- Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett’s oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.
Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily attributable to its symptom-based […]
- Artificial intelligence and colonoscopy experience: lessons from two randomised trials.
Artificial intelligence has been shown to increase adenoma detection rate (ADR) as […]
- Identification of the source events for aerosol generation during oesophago-gastro-duodenoscopy.
To determine if oesophago-gastro-duodenoscopy (OGD) generates increased levels of aerosol in conscious […]
- Risk of Hepatitis B Virus Reactivation in Patients Treated with Immunotherapy for Anti-cancer Treatment.
Hepatitis B virus (HBV) reactivation is a well-known complication in patients with […]
- Long-Term Treatment of Eosinophilic Esophagitis with Budesonide Oral Suspension.
We evaluated treatment withdrawal, long-term outcomes and safety of budesonide oral suspension […]
- Endoscopic Submucosal Dissection in Europe: Results of 1000 neoplastic lesions from the German ESD Registry.
Endoscopic submucosal dissection (ESD) enables the curative resection of early malignant lesions […]
- Alterations in the gut virome in obesity and type 2 diabetes mellitus.
Obesity and type 2 diabetes mellitus (T2DM) are associated with changes in […]
- Painful chronic pancreatitis – new approaches for evaluation and management.
Management of abdominal pain in patients with chronic pancreatitis is often suboptimal. […]
- Histopathological effects of electrosurgical interventions in an in vivo porcine model of colonic endoscopic mucosal resection.
Endoscopic mucosal resection (EMR) in the colon has been widely adopted, but […]
- Cascade of care during the first 36 months of the treatment as prevention for hepatitis C (TraP HepC) programme in Iceland: a population-based study.
WHO has set targets to eliminate hepatitis C virus (HCV) infection as […]
- T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice.
Hepatitis B virus (HBV) infection is a global health threat responsible for […]
- ADVANCED PRECLINICAL MODELS FOR EVALUATION OF DRUG INDUCED LIVER INJURY – CONSENSUS STATEMENT BY THE EUROPEAN DRUG-INDUCED LIVER INJURY NETWORK [PRO-EURO-DILI-NET].
Drug induced liver injury (DILI) is a major cause of acute liver […]
- ‘Equity’ and ‘justice’ for patients with acute-on chronic liver failure: A call to action.
Acute-on chronic liver failure (ACLF) occurs in hospitalised patients with cirrhosis and […]
- Limited tumor progression beyond Milan criteria while on the waiting list does not result in unacceptable impairment of survival.
Defining optimum management of patients progressing beyond Milan criteria on the waiting […]
- Single-cell RNA-sequencing atlas reveals an MDK-dependent immunosuppressive environment in ErbB pathway-mutated gallbladder cancer.
Our previous genomic whole-exome sequencing (WES) data identified the key ErbB pathway […]
- IDENTIFICATION OF OPTIMAL THERAPEUTIC WINDOW FOR STEROID USE IN SEVERE ALCOHOL-ASSOCIATED HEPATITIS: A WORLDWIDE STUDY.
Corticosteroids are the only effective therapy for severe alcohol-associated hepatitis (AH), defined […]
- TOWARDS A NEW DEFINITION OF DECOMPENSATED CIRRHOSIS.
There is a universal agreement on the fact that the occurrence of […]
- Role of standardized reporting and novel imaging markers in chronic pancreatitis.
This article reviews recent efforts about standardized imaging features and reporting of […]
- Consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer: achievements and future directions.
To answer several important clinical questions, the Consortium for the study of […]
- Bilirubin: the yellow hormone?
Bilirubin is a tetrapyrrolic compound originating from heme catabolism. Although originally considered […]
- Deficits in geriatric assessment associate with disease activity and -burden in older patients with inflammatory bowel disease.
We aimed to perform geriatric assessment in older inflammatory bowel disease (IBD) […]
- Efficacy and safety of adalimumab in paediatric patients with moderate-to-severe ulcerative colitis (ENVISION I): a randomised, controlled, phase 3 study.
Biologic treatment options are limited for children with ulcerative colitis. The aim […]
- Esophageal Hypervigilance and Symptom Specific Anxiety in Patients with Eosinophilic Esophagitis.
Patient symptom reporting often does not correlate with pathophysiological markers of esophageal […]
- IFNγ-producing CD8+ tissue resident memory T cells are a targetable hallmark of immune checkpoint inhibitor-colitis.
The pathogenesis of immune checkpoint inhibitor (ICI)-colitis remains incompletely understood. We sought […]
- Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis.
Irritable bowel syndrome (IBS) and inflammatory bowel diseases result in a substantial […]
- Calprotectin: from biomarker to biological function.
The incidence of inflammatory bowel diseases (IBD) emerged with Westernisation of dietary […]
- Histologic Outcomes With Vedolizumab Versus Adalimumab in Ulcerative Colitis: Results From VARSITY.
VARSITY showed superior clinical remission and endoscopic improvement in ulcerative colitis with […]
- NON INVASIVE MONITORING AFTER AZATHIOPRINE WITHDRAWAL IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE IN DEEP REMISSION.
There is uncertainty regarding the optimal duration of treatment with azathioprine (AZA) […]
- Genetically predicted adiposity, diabetes and lifestyle factors in relation to diverticular disease.
Adiposity, type 2 diabetes, alcohol and coffee consumption and smoking have been […]
- Complications of chronic pancreatitis in children.
In children, chronic pancreatitis is infrequent but may be associated with serious […]
- Loss of hepatocyte identity following aberrant YAP activation: a key mechanism in alcoholic hepatitis.
Alcoholic hepatitis (AH) is a life-threatening disease with limited therapeutic options, because […]
- Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies.
Tryptophan can be catabolised to various metabolites through host kynurenine and microbial […]
- Development and prognostic relevance of a histologic grading and staging system for alcohol-related liver disease.
The SALVE Histopathology Group (SHG) developed and validated a grading and staging […]
- Evidence-based management of HCC: Systematic review and meta-analysis of randomized controlled trials (2002-2020).
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality with a […]
- Faecal microbiota transplantation influences procarcinogenic Escherichia coli in recipient recurrent Clostridioides difficile patients.
Patients suffering from multiple recurrent Clostridioides difficile infections (rCDI) have a disturbed […]
- Anti-TL1A Antibody PF-06480605 Safety and Efficacy for Ulcerative Colitis: A Phase 2a Single-Arm Study [102/120 characters including spaces].
An immune component of inflammatory bowel disease is upregulated tumor necrosis factor-like […]
- Dynamic Changes in Ultrasound Quality for Hepatocellular Carcinoma Screening in Patients with Cirrhosis.
Identifying patients in whom ultrasound may be inadequate to exclude the presence […]
- Early-age onset colorectal neoplasia in average risk individuals undergoing screening colonoscopy: a systematic review and meta-analysis.
Incidence and mortality associated with early age onset colorectal cancer (EAO-CRC) is […]
- Demographics and risk factors for pediatric recurrent acute pancreatitis.
Approximately 20-30% of children who experience one episode of acute pancreatitis will […]
- Prognostic performance of seven biomarkers compared to liver biopsy in early alcohol-related liver disease.
Alcohol is the most common cause of liver-related mortality and morbidity. We […]
- Hepatitis D virus in 2021: virology, immunology and new treatment approaches for a difficult-to-treat disease.
Approximately 5% of individuals infected with hepatitis B virus (HBV) are coinfected […]
- Understanding the role of the gut in undernutrition: what can technology tell us?
Gut function remains largely underinvestigated in undernutrition, despite its critical role in […]
- Incorporating image enhanced endoscopy in your everyday practice.
The purpose of this review is to analyze newly available image enhanced […]
- Decoy bypass for appetite suppression in obese adults: role of synergistic nutrient sensing receptors GPR84 and FFAR4 on colonic endocrine cells.
Colonic enteroendocrine cells (EECs) store and release potent anorectic hormones that are […]
- Lenvatinib versus sorafenib for first-line treatment of unresectable hepatocellular carcinoma: patient-reported outcomes from a randomised, open-label, non-inferiority, phase 3 trial.
Hepatocellular carcinoma is the third-leading cause of cancer-related death worldwide. Preservation of […]
- Linked Colour imaging for the detection of polyps in patients with Lynch syndrome: a multicentre, parallel randomised controlled trial.
Despite regular colonoscopy surveillance, colorectal cancers still occur in patients with Lynch […]
- The role of the allergist in the management of eosinophilic esophagitis.
The purpose of this review is to provide the current understanding of […]
- Long-Lasting Dissociation of Esophageal Eosinophilia and Symptoms Following Dilation in Adults with Eosinophilic Esophagitis.
Esophageal dilation improves dysphagia but not inflammation in eosinophilic esophagitis (EoE) patients. […]
- Management of the patient with esophagogastric junction outflow obstruction.
Esophagogastric junction outflow obstruction (EGJOO), defined as elevated integrated residual pressure (IRP) […]
- New targets in inflammatory bowel disease therapy: 2021.
In the rapidly progressing world of inflammatory bowel disease, this review discusses […]
- The role of the allergist in the management of eosinophilic esophagitis.
The purpose of this review is to provide the current understanding of […]
- Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer.
Enhancer aberrations are beginning to emerge as a key epigenetic feature of […]
- Diabetes in chronic pancreatitis: risk factors and natural history.
The purpose of this review is to delineate risk factors for the […]
- Long-Lasting Dissociation of Esophageal Eosinophilia and Symptoms Following Dilation in Adults with Eosinophilic Esophagitis.
Esophageal dilation improves dysphagia but not inflammation in eosinophilic esophagitis (EoE) patients. […]
- Management of the patient with esophagogastric junction outflow obstruction.
Esophagogastric junction outflow obstruction (EGJOO), defined as elevated integrated residual pressure (IRP) […]
- New targets in inflammatory bowel disease therapy: 2021.
In the rapidly progressing world of inflammatory bowel disease, this review discusses […]
- Early liver transplantation for acute alcoholic hepatitis: we can’t say no.
In patients with severe alcoholic hepatitis not responding to medical therapy, it […]
- Psychiatric comorbidities are highly prevalent in non-esophageal eosinophilic gastrointestinal diseases.
The prevalence of psychiatric comorbidity in non-esophageal eosinophilic gastrointestinal disorders (EGIDs) has […]
- A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults with Crohn’s Disease.
This study compared the effectiveness of the Specific Carbohydrate Diet (SCD) to […]
- Coexpression gene network analysis reveals novel regulatory pathways involved in porto-sinusoidal vascular disease.
Porto-sinusoidal vascular disease (PSVD) is a rare vascular liver disease of unknown […]
