The latest gastro & hepatology articles
ClinOwl brings you the latest gastro & hepatology articles from the leading medical journals in a single view.
Latest gastro & hepatology
- Contained Aortic Rupture With Hematoma and Gastrointestinal Bleeding.Click here to read the full article @ Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
- First- and Second-line Pharmacotherapies for Patients with Moderate to Severely Active Ulcerative Colitis: An Updated Network Meta-Analysis.We compared the efficacy and safety of different first-line (biologic-naïve) and second-line (prior exposure to tumor necrosis factor [TNF] antagonists) agents for treatment of moderate to severely active … Read more
- DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia.Intestinal metaplasia (IM) is a premalignant stage that poses a greater risk for subsequent gastric cancer (GC). However, factors regulating IM to GC progression remain unclear. Previously, activated … Read more
- Non-steroidal anti-inflammatory drug (NSAID) therapy in patients with hypertension, cardiovascular, renal or gastrointestinal comorbidities: joint APAGE/APLAR/APSDE/APSH/APSN/PoA recommendations.Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed medications, but they are associated with a number of serious adverse effects, including hypertension, cardiovascular disease, kidney … Read more
- Hepatitis C Care Pathway Associated with Increased Screening, Confirmation, and Diagnosis Communication to Patients.Click here to read the full article @ Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Gastrointestinal cancer
- Suboptimal endoscopic cancer recognition in colorectal lesions in a national bowel screening programme.Click here to read the full article @ Gut
- Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer.To provide an understanding of the role of common genetic variations in colorectal cancer (CRC) risk, we report an updated field synopsis and comprehensive assessment of evidence to … Read more
- Genetic Variant Associated with Survival of Patients with Stage II-III Colon Cancer.Many genetic variants have been associated with colorectal cancer risk, although few have been associated with survival times of patients. Identification of genetic variants associated with survival times … Read more
- New-onset Diabetes, Longitudinal Trends in Metabolic Markers, and Risk of Pancreatic Cancer in a Heterogeneous Population.Observational studies of predominantly white populations have found new-onset diabetes to be associated with increased risk of pancreatic cancer. We sought to determine whether this relationship applies to … Read more
- Prevalence of a First-Degree Relative with Colorectal Cancer and Uptake of Screening Among Persons 40 to 54 Years Old.People with a first-degree relative with colorectal cancer (CRC) are recommended to start CRC screening at age 40. However, there is limited information on how many people in … Read more
Hepatology
- MUC13 promotes intrahepatic cholangiocarcinoma progression via EGFR/PI3K/AKT pathways.MUC13 is reportedly overexpressed in human malignancies. However, the clinicopathological and biological significance of MUC13 in human intrahepatic cholangiocarcinoma (iCCA) remain unclear. The aim of this study was … Read more
- Non-enhanced Magnetic Resonance Imaging as a Surveillance Tool for Hepatocellular Carcinoma: Comparison with Ultrasound.Recently revised international guidelines for hepatocellular carcinoma (HCC) suggest that patients with inadequate ultrasonography be assessed by alternative imaging modalities. Given short scan time and the absence of … Read more
- PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target.C-C motif chemokine receptor 2 (CCR2) has been recognized as a promising target for the treatment of liver fibrosis. PC3-secreted microprotein (PSMP)/microseminoprotein (MSMP) is a novel chemotactic cytokine … Read more
- Low Testosterone Is Associated With Nonalcoholic Steatohepatitis (NASH) and Severity of NASH Fibrosis in Men With NAFLD.Click here to read the full article @ Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
- Progress and Challenges in a Pioneering Hepatitis C Elimination Program in the Country of Georgia, 2015-2018.Georgia, with a high prevalence of hepatitis C virus (HCV) infection, launched the world's first national hepatitis C elimination program in April 2015. A key strategy is the … Read more
Inflammatory bowel disease
- Long-term prognosis of ulcerative colitis and its temporal changes between 1986 and 2015 in a population-based cohort in the Songpa-Kangdong district of Seoul, Korea.No population-based study has evaluated the natural course of UC over three decades in non-Caucasians. We aimed to assess the long-term natural course of Korean patients with UC … Read more
- Ustekinumab Pharmacokinetics and Exposure Response in a Phase 3 Randomized Trial of Patients With Ulcerative Colitis: Ustekinumab PK and exposure-response in UC.The efficacy of antibody-based therapeutics depends on their pharmacokinetics. The pharmacokinetic and exposure response profiles of ustekinumab, a monoclonal antibody against interleukin 12/interleukin 23, are known in patients … Read more
- Histologic Healing is More Strongly Associated with Clinical Outcomes in Ileal Crohn’s Disease than Endoscopic Healing.Deep remission, based on clinical remission and evidence of healing during endoscopic evaluation, are goals of medical treatments for Crohn's disease (CD). We investigated whether histologic healing is … Read more
- Use of Cross-sectional Imaging for Tight Monitoring of Inflammatory Bowel Diseases.A "treat-to-target" strategy with close monitoring of intestinal inflammation is recommended in inflammatory bowel disease (IBD). Ileocolonoscopy (CS) remains the gold-standard for assessing disease activity in IBD but … Read more
- Diet in treatment of Inflammatory Bowel Diseases.There has been an alarming increase in the incidence of inflammatory bowel diseases (IBD) worldwide over the past several decades. The pathogenesis of IBD involves genetic and environmental … Read more
Luminal gastroenterology
- FUNCTIONAL LUMINAL IMAGING PROBE PANOMETRY IDENTIFIES ACHALASIA-TYPE ESOPHAGOGASTRIC JUNCTION OUTFLOW OBSTRUCTION.The etiologies of esophagogastric junction outflow obstruction (EGJOO) vary, as do their therapeutic implications. We aimed to identify patients with EGJOO most likely to benefit from achalasia-type treatment, … Read more
- Association between polyp detection rate and post colonoscopy cancer among patients undergoing diagnostic colonoscopy.Click here to read the full article @ Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
- Efficacy and Tolerability of High- vs Low-Volume Split-Dose Bowel Cleansing Regimens for Colonoscopy: a Systematic Review and Meta-analysis.Efficacy of bowel preparation is an important determinant of outcomes of colonoscopy. It is not clear whether approved low-volume polyethylene glycol (PEG) and non-PEG regimens are as effective … Read more
- National survey of UK endoscopists showing variation in diathermy practice for colonic polypectomy: a JAG perspective.Click here to read the full article @ Frontline gastroenterology
- Interobserver variability in comfort scores for screening colonoscopy.To investigate the agreement in comfort scores between patients, endoscopist and specialist screening practitioner (SSP) for colonoscopy, and which factors influence comfort.Prospective observational study.Single-centre UK Bowel Cancer Screening … Read more
Upper GI
- Association Between Beverage Intake and Incidence of Gastroesophageal Reflux Symptoms: Beverages and GER symptoms.Patients are frequently advised to eliminate coffee, tea, and/or soda to reduce symptoms of gastroesophageal reflux (GER), such as heartburn or regurgitation. However, there are no data from … Read more
- Prevalence and Characteristics of Dysphagia Based on a Population-Based Survey.Although dysphagia is common, there is limited information about the prevalence and burden of illness of dysphagia in the United States. We performed a population-based survey of more … Read more
- Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn.Heartburn that persists despite proton-pump inhibitor (PPI) treatment is a frequent clinical problem with multiple potential causes. Treatments for PPI-refractory heartburn are of unproven efficacy and focus on … Read more
- Real-time artificial intelligence for detection of upper gastrointestinal cancer by endoscopy: a multicentre, case-control, diagnostic study.Abstract: Upper gastrointestinal cancers (including oesophageal cancer and gastric cancer) are the most common cancers worldwide. Artificial intelligence platforms using deep learning algorithms have made remarkable progress in … Read more
- A case of amyloid light-chain amyloidosis presenting with submucosal hematoma and bleeding in the upper gastrointestinal tract.Abstract: Abstract empty Click here to read full article on original source website