The Latest Glaucoma Journal Articles

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Keep up to date with the latest in glaucoma. Check out the latest glaucoma articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily

  • A Global Assessment of Eye Health and Quality of Life: A Systematic Review of Systematic Reviews.
    More than 1 billion people worldwide have vision impairment or blindness from potentially preventable or correctable causes. Quality of life, an important measure of physical, emotional, and social well-being, appears to be negatively associated with vision impairment, and increasingly, ophthalmic interventions are being assessed for their association with quality of life.To examine the association between […]
  • Glaucoma Expert-level Detection of Angle Closure in Goniophotographs with Convolutional Neural Networks: The Chinese American Eye Study: Automated Angle Closure Detection in Goniophotographs.
    To compare the performance of a novel convolutional neural network (CNN) classifier and human graders in detecting angle closure in EyeCam goniophotographs.Retrospective cross-sectional study.Subjects from the Chinese American Eye Study (CHES) underwent EyeCam goniophotography in four angle quadrants. A CNN classifier based on the ResNet-50 architecture was trained to detect angle closure, defined as inability […]
  • Herpes zoster ophthalmicus clinical presentation and risk factors for loss of vision.
    To determine the rate of moderate and severe vision loss following herpes zoster ophthalmicus (HZO) and to identify associated factors.Retrospective cohort study.All subjects with acute HZO seen at a single center from 2006 to 2016 were included in the study. The primary outcome measure was the proportion of individuals with moderate and/or severe loss of […]
  • Robotic assisted CyberKnife radiosurgery for the treatment of choroidal metastasis.
    Choroidal metastases occur in many patients with systemic cancer and limit quality of life due to visual deterioration or pain. The limited prognosis of these patients demand treatment approaches that aim at a quick response and easy application. We evaluated a robotic assisted radiosurgery device, the CyberKnife, in the treatment of choroidal metastasis.Following retrobulbar anaesthesia, […]
  • Predicting glaucoma development with longitudinal deep learning predictions from fundus photographs.
    To assess whether longitudinal changes in a deep learning algorithm’s predictions of retinal nerve fiber layer (RNFL) thickness based on fundus photographs can predict future development of glaucomatous visual field defects.Retrospective cohort study METHODS: This study included 1072 eyes of 827 glaucoma-suspect patients with an average follow-up of 5.9 ± 3.8 years. All eyes had […]
  • Evaluation of aqueous humor and serum clusterin levels in patients with glaucoma.
    To compare the aqueous humor (AH) and the serum clusterin levels of patients with pseudoexfoliation syndrome (PEX), pseudoexfoliation glaucoma (PEXG), and primary open-angle glaucoma (POAG) with each other and with an age- and sex-matched control group.This prospective, cross-sectionalstudy evaluated 92 eyes from 92 adult cases of uncomplicated phacoemulsification and posterior chamber intraocular lens (IOL) implantation. […]
  • Screening first-degree relatives of glaucoma patients reveals barriers to participation.
    To report the results of a glaucoma screening campaign targeting first-degree relatives of glaucoma patients in South India.1598 glaucoma patients were contacted via letter or letter and phone call and asked to bring their siblings and children to a glaucoma screening. Participants underwent standardised eye examinations and completed questionnaires that assessed barriers to participation and […]
  • Global optical coherence tomography measures for detecting the progression of glaucoma have fundamental flaws.
    To understand the problems involved in using global OCT measures for detecting progression in early glaucoma.Eyes from 76 patients and 28 healthy controls (HC) had a least two OCT scans at least 1 year apart. To determine the 95% confidence intervals (CI), 151 eyes (49 HC and 102 patients) had at least two scans within […]
  • Corneal endothelial cell loss after trabeculectomy and phacoemulsification in one or two steps: a prospective study.
    The objective of this study was to analyse the results of the surgical treatment of coexisting cataract and glaucoma and its effects on corneal endothelial cell density (CECD).We include two longitudinal prospective studies: one randomised that included 40 eyes with open angle glaucoma that received one- (n = 20) or two-step (n = 20) phacotrabeculectomy and another that included […]
  • Genetic pre-screening for glaucoma in population-based epidemiology: protocol for a double-blind prospective screening study within Lifelines (EyeLife).
    Early detection of glaucoma is paramount to maintain patients’ eyesight, however glaucomatous vision loss tends to begin in the periphery with up to 50% of patients unaware they are affected. Because glaucomatous vision loss is permanent, screening appears attractive, but currently is not cost-effective. Therefore we aim to investigate the utility of genetic pre-screening for […]
  • Ex-PRESS shunt implantation for intractable glaucoma with posterior chamber phakic intraocular lens: a case report.
    Implantation of the posterior chamber phakic intraocular lens has been widely performed to correct high and extreme myopia. Chronic intraocular pressure (IOP) elevation may occur in its late postoperative period. For medically uncontrolled cases, surgical treatment is necessary, and benefits should be weighed against risks when determining whether to remove the lens.A 32-year-old man with […]
  • Postoperative complicated peripheral cortical cataract after ultrasound cycloplasty: a case report.
    Ultrasound cycloplasty (UCP) is a non-invasive procedure for glaucoma treatment. Using high-intensity focused ultrasound to work on the ciliary body, the generation of aqueous humor can be reduced and the drainage of aqueous humor through the uveoscleral pathway can be enhanced. Recently, this therapy is gradually gaining clinical recognition. We report a case of a […]
  • Sturge-Weber syndrome coexisting with polydactyly: a case report.
    Sturge-Weber syndrome (SWS) is a sporadic congenital disorder, characterized by unilateral facial nevus flammeus associated with ipsilateral glaucoma, choroidal angioma and leptomeningeal hemangiomas. SWS can comorbid with other disorders in some patients, however, there has been no prior described case of SWS and polydactyly occurring in the same patient.A 15-year-old girl with diagnosis of SWS […]
  • Short-term efficacy of latanoprostene bunod for the treatment of open-angle glaucoma and ocular hypertension: a systematic literature review and a network meta-analysis.
    To assess the comparative efficacy of latanoprostene bunod (LBN), a novel prostaglandin analogue (PGA), to other medications for open-angle glaucoma and ocular hypertension on lowering intraocular pressure (IOP).A systematic literature review adapted from the Li et al (Ophthalmology, 2016) study was conducted. Medline, Embase and PubMed were searched for randomised controlled trials published between 1 […]
  • Effect of Mindfulness Meditation on Intraocular Pressure and Trabecular Meshwork Gene Expression: A Randomized Controlled Trial.
    To evaluate the effect of mindfulness meditation (MM) on intraocular pressure (IOP) and trabecular meshwork (TM) gene expression in patients with medically uncontrolled primary open angle glaucoma (POAG).Parallel arm, single-masked, randomized controlled trial.Sixty POAG patients with IOP ≥21 mm Hg taking maximal topical medication and scheduled for trabeculectomy were included in this study at a tertiary […]
  • Artificial intelligence and complex statistical modeling in glaucoma diagnosis and management.
    The field of artificial intelligence has grown exponentially in recent years with new technology, methods, and applications emerging at a rapid rate. Many of these advancements have been used to improve the diagnosis and management of glaucoma. We aim to provide an overview of recent publications regarding the use of artificial intelligence to enhance the […]
  • Advances in medical therapy for glaucoma.
    To discuss a new class of medication that has recently become available for the treatment of glaucoma; as well as share insights into developments in glaucoma medicine administration which has the potential to revolutionize medical therapy for glaucoma.Newly available eye drops, netarsudil 0.02% and latanoprostene bunod 0.024%, are improving aqueous outflow through the conventional outflow […]
  • Ocular Involvement in Sjogren’s Syndrome: Risk Factors for Severe Visual Impairment and Vision-Threatening Corneal Complications.
    To assess the risk factors for severe visual impairment (SVI) and corneal complications in primary and secondary Sjogren’s syndrome (SS).Retrospective case series.Ocular data of all consecutive SS patients presenting to an eye-care network and diagnosed as per the 2012 American College of Rheumatology criteria over the past eight years were reviewed.The risk factors associated with […]
  • Future IOL Technologies.
    Over the last couple of years, cataract surgery – already an intervention of high efficiency and safety – has undergone further refinement, not least because of new IOL technologies that have entered the market. In this overview, innovative IOL designs will be presented, some of which are already in clinical use (though sometimes primarily at […]
  • Risk factors for blindness in children with primary congenital glaucoma – follow-up of a registry cohort.
    The aim of this study was to evaluate the baseline features associated with blindness in a cohort of children with primary congenital glaucoma (PCG) from a hospital registry.Setting: Observational cohort study DESIGN: Retrospective clinical cohort study STUDY POPULATION: The registry included all children who presented to our tertiary care institute between 1995 and 2014 with […]
  • Assessing Glaucoma Progression Using Machine Learning Trained on Longitudinal Visual Field and Clinical Data.
    Rule-based approaches to determining glaucoma progression from visual fields alone are discordant and have tradeoffs. To better detect when glaucoma progression is occurring, we utilized a longitudinal data set of merged VF and clinical data to assess the performance of a Convolutional Long Short-Term Memory (LSTM) neural network.Retrospective analysis of longitudinal clinical and visual field […]
  • Rates of RNFL Thinning in Patients with Suspected or Confirmed Glaucoma Receiving Unilateral Intravitreal Injections for Exudative AMD.
    To evaluate whether the rate of retinal nerve fiber layer (RNFL) thinning is faster in eyes receiving intravitreal injections compared to fellow uninjected eyes among patients with suspected or confirmed glaucoma and exudative age-related macular degeneration (AMD).Retrospective comparative cohort study.Patients diagnosed with unilateral exudative AMD and confirmed or suspected glaucoma in both eyes receiving unilateral […]
  • Progression of Macular Vessel Density in Primary Open-Angle Glaucoma: A Longitudinal Study.
    To evaluate the rate of progression of macular vessel density (mVD) in primary open-angle glaucoma (POAG) and explore the relationship between the progression of mVD and macular ganglion cell-inner plexiform layer (mGCIPL) thickness and parapapillary retinal nerve fiber layer (pRNFL) thickness.Prospective cohort study.In this study, 102 eyes with POAG were followed for 36.6 ± 6.4 months. […]
  • Characterization of Retinal Microvascular and Choroidal Structural Changes in Parkinson Disease.
    Noninvasive retinal imaging may detect structural changes associated with Parkinson disease (PD) and may represent a novel biomarker for disease detection.To characterize alterations in the structure and microvasculature of the retina and choroid in eyes of individuals with PD and compare them with eyes of age- and sex-matched cognitively healthy control individuals using optical coherence […]
  • Proton beam irradiation of uveal melanoma involving the iris, ciliary body and anterior choroid without surgical localisation (light field).
    To assess treatment outcomes after proton beam irradiation (PBI) without surgical localisation of uveal melanomas involving the iris, ciliary body and anterior choroid.Retrospective chart review of 125 patients evaluated at Massachusetts Eye and Ear and treated with PBI using a light field set-up without localisation surgery between November 1975 and April 2017. The tumours were […]
  • Peripapillary sclera exhibits a v-shaped configuration that is more pronounced in glaucoma eyes.
    To compare the shape of the anterior surface of the peripapillary sclera (PPS) between glaucoma and healthy subjects.88 primary open angle glaucoma (POAG), 98 primary angle closure glaucoma (PACG) and 372 age-matched and gender-matched healthy controls were recruited in this study. The optic nerve head of one randomly selected eye of each subject was imaged […]
  • Brimonidine-associated uveitis – a descriptive case series.
    Anterior uveitis secondary to topical brimonidine administration is rare and not well-defined. In glaucoma patients using brimonidine, one must consider this phenomenon to avoid mis-diagnosis and over-treatment with topical steroids which in turn may increase intraocular pressure (IOP). This is the largest case series including the longest patient follow-up in the current literature.Sixteen patients (26 […]
  • Outcome of a single XEN microstent implant for glaucoma patients with different types of glaucoma.
    The aim of this retrospective study was to compare the efficacy and safety profile of a single XEN-microstent in different types of primary and secondary open angle glaucoma.A single XEN microstent was implanted in patients with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), pseudoexfoliation glaucoma (PEX) and secondary glaucoma (Sec.Gl). The intraocular pressure (IOP), the […]
  • Peripapillary sclera exhibits a v-shaped configuration that is more pronounced in glaucoma eyes.
    To compare the shape of the anterior surface of the peripapillary sclera (PPS) between glaucoma and healthy subjects.88 primary open angle glaucoma (POAG), 98 primary angle closure glaucoma (PACG) and 372 age-matched and gender-matched healthy controls were recruited in this study. The optic nerve head of one randomly selected eye of each subject was imaged […]
  • Brimonidine-associated uveitis – a descriptive case series.
    Anterior uveitis secondary to topical brimonidine administration is rare and not well-defined. In glaucoma patients using brimonidine, one must consider this phenomenon to avoid mis-diagnosis and over-treatment with topical steroids which in turn may increase intraocular pressure (IOP). This is the largest case series including the longest patient follow-up in the current literature.Sixteen patients (26 […]
  • Outcome of a single XEN microstent implant for glaucoma patients with different types of glaucoma.
    The aim of this retrospective study was to compare the efficacy and safety profile of a single XEN-microstent in different types of primary and secondary open angle glaucoma.A single XEN microstent was implanted in patients with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), pseudoexfoliation glaucoma (PEX) and secondary glaucoma (Sec.Gl). The intraocular pressure (IOP), the […]
  • Intraocular pressure, glaucoma and dietary caffeine consumption: a gene-diet interaction study from the UK Biobank.
    We examined the association of habitual caffeine intake with intraocular pressure (IOP) and glaucoma and whether these associations were modified by genetic predisposition to higher IOP. We also assessed whether genetic predisposition to higher coffee consumption was related to IOP.A cross-sectional study in the UK Biobank.We included 121,374 participants (baseline ages 39-73 years) with data […]
  • Trabeculectomy in patients with diabetes: subconjunctival Mitomycin C with or without intravitreal bevacizumab.
    To evaluate the success of Mitomycin C (MMC) augmented trabeculectomy with or without intravitreal bevacizumab in patients with diabetes without neovascular glaucoma.Fifty-six patients with diabetes who needed trabeculectomy were randomised to either combination of 2.5 mg intravitreal bevacizumab and subconjunctival MMC (group A, 28 eyes) or subconjunctival MMC alone (group B, 28 eyes). The main outcome […]
  • Health-related quality of life in Ahmed FP7, and Baerveldt 250 and 350 patients compared with medical controls.
    To compare health-related quality of life (HRQoL) in patients with Ahmed FP7 (FP7), Baerveldt 250 (B250) and Baerveldt 350 (B350) glaucoma drainage device (GDDs), and medically treated controls.This was a prospective cohort study from August 2017 to July 2019. The NEI 25-Item Visual Function Questionnaire (VFQ-25), the Adult Strabismus-20 questionnaire (AS-20) and the Diplopia Questionnaire […]
  • Pseudoexfoliation syndrome and glaucoma: from genes to disease mechanisms.
    The genetic basis of pseudoexfoliation (PEX) syndrome, the most common identifiable cause of open-angle glaucoma, is steadily being elucidated. This review summarizes the recent advances on genetic risk factors for PEX syndrome/glaucoma and their potential functional implications in PEX pathophysiology.As of today, seven loci associated with the risk of PEX surpassing genome-wide significance have been […]
  • Recent developments in the use of optical coherence tomography for glaucoma.
    The aim of this article is to summarize findings of recent reports highlighting the utility of novel optical coherence tomography (OCT) parameters in the diagnosis and monitoring of glaucomatous optic neuropathy.Optic nerve head (ONH), retinal nerve fiber layer (RNFL), and macular parameters show high levels of diagnostic capability. The Bruch’s membrane opening-minimum rim width (BMO-MRW) […]
  • Predicting the Future of Genetic Risk Profiling of Glaucoma: A Narrative Review.
    Glaucoma is the world’s leading cause of irreversible blindness. Primary open-angle glaucoma (POAG) is typically asymptomatic early in the disease process, and unfortunately, many are diagnosed too late to prevent vision loss.Genome-wide association studies, which evaluate the association between genetic variants and phenotype across the genome, have mapped many genes for POAG. As well as […]
  • Glaucoma-Related Adverse Events at 10 Years in the Infant Aphakia Treatment Study: A Secondary Analysis of a Randomized Clinical Trial.
    Glaucoma-related adverse events constitute serious complications of cataract removal in infancy, yet long-term data on incidence and visual outcome remain lacking.To identify and characterize incident cases of glaucoma and glaucoma-related adverse events (glaucoma + glaucoma suspect) among children in the Infant Aphakia Treatment Study (IATS) by the age of 10.5 years and to determine whether […]
  • Automated Evaluation of Parapapillary Choroidal Microvasculature in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.
    To determine whether parapapillary choroidal microvasculature (PPCMv) density as measured by optical coherence tomography angiography (OCT-A) differs between pseudoexfoliation syndrome (PXS) and pseudoexfoliation glaucoma (PXG).Cross-sectional study METHODS: One hundred ninety-two eyes of 120 subjects from two academic referral institutions were enrolled. Automated PPCMv density was calculated using custom Matlab software in inner and outer annuli […]
  • Surgical Outcomes of Superotemporal Versus Inferonasal Placement of Aurolab Aqueous Drainage Implant in Refractory Pediatric Glaucoma.
    To describe the outcomes of the Aurolab Aqueous Drainage Implant (AADI) placed in the superotemporal (ST) versus the inferonasal (IN) quadrant in pediatric eyes with refractory glaucoma.Retrospective comparative interventional case series METHOD: s: This was a retrospective study of patients age 18 years and younger who underwent AADI implantation and completed a minimum of 2-year […]
  • Safety profile of minimally invasive glaucoma surgery.
    This article reviews the safety profile of trabecular meshwork/Schlemm’s canal-based, subconjunctival, and suprachoroidal minimally invasive glaucoma surgery (MIGS).Prospective randomized clinical trials and metaanalyses published during the 2019-2020 review period provided important data regarding the safety profile of trabecular meshwork/Schlemm’s canal-based MIGS. Transient hyphema and intraocular pressure spikes are among the most common complications associated with […]
  • Glaucoma care during the coronavirus disease 2019 pandemic.
    The current article reviews the impact of the coronavirus disease 2019 (COVID-19) pandemic on the delivery of ophthalmic, and specifically, glaucoma care.Literature from the review period includes case series demonstrating the presence of severe acute respiratory syndrome coronavirus 2 RNA in the conjunctival secretions of patients with laboratory-confirmed COVID-19. The global ophthalmology community published reports […]
  • History, presence, and future of mitomycin C in glaucoma filtration surgery.
    Mitomycin C (MMC) is an alkylating agent with extraordinary ability to crosslink DNA, preventing DNA synthesis. By this virtue, MMC is an important antitumor drug. In addition, MMC has become the gold standard medication for glaucoma filtration surgery (GFS). This eye surgery creates a passage for drainage of aqueous humor (AqH) out of the eye […]
  • The Tube Versus Trabeculectomy IRIS® Registry Study: Cohort Selection and Follow-up and Comparisons to the Randomized Controlled Trial.
    Assess the feasibility of replicating a randomized control trial (RCT) with a cohort of eyes, from IRIS® Registry data, analogous to the Tube Versus Trabeculectomy (TVT) RCT cohort and compare characteristics and follow-up.Comparison of RCT and IRIS Registry cohorts and follow-up METHODS: We identified a cohort of IRIS Registry eyes (2013-2017) that received either a […]
  • Determinants of Optical Coherence tomography parameters in a population-based study.
    To study the effects of age, gender, intraocular pressure, corneal thickness, axial length, disc area and the signal strength of the scan on optical coherence tomography (OCT) parameters of normal subjects in L V Prasad Eye Institute-Glaucoma Epidemiological and Molecular Genetic Study (LVPEI-GLEAMS), a population-based study.Cross-sectional study METHODS: 1100 eyes (1100 subjects) of normal adults […]
  • Cascade screening for glaucoma in high-risk family members of African-Caribbean glaucoma patients in an urban population in London.
    Cascade screening has been used successfully in relatives of patients with inherited cancers and other genetic diseases to identify presymptomatic disease. This study was designed to examine if this approach would be successful in a high-risk group: first-degree relatives (FDR) of African-Caribbean glaucoma patients resident in London.African-Caribbean patients (probands) with glaucoma from an inner London […]
  • Comparison of the structure-function relationship between compass microperimetry and Humphrey field analyser in myopic open-angle glaucoma eyes.
    To compare the structure-function relationship between compass microperimetry (CMP; CenterVue, Padova, Italy) and Humphrey field analyser (HFA; Carl Zeiss Meditec, Dublin, California, USA) in open-angle glaucoma (OAG) eyes with myopia.Circumpapillary retinal nerve fibre layer thickness (cpRNFLT) and visual field (VF) mean sensitivity (MS) were obtained in 90 OAG subjects using the optical coherence tomography, CMP […]
  • Estimation of Goldmann applanation tonometer intraocular pressure (IOP) from scleral Schiotz IOP values in eyes with type-1 keratoprostheses.
    To validate estimation of Goldmann applanation tonometer (GAT) intraocular pressure (IOP) from scleral Schiotz IOP measurements using a regression model in normal eyes and eyes with type-1 keratoprostheses.In this prospective cross-sectional study, cohort-1 had 253 normal anterior segment eyes, and cohort-2 had 100 eyes with type-1 keratoprostheses. Scleral Schiotz IOP measurements were used (in a […]
  • Corneal Transplant Follow-up Study II: a randomised trial to determine whether HLA class II matching reduces the risk of allograft rejection in penetrating keratoplasty.
    A randomised trial to test the hypothesis that human leucocyte antigen (HLA) class II matching reduces the risk of allograft rejection in high-risk penetrating keratoplasty (PK).All transplants were matched for HLA class I antigens (≤2 mismatches at the A and B loci) and corneas were allocated to patients by cohort minimisation to achieve 0, 1 […]
  • Clinical profile and outcome of early surgery in neonatal-onset glaucoma presenting over a 5-year period.
    Neonatal-onset glaucoma (NOG) is a severe form of childhood glaucoma and is not always due to primary congenital glaucoma (PCG). Due to advances in neonatal care, the incidence of NOG is rising, but it remains an under-reported entity. The objective of the paper was to study the clinical profiles, surgical and visual outcomes of NOG […]
  • Outcomes of gonioscopy-assisted transluminal trabeculotomy in juvenile-onset primary open-angle glaucoma.
    To report the outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) for juvenile-onset primary open-angle glaucoma (JOAG).A consecutive case series of JOAG patients who underwent GATT was reviewed with follow-up period of up to 18 months. Intraocular pressure (IOP), number of glaucoma medications and success rate were compared between eyes with and without prior glaucoma surgery, and […]
  • Comparative Study of Long-term Graft Survival between Penetrating Keratoplasty and Deep Anterior Lamellar Keratoplasty.
    Endothelial failure and immunological graft rejection remain long-term complications leading to late graft failure in Penetrating keratoplasty (PK). Deep anterior lamellar keratoplasty (DALK) has emerged as a viable alternative that enables preservation of the host’s endothelial cells to eliminate risks of endothelial rejection and failure. The aim of this study was to compare long-term graft […]
  • Optic nerve head vessel density in different stages of pseudoexfoliation disease.
    To evaluate the superficial vascular density of the optic nerve head in different stages of pseudoexfoliation disease using optical coherence tomography angiography (OCTA).In this cross-sectional study, 57 normal eyes, 41 eyes with pseudoexfoliation syndrome (PXS), 82 eyes with pseudoexfoliation glaucoma (PXG) and 27 non-glaucomatous fellow eyes of PXG (NL-PXG) that had OCTA were included. Circumpapillary […]
  • Corneal stiffness parameters are predictive of structural and functional progression in glaucoma suspects.
    To investigate corneal stiffness parameters as predictors of future progression risk in glaucoma suspect eyes.Prospective longitudinal study.371 eyes from 228 primary open angle glaucoma suspects, based on the optic disc appearance, with a normal baseline Humphrey Visual Field (HVF).Baseline corneal stiffness parameters were measured using Corvis ST. Participants were followed up 6-monthly with clinical examination, […]
  • Time trends, associations and global burden of intraocular foreign bodies.
    To estimate the disease burden due to intraocular foreign bodies (IOFBs) and evaluate contributions of various risk factors to IOFB-associated disability-adjusted life-years (DALYs).Global, regional and country-level number, rate and age-standardised rate of DALYs due to IOFBs were acquired from the Global Burden of Disease Study 2017 database. The Human Development Index (HDI) and other region […]
  • The role of EP2 receptors in mediating the ultra-long-lasting intraocular pressure reduction by JV-GL1.
    A single application of JV-GL1 substantially lowers non-human primate intraocular pressure (IOP) for about a week, independent of dose. This highly protracted effect does not correlate with its ocular biodisposition or correlate with the once-daily dosing regimen for other prostanoid EP2 receptor agonists such as trapenepag or omidenepag. The underlying pharmacological mechanism for the multiday […]
  • Association of Anterior Uveitis With Acute Zika Virus Infection in Adults.
    Acute anterior uveitis has been reported to be associated with Zika virus (ZIKV) infection in case reports and retrospective studies based on systemic clinical signs of ZIKV and positive serologic tests.To describe the ophthalmic findings associated with systemic ZIKV infection during the 2016 ZIKV outbreak in Guadeloupe in the French West Indies.This cohort study assessed […]
  • Outcomes and risk factors for failure after trabeculectomy in Taiwanese patients: medical chart reviews from 2006 to 2017.
    To determine long-term outcomes and risk factors for failure after mitomycin C (MMC)-augmented initial trabeculectomy (IT) in Taiwanese patients.We reviewed medical records of patients with glaucoma undergoing IT during December 2006-December 2016. We defined complete success as an intraocular pressure (IOP) of >5 or ≤21 mm Hg or IOP reduction of ≥20% from baseline without supplemental medications […]
  • Outcomes and risk factors for failure after trabeculectomy in Taiwanese patients: medical chart reviews from 2006 to 2017.
    To determine long-term outcomes and risk factors for failure after mitomycin C (MMC)-augmented initial trabeculectomy (IT) in Taiwanese patients.We reviewed medical records of patients with glaucoma undergoing IT during December 2006-December 2016. We defined complete success as an intraocular pressure (IOP) of >5 or ≤21 mm Hg or IOP reduction of ≥20% from baseline without supplemental medications […]
  • Uptake, persistence, and performance of weekly home monitoring of visual field in a large cohort of patients with glaucoma.
    This study examines the short-term uptake, compliance, and performance of a tablet device used for home monitoring of visual field (VF-Home) by glaucoma patients.Single-centre, observational, longitudinal, compliance study.Participants who were glaucoma suspects or had stable glaucoma in at least one eye were recruited during a regular clinic review. Baseline in-clinic visual field (VF) was recorded […]