Association between proton pump inhibitor use and gastric cancer: a population-based cohort study using two different types of nationwide databases in Korea. 12th May 2021 The association between proton pump inhibitor (PPI) use and gastric cancer related […]
Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health. 12th May 2021 Gut microbial products are involved in regulation of host metabolism. In human […]
Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP). 12th May 2021 To investigate the incidence of gastric cancer (GC) attributed to gastric intestinal […]
The optimal age to stop endoscopic surveillance of Barrett’s esophagus patients based on sex and comorbidity: a comparative cost-effectiveness analysis. 11th May 2021 Current guidelines recommend surveillance for non-dysplastic Barrett’s esophagus (NDBE) patients but do […]
Apatinib as second-line or later therapy in patients with advanced hepatocellular carcinoma (AHELP): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. 10th May 2021 Inhibition of vascular endothelial growth factor receptor (VEGFR) has shown antitumour activity […]
Glucocorticoids and androgens protect from gastric metaplasia by suppressing group 2 innate lymphoid cell activation. 10th May 2021 The immune compartment is critical for maintaining tissue homeostasis. A weak immune […]
Evaluation of hepatitis C treatment-as-prevention within Australian prisons (SToP-C): a prospective cohort study. 9th May 2021 Limited empirical evidence exists for the effectiveness of hepatitis C virus (HCV) […]
Surveillance of patients with cirrhosis remains suboptimal in the United States. 9th May 2021 Regular monitoring/surveillance for liver complications is crucial in the management of patients […]
Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease. 8th May 2021 Nonalcoholic Fatty Liver Disease (NAFLD), the hepatic correlate of the metabolic syndrome, […]
Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum. 8th May 2021 Although immunoglobulin A (IgA) is abundantly expressed in the gut and known […]
Non-alcoholic fatty liver disease: a multisystem disease requiring a multidisciplinary and holistic approach. 7th May 2021 Non-alcoholic fatty liver disease (NAFLD) is a public health problem worldwide. This […]
Global burden of acute viral hepatitis and its association with socioeconomic development status, 1990-2019. 7th May 2021 Acute viral hepatitis (AVH) represents an important global health problem; however, the […]
Glutaminolysis-induced mTORC1 activation drives non-alcoholic steatohepatitis progression. 7th May 2021 A holistic insight on the relationship between obesity and metabolic dysfunction-associated fatty […]
Resolution of hepatitis E virus infection in CD8+ T cell depleted rhesus macaques. 7th May 2021 HEV is a significant cause of acute hepatitis globally. Some genotypes establish […]
Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women. 7th May 2021 Sugar-sweetened beverage (SSB) consumption had substantially increased across successive US birth cohorts […]
EGF and BMPs govern differentiation and patterning in human gastric glands. 6th May 2021 The homeostasis of the gastrointestinal epithelium relies on cell regeneration and differentiation […]
International consensus to standardise histopathological scoring for small bowel strictures in Crohn’s disease. 6th May 2021 Effective medical therapy and validated trial outcomes are lacking for small bowel […]
The times they are a-changing – A refined proposal for finite HBV nucleos(t)ide analog therapy. 6th May 2021 Although discontinuation of nucleos(t)ide analogue (NA) treatment before HBsAg loss is part […]
Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: results of the ELITA/EF-CLIF collaborative study (ECLIS). 5th May 2021 Liver transplantation (LT) has been proposed to be an effective salvage therapy […]
Approach to the management of recently diagnosed inflammatory bowel disease patients: a user’s guide for adult and pediatric gastroenterologists. 3rd May 2021 Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), […]
TGF-β signaling in Liver, Pancreas, and Gastrointestinal Diseases and Cancer. 3rd May 2021 Genetic alterations affecting transforming growth factor β (TGF-β) signaling are exceptionally common […]
Current knowledge and management of portal vein thrombosis in cirrhosis. 30th April 2021 Portal vein thrombosis (PVT) is a complication of cirrhosis that is being […]
Genetic and epigenetic characteristics of inflammatory bowel disease associated colorectal cancer. 30th April 2021 Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder associated with […]
Interplay between diet and gut microbiome, and circulating concentrations of trimethylamine N-oxide: findings from a longitudinal cohort of US men. 30th April 2021 Gut-produced trimethylamine N-oxide (TMAO) is postulated as a possible link between red […]
Standards for the provision of antenatal care for patients with inflammatory bowel disease: guidance endorsed by the British Society of Gastroenterology and the British Maternal and Fetal Medicine Society. 29th April 2021 Pregnant women with inflammatory bowel disease (IBD) are at increased risk of […]
TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes. 29th April 2021 Pancreatic ductal adenocarcinoma (PDAC) is characterised by advanced disease stage at presentation, […]
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. 29th April 2021 Ursodeoxycholic acid is commonly used to treat intrahepatic cholestasis of pregnancy, yet […]
Health service usage and re-referral rates: comparison of a dietitian-first clinic with a medical specialist-first model of care in a cohort of gastroenterology patients. 29th April 2021 The dietitian-first gastroenterology clinic (DFGC) is an expanded scope of practice initiative […]
IBD in pregnancy: recent advances, practical management. 29th April 2021 Inflammatory bowel disease (IBD) poses complex issues in pregnancy, but with high-quality […]
Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial. 29th April 2021 The benefit and safety of laparoscopic pancreatoduodenectomy (LPD) for the treatment of […]
Obesity management for the gastroenterologist. 29th April 2021 Obesity has reached epidemic levels in the United Kingdom. Obesity is associated […]
Data from a large Western centre exploring the impact of COVID-19 pandemic on endoscopy services and cancer diagnosis. 28th April 2021 The global COVID-19 pandemic has changed healthcare across the world. Efforts have […]
Specialist inflammatory bowel disease nursing in the UK: current situation and future proofing. 28th April 2021 To determine the impact to date of the ongoing Crohn’s & Colitis […]
Steroid use and misuse: a key performance indicator in the management of IBD. 28th April 2021 Corticosteroids remain an important tool for inducing remission in inflammatory bowel disease […]
Venting issues. 28th April 2021 Introduction: A 65-year-old woman with type 3 intestinal failure secondary to scleroderma […]
British Society of Gastroenterology guidelines on the management of irritable bowel syndrome. 28th April 2021 Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders […]
Development and evaluation of a novel protective device for upper gastrointestinal endoscopy in the COVID-19 pandemic: the EBOX. 27th April 2021 During the COVID-19 pandemic, aerosol-generating procedures such as upper gastrointestinal endoscopy (UGIE) […]
Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD. 27th April 2021 Delayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for a lower level […]
Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target. 27th April 2021 We evaluated the influence of sex on the pathophysiology of non-alcoholic fatty […]
Bacterial infections adversely influence the risk of decompensation and survival in compensated cirrhosis. 27th April 2021 Prognosis of compensated cirrhosis is good until decompensation. In decompensated cirrhosis, bacterial […]
COVID-19-related health anxieties and impact of specific interventions in patients with inflammatory bowel disease in the UK. 27th April 2021 Health-related concerns brought on by the COVID-19 pandemic and the impact of […]
Esophageal afferent innervation and its role in gastro-esophageal reflux disease symptoms. 26th April 2021 Despite the wide prevalence of gastro-esophageal reflux disease (GERD), the neurophysiological mechanisms […]
MondoA-TXNIP axis maintains regulatory T cell identity and function in colorectal cancer microenvironment. 26th April 2021 The metabolic features and function of intratumoral Tregs are ambiguous in colorectal […]
Multidisciplinary management of perianal Crohn’s disease. 26th April 2021 Multiple new medications with novel mechanisms of action are now available to […]
Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): 10-year follow-up of an open-label, non-inferiority, randomised controlled trial. 25th April 2021 Laparoscopic surgery has been widely used for rectal cancer; however, its long-term […]
A diffusion-like process accommodates new crypts during clonal expansion in human colonic epithelium. 25th April 2021 Colorectal cancer (CRC) is thought to arise when the cumulative mutational burden […]
Colonic Motility is Improved by the Activation of 5-HT2B Receptors on Interstitial Cells of Cajal in Diabetic Mice. 25th April 2021 Constipation is commonly associated with diabetes. Serotonin (5-HT), produced predominantly by enterochromaffin […]
Non-food prebiotic, probiotic, and synbiotic use has increased in U.S. adults and children from 1999 to 2018. 25th April 2021 Public interest in pre- , pro-, and synbiotic products is increasing because […]
Tumor secreted extracellular vesicles regulate T-cell costimulation and can be manipulated to induce tumor specific T-cell responses. 25th April 2021 Colorectal Cancer is a major cause of cancer-related deaths worldwide. Immune checkpoint […]
A pilot study of Golexanolone, a new GABA-A receptor modulating steroid antagonist, in patients with covert hepatic encephalopathy. 24th April 2021 Golexanolone is a novel small molecule GABA-A receptor modulating steroid antagonist under […]
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease. 23rd April 2021 Haemorrhoidal disease (HEM) affects a large and silently suffering fraction of the […]
Impact of alcohol on the progression of HCV-related liver disease: A systematic review and meta-analysis. 23rd April 2021 Despite a marked reduction in new cases of liver cirrhosis caused by […]
Low immunogenicity to SARS-CoV-2 vaccination among liver transplant recipients. 23rd April 2021 Two SARS-CoV-2 mRNA vaccines were approved to prevent COVID-19 infection, with reported […]
Disease-specific eQTL screening reveals an anti-fibrotic effect of AGXT2 in non-alcoholic fatty liver disease. 23rd April 2021 Nonalcoholic fatty liver disease (NAFLD) poses an impending clinical burden. Genome-wide association […]
Falls are common, morbid, and predictable in patients with cirrhosis. 22nd April 2021 Falls are a devastating complication of cirrhosis. The risk of falls in […]
FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted. 22nd April 2021 Cholangiocarcinoma (CCA) is a neoplasia of the biliary tract driven by genetic, […]
Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis. 22nd April 2021 Obesity often leads to nonalcoholic fatty liver disease (NAFLD), which can progress […]
How extent of Barrett’s metaplasia influences the risk of esophageal adenocarcinoma. 22nd April 2021 This review will focus on how the extent of Barrett’s metaplasia influences […]
The role of magnetic sphincter augmentation in the treatment of gastroesophageal reflux disease. 22nd April 2021 Magnetic sphincter augmentation (MSA) has been designed as a less disruptive and […]
Clinical utility of 30% relative decline in MRI-PDFF in predicting fibrosis regression in non-alcoholic fatty liver disease. 22nd April 2021 Emerging data suggest that a 30% relative decline in liver fat, as […]
