The Latest Bone Diseases Journal Articles

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Keep up to date with the latest in bone diseases. Check out the latest bone disease articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily

  • Incidence of Paget’s Disease of Bone in the UK: Evidence of a Continuing Decline.
    To characterise the incidence of clinically diagnosed Paget’s disease of bone in the UK during 1999-2015 and to determine variation in incidence of disease by age, sex, geography and level of deprivation.Incident cases of Paget’s disease occurring between 1999-2015 were identified from primary care records. Overall crude incidence and incidence stratified by age and sex […]
  • Real-Life Analysis of the Causes of Death in Patients Consecutively Followed for Giant Cell Arteritis in a French Center of Expertise.
    To describe, in a real-life setting, the direct causes of death in a cohort of consecutive patients with giant cell arteritis (GCA).We retrospectively analyzed the deaths that occurred in a cohort of 470 consecutive GCA patients from a center of expertise between January 2000 and December 2019. Among the 120 patients who died, we retrieved […]
  • Management of Crohn Disease: A Review.
    Crohn disease, a chronic gastrointestinal inflammatory disease, is increasing in incidence and prevalence in many parts of the world. Uncontrolled inflammation leads to long-term complications, including fibrotic strictures, enteric fistulae, and intestinal neoplasia. Therefore, early and effective control of inflammation is of critical importance.The optimal management approach for Crohn disease incorporates patient risk stratification, patient […]
  • Osteosarcopenia: where osteoporosis and sarcopenia collide.
    The coexistence of osteoporosis and sarcopenia has been recently considered in some groups as a syndrome termed ‘osteosarcopenia’. Osteoporosis describes low bone mass and deterioration of the micro-architecture of the bone, whereas sarcopenia is the loss of muscle mass, strength and function. With an ageing population the prevalence of both conditions is likely to increase […]
  • Meta-analysis Reveals Genetic Correlates of Osteoporosis Pathogenesis.
    Osteoporosis is a growing health care burden. By identifying osteoporosis promoting genetic variations, we can spotlight targets for new pharmacologic therapies that will improve patient outcomes. In this meta-analysis, we analyzed mesenchymal stem cell biomarkers in patients with osteoporosis.We employed our Search Tag Analyze Resource (STARGEO) platform to conduct a meta-analysis to define osteoporosis pathogenesis. […]
  • STAT3 Phosphorylation Inhibition for Treating Inflammation and New Bone Formation in Ankylosing Spondylitis.
    Ankylosing spondylitis (AS) is a rheumatic disease characterized by chronic inflammation and bony ankylosis. This study was to evaluate whether a signal transducer and activator of transcription 3 phosphorylation inhibitor (stat3-p Inh) could treat both chronic inflammation and bone formation in AS.Primary AS osteoprogenitor cells and spinal entheseal cells were examined for osteogenic differentiation. Synovial […]
  • Fracture risk in systemic lupus erythematosus patients over 28 years.
    Chronic glucocorticoid use is complicated by osteoporosis and increases the risk of fragility fractures. EULAR guidelines on SLE management recommend reducing chronic glucocorticoid dosage to ≤7.5 mg/day to minimize this risk. We examined the relationship of glucocorticoid dose to fragility fracture risk in a cohort of SLE patients.Retrospective analysis of SLE patients attending University College Hospital […]
  • Machine-learning, MRI bone shape and important clinical outcomes in osteoarthritis: data from the Osteoarthritis Initiative.
    Osteoarthritis (OA) structural status is imperfectly classified using radiographic assessment. Statistical shape modelling (SSM), a form of machine-learning, provides precise quantification of a characteristic 3D OA bone shape. We aimed to determine the benefits of this novel measure of OA status for assessing risks of clinically important outcomes.The study used 4796 individuals from the Osteoarthritis […]
  • Medical Care of Adults With Down Syndrome: A Clinical Guideline.
    Down syndrome is the most common chromosomal condition, and average life expectancy has increased substantially, from 25 years in 1983 to 60 years in 2020. Despite the unique clinical comorbidities among adults with Down syndrome, there are no clinical guidelines for the care of these patients.To develop an evidence-based clinical practice guideline for adults with […]
  • Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and Mendelian randomisation study.
    With 432 513 samples from UK Biobank dataset, multivariable linear/logistic regression were used to estimate the relationship between psoriasis/psoriatic arthritis (PsA) and estimated bone mineral density (eBMD)/osteoporosis, controlling for potential confounders. Here, confounders were set in three ways: model0 (including age, height, weight, smoking and drinking), model1 (model0 +regular physical activity) and model2 (model1 +medication treatments). […]
  • Comparable or higher prevalence of comorbidities in antiphospholipid syndrome vs rheumatoid arthritis: a multicenter, case-control study.
    Evidence on comorbidity prevalence in antiphospholipid syndrome (APS) and its difference from high comorbidity burden rheumatic diseases is limited. Herein, we compare multiple comorbidities between APS and RA.A total of 326 patients from the Greek APS registry [237 women, mean age 48.7 (13.4) years, 161 primary APS (PAPS), 165 SLE-APS] were age/sex matched (1:2 ratio) with 652 […]
  • Clinical phenotypes of IgG4-related disease reflect different prognostic outcomes.
    Four clinical phenotypes of IgG4-related disease (IgG4-RD) have been recently identified by latent class analysis (LCA): pancreato-biliary (group 1); retroperitoneum/aortitis (group 2); head and neck limited (group 3); and Mikulicz/systemic (group 4). The reproducibility of this classification in clinical practice and its relevance for patient management, however, remain unknown.The study included 179 patients. Four IgG4-RD […]
  • Handgrip strength is a comorbidity marker in systemic necrotizing vasculitides and predicts the risk of fracture and serious adverse events.
    Sarcopenia has been associated with poor outcomes in various medical and surgical conditions. However, its impact in systemic necrotizing vasculitides (SNV) had never been characterized. We aimed to assess the prevalence, associated factors and prognostic impact of sarcopenia in SNV.Patients with SNV were successively included in a prospective longitudinal study assessing comorbidities. At inclusion, we […]
  • 2019 EULAR points to consider for non-physician health professionals to prevent and manage fragility fractures in adults 50 years or older.
    To establish European League Against Rheumatism (EULAR) points to consider for non-physician health professionals to prevent and manage fragility fractures in adults 50 years or older.Points to consider were developed in accordance with EULAR standard operating procedures for EULAR-endorsed recommendations, led by an international multidisciplinary task force, including patient research partners and different health professionals […]
  • The risk and consequences of vertebral fracture in patients with Ankylosing Spondylitis: a population-based data linkage study.
    To compare the long-term prevalence, incidence and outcomes of vertebral fracture (VF) between ankylosing spondylitis (AS) patients and matched controls, including the role of extra-articular manifestations (EAM) and osteoporosis.State-wide observational study using linked health data for 2,321 AS patients and 22,976 controls presenting to hospital from 1980-2015. Data were analysed using incidence rates (per 1000 […]
  • Response to: ‘Association between osteoporosis and statin therapy: the story continues’ by Burden and Weiler.
    Click here to read the full article @ Annals of the rheumatic diseases
  • Validation of the self-administered comorbidity questionnaire adjusted for spondyloarthritis: results from the ASAS-COMOSPA study.
    To confirm validity of the Self-administered Comorbidity Questionnaire modified for patients with SpA (mSCQ), and assess whether validity improves when adding items on extra-articular manifestations (EAMs), i.e. uveitis, psoriasis, and IBD, and osteoporosis and fractures.Data from the Assessment in SpondyloArthritis international Society COMOrbidities in SPondyloArthritis study were used. Criterion validity of presence of EAMs, osteoporosis […]
  • Response to: ‘The association between osteoporosis and statins therapy’ by Lai.
    Click here to read the full article @ Annals of the rheumatic diseases
  • The jigsaw puzzle of chronic non-bacterial osteomyelitis: are anti-IL17 therapies the next piece?
    Abstract: Abstract empty Click here to read the full article @ Rheumatology (Oxford, England)
  • Trabecular bone score improves fracture risk assessment in glucocorticoid-induced osteoporosis.
    Abstract: To analyse the clinical utility of trabecular bone score (TBS) evaluation for fracture risk assessment in glucocorticoid (GC)-treated patients compared with BMD assessment.One hundred and twenty-seven patients on GC treatment were included [mean age 62 (18) years, 63% women] in this cross-sectional study. The medical history, anthropometric data, lumbar and femoral BMD (DXA) [considering […]
  • Analysis of bone impairment by 3D DXA hip measures in patients with primary hyperparathyroidism: a pilot study.
    Abstract: primary hyperparathyroidism (PHPT) has been related to bone loss. Dual-energy X-ray absorptiometry (DXA) cannot distinguish between trabecular and cortical bone compartments but the recently developed 3D-DXA software might overcome this examine the differences in DXA-derived areal bone mineral density (aBMD) and 3D-DXA parameters at the hip site between patients with PHPT and a […]
  • Development of CROMRIS (ChRonic nonbacterial Osteomyelitis MRI Scoring) Tool and Evaluation of its Interrater Reliability.
    Abstract: Serial MRI exams are often needed in chronic nonbacterial osteomyelitis (CNO) to determine the objective response to treatment. Our objectives were: 1) to develop a consensus-based MRI scoring tool for clinical and research use in CNO; 2) to evaluate interrater reliability and agreement using whole body (WB) MRI from children with CNO.Eleven pediatric radiologists […]
  • Diagnosis of osteoporosis in statin-treated patients is dose-dependent.
    Abstract: Whether HMG-CoA-reductase inhibition, the main mechanism of statins, plays a role in the pathogenesis of osteoporosis, is not entirely known so far. Consequently, this study was set out to investigate the relationship of different kinds and dosages of statins with osteoporosis, hypothesising that the inhibition of the synthesis of cholesterol could influence sex-hormones and […]
  • The prevalence of osteoporosis tested by quantitative computed tomography in patients with different glucose tolerances.
    Abstract: The objectives of the present study were to compare bone characteristics with QCT and other metabolic factors relevant to bone health in subjects with normal glucose tolerance, impaired glucose tolerance and diabetes and to evaluate the association of various lab factors with bone characteristics qualified by QCT.This cross-sectional population-based survey of diabetes and metabolic […]
  • Management of Osteoporosis in Survivors of Adult Cancers With Nonmetastatic Disease: ASCO Clinical Practice Guideline.
    Abstract: The aim of this work is to provide evidence-based guidance on the management of osteoporosis in survivors of adult cancer.ASCO convened a multidisciplinary Expert Panel to develop guideline recommendations based on a systematic review of the literature.The literature search of the 2018 systematic review by the US Preventive Services Task Force in the noncancer […]
  • High Expression of Acid-Sensing Ion Channel 2 (ASIC2) in Bone Cells in Osteoporotic Vertebral Fractures.
    Abstract: Little is known about the function of acid-sensing ion channels (ASICs) in bone cells or osteoporotic vertebral fractures (OVF). This study delineated ASICs expression in adult human bone marrow-mesenchymal stem cells- (BM-MSC-) derived osteoblasts and in OVF bone cells. Adult BM-MSC-derived osteoblasts were isolated and cultured in different pH values. Osteogenic markers as alkaline […]
  • Efficacy and Safety of First- and Second-Line Drugs to Prevent Glucocorticoid-Induced Fractures: A Network Meta-Analysis.
    Abstract: The evidence about benefits and harms of drugs for glucocorticoid-induced osteoporosis (GIOP) is limited, and the comparative efficacy and safety of first-line and second-line agents to prevent glucocorticoid-induced (GI) fractures remains unclear.To assess the comparative clinical efficacy, safety and tolerability of first-line and second-line agents in preventing GI fractures.We searched three different databases through […]
  • National Audit on the Management of Bullous Pemphigoid.
    Abstract: Bullous pemphigoid (BP) is an autoimmune sub-epidermal blistering condition which typically affects the elderly population.To undertake a national clinical audit based on standards derived from the British Association of Dermatologists (BAD) clinical guidelines on the management of bullous pemphigoid.In 2018 BAD members were invited to submit data for five consecutive adults with BP, per […]
  • Zoledronic acid is effective and safe in migratory osteoporosis.
    Abstract: Abstract empty Click here to read full article on original source website
  • Gut microbiota alterations associated with reduced bone mineral density in older adults.
    Abstract: To investigate compositional differences in the gut microbiota associated with bone homeostasis and fractures in a cohort of older adults.Faecal microbiota profiles were determined from 181 individuals with osteopenia (n = 61) or osteoporosis (n = 60), and an age- and gender-matched group with normal BMD (n = 60). Analysis of the 16S (V3-V4 […]
  • Prevalence and risk factors for osteoporosis in individuals with chronic obstructive pulmonary disease: a systematic review and meta-analysis.
    Osteoporosis is prevalent in individuals with chronic obstructive pulmonary disease (COPD). Updated evidence is required to complement the previous systematic review on this topic in order to provide best practice. The aim of this systematic review and meta-analysis was to quantitatively synthesize data from studies with respect to the prevalence and risk factors for osteoporosis among individuals with COPD.EMBASE, CINAHL MEDLINE, and PubMed databases were searched for articles containing the keywords “COPD”, “osteoporosis”, “prevalence”, and “risk factor”. Eligibility screening, data extraction, and quality assessment of the retrieved articles were conducted independently by two reviewers. Meta-analyses were performed to determine osteoporosis prevalence and risk factors in individuals with COPD. Meta-regression analyses were conducted to explore the sources of heterogeneity.The pooled global prevalence from 58 studies was 38% (95% CI= 34, 43). The presence of COPD increased the likelihood of having osteoporosis (OR= 2.83). Other significant risk factors for osteoporosis in COPD patients were body mass index < 18.5 kg/m2 (OR=4.26) and the presence of sarcopenia (OR= 3.65).Osteoporosis is prevalent in individuals with COPD and the prevalence appears to be high and similar in many countries. COPD patients should be screened for osteoporosis and contributing risk factors.
  • Neglected bodily senses in women living with vertebral fracture: a focus group study.
    Older women are at particular risk of osteoporosis. Among women with osteoporosis, fractures of the vertebra (vertebral fracture) are common, hard to detect and associated with risk of further fracture. Identifying vertebral fracture in a timely manner allows instigation of preventive measures to reduce the risk of further fracture. Although detection of vertebral fracture requires spinal radiograph, many women do not receive referral. To begin development of a screening tool to identify women in need of referral we undertook a qualitative study to characterize women’s experiences of vertebral fracture, using Eccleston’s ‘Ten Neglected Bodily Senses’.Four qualitative focus groups were conducted with women who had been diagnosed with vertebral fracture (n = 19, age 60-91 years). Data were audio-recorded, transcribed and analysed thematically using the ‘Ten Neglected Bodily Senses’.Women’s experiences of vertebral fractures related to seven senses: pain, movement, fatigue, balance, pressure, appetite and breathing. Pain was the dominant sense and all participants explained how pain increased with activity, reaching a crescendo, and described strategies to minimize this disruption. Most participants had become physically shorter, making some feel ‘squashed’, putting pressure on other body parts. Some described appetite loss or a sense of restricted breathing. Participants experienced a sense of being ‘pulled’ forwards, impacting on balance and exacerbating fear of falling.The study found senses that have not been previously described in the experiences of women with vertebral fracture. These will be used to inform the design of a new screening tool for use in primary care.
  • Predictors of Poor Bone Microarchitecture Assessed by Trabecular Bone Score (TBS) in Postsurgical Hypoparathyroidism.
    The effects of parathyroid hormone deprivation on bone are still unclear. Our objective was to report the characteristics of patients with postsurgical hypoparathyroidism (PsH) at a specialized outpatient service and correlate their trabecular bone score (TBS) values to clinical, densitometric, and laboratory findings. A secondary objective was to evaluate the fracture rates and look for associations between these events and the collected data.Eighty-two patients were enrolled, of whom 70 (85.4%) were female and 17 (20.7%) had type 2 diabetes mellitus (T2DM). The median body mass index (BMI) was 27.7 kg/m2 and the median age was 59 years. Of 68 DXA scans performed, osteopenia and osteoporosis were present in 32.4% and 2.9%, respectively. In all, 62 lumbar scans were analyzed using TBS. The mean TBS value was 1.386±0.140, and 32.2% of the results were below 1.310. TBS values correlated negatively with BMI (mainly above 30kg/m2), age (mainly above 60 years), and glycemia, while abnormal TBS correlated with osteopenia, T2DM, low impact fracture, and menopause. Six female patients had low impact fractures, which were associated with a lower TBS (1.178±0.065 vs. 1.404±0.130 in the group without fractures, p<0.001), greater age, higher BMI, impaired renal function, abnormal glycemia, and osteopenia.This study suggested that known risk factors for bone loss compromise the bone microarchitecture of individuals with PsH, despite DXA results. PsH menopausal women, PsH patients who are older, osteopenic and have a higher BMI or T2DM may be candidates for a more detailed assessment using, for example, TBS.
  • Response to Letter to the Editor: Two-thirds of all fractures are not attributable to osteoporosis and advancing age: implication for fracture prevention.
    Abstract empty
  • Letter to the Editor: Two-thirds of all fractures are not attributable to osteoporosis and advancing age: implication for fracture prevention.
    Abstract empty
  • Endocrine and metabolic disorders in survivors of childhood cancers and health-related quality of life and physical activity.
    Childhood cancer survivors experience chronic health conditions that impact health related quality of life (HRQOL) and participation in optimal physical activity.The study aimed to determine independent effects of endocrine and metabolic disorders on HRQOL and physical activity.Retrospective cohort with longitudinal follow-up of survivors of childhood cancer enrolled in the North American Childhood Cancer Survivor Study.Medical Outcomes Short Form-36 estimated HRQOL while participation in physical activity was dichotomized as meeting or not meeting recommendations from the Center for Disease Control and Prevention. Log binomial regression evaluated the association of each endocrine/metabolic disorder with HRQOL scales and physical activity.Of 7,287 survivors, median age 32 years (18-54) at their last follow-up survey, 4,884 (67%) reported one or more endocrine/metabolic disorders. Survivors with either disorder were significantly more likely to be male, older, received radiation treatment, and experience other chronic health conditions. After controlling for covariates, survivors with any endocrine/metabolic disorder were more likely to report poor physical function risk ratio ([RR] 1.25; 95% confidence interval [CI] 1.05-1.48), increased bodily pain (RR 1.27; CI 1.12-1.44), poor general health (RR 1.49; CI 1.32-1.68) and lower vitality (RR 1.21; CI 1.09-1.34) compared to survivors without. The likelihood of meeting recommended physical activity was lower among survivors with growth disorders (RR 0.90; CI=0.83-0.97), osteoporosis (RR 0.87; CI=0.76-0.99), and overweight/obesity (RR 0.92; CI 0.88-0.96).Endocrine and metabolic disorders are independently associated with poor HRQOL and sub-optimal physical activity among childhood cancer survivors.
  • Comparison of Teriparatide and Denosumab in Patients Switching from Long-Term Bisphosphonate Use.
    Teriparatide and denosumab are effective treatments for osteoporosis and typically reserved as second-line options after patients have used bisphosphonates. However, limited head-to-head comparative effectiveness data exist between teriparatide and denosumab.We compared changes in bone mineral density (BMD) between groups treated with teriparatide or denosumab after using bisphosphonates, focusing on the change in BMD while on either drug over 2 years.Observational cohort study using electronic medical records from two academic medical centers in the US.The study population included osteoporotic patients > 45 years who received bisphosphonates over one year prior to switching to teriparatide or denosumab.Annualized BMD change from baseline at the lumbar spine, total hip and femoral neck.Patients treated with teriparatide (n=110) were compared to those treated with denosumab (n=105); the mean (SD) age was 70 (10) years and median duration (IQR) of bisphosphonate use was 7.0 (5.6-9.7) years. Compared to denosumab users, teriparatide users had higher annualized BMD change at the spine by 1.3% (95% CI 0.02, 2.7%), but lower at the total hip by -2.2% (95% CI -2.9 to -1.5%) and the femoral neck by -1.1% (95% CI -2.1 to -0.1%). Those who switched to teriparatide had a transient loss of hip BMD for the first year, with no overall increase in the total hip BMD over two years.Among patients who use long-term bisphosphonates, the decision of switching to teriparatide should be made with caution, especially for patients at high risk of hip fracture.
  • Association between urinary triclosan with bone mass density and osteoporosis in the US adult women, 2005-2010.
    Abstract: Laboratory studies have demonstrated that Triclosan (TCS) could result in significant interstitial collagen accumulation and an increase in trabecular bone. However, little is known about the relationship between TCS exposure and human bone health.We used 2005-2010 National Health and Nutrition Examination Survey data to examine the association between urinary TCS concentrations with BMD and […]
  • Testing and management for monoclonal gammopathy of uncertain significance and myeloma patients presenting with osteoporosis and fragility fractures.
    Abstract: Multiple myeloma, the second most frequent blood cancer, and its precursor, monoclonal gammopathy of uncertain significance, are associated with an increased risk of fragility fractures. However, current guidelines fail to offer explicit indications for healthcare professionals in terms of testing and thresholds for onward referral. The purpose of this review is to present the […]
  • Management of pancreatic exocrine insufficiency.
    Abstract: Pancreatic exocrine insufficiency (PEI) is one of the well known causes of malabsorption syndrome. An insufficient secretion of pancreatic enzymes and bicarbonate secondary to different pancreatic diseases and upper gastrointestinal and pancreatic surgery leads to maldigestion and malabsorption of nutrients. Patients with PEI may present with symptoms of malabsorption and different nutritional deficiencies. Recent […]
  • Identifying and Addressing Osteoporosis Knowledge Gaps in Women with Premature Ovarian Insufficiency and Early Menopause: A mixed methods study.
    Osteoporosis associated with premature ovarian insufficiency (POI) and early menopause (EM) is a major concern for women. We aimed to (i) identify information and knowledge gaps and behaviours regarding bone health in women with POI/EM; and (ii) co-design an osteoporosis factsheet.Mixed-methods study: survey of women and online resource appraisals to develop and refine, using semi-structured interviews, an osteoporosis factsheet.Women with POI/EM (menopause before ages 40 and 45 years respectively).Demographics, comorbidities, information needs, calcium intake, exercise, osteoporosis knowledge (OKAT), beliefs and self-efficacy, DISCERN appraisal (validated scales).descriptive statistics, logistic regression and thematic analysis of interviews.Median age of survey respondents (n=316) was 54(IQR47-63) years, median age of menopause was 40(IQR38-43) years, and osteoporosis diagnosis was reported in 19%. Most reported inadequate dietary calcium intake (99%) and exercise (65%). Median OKAT score 8[IQR6-10]/19 indicated knowledge gaps regarding risk factors and treatment options. Adjusting for age and education, OKAT predicted calcium intake [OR1.126(CI 1.035-1.225); p=0.006) and screening [OR1.186(CI 1.077-1.305; p=0.001); beliefs predicted screening [OR1.027(CI 1.004-1.050); p=0.019]; and self-efficacy predicted calcium intake [OR1.040(CI 1.013-1.069); p=0.003] and exercise [OR1.117(CI 1.077-1.160); p<0.001]. Current online resources have deficiencies. Five themes identified from 2 interview rounds (n=10/ round) were: content, emotional response, design, perceived usefulness and clinical considerations. The final factsheet was considered acceptable and useful in addressing knowledge gaps, promoting information-seeking, impacting behaviours and facilitating healthcare discussions.A co-designed factsheet is acceptable and addresses identified osteoporosis knowledge gaps in women with POI/EM. This article is protected by copyright. All rights reserved.
  • Transdermal delivery of fluvastatin loaded nanoemulsion gel: Preparation, characterization and in vivo anti-osteoporosis activity.
    Abstract: The objective of present study was to develop hydrogel based nanoemulsion (NE) drug delivery system for transdermal delivery and evaluate its potential in in vivo anti-osteoporotic activity. NE was prepared using aqueous phase titration method and characterized for droplet size, zeta potential and morphology. It was then formulated into hydrogel based NE gel using […]
  • A System to Determine Risk of Osteoporosis in Patients With Autoimmune Hepatitis.
    Abstract: Osteoporosis is a feared complication of autoimmune hepatitis (AIH), but bone disease has not been well studied in these patients. We aimed to identify specific risk factors for osteoporosis in patients with AIH and to develop a scoring system that could be used to identify patients with increased risk of osteoporosis.We performed a retrospective […]