Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer.

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Metastatic castration-resistant prostate cancer remains fatal despite recent advances. Prostate-specific membrane antigen (PSMA) is highly expressed in metastatic castration-resistant prostate cancer. Lutetium-177 (177Lu)-PSMA-617 is a radioligand therapy that delivers beta-particle […]

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Randomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia.

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Observational studies have shown that fetoscopic endoluminal tracheal occlusion (FETO) has been associated with increased survival among infants with severe pulmonary hypoplasia due to isolated congenital diaphragmatic hernia on the […]

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Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma.

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The role of adjuvant treatment in high-risk muscle-invasive urothelial carcinoma after radical surgery is not clear.In a phase 3, multicenter, double-blind, randomized, controlled trial, we assigned patients with muscle-invasive urothelial […]

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Final Report of a Trial of Intensive versus Standard Blood-Pressure Control.

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In a previously reported randomized trial of standard and intensive systolic blood-pressure control, data on some outcome events had yet to be adjudicated and post-trial follow-up data had not yet […]

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Physical Rehabilitation for Older Patients Hospitalized for Heart Failure.

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Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poor quality of life, delayed recovery, and frequent rehospitalizations. Interventions to address physical frailty […]

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