Population-level configurations of gut mycobiome across six ethnicities in urban and rural China. 21st September 2020 Beyond bacteria, the human gastrointestinal tract is host to a vast diversity […]
DDIT4 licenses only healthy cells to proliferate during injury-induced metaplasia. 21st September 2020 In stomach, metaplasia can arise from differentiated chief cells that become mitotic […]
Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models. 20th September 2020 polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of […]
A placebo-controlled randomised trial of budesonide for primary biliary cholangitis following an insufficient response to UDCA. 20th September 2020 In patients with primary biliary cholangitis (PBC) the utility of budesonide, a […]
AGA White Paper: Interventional Endoscopic Ultrasound – Current Status and Future Directions. 20th September 2020 The evolution of endoscopic ultrasound (EUS) from a diagnostic to a therapeutic […]
Efficacy and Safety of Continued Treatment with Mirikizumab in a Phase 2 Trial of Patients with Ulcerative Colitis. 20th September 2020 Mirikizumab is an antibody against the p19 subunit of interleukin 23 that […]
Epidemiology, Presentation, and Diagnosis of Celiac Disease. 20th September 2020 The incidence of celiac disease is increasing, partly due to improved recognition […]
AMBULATORY REFLUX MONITORING GUIDES PROTON PUMP INHIBITOR DISCONTINUATION IN PATIENTS WITH GASTROESOPHAGEAL REFLUX SYMPTOMS: A CLINICAL TRIAL. 19th September 2020 Proton pump inhibitor (PPI) therapy fails to provide adequate symptom control in […]
Exploring the early phase of Crohn’s disease. 19th September 2020 The development of Crohn’s disease is characterized by a breakdown of homeostatic […]
Reduction of squalene epoxidase by cholesterol accumulation accelerates colorectal cancer progression and metastasis. 18th September 2020 Squalene epoxidase (SQLE), a rate-limiting enzyme in cholesterol biosynthesis, is suggested as […]
From birth to overweight and atopic disease: multiple and common pathways of the infant gut microbiome. 18th September 2020 Few studies, even those with cohort designs, test the mediating effects of […]
Non-alcoholic fatty liver disease and risk of incident diabetes mellitus: an updated meta-analysis of 501 022 adult individuals. 17th September 2020 Follow-up studies have shown that non-alcoholic fatty liver disease (NAFLD) is associated […]
Expression of R-spondin1 in ApcMin/+ Mice Reduces Growth of Intestinal Adenomas by Altering Wnt and TGFB Signaling. 17th September 2020 Mutations in the APC gene and other genes in the Wnt signaling […]
ALTERATIONS IN GUT MICROBIOME IN CIRRHOSIS AS ASSESSED BY QUANTITATIVE METAGENOMICS. RELATIONSHIP WITH ACUTE-ON-CHRONIC LIVER FAILURE AND PROGNOSIS. 17th September 2020 Cirrhosis is associated with changes in gut microbiome composition. Although ACLF is […]
Clinical and genomic characterisation of mismatch repair deficient pancreatic adenocarcinoma. 16th September 2020 To describe the clinical, pathological and genomic characteristics of pancreatic cancer with […]
Composition of HBsAg is predictive of HBsAg loss during treatment in patients with HBeAg-positive chronic hepatitis B. 15th September 2020 During treatment of chronic hepatitis B virus (HBV) infections, loss or seroconversion […]
Reduced incidence of hepatitis C in nine villages in rural Egypt: Progress towards national elimination goals. 15th September 2020 Egypt has a major treatment programme, with an ambitious goal of HCV […]
High hepatitis C treatment uptake among people with recent drug dependence in New South Wales, Australia. 15th September 2020 High HCV treatment among people at most risk of transmission is essential […]
IMPACT OF PHYSICIANS’ AND PATIENTS’ COMPLIANCE ON OUTCOMES OF COLONOSCOPIC POLYPECTOMY WITH ANTI-THROMBOTIC THERAPY. 15th September 2020 Although there are international guidelines on the management of anti-thrombotic therapy in […]
Higher adenoma detection rates at screening associated with lower long-term colorectal cancer incidence and mortality. 15th September 2020 Detection and removal of adenomas reduces colorectal cancer (CRC) risk. The impact […]
Biologics for Inflammatory Bowel Disease and their Safety in Pregnancy: A Systematic Review and Meta-analysis. 15th September 2020 Biologics are routinely used in pregnant women with inflammatory bowel disease (IBD) […]
Nurse-Administered Propofol Continuous Infusion Sedation for Gastrointestinal Endoscopy in Patients Who Are Difficult To Sedate. 15th September 2020 Patients who chronically use alcohol, marijuana or opioids, or suffer from post-traumatic […]
Duodenal chemosensory system: enterocytes, enteroendocrine cells, and tuft cells. 14th September 2020 The gut barrier serves as the primary interface between the environment and […]
Provider attitudes toward risk-based hepatocellular carcinoma surveillance in patients with cirrhosis in the U.S. 14th September 2020 Hepatocellular carcinoma (HCC) surveillance rates are suboptimal in clinical practice. We aimed […]
Gastric vascular abnormalities: diagnosis and management. 14th September 2020 Gastric vascular abnormalities are a well known cause of gastrointestinal bleeding. Due […]
Duodenal chemosensory system: enterocytes, enteroendocrine cells, and tuft cells. 14th September 2020 The gut barrier serves as the primary interface between the environment and […]
Gastric vascular abnormalities: diagnosis and management. 14th September 2020 Gastric vascular abnormalities are a well known cause of gastrointestinal bleeding. Due […]
Benefits and Harms of Hepatocellular Carcinoma Surveillance in a Prospective Cohort of Patients with Cirrhosis. 13th September 2020 The value of a cancer screening programs is defined by its balance […]
Histologic Features of Colon Biopsies (Geboes Score) Associated With Progression of Ulcerative Colitis for the First 36 Months After Biopsy. 13th September 2020 In addition to findings from endoscopy, histologic features of colon biopsies have […]
Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting β-galactosidase. 13th September 2020 Streptococcus thermophilus was identified to be depleted in patients with colorectal cancer […]
Clinical and neurological outcomes in acetaminophen-induced acute liver failure: a twenty-one-year multicenter cohort study. 13th September 2020 Acetaminophen (APAP)-induced acute liver failure (ALF) is a rare disease associated with […]
Mucus barrier, mucins and gut microbiota: the expected slimy partners? 12th September 2020 The gastrointestinal tract is often considered as a key organ involved in […]
RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma. 12th September 2020 Background and Aims Mutational profiling of patient tumors has suggested that hepatocellular […]
Natural history of acute kidney disease in patients with cirrhosis. 12th September 2020 In 2012, KDIGO group proposed new definitions for Acute Kidney Injury (AKI), […]
Sex-Specific Genetic Associations for Barrett’s Esophagus and Esophageal Adenocarcinoma. 12th September 2020 Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett’s esophagus (BE), are characterized […]
Acute upper GI bleeding: good night, sleep tight, endoscopy can wait until morning light. 12th September 2020 Gastrointestinal hemorrhage is the leading cause of hospitalization in gastroenterology (Gastroenterology 2019;156:254-272). […]
Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. 11th September 2020 Angiocrine signaling by liver sinusoidal endothelial cells (LSEC) regulates liver functions such […]
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms. 10th September 2020 Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on […]
Performance and predictors of migration of partially and fully covered esophageal self-expanding metal stents for malignant dysphagia. 8th September 2020 Self-expanding metal stents (SEMS) are routinely used to palliate malignant dysphagia. However […]
Impact of SARS-CoV-2 pandemic on colorectal cancer screening delay: effect on stage shift and increased mortality. 8th September 2020 The SARS-CoV-2 pandemic had a sudden, dramatic impact on healthcare. In Italy, […]
Equivalent performance of single-use and reusable duodenoscopes in a randomised trial. 8th September 2020 Single-use duodenoscopes have been recently developed to eliminate risk of infection transmission […]
WASh multicentre randomised controlled trial: water-assisted sigmoidoscopy in English NHS bowel scope screening. 8th September 2020 The English Bowel Cancer Screening Programme invites 55 year olds for a sigmoidoscopy […]
Inflammatory bowel diseases among first-generation and second-generation immigrants in Denmark: a population-based cohort study. 8th September 2020 Our objective was to estimate the relative risk of IBD among first-generation […]
ENDPOINTS AND DESIGN OF CLINICAL TRIALS IN PATIENTS WITH DECOMPENSATED CIRRHOSIS: POSITION PAPER OF THE LIVERHOPE CONSORTIUM. 8th September 2020 Management of decompensated cirrhosis is currently geared towards the treatment of complications […]
eHealth technologies for screening, diagnosis and management of viral hepatitis: A systematic review. 8th September 2020 Chronic viral hepatitis is a leading cause of worldwide liver-related morbidity and […]
Group 2 innate lymphoid cells coordinate damage response in the stomach. 6th September 2020 Severe injury to the lining of the stomach leads to changes in […]
Endoscopic diagnosis and management of gastric subepithelial lesions. 5th September 2020 The purpose of this manuscript is to provide an in-depth review of […]
Innate and adaptive immunity in celiac disease. 5th September 2020 The current review is prompted by recent studies indicating that adaptive immunity […]
Advances in the treatment of gastric cancer. 5th September 2020 To provide an up-to-date review on the management of cancers of the […]
Immune landscape, evolution, hypoxia-mediated viral mimicry pathways and therapeutic potential in molecular subtypes of pancreatic neuroendocrine tumours. 5th September 2020 A comprehensive analysis of the immune landscape of pancreatic neuroendocrine tumours (PanNETs) […]
Liquid biopsy in the clinical management of hepatocellular carcinoma. 5th September 2020 With increasing knowledge on molecular tumour information, precision oncology has revolutionised the […]
Gastropexy can be as safe as conventional percutaneous endoscopic gastrostomy (PEG), and biomarkers do not predict short-term or long-term outcomes: a 7-year follow-up audit. 5th September 2020 Gastrostomy facilitates artificial enteral feeding but controversy exists around associated morbidity and […]
Jejunal feeding: when is it the right thing to do? 5th September 2020 The decision to commence jejunal feeding in patients with structural abnormalities, which […]
Phase angle from bioelectrical impedance for the assessment of sarcopenia in cirrhosis with or without ascites. 5th September 2020 Skeletal muscle index (SMI) from computed tomography (CT) reliably assesses sarcopenia, however, […]
Refeeding syndrome : physiological background and practical management. 5th September 2020 Refeeding problems have been recognised since the the liberation of starved communities […]
Functional Abdominal Pain Disorders and Constipation in Children on Gluten-Free Diet. 5th September 2020 We studied the prevalence of functional abdominal pain disorders (FAPDs) and functional […]
Ultra long-term follow-up of interferon-alpha treatment for HBeAg-positive chronic hepatitis B virus infection. 5th September 2020 Interferon-alpha (IFN-α) treatment for chronic hepatitis B (CHB) virus infection is finite […]
Development and validation of a model to predict survival in colorectal cancer using a gradient-boosted machine. 5th September 2020 The success of treatment planning relies critically on our ability to predict […]
A Novel Blood-based Panel of Methylated DNA and Protein Markers for Detection of Early-Stage Hepatocellular Carcinoma. 5th September 2020 Hepatocellular carcinoma (HCC) can be treated effectively if detected at an early […]
Hepatic decompensation in cirrhotic patients receiving antiviral therapy for chronic hepatitis B. 5th September 2020 It is unclear if anti-hepatitis B virus (HBV) treatment can eliminate incident […]
