The Latest Gynaecological Cancer
Keep up to date with the latest in gynaecological cancer. Check out the latest gynaecological cancer articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily
- Sentinel lymph node biopsy in high-grade endometrial cancer: a systematic review and meta-analysis of performance characteristics.Sentinel lymph node biopsy (SLNB) is widely accepted as the standard of care for surgical staging in low-grade endometrial cancer (EC), but its value in high-grade EC remains controversial. The aim of this systematic review and meta-analysis was to evaluate the performance characteristics of SLNB in EC patients with high-grade histology (PROSPERO CRD42020160280).We systematically searched […]
- Gestational Trophoblastic Neoplasia After Human Chorionic Gonadotropin Normalization in a Retrospective Cohort of 7761 Patients in France.The risk of malignant transformation of molar pregnancies after human chorionic gonadotropin (hCG) levels return to normal is low, roughly 0.4%, but may justify an adaptation of monitoring strategies for certain patients.The aims of this study were to determine the risk of gestational trophoblastic neoplasia after hCG normalization in women with molar pregnancy and identify […]
- IMPACT OF HORMONAL BIOMARKERS ON RESPONSE TO HORMONAL THERAPY IN ADVANCED AND RECURRENT ENDOMETRIAL CANCER.Around 20% of women with endometrial cancer have advanced stage disease or suffer from a recurrence. For these women, prognosis is poor and palliative treatment options include hormonal therapy and chemotherapy. Lack of predictive biomarkers and suboptimal use of existing markers for response to hormonal therapy have resulted in overall limited efficacy.To improve efficacy of […]
- Secondary Cytoreduction and Carboplatin Hyperthermic Intraperitoneal Chemotherapy for Platinum-Sensitive Recurrent Ovarian Cancer: An MSK Team Ovary Phase II Study.The purpose of this phase II study was to evaluate hyperthermic intraperitoneal chemotherapy (HIPEC) with carboplatin for recurrent ovarian cancer during secondary cytoreductive surgery.Patients were intraoperatively randomly assigned to carboplatin HIPEC (800 mg/m2 for 90 minutes) or no HIPEC, followed by five or six cycles of postoperative IV carboplatin-based chemotherapy, respectively. Based on a binomial […]
- Persistence and clearance of high-risk human papillomavirus and cervical dysplasia at one year in women living with human immunodeficiency virus: a prospective cohort study.Evaluate one-year outcomes of cervical cancer screening and treatment using primary high-risk human papillomavirus (HPV) testing in women living with human immunodeficiency virus (HIV).Prospective cohort study SETTING: HIV treatment center in Botswana POPULATION: Women living with HIV METHODS: Participants underwent cervical cancer screening with high-risk HPV testing and triage evaluation at baseline and one-year follow-up. […]
- Ultrasound characteristics of early stage high-grade serous ovarian cancer.As ovarian cancer survival is strongly dependent on stage at diagnosis, when confronted with a woman with an isolated adnexal mass, clinicians worry about missing an opportunity to detect an early stage cancer. High grade serous ovarian cancers account for 80% of ovarian cancer deaths, largely due to their tendency to be diagnosed at late […]
- Validation of cobas 4800 HPV assay in SurePath Papanicolaou specimens for cervical cancer screening.The cobas (Roche Diagnostics, Indianapolis, IN) HPV assay was approved by the US Food and Drug Administration for human papillomavirus (HPV) testing in SurePath (Becton Dickinson, Franklin Lakes, NJ) Papanicolaou specimens for cervical cancer prevention. To validate the cobas HPV assay in SurePath specimens in our institution, we compared its accuracy and clinical efficacy to […]
- Primary cytoreductive surgery for advanced stage endometrial cancer: A systematic review and meta-analysis.Endometrial cancer uncommonly presents at an advanced stage, and little prospective evidence exists to guide management. We aimed to summarize evidence on primary cytoreductive surgery (PCS) in the treatment of advanced stage endometrial cancer.MEDLINE, Embase, and Scopus databases were searched from inception to September 11, 2020, using search terms representing the themes “endometrial cancer,” “advanced […]
- Frequency of high grade squamous cervical lesions among women over age 65 years living with the human immunodeficiency virus.Current U.S. cervical cancer screening guidelines recommend a stop to screening at age 65 years provided women have adequate prior screening and no history of precancer. Women living with the human immunodeficiency virus (HIV) are at higher risk for cervical cancer than uninfected women, but data a few to quantify risk among women who otherwise […]
- Outcomes of the First Pregnancy After Fertility-Sparing Surgery for Early-Stage Ovarian Cancer.To evaluate the outcomes of the first pregnancy after fertility-sparing surgery in patients treated for early-stage ovarian cancer.We performed a retrospective study of women aged 18-45 years with a history of stage IA or IC ovarian cancer reported to the California Cancer Registry for the years 2000-2012. These data were linked to the 2000-2012 California […]
- Prevalence and carcinogenic risk of high-risk human papillomavirus subtypes in different cervical cytology: a study of 124,251 cases from the largest academic center in China.We investigated the prevalence and carcinogenic risks of individual high-risk human papillomavirus (HR-HPV) in all types of cervical cytology specimens in the Shanghai population.A total of 124,251 cases with cotesting of cytology and HPV genotyping between October 2017 and February 2020 were included.The overall HPV positive rate was 24.3%, with 22.9% for HR-HPV and 6.1% […]
- Evaluation of high-risk human papillomavirus testing and anal cytology to detect high-grade anal intraepithelial neoplasia.Optimal screening for detection of anal precancer has not been established, and most studies involve very high-risk populations. We evaluated high-risk human papillomavirus (HPV) testing and anal cytology to detect high-grade anal intraepithelial neoplasia (≥AIN2) in a cohort with mostly moderate risk factors for AIN.Patients ≥35 years old undergoing anal biopsy for various lesions received […]
- Atezolizumab, Bevacizumab, and Chemotherapy for Newly Diagnosed Stage III or IV Ovarian Cancer: Placebo-Controlled Randomized Phase III Trial (IMagyn050/GOG 3015/ENGOT-OV39).To evaluate the addition of the humanized monoclonal antiprogrammed death ligand-1 (PD-L1) antibody, atezolizumab, to platinum-based chemotherapy and bevacizumab in newly diagnosed stage III or IV ovarian cancer (OC).This multicenter placebo-controlled double-blind randomized phase III trial (ClinicalTrials.gov identifier: NCT03038100) enrolled patients with newly diagnosed untreated International Federation of Gynecology and Obstetrics (FIGO) stage III or […]
- The IMPACT trial: human papillomavirus, cervical cytology and histopathological results from the baseline and 1-year follow-up phase.An increase in human papillomavirus (HPV) test volumes is expected in the near future as HPV-based screening protocols are expected to become more broadly adopted.The IMproving Primary screening And Colposcopy Triage (IMPACT) trial, a prospective, multicenter US cervical cancer screening trial, was conducted to obtain FDA approvals for the new high-throughput cobas HPV for use […]
- Inflammatory breast cancer: early recognition and diagnosis is critical.Inflammatory breast cancer (IBC) is a rare and aggressive malignancy that is often initially misdiagnosed due to its similar presentation to more benign breast pathology such as mastitis, resulting in treatment delays. Presenting symptoms of IBC include erythema, skin changes such as peau d’ orange or nipple inversion, edema, and warmth of the affected breast. […]
- Efficacy and safety of tisotumab vedotin in previously treated recurrent or metastatic cervical cancer (innovaTV 204/GOG-3023/ENGOT-cx6): a multicentre, open-label, single-arm, phase 2 study.Few effective second-line treatments exist for women with recurrent or metastatic cervical cancer. Accordingly, we aimed to evaluate the efficacy and safety of tisotumab vedotin, a tissue factor-directed antibody-drug conjugate, in this patient population.This multicentre, open-label, single-arm, phase 2 study was done across 35 academic centres, hospitals, and community practices in Europe and the USA. […]
- Controversies in Hereditary Cancer Management.Personalized management of patients at risk ideally should involve a multidisciplinary team of not only genetic counselors and surgeons, but also women’s health or menopause specialists, knowledgeable psychologists, and primary care providers or obstetrician-gynecologists aware of the risks and fears “previvors” (survivors of a predisposition to cancer who have not had the disease) face as […]
- Outcomes of Women Undergoing Excision of the Retained Cervix After Supracervical Hysterectomy.To characterize the indications for and complication rates of excision of the retained cervix after supracervical hysterectomy.We performed a retrospective cohort study of women undergoing excision of the retained cervix after supracervical hysterectomy in the 2010-2014 National Inpatient Sample. International Classification of Diseases, Ninth Revision codes were used to identify indication for the procedure and […]
- Clinical evaluation of p16INK4a immunocytology in cervical cancer screening: A population-based cross-sectional study from rural China.Cervical cancer screening with cytology suffers from low sensitivity, whereas the efficiency of human papillomavirus (HPV)-based screening is limited by low specificity. The authors evaluated a novel p16INK4a immunocytology approach in cervical cancer screening compared with HPV-based and cytology-based screening.In total, 2112 women aged 49 to 69 years from Shanxi, China were screened from March […]
- The Impact of Opportunistic Salpingectomy on Ovarian Cancer Mortality and Healthcare Costs: A Call For Universal Insurance Coverage.Opportunistic salpingectomy at the time of hysterectomy, or as an alternative to bilateral tubal ligation may reduce the incidence of ovarian cancer as it has been demonstrated that most serous ovarian cancers begin in the fallopian tubes. However, salpingectomy at the time of sterilization is not always financially covered by third party payers and this […]
- Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study.Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Adopting a genome-wide approach, we aimed […]
- MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.The concept of the use of MRI for image-guided adaptive brachytherapy (IGABT) in locally advanced cervical cancer was introduced 20 years ago. Here, we report on EMBRACE-I, which aimed to evaluate local tumour control and morbidity after chemoradiotherapy and MRI-based IGABT.EMBRACE-I was a prospective, observational, multicentre cohort study. Data from patients from 24 centres in […]
- Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial.Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has previously been shown to extend progression-free survival versus placebo when given to patients with relapsed high-grade serous or endometrioid ovarian cancer who were platinum sensitive and who had a BRCA1 or BRCA2 (BRCA1/2) mutation, as part of the SOLO2/ENGOT-Ov21 trial. The aim of this final analysis is […]
- Cervical Papanicolaou tests in the female-to-male transgender population: should the adequacy criteria be revised in this population? An Institutional Experience.It is recommended that female-to-male (FTM) transgender patients with a cervix follow the same cervical cancer screening guidelines as cisgender women. This study analyzes Papanicolaou tests, HPV results, and follow-up histology in FTM patients, and compares those results to other atrophic populations at our institution.A cohort of FTM patients receiving androgen therapy was identified through […]
- Racial-Ethnic Comparison of Guideline-Adherent Gynecologic Cancer Care in an Equal-Access System.To compare receipt of National Comprehensive Cancer Network Guideline-adherent treatment for gynecologic cancers, inclusive of uterine, cervical, and ovarian cancer, between non-Hispanic White women and racial-ethnic minority women in the equal-access Military Health System.We accessed MilCanEpi, which links data from the Department of Defense Central Cancer Registry and Military Health System Data Repository administrative claims […]
- Secondary cytoreduction followed by chemotherapy versus chemotherapy alone in platinum-sensitive relapsed ovarian cancer (SOC-1): a multicentre, open-label, randomised, phase 3 trial.The benefits of secondary cytoreduction for platinum-sensitive relapsed ovarian cancer are still widely debated. We aimed to assess the efficacy of secondary cytoreduction plus chemotherapy versus chemotherapy alone in this patient population.This multicentre, open-label, randomised, controlled, phase 3 trial (SOC-1), was done in four primarily academic centres in China (two in Shanghai, one in Hangzhou, […]
- Risk stratification of HPV positive women in routine cervical screening.High risk HPV primary screening is replacing organised cytology-based screening based on increased sensitivity to detect high grade intra-epithelial neoplasia and the very high negative predictive value which will allow extended screening intervals. The benefit of increased CIN detection and cancer prevention needs to balance against the disbenefits to screen positive women in over investigation […]
- The Systemic Treatment of Recurrent Ovarian Cancer revisited.Treatment approaches for relapsed ovarian cancer have evolved over the past decade from a calendar-based decision tree to a patient-oriented biologically-driven algorithm. Nowadays, platinum-based chemotherapy should be offered to all patients with a reasonable chance of responding to this therapy. The treatment-free interval for platinum is only one of many factors affecting patients’ eligibility for […]
- Phase III, randomized trial of mirvetuximab soravtansine versus chemotherapy in patients with platinum-resistant ovarian cancer: primary analysis of FORWARD I.Mirvetuximab soravtansine is an antibody-drug conjugate comprising a folate receptor-alpha (FRα)-binding antibody, cleavable linker, and the maytansinoid DM4, a potent tubulin-targeting agent. The randomized, open label, phase III study FORWARD I compared mirvetuximab soravtansine and investigator’s choice chemotherapy in patients with platinum-resistant epithelial ovarian cancer (EOC).Eligible patients with 1-3 prior lines of therapy and whose […]
- Incidental Findings at the Time of Cystoscopy: Clinical Updates in Women’s Health Care Primary and Preventive Care Review.Cystourethroscopy can be performed by obstetrician-gynecologists for diagnostic and occasional operative indications. Intraoperative use of cystourethroscopy to confirm urinary tract (urethral, bladder, and ureteral) integrity is one of the most important indications, because these findings can greatly affect patient care. This monograph provides an overview of appropriate instrumentation and technique for cystourethroscopy in women with […]
- Uterine Morcellation for Presumed Leiomyomas: ACOG Committee Opinion Summary, Number 822.Morcellation is a surgical technique used to reduce the size of the uterus or myomas by creating smaller pieces to allow the tissue to be removed through small incisions or with laparoscopic instruments. Open (uncontained) morcellation of the uterus and myomas has been scrutinized because of the possible spread of an unsuspected leiomyosarcoma while using […]
- Uterine Morcellation for Presumed Leiomyomas: ACOG Committee Opinion, Number 822.Morcellation is a surgical technique used to reduce the size of the uterus or myomas by creating smaller pieces to allow the tissue to be removed through small incisions or with laparoscopic instruments. Open (uncontained) morcellation of the uterus and myomas has been scrutinized because of the possible spread of an unsuspected leiomyosarcoma while using […]
- Association of Infertility and All-Cause Mortality: Analysis of US Claims Data.The consequences of an infertility diagnosis extend beyond the pursuit of family building, as infertile women also face increased risks of severe maternal morbidity, cancer, and chronic disease.To examine the association between female infertility and all-cause mortality.Retrospective analysis of 72,786 infertile women identified in the Optum Clinformatics Datamart from 2003-2019 by infertility diagnosis, testing and […]
- Five-year retrospective review in gynecologic cytopathology: is it time to amend?According to the Clinical Laboratory Improvement Amendments 1988 regulations, 5-year retrospective review (5YRR) of normal Papanicolaou tests in patients with a newly diagnosed high grade squamous intraepithelial lesion or above (HSIL+) is mandatory. Since this mandate has been in place, a multitude of changes have taken place in the screening and management guidelines of cervical […]
- Ovarian conservation for young women with early-stage low-grade endometrial cancer: A proposal for a two-step approach.In 2020, endometrial cancer continues to be the most common gynecologic malignancy in the United States. The majority of endometrial cancer is low-grade, and nearly one out of every eight low-grade endometrial cancer diagnoses occurs in women younger than 50 with early-stage disease. The incidence of early-stage, low-grade endometrial cancer is increasing in particular among […]
- Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants.Two cases of pediatric lung cancer (in 23-month-old and 6-year-old boys) resulting from mother-to-infant transmission of uterine cervical tumors were incidentally detected during routine next-generation sequencing of paired samples of tumor and normal tissue. Spontaneous regression of some lesions in the first child and slow growth of the tumor mass in the second child suggested […]
- Options for Prevention and Management of Menstrual Bleeding in Adolescent Patients Undergoing Cancer Treatment: ACOG Committee Opinion, Number 817.Obstetrician-gynecologists frequently are consulted either before the initiation of cancer treatment to request menstrual suppression or during an episode of severe heavy bleeding to stop bleeding emergently. Adolescents presenting emergently with severe uterine bleeding usually require only medical management; surgical management rarely is required. Surgical management should be considered for patients who are not clinically […]
- Options for Prevention and Management of Menstrual Bleeding in Adolescent Patients Undergoing Cancer Treatment: ACOG Committee Opinion Summary, Number 817.Obstetrician-gynecologists frequently are consulted either before the initiation of cancer treatment to request menstrual suppression or during an episode of severe heavy bleeding to stop bleeding emergently. Adolescents presenting emergently with severe uterine bleeding usually require only medical management; surgical management rarely is required. Surgical management should be considered for patients who are not clinically […]
- Objective responses to first-line neoadjuvant carboplatin-paclitaxel regimens for ovarian, fallopian tube, or primary peritoneal carcinoma (ICON8): post-hoc exploratory analysis of a randomised, phase 3 trial.Platinum-based neoadjuvant chemotherapy followed by delayed primary surgery (DPS) is an established strategy for women with newly diagnosed, advanced-stage epithelial ovarian cancer. Although this therapeutic approach has been validated in randomised, phase 3 trials, evaluation of response to neoadjuvant chemotherapy using Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST), and cancer antigen 125 (CA125) […]
- Low incidence of pulmonary metastases in vulvar cancer patients; limited value of routine chest imaging based on a cohort study.To evaluate the incidence of pulmonary metastases in the preoperative work-up of patients with primary vulvar squamous cell carcinoma (SCC).Retrospective cohort study SETTING: Tertiary referral center POPULATION: Patients treated for primary vulvar SCC from 2000-2018 METHODS: The preoperative chest imaging of 452 consecutively treated patients was documented with a minimal follow-up period of two years […]
- Cancer in pregnancy increases the risk of venous thromboembolism: A nationwide cohort study.To investigate if cancer in pregnancy causes a higher risk of venous thromboembolism (VTE) during pregnancy and postpartum compared to pregnant patients without cancer.A historical prospective cohort study using data from nationwide registries.We assessed all pregnancies in Denmark between January 1, 1977 to December 31, 2017.We linked information concerning cancer diagnosis, pregnancy and VTE diagnosis […]
- Cervical cancer risk and screening among women seeking assistance with basic needs.In the United States more than half of cervical cancers occur in women who are inadequately screened. Interventions to improve access to cervical cancer preventive care is critical to reduce health inequities.We aimed to evaluate need for cervical cancer screening among women seeking assistance with basic needs and to assess best approaches to facilitate Papanicolaou […]
- Less-radical Surgery for Early Stage Cervical Cancer: A Systematic Review.A systematic review was performed to examine the outcomes of simple hysterectomy for women with low-risk, early-stage cervical cancer.MEDLINE, Embase, Web of Science, and ClinicalTrials.gov were searched from inception until November 4, 2020.Original research reporting recurrence and/or survival outcomes among women with early stage (defined as IA2-IB1) cervical cancer who were treated with simple hysterectomy.Data […]
- Impact of socioeconomic deprivation on endometrial cancer survival in the North West of England: a prospective database analysis.To assess the impact of socioeconomic deprivation on endometrial cancer survival.Single centre prospective database study.North West England.Women with endometrial cancer treated between 2010 and 2015 METHODS: Areal-level socioeconomic status, using English Indices of Multiple Deprivation from residential postcodes, was analysed in relation to survival using Kaplan-Meier estimation and multivariable Cox-regression.Overall survival, cancer-specific survival, patterns and […]
- Updates and New Options in Advanced Epithelial Ovarian Cancer Treatment.The medical and surgical treatment strategies for women with epithelial ovarian cancer continue to evolve. In the past several years, there has been significant progress backed by landmark clinical trials. Although primary epithelial ovarian cancer is still treated with a combination of surgery and systemic therapy, more complex surgical procedures and novel therapeutics have emerged […]
- Gemogenovatucel-T (Vigil) immunotherapy as maintenance in frontline stage III/IV ovarian cancer (VITAL): a randomised, double-blind, placebo-controlled, phase 2b trial.Gemogenovatucel-T is an autologous tumour cell vaccine manufactured from harvested tumour tissue, which specifically reduces expression of furin and downstream TGF-β1 and TGF-β2. The aim of this study was to determine the safety and efficacy of gemogenovatucel-T in front-line ovarian cancer maintenance.This randomised, double-blind, placebo-controlled, phase 2b trial involved 25 hospitals in the USA. Women […]
- Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm, phase 2 trial.Survival outcomes for patients with recurrent or advanced cervical cancer are poor. Pembrolizumab has been approved for the treatment of recurrent or metastatic cervical cancer, with an overall response rate of 14·3%. GX-188E vaccination has been shown to induce human papillomavirus (HPV) E6-specific and E7-specific T-cell responses and cervical lesion regression in patients with cervical […]
- Efficacy of the bivalent HPV vaccine against HPV 16/18-associated precancer: long-term follow-up results from the Costa Rica Vaccine Trial.Oncogenic human papillomavirus (HPV) infections cause most cases of cervical cancer. Here, we report long-term follow-up results for the Costa Rica Vaccine Trial (publicly funded and initiated before licensure of the HPV vaccines), with the aim of assessing the efficacy of the bivalent HPV vaccine for preventing HPV 16/18-associated cervical intraepithelial neoplasia grade 2 or […]
- Assessing novel therapies for vulval neoplasia.Vulval cancer is a potential outcome of two separate pathological processes. Human Papilloma Virus (HPV) infection and subsequent clearance is so common as to be normal, but it can sometimes persist and ultimately lead to invasive disease. Lichen sclerosus is a vulval dermatosis that is estimated to progress to vulval cancer in less than 5% […]
- Quantitative and Qualitative Assessment of an All-Inclusive Postpartum Human Papillomavirus Vaccination Program.A postpartum human papillomavirus (HPV) vaccination program was locally implemented to address low initiation rates among young adults. Within 20 months, the program achieved high vaccine initiation and series completion rates. Based on the program’s success, it was expanded to all 36 counties served by a public hospital.To conduct a quantitative and qualitative evaluation to […]
- Pelvic Organ Prolapse after Three Modes of Hysterectomy: Long-Term Follow Up.There are various indications and approaches for hysterectomy; yet, the difference in long-term risk of subsequent prolapse after surgery is not well studied.To assess the risk of prolapse after abdominal, vaginal and laparoscopic/robotic hysterectomy for up to 17 years from surgery.A retrospective chart review study of women undergoing hysterectomy across all indications (benign and malignant) […]
- Treatment of epithelial ovarian cancer.Ovarian cancer is the third most common gynecologic malignancy worldwide but accounts for the highest mortality rate among these cancers. A stepwise approach to assessment, diagnosis, and treatment is vital to appropriate management of this disease process. An integrated approach with gynecologic oncologists as well as medical oncologists, pathologists, and radiologists is of paramount importance […]
- Effects of arsenic trioxide combined with platinum drugs in treatment of cervical cancer: A protocol for systematic review and meta-analysis of randomized controlled trials.Cervical cancer is the second largest tumor disease threatening female reproductive tract health. AS2O3 is a multi-directional and multi-target anti-cervical cancer drug. It can be combined with platinum drugs to treat cervical cancer. The literatures of AS2O3 combined with platinum drugs related to cervical cancer have shown inconsistent results, and there is currently no high […]
- Adherence to Oral Anticancer Therapeutics in the Gynecologic Oncology Population.To gain a better understanding of gynecologic oncology patient adherence to oral anticancer agents through both a cross-sectional survey of adherence and qualitative interviews with patients and clinicians regarding their experience with these medications.Eligible participants completed a survey for this cross-sectional study that included an assessment of adherence, distress, quality of life, and health literacy. […]
- Fertility-Sparing Treatment for Early-Stage Cervical, Ovarian, and Endometrial Malignancies.Approximately 20% of gynecologic malignancies are diagnosed in reproductive-aged women, and standard-of-care surgical treatment often precludes future fertility. In early-stage disease, shared decision making about fertility-sparing medical and surgical approaches may give well-selected patients the opportunity to pursue their family-building goals without compromising long-term survival. Although future fertility is an important consideration for young women […]
- Determinants of p16/Ki-67 adequacy and positivity in HPV-positive women from a screening population.The objective of this study was to describe the determinants of adequacy and positivity of the p16/Ki-67 assay in a human papillomavirus (HPV)-positive screening population enrolled within the New Technologies for Cervical Cancer 2 (NTCC2) study.ThinPrep slides were immunostained for p16/Ki-67; each slide had 3 reports from different laboratories. The authors included population-related, sampling-related/staining-related, and […]
- An Ecological Evaluation of the Increasing Incidence of Endometrial Cancer and the Obesity Epidemic.The prevalence of obesity has increased significantly in recent decades, particularly among younger women, and is a known risk factor for endometrial cancer.The objective of this study was to evaluate the trend in the prevalence of obesity and the incidence of type I endometrial cancer over time in various age categories to determine if an […]
- New-Onset myocardial injury in COVID-19 Pregnant Patients: A Case Series of 15 Patients.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the new coronavirus responsible for the coronavirus disease (COVID-19), characterized by acute respiratory distress syndrome and atypical pneumonia. In non-pregnant women, studies have shown that SARS-CoV-2 causes cardiac injury, which can result in myocardial inflammation and damage. Despite many studies investigating the extent of cardiac compromise in […]
- A meta-analysis of reversion mutations in BRCA genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistance.Germline mutations in the BRCA1 or BRCA2 (BRCA) genes predispose to hereditary breast and ovarian cancer and, mostly in the case of BRCA2, are also prevalent in cases of pancreatic and prostate malignancies. Tumours from these patients tend to lose both copies of the wild type BRCA gene, which makes them exquisitely sensitive to platinum […]
- An evolution in sentinel node mapping for cervical cancer.The technique of sentinel lymph node (SLN) biopsy has emerged as an alternative to complete pelvic lymphadenectomy to establish lymph node status in early stage cervical cancers. Traditional lymph node stripping techniques are associated with high rates of patient morbidity, such as lymphedema. For the majority of patients who are free of lymph node metastases […]