The Effect of Chitosan in Wound Healing: A Systematic Review.
To systematically review the effectiveness of chitosan in wound healing.References were retrieved from PubMed, EMBASE, the Cochrane library and Web of Science based on medical subject headings (MeSH) and keywords (“chitosan” OR “chitin” OR “poliglusam” AND “wound healing”).Eligible articles were randomized controlled trials (RCTs) that required interventions for chitosan and its derivative dressings and included endpoints associated with wound healing. In summary, five RCTs (N = 319) were included in the final analysis.Only two RCTS (40%) reported significant beneficial effects of chitosan on wound healing compared with conventional gauze dressings. The remaining three studies reported that chitosan had no significant effect on clinical wound healing compared with other biological dressings.Although the number of trials of new chitosan dressings has been increasing, studies on the relationship between chitosan and wound healing have been limited. Current data suggest that chitosan does not slow wound healing. However, the small number of available trials restricted the adequate interpretation of the existing results. Future research needs to be rigorously designed to confirm the effect of chitosan in clinical wound healing.