Estimating global prevalence of metabolic dysfunction-associated fatty liver disease in overweight or obese adults. 22nd February 2021 Metabolic dysfunction-associated fatty liver disease (MAFLD) is a new terminology updated from […]
Ethics of providing clinically assisted nutrition and hydration: current issues. 22nd February 2021 The provision of clinically assisted nutrition and hydration (CANH) often presents clinicians […]
Evaluation of a primary to secondary care referral pathway and novel nurse-led one-stop clinic for patients with suspected non-alcoholic fatty liver disease. 22nd February 2021 Non-alcoholic fatty liver disease (NAFLD) affects approximately one in four adults of […]
Five-year Efficacy and Safety of Ustekinumab Treatment in Crohn’s Disease: the IM-UNITI trial. 22nd February 2021 The IM-UNITI study and long-term extension (LTE) evaluated the long-term efficacy, safety, […]
Guideline review: Tofacitinib for adults with moderately to severely active ulcerative colitis – NICE guidance. 22nd February 2021 Tofacitinib is an oral, Janus kinase (JAK) molecule, which selectively inhibits Janus-associated […]
Incidence, pattern and severity of abnormal liver blood tests among hospitalised patients with SARS-COV2 (COVID-19) in South Wales. 22nd February 2021 SARS-CoV-2 (COVID-19) is a novel coronavirus that emerged in Wuhan, China in […]
Inflammatory bowel disease psychological support pilot reduces inflammatory bowel disease symptoms and improves psychological wellbeing. 22nd February 2021 This prospective service evaluation aimed to determine if integrated psychological support for […]
Outcomes and adverse factors for endoscopic mucosal resection (EMR) of colorectal polyps in elderly patients. 22nd February 2021 Endoscopic mucosal resection (EMR) is an invaluable technique, however it is associated […]
Outcomes of precut sphincterotomy techniques in cases of difficult biliary access. 22nd February 2021 Our study aims to define success and complication rates of precut sphincterotomy […]
Patient Preferences for Hepatocellular Carcinoma Surveillance Parameters. 22nd February 2021 Professional societies recommend abdominal ultrasound (US) with or without alpha fetoprotein (AFP) […]
The Colonic Mucosal MicroRNAs, MicroRNA-219a-5p and MicroRNA-338-3p, are Downregulated in Irritable Bowel Syndrome and are Associated with Barrier Function and MAPK signaling. 22nd February 2021 Alterations in microRNA (miRNA) and in the intestinal barrier are putative risk […]
Adenoma Detection Rate (ADR) Irrespective of Indication is Comparable to Screening ADR: Implications for Quality Monitoring. 22nd February 2021 Adenoma detection rate (ADR) is a key measure of colonoscopy quality. However, […]
The gut microbiome: what every gastroenterologist needs to know. 22nd February 2021 The mucosal surfaces of the body are characterised by complex, specialised microbial […]
Tunnelled peritoneal drainage catheter placement for the palliative management of refractory ascites in patients with liver cirrhosis. 22nd February 2021 Refractory ascites is an established indication for liver transplantation. While transplantation is […]
Bile formation and Secretion: An update. 22nd February 2021 Bile formation is a fundamental physiological process that is vital to the […]
Endoscopic Submucosal Dissection (ESD) in North America: A Large Prospective Multicenter Study. 21st February 2021 Endoscopic submucosal dissection (ESD) in Asia has been shown to be superior […]
Interleukin-20 exacerbates acute hepatitis and bacterial infection by downregulating IκBζ target genes in hepatocytes. 21st February 2021 Interleukin-20 (IL-20) and IL-22 belong to the IL-10 family. IL-10 is a […]
An international consensus to standardize integration of histopathology in ulcerative colitis clinical trials. 21st February 2021 Histopathology is an emerging treatment target in ulcerative colitis (UC) clinical trials. […]
Acute-on-chronic liver failure: update on pathogenesis, therapeutic targets, predictive models, and liver transplantation. 19th February 2021 Acute-on-chronic liver failure (ACLF) is a clinical syndrome in patients with chronic […]
Systemic manifestations – do not forget the small bowel. 19th February 2021 Systemic diseases can afflict the small bowel (SB) but be challenging to […]
Safety and efficacy of hydrothermal duodenal mucosal resurfacing in patients with type 2 diabetes: the randomised, double-blind, sham-controlled, multicentre REVITA-2 feasibility trial. 18th February 2021 Hydrothermal duodenal mucosal resurfacing (DMR) is a safe, outpatient endoscopic procedure. REVITA-2, […]
Peutz-Jeghers syndrome. 17th February 2021 Peutz-Jeghers syndrome is a rare, autosomal dominant, hereditary polyposis syndrome defined by […]
Small bowel radiology. 17th February 2021 Recent advances in computed tomography (CT), ultrasound (US), magnetic resonance imaging (MRI), […]
Gut mucosa alterations and loss of segmented filamentous bacteria in type 1 diabetes are associated with inflammation rather than hyperglycaemia. 17th February 2021 Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction […]
Multiomics analysis reveals the presence of a microbiome in the gut of fetal lambs. 16th February 2021 Microbial exposure is critical to neonatal and infant development, growth and immunity. […]
Mortality, reoperation and hospital stay within 90 days of primary and secondary antireflux surgery in a population-based multinational study. 15th February 2021 Absolute rates and risk factors of short-term outcomes after antireflux surgery remain […]
Transient Elastography Accurately Screens for Compensated Advanced Chronic Liver Disease in Patients with Ongoing or Recent Alcohol Withdrawal. 15th February 2021 Liver stiffness measurement by transient elastography (TE) is a promising method for […]
Common mental disorders in irritable bowel syndrome: pathophysiology, management, and considerations for future randomised controlled trials. 15th February 2021 The frequent co-occurrence of irritable bowel syndrome and the common mental disorders […]
Identification of an Anti-Integrin αvβ6 Autoantibody in Patients with Ulcerative Colitis. 14th February 2021 Ulcerative colitis is the most frequent type of inflammatory bowel disease and […]
Prevention and treatment of nutritional complications after bariatric surgery. 14th February 2021 Obesity and the corresponding burden of related diseases is a major public […]
Adaptations in gastrointestinal physiology after sleeve gastrectomy and Roux-en-Y gastric bypass. 14th February 2021 Linked to the growing obesity epidemic, demand for bariatric and metabolic surgery […]
Antiviral therapy in the palliative setting of HCC (BCLC B and C). 14th February 2021 The potential impact of direct-acting antivirals (DAAs) in patients with Barcelona Clinic […]
UTILITY AND COST-EFFECTIVENESS OF A NON-ENDOSCOPIC APPROACH TO BARRETT’S ESOPHAGUS SURVEILLANCE AFTER ENDOSCOPIC THERAPY. 13th February 2021 A non-endoscopic approach to Barrett’s esophagus (BE) surveillance after radiofrequency ablation (RFA) […]
In Esophageal Squamous Cells from Eosinophilic Esophagitis Patients, Th2 Cytokines Increase Eotaxin-3 Secretion through Effects on Intracellular Calcium and a Non-Gastric Proton Pump. 13th February 2021 In upper airway cells, Th2 cytokines that signal through IL-4 receptor alpha […]
Microbial community heterogeneity within colorectal neoplasia and its correlation with colorectal carcinogenesis. 13th February 2021 Gut microbial dysbiosis has pivotal involvement in colorectal cancer (CRC). However, the […]
Oncogenetic landscape of lymphomagenesis in coeliac disease. 13th February 2021 Enteropathy-associated T-cell lymphoma (EATL) is a rare but severe complication of coeliac […]
Validation of the Lyon classification for GORD diagnosis: acid exposure time assessed by prolonged wireless pH monitoring in healthy controls and patients with erosive oesophagitis. 13th February 2021 Acid exposure time (AET) from ambulatory pH studies and reflux oesophagitis are […]
A structurally optimized FXR agonist, MET409, reduced liver fat content over 12 weeks in patients with non-alcoholic steatohepatitis. 13th February 2021 Farnesoid X receptor (FXR) agonists have been validated to benefit patients with […]
Colorectal Cancer Incidence after Colonoscopy at Ages 45-49 or 50-54 Years. 12th February 2021 Colorectal cancer (CRC) incidence at ages <50 years is increasing, leading to […]
Diagnosis and management of secondary causes of steatohepatitis. 12th February 2021 The term non-alcoholic liver disease (NAFLD) was originally coined to describe hepatic […]
Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation. 12th February 2021 Fecal microbiota transplantation (FMT) is an effective therapy for recurrent Clostridioides difficile […]
TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis. 12th February 2021 Gain of function (GOF) mutation of CTNNB1 gene is one of the […]
Established and novel therapeutic options for autoimmune hepatitis. 11th February 2021 Autoimmune hepatitis is an immune-mediated disorder characterised by hypergammaglobulinaemia, autoantibodies, and interface […]
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism. 11th February 2021 Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and lacks effective […]
Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH. 11th February 2021 Perturbations of intracellular magnesium (Mg2+) homeostasis have implications for cell physiology. The […]
Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma. 10th February 2021 Infection by HBV is the main risk factor for hepatocellular carcinoma (HCC) […]
Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence. 10th February 2021 Alterations in the intestinal microbiota are linked with a wide range of […]
EASL position paper on the use of COVID-19 vaccines in patients with chronic liver diseases, hepatobiliary cancer and liver transplant recipients. 10th February 2021 According to a recent World Health Organization estimate, the severe acute respiratory […]
Prostaglandin E2 receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation. 9th February 2021 Dysfunctional resolution of intestinal inflammation and altered mucosal healing are essential features […]
Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn. 9th February 2021 Stroke is a leading cause of death and disability worldwide. Neuroprotective approaches […]
End-points in clinical trials for liver cancer and their value in evidence based clinical decision making: an unresolved Gordian knot. 8th February 2021 Design and execution of clinical trials use definitions and criteria to permit […]
Spatial Evolution of Histologic and Endoscopic Healing in Left and Right Colon in Patients with Ulcerative Colitis. 8th February 2021 Despite increasing interest in histologic remission as a treatment target in ulcerative […]
Characterization of Prevalent, Post-Endoscopy, and Incident Esophageal Cancer in the United States: A Large Retrospective Cohort Study. 7th February 2021 Efforts to assess and improve the effectiveness of Barrett’s esophagus (BE) screening […]
Endoscopic phenotype of the J pouch in patients with inflammatory bowel disease: A new classification for pouch outcomes. 7th February 2021 Pouchitis is a common complication of ileal pouch-anal anastomosis (IPAA) in patients […]
Feasibility and safety of tethered capsule endomicroscopy in patients with Barrett’s esophagus in a multi-center study. 7th February 2021 Tethered capsule endomicroscopy (TCE) involves swallowing small tethered pill that implements optical […]
Primary Sclerosing Cholangitis-Associated Pouchitis: A Distinct Clinical Phenotype. 7th February 2021 Patients with primary sclerosing cholangitis (PSC) commonly undergo ileal pouch-anal anastomosis (IPAA) […]
Transient elastography assessed hepatic steatosis and fibrosis are associated with body composition in the United States. 7th February 2021 We examined transient elastography assessed hepatic steatosis and fibrosis distributions and relationships […]
Abbreviated MRI for hepatocellular carcinoma screening: A systematic review and meta-analysis. 6th February 2021 Biannual ultrasound (US) has poor sensitivity in screening of hepatocellular carcinoma (HCC). […]
SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study. 6th February 2021 There is emerging evidence that the pancreas may be a target organ […]
FOXA3 induction under endoplasmic reticulum stress contributes to non-alcoholic fatty liver disease. 6th February 2021 Chronic ER stress in liver have been shown to play a causative […]
