The Latest Glaucoma Journal Articles

Please login or register to bookmark this article feed
Bookmark this %label%

Keep up to date with the latest in glaucoma. Check out the latest glaucoma articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily

  • Deep learning for automated glaucomatous optic neuropathy detection from ultra-widefield fundus images.
    To develop a deep learning system for automated glaucomatous optic neuropathy (GON) detection using ultra-widefield fundus (UWF) images.We trained, validated and externally evaluated a deep learning system for GON detection based on 22 972 UWF images from 10 590 subjects that were collected at 4 different institutions in China and Japan. The InceptionResNetV2 neural network architecture was […]
  • Genetic analysis of primary open-angle glaucoma-related risk alleles in a Korean population: the GLAU-GENDISK study.
    To validate six previously known primary open-angle glaucoma (POAG)-related loci in a Korean population.Representative POAG-related single-nucleotide polymorphisms (SNPs) from six loci (cyclin-dependent kinase 4 inhibitor B antisense RNA 1 (CDKN2B)-AS1, sineoculis homeobox homolog 1/sineoculis homeobox homolog 6(SIX1/SIX6), atonal BHLH transcription factor 7 (ATOH7), cell division cycle 7-transforming growth factor beta receptor 3, CAV1, transmembrane and […]
  • Text Parsing-Based Identification of Patients with Poor Glaucoma Medication Adherence in the Electronic Health Record.
    To assess the feasibility of automated text parsing screening of physician notes in the electronic health record (EHR) to identify glaucoma patients with poor medication compliance.Cross-Sectional Study.An automated EHR pull identified a cohort of patients at the University of Michigan with a diagnosis of glaucoma, ≥40 years old, taking ≥1 glaucoma medication, and have no […]
  • Dual-input convolutional neural network for glaucoma diagnosis using spectral-domain optical coherence tomography.
    To evaluate, with spectral-domain optical coherence tomography (SD-OCT), the glaucoma-diagnostic ability of a deep-learning classifier.A total of 777 Cirrus high-definition SD-OCT image sets of the retinal nerve fibre layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) of 315 normal subjects, 219 patients with early-stage primary open-angle glaucoma (POAG) and 243 patients with moderate-to-severe-stage POAG were […]
  • Intrasession repeatability and intersession reproducibility of peripapillary OCTA vessel parameters in non-glaucomatous and glaucomatous eyes.
    To compare intrasession repeatability versus intersession reproducibility of the peripapillary vessel parameters using optical microangiography-based optical coherence tomography angiography (OCTA) in non-glaucomatous and glaucomatous eyes.In an observational, longitudinal study, peripapillary OCTA scans were collected to evaluate intrasession repeatability and intersession reproducibility using within-eye coefficient of variation (CVW) and intraclass correlation coefficient (ICC). Images were quantified […]
  • Relationship between 3D-MRI Eyeball shape and Optic Nerve Head Morphology.
    To determine if the three-dimensional eyeball shape is associated with the positions of the central retinal vascular trunk (CRVT) and the externally oblique border (EOB) in the optic nerve head (ONH).Prospective cross-sectional study PARTICIPANTS: Fifty-six (56) subjects (112 eyes) with a diagnosis of glaucoma or glaucoma suspect METHODS: The three-dimensional shape of the eyeball on […]
  • Outcome of trabeculectomy versus Ahmed glaucoma valve implantation in the surgical management of glaucoma in patients with Sturge-Weber syndrome.
    To compare the surgical outcomes of trabeculectomy versus Ahmed glaucoma valve (AGV) implantation in the surgical management of glaucoma in patients with Sturge-Weber syndrome (SWS).A retrospective chart review was performed on 40 eyes of secondary glaucoma in patients with SWS separated into two groups: AGV (N=20) and trabeculectomy with mitomycin C (N=20). Demographic data, intraocular […]
  • Risk factors for exposure of Baerveldt glaucoma drainage implants: a case-control study.
    Glaucoma drainage implant exposure is one of the serious complications after glaucoma drainage implant surgery. The purpose of this study is to evaluate the risk factors for exposure of the device after implantation of a Baerveldt glaucoma drainage implant.This is a retrospective review of the medical records of all patients who underwent Baerveldt glaucoma drainage […]
  • Conjunctival thickness as a predictive imaging biomarker for the glaucoma filtration surgery outcome: An optical coherence tomography study.
    To analyze the pre-operative conjunctival thickness in glaucomatous patients undergoing filtration surgery (FS), using optical coherence tomography (OCT).The conjunctival status represents one of the most critical determinants of the FS outcome.Retrospective study.Sixty-seven patients candidate to FS for uncontrolled glaucoma were enrolled.OCT was performed at the superior bulbar conjunctiva before FS, and at bleb site at […]
  • Utility of 10-2 Visual Field Testing in Glaucoma Patients with Early 24-2 Visual Field Loss.
    To determine whether the 10-2 test of the Humphrey Field Analyzer detected a higher proportion of abnormal visual fields compared to the 24-2 test in the central 10° in patients with early visual field damage.Prospective observational study.Patients with early open-angle glaucoma and healthy controls.All subjects underwent a 24-2 and 10-2 test. Only the 12 central […]
  • Glaucoma conversion of the contralateral eye in unilateral normal-tension glaucoma patients: a 5-year follow-up study.
    To investigate clinical characteristics and risk factors for glaucoma conversion of the contralateral eye in unilateral normal-tension glaucoma (NTG) patients.A retrospective observational cohort study was conducted on a total of 76 subjects who had been diagnosed with unilateral NTG at the baseline and followed up for more than 5 years. Glaucoma conversion in the contralateral eye […]
  • Laser trabeculoplasty for open-angle glaucoma: a systematic review and network meta-analysis.
    To comprehensively evaluate the effectiveness of different types of laser trabeculoplasty (LT) in the treatment of open-angle glaucoma.Systematic review and network meta-analysis.Eligible randomized controlled trials (RCT) were identified by searching PubMed, EMBASE, Cochrane Library, SCOPUS, CNKI, and CBM for studies published between January 1, 2000 and April 20, 2020. Eight interventions were evaluated, including argon […]
  • Matching the Patient to the Intraocular Lens: Preoperative Considerations to Optimize Surgical Outcomes.
    The intraocular lens (IOL) selection process for patients is a thoughtful one which requires objective assessment of patient-specific ocular characteristics, including the quality and quantity of the corneal astigmatism, the health of the ocular surface, and other ocular comorbidities. Potential issues that could be considered complications following surgery, including dry eye disease, anterior or epithelial […]
  • Glaucoma home-monitoring using a tablet-based visual field test (Eyecatcher): An assessment of accuracy and adherence over six months.
    To assess accuracy and adherence of visual field (VF) home-monitoring in a pilot sample of glaucoma patients.Prospective longitudinal feasibility and reliability study.Twenty adults (median 71 years) with an established diagnosis of glaucoma were issued a tablet-perimeter (Eyecatcher), and were asked to perform one VF home-assessment per eye, per month, for 6 months (12 tests total). […]
  • Outcomes of suprachoroidal haemorrhage drainage with and without vitrectomy: a 10-year study.
    The management of suprachoroidal haemorrhage (SCH) remains a challenge. We aimed to analyse and discuss the safety and efficacy outcomes of SCH drainage surgery over a 10-year period in one of the largest tertiary centres in the UK.Retrospective observational study of consecutive patients who underwent SCH drainage in Manchester Royal Eye Hospital over a 10-year […]
  • Glaucoma and glare.
    To determine whether a purpose-built glare tester, in combination with new glare-specific questions, can better assess glaucoma patients’ experience of glare and visual disability than visual acuity (VA) or visual fields alone.Consecutive patients attending for visual fields in a single glaucoma clinic from 03/06/2019-01/11/2019 underwent VA assessment using a Brightness Acuity Tester as a glare […]
  • Uveitis in Juvenile Idiopathic Arthritis: 18-year Outcome in the Population-based Nordic Cohort Study.
    To assess the long-term outcome of uveitis in juvenile idiopathic arthritis (JIA).Population-based, multicenter, prospective JIA cohort, with a cross-sectional assessment of JIA-associated uveitis (JIA-U) 18 years after the onset of JIA.434 patients with JIA, of these 96 with uveitis, from defined geographical areas of Denmark, Finland, Norway, and Sweden.Patients with onset of JIA between January […]
  • Impact of anxiety and depression on progression to glaucoma among glaucoma suspects.
    To assess the impact of anxiety and depression in the risk of converting to glaucoma in a cohort of glaucoma suspects followed over time.The study included a retrospective cohort of subjects with diagnosis of glaucoma suspect at baseline, extracted from the Duke Glaucoma Registry. The presence of anxiety and depression was defined based on electronic […]
  • Follow-Up Adherence and Barriers to Care for Pediatric Glaucomas at a Tertiary Care Center.
    To determine the percent adherence to follow-up for patients with pediatric glaucomas seen at a tertiary care center and to elucidate risk factors.Retrospective cohort study METHODS: Patients with pediatric glaucomas seen at the University of Minnesota over 8.5 years were classified as adherent (A), nonadherent (NA), or lost to tertiary follow-up (LTTF) if they followed […]
  • Follow-Up Adherence and Barriers to Care for Pediatric Glaucomas at a Tertiary Care Center.
    To determine the percent adherence to follow-up for patients with pediatric glaucomas seen at a tertiary care center and to elucidate risk factors.Retrospective cohort study METHODS: Patients with pediatric glaucomas seen at the University of Minnesota over 8.5 years were classified as adherent (A), nonadherent (NA), or lost to tertiary follow-up (LTTF) if they followed […]
  • Agreement amongst consultant ophthalmologists on levels of visual disability required for eligibility for certificate of sight impairment : Sight impairment registration using binocular composite visual fields.
    Registration as sight impaired allows access to services important for patients. The rates of sight impairment due to visual field loss are underestimated. Previous work has shown that evaluation of visual field defects in both eyes produces poor agreement among ophthalmologists for categorisation of patients as eligible for sight impairment registration.To evaluate the impact of […]
  • 12-month randomised trial of 360° and 180° Schlemm’s canal incisions in suture trabeculotomy ab interno for open-angle glaucoma.
    To perform a 12-month comparison between the different extents and locations of Schlemm’s canal incisions during suture trabeculotomy ab interno for open-angle glaucoma (OAG).This is a prospective, single-centre, three-arm randomised trial. A total of 99 eyes of 99 patients were randomly assigned to one of three groups: the 360° incision group (n=34), the upper-180° incision […]
  • Long-term anatomical and functional outcomes after autokeratoplasty.
    To evaluate the anatomical and functional outcomes of autologous contralateral penetrating keratoplasty (autokeratoplasty).Kaplan-Meier survival analyses were retrospectively performed. Anatomical failure was defined as regraft or graft permanently cloudy at any time during follow-up. Functional failure was defined as the final best-corrected visual acuity (BCVA) <20/400.Thirty-one eyes of 31 patients (19 men), with a mean age […]
  • Cataract Surgery Complexity and Surgical Complication Rates among Medicare Beneficiaries with and without Dementia.
    To evaluate cataract surgery complexity and complications among US Medicare beneficiaries with and without dementia.Retrospective claims-based cohort study PARTICIPANTS: A 20% representative sample of Medicare beneficiaries, 2006-2015.Dementia was identified from diagnosis codes on or prior to each beneficiary’s first-eye cataract surgery. For each surgery, we identified setting, routine versus complex coding, anesthesia provider type, duration, […]
  • Discrepancy in loss of macular perfusion density and ganglion cell layer thickness in early glaucoma.
    To identify characteristics of patients with early open-angle glaucoma exhibiting greater macular perfusion density (PD) loss compared to macular ganglion cell layer (GCL) thickness loss.Cross-sectional study.Optical coherence tomography (OCT) imaging of the optic nerve head and macula was conducted in patients and healthy control subjects. Minimum rim width, retinal nerve fibre layer (RNFL) and ganglion […]
  • Incidence and Outcomes of Hypertensive Phase Following Aurolab Aqueous Drainage Implant Surgery in Adults with Refractory Glaucoma.
    To report the incidence and outcomes of hypertensive phase (HP) following Aurolab Aqueous Drainage Implant (AADI) (Aurolab, Madurai, India) surgery in adults with refractory glaucoma.Retrospective, noncomparative, interventional case series.All eyes that received the AADI and had a minimum of 2-year follow-up were identified, and data of patients who had intraocular pressure (IOP) < 21 mmHg […]
  • Aqueous outflow imaging techniques and what they tell us about intraocular pressure regulation.
    Recent advances in the medical and surgical management of open-angle glaucoma have increased the number of treatment options available. Several new intraocular pressure (IOP)-lowering treatments target the conventional aqueous outflow (AO) system. However, success rates are variable and outcomes in individual patients are often difficult to predict. Variable treatment responses remain unexplained and highlight deficiencies […]
  • One-year results of two-site trabeculotomy in paediatric glaucoma following cataract surgery.
    The management of glaucoma following cataract surgery (GFCS) in children is challenging. This study looks at the results of two-site trabeculotomy in paediatric aphakic/pseudophakic glaucoma, 1-year post operatively.This prospective, institutional study was performed on 33 eyes with GFCS in patients aged ≤14 years. Patients underwent two-site trabeculotomy using the rigid-probe trabeculotome, through a superonasal and […]
  • Strabismus after Ahmed Glaucoma Valve Implantation.
    Most reports of strabismus after glaucoma drainage device implantation study larger devices and rarely note the incidence of strabismus after Ahmed glaucoma valve (AGV) implantation. It is unknown if the pattern of strabismus is similar with smaller devices. We investigated characteristics of strabismus after AGV implantation.Retrospective case series METHODS: Institutional study of 732 patients at […]
  • Impact of artifacts from optical coherence tomography retinal nerve fiber layer and macula scans on detection of glaucoma progression.
    To determine the prevalence of artifacts on segmented SDOCT images and assess their impact on the interpretation of glaucomatous progression in the retinal nerve fiber layer (RNFL) profile and macular thickness map.Retrospective reliability analysis METHODS: Retrospective review of glaucoma and glaucoma suspect eyes imaged with SDOCT during a one-month period. All cases had at least […]
  • Clinicopathologic correlations of retrocorneal membranes associated with endothelial corneal graft failure.
    To provide clinicopathologic correlations for retrocorneal membranes associated with Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) failure.Retrospective case series.The specimens and medical records of the patients diagnosed with clinically significant retrocorneal membranes associated with DSAEK failure at the Bascom Palmer Eye Institute or the University of Miami Veterans Hospital between October 2015 and March 2020, were […]
  • Effect of ICD-9 to ICD-10 Transition on Accuracy of Codes for Stage of Diabetic Retinopathy and Related Complications: Results from the CODER Study.
    When International Classification of Disease (ICD) version 9 (ICD-9) transitioned to ICD-10, there was a marked increase in the complexity of ICD codes with potential for improved specificity in clinical database research. The purpose of this study was to characterize the accuracy of coding for stage of diabetic retinopathy (DR) and DR-related complications (including vitreous […]
  • Facial Port-Wine Stain Phenotypes Associated with Glaucoma Risk in Neonates.
    To determine if the size and location of facial port-wine stain (PWS) can predict glaucoma risk for neonates.Retrospective cohort study METHODS: Children with facial PWS who had undergone ophthalmologic examination within four weeks of their birth were included. Clinical information including facial photograph, intraocular pressure, corneal diameter, optic-disc cup-to-disc ratio, and Sturge-Weber syndrome (SWS) diagnosis […]
  • Corneal graft failure: an update.
    Corneal graft surgery is one of the most successful forms of human solid-tissue transplantation, and nowadays, there is a worldwide expansion of the surgical volume of corneal grafts. This surgery is continuously evolving, with new surgical techniques and postoperative treatments that have considerably increased the chance of survival for the grafts. Despite the high rate […]
  • Relationship between peripapillary vessel density and visual field in glaucoma: a broken-stick model.
    To determine the tipping point at which peripapillary vessel density (pVD), measured using optical coherence tomography angiography (OCT-A), is associated with detectable visual field (VF) loss in cases of open-angle glaucoma (OAG).Peripapillary retinal nerve fibre layer (pRNFL) thickness and pVD were measured using OCT and OCT-A in 166 healthy participants, those with suspected glaucoma and […]
  • Risk factors for repeat keratoplasty after endothelial keratoplasty in the Medicare population.
    To evaluate long-term rates of repeat keratoplasty after endothelial keratoplasty (EK), and, explore risk factors associated with graft failure DESIGN: Retrospective, cohort study Methods SETTING: Population-based using 2010-2019 Medicare carrier claims STUDY POPULATION: Medicare beneficiaries aged ≥65 years who underwent EK procedures MAIN OUTCOME MEASURES: 1) Occurrence of repeat keratoplasty for the overall cohort as […]
  • Ethnicity-specific database improves the diagnostic ability of peripapillary retinal nerve fiber layer thickness to detect glaucoma.
    To determine the changes in optical coherence tomography (OCT) color probability codes and diagnostic ability for peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell complex (GCC) analysis after applying a Chinese and Caucasian normative database.Cross-sectional study.This study enrolled 219 healthy eyes (108 Caucasian and 111 Chinese) to construct an ethnicity-specific normative database for pRNFL […]
  • An Evaluation of a New 24-2 Metric for Detecting Early Central Glaucomatous Damage.
    To test the hypothesis that a recently proposed pattern standard deviation (PSD) metric, based upon the 24-2 visual field (VF) test, as well as the PSD of the 10-2 VF, will miss central glaucomatous damage confirmed with an objective structure-function method.Cross-sectional case-control study METHODS: A glaucoma (G) group (70 eyes/patients) diagnosed as glaucoma, with a […]
  • A strategy for seeding point error assessment for retesting (SPEAR) in perimetryapplied tonormal, suspect and glaucoma patients.
    To determine the impact of seeding point errors (SPE) as a source of low-test reliability in perimetry, and to develop a strategy to mitigate this error early in the test.Cross-sectional study METHODS: Visual field test results from one eye of 364 patients (77 normal, 178 glaucoma suspect and 109 glaucoma) was used to develop models […]
  • Comparison of visual field progression in new-diagnosed primary open-angle and exfoliation glaucoma patients in Sweden.
    The present study aimed to compare visual field progression in new-diagnosed exfoliation versus open-angle glaucoma patients.Retrospective study. The study included patients with new-diagnosed primary open-angle and exfoliation glaucoma. All patients were followed for 3 years with reliable visual fields. At least five reliable fields were needed for inclusion. Exfoliation and open-angle glaucoma were defined based […]
  • Using an open-source tablet perimeter (Eyecatcher) as a rapid triage measure for glaucoma clinic waiting areas.
    Glaucoma services are under unprecedented strain. The UK Healthcare Safety Investigation Branch recently called for new ways to identify glaucoma patients most at risk of developing sight loss, and of filtering-out false-positive referrals. Here, we evaluate the feasibility of one such technology, Eyecatcher: a free, tablet-based ‘triage’ perimeter, designed to be used unsupervised in clinic […]
  • Time to Presentation after Symptom Onset in Endophthalmitis: Clinical Features and Visual Outcomes.
    To investigate the impact of time from symptom onset to presentation on the clinical course and outcomes of eyes with endophthalmitis.Retrospective longitudinal cohort study.One hundred and thirty-three eyes of 130 patients with endophthalmitis.Adults diagnosed with endophthalmitis at the Duke Eye Center from January 1, 2009 to January 1, 2018 were identified utilizing Duke Enterprise Data […]
  • Fundamentals of artificial intelligence for ophthalmologists.
    As artificial intelligence continues to develop new applications in ophthalmic image recognition, we provide here an introduction for ophthalmologists and a primer on the mechanisms of deep learning systems.Deep learning has lent itself to the automated interpretation of various retinal imaging modalities, including fundus photography and optical coherence tomography. Convolutional neural networks (CNN) represent the […]
  • Association of Anti-hypertensive Medication with Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Thickness.
    To evaluate the association between different classes of anti-hypertensive medication with retina nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) thickness in a non-glaucomatous multi-ethnic Asian population.Population-based, cross-sectional study.A total of 9,144 eyes for RNFL analysis (2,668 Malays, 3,554 Indians and 2,922 Chinese) and 8,549 eyes for GC-IPL analysis (2,460 Malays, 3,230 Indians […]
  • Determinants of corneal endothelial cell loss after sulcus placement of Ahmed and Baerveldt drainage device surgery.
    In patients who underwent multiple intraocular surgeries, we evaluated determinants of decreased corneal endothelial cell density (CECD) after sulcus placement following Ahmed and Baerveldt drainage device surgery.We retrospectively reviewed consecutive patients with glaucoma who underwent sulcus placement with an Ahmed glaucoma valve or a Baerveldt glaucoma implant. We compared presurgical and postsurgical CECD and risk […]
  • Detection of Progressive Glaucomatous Optic Nerve Damage on Fundus Photographs with Deep Learning.
    To investigate whether predictions of retinal nerve fiber layer (RNFL) thickness obtained from a deep learning model applied to fundus photographs can detect progressive glaucomatous changes over time.Retrospective cohort study PARTICIPANTS: 86,123 pairs of color fundus photos and spectral-domain optical coherence tomography (SD OCT) scans collected over 21,232 visits from 8,831 eyes of 5,529 patients […]
  • Plateau iris and severity of primary angle closure glaucoma.
    To compare the distribution of plateau iris in eyes across varying severity of primary angle-closure glaucoma (PACG) using standardized ultrasound biomicroscopy (UBM) criteria.Cross-sectional study METHODS: UBM was performed on 210 PACG subjects who had previously undergone laser peripheral iridotomy. Plateau iris was defined as the presence of all the following UBM criteria in at least […]
  • Cardiovascular Disease predicts structural and functional progression in early glaucoma.
    To investigate the association between cardiovascular disease and baseline structural defects and longitudinal disease progression in glaucoma.Prospective longitudinal cohort study of pre-perimetric and perimetric glaucoma.2628 eyes from 1314 participants recruited to the Progression Risk of Glaucoma: RElevant SNPs with Significant Association (PROGRESSA) study were evaluated for baseline and longitudinal structural thinning on Spectral Domain Optical […]
  • Outcomes of gonioscopy-assisted transluminal trabeculotomy in pseudoexfoliative glaucoma: 24-month follow-up.
    To report on outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in eyes with pseudoexfoliative glaucoma (PXG).Prospective, interventional, non-comparative case series. A total of 103 eyes from 84 patients with PXG were enrolled to undergo a 360-degree ab interno trabeculotomy with gonioscopic assistance using either a 5.0 polypropylene suture or an illuminated microcatheter with up to 24 months […]
  • Use of a novel telemetric sensor to study interactions of intraocular pressure and ganglion-cell function in glaucoma.
    (1) To test the feasibility of simultaneous steady-state pattern electroretinogram (ssPERG) and intraocular pressure (IOP) measurements with an implanted IOP sensor. (2) To explore the scope of this approach for detecting PERG changes during IOP manipulation in a model of lateral decubitus positioning (LDP; lateral position).15 healthy controls and 15 treated glaucoma patients participated in […]
  • Asian-specific vertical cup-to-disc ratio cut-off for glaucoma screening: An evidence-based recommendation from a multi-ethnic Asian population.
    Evidence-based guidelines are essential for glaucoma screening to work effectively.To derive a vertical cup-to-disc ratio (VCDR) cut-off for glaucoma screening in a multi-ethnic Asian population.The Singapore Epidemiology of Eye Diseases (SEED) study is a population-based study conducted from 2004 to 2011 in a single tertiary care research institute.SEED comprised of 10 033 Chinese, Malay and Indian […]
  • Retinal vasculometry associations with glaucoma; findings from the European Prospective Investigation of Cancer-Norfolk Eye study.
    To examine retinal vasculometry associations with different glaucomas in older British people.Cross-sectional study METHODS: 8,623 European Prospective Investigation into Cancer-Norfolk Eye study participants were examined, who underwent retinal imaging, ocular biometry assessment, and clinical ascertainment of ocular hypertensive or glaucoma status (including glaucoma suspect [GS], high tension open-angle glaucoma [HTG], and normal tension glaucoma [NTG]). […]
  • Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial.
    Retinal ganglion cells endure significant metabolic stress in glaucoma but maintain capacity to recover function. Nicotinamide, a precursor of NAD+ , is low in serum of glaucoma patients and its supplementation provides robust protection of retinal ganglion cells in preclinical models. However, the potential of nicotinamide in human glaucoma is unknown.To examine the effects of […]
  • Functional imaging of mitochondria in retinal diseases using flavoprotein fluorescence.
    Mitochondria are critical for cellular energy production and homeostasis. Oxidative stress and associated mitochondrial dysfunction are integral components of the pathophysiology of retinal diseases, including diabetic retinopathy (DR), age-related macular degeneration, and glaucoma. Within mitochondria, flavoproteins are oxidized and reduced and emit a green autofluorescence when oxidized following blue light excitation. Recently, a noninvasive imaging […]
  • A Composite Risk Score for Capsule Complications based on data from the Swedish National Cataract Register; Relation to Surgery Volumes.
    To investigate case mix in relation to capsule complication, possible associations between case mix and operation volume and change in case mix over time.Register-based study.Swedish patients subjected to cataract surgery between 2007 and 2016.Demographics and data on ocular comorbidity, intraoperative difficulties and capsule complications were registered from 2007 to 2016 and analyzed retrospectively in relation […]
  • Diagnostic validity of optic nerve head colorimetric assessment and optical coherence tomography angiography in patients with glaucoma.
    The aim of this study was to assess the optic nerve head (ONH) and macular vessel density with optical coherence tomography angiography (OCT-A) and the ONH haemoglobin (ONH Hb) amount with Laguna ONhE program in open-angle glaucoma (OAG) patients.In this prospective observational cross-sectional study, 67 OAG patients and 41 healthy age-sex frequency matched subjects were […]
  • Epidemiology and the Estimated Burden of Microbial Keratitis on the Health Care System in Taiwan: A 14-Year Population-Based Study.
    To investigate the epidemiological characteristics of microbial keratitis and its overall burden on the healthcare system in Taiwan.Retrospective, population-based study.We conducted a study using claims data in the Taiwan National Health Insurance Research Database in 2000-2013, employing diagnoses, drugs and procedure codes to define diseases and procedures. Participants were classified into groups according to the […]
  • Defining glaucomatous optic neuropathy using objective criteria from structural and functional testing.
    To identify objective criteria from optical coherence tomography (OCT) and perimetry that denote a useful, specific definition of glaucomatous optic neuropathy (GON) in eyes with open-angle glaucoma for comparisons among glaucoma research studies.A cross-sectional study of adult patients with glaucoma from nine centres on five continents evaluated de-identified physician diagnosis, OCT and perimetry results for […]
  • Filtering-associated Endophthalmitis Following Trabeculectomy or Tube-shunt Implant.
    To determine the rate, clinical features, and outcomes of filtering-associated endophthalmitis in eyes that underwent trabeculectomy or tube-shunt implantation.Retrospective database study with selective chart review.Eyes that underwent incisional glaucoma surgery at our institution between January 1, 2012, and December 31, 2019.An electronic medical record database was used to identify all eyes that underwent trabeculectomy or […]
  • Reduction of corneal epithelial thickness during medical treatment for myopic regression following FS-LASIK.
    To evaluate corneal epithelial thickness change during medical treatment for eyes with myopic regression after femtosecond laser-assisted in situ keratomileusis (FS-LASIK).This study included 84 eyes of 54 subjects diagnosed with myopic regression after FS-LASIK and treated using topical steroid and anti-glaucoma drugs. Corneal epithelial thickness was measured using Fourier-domain optical coherence tomography before and after […]