]
- Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study.Poly (ADP-ribose) polymerase inhibitors combined with immunotherapy have shown antitumour activity in preclinical studies. We aimed to assess the safety and activity of olaparib in combination with the PD-L1-inhibitor, durvalumab, in patients with germline BRCA1-mutated or BRCA2-mutated metastatic breast cancer.The MEDIOLA trial is a multicentre, open-label, phase 1/2, basket trial of durvalumab and olaparib in […]