Sotatercept for the Treatment of Pulmonary Arterial Hypertension.

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Pulmonary arterial hypertension is characterized by pulmonary vascular remodeling, cellular proliferation, and poor long-term outcomes. Dysfunctional bone morphogenetic protein pathway signaling is associated with both hereditary and idiopathic subtypes. Sotatercept, […]

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Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria.

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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease characterized by chronic complement-mediated hemolysis. C5 inhibition controls intravascular hemolysis in untreated PNH but cannot address extravascular hemolysis. Pegcetacoplan, a pegylated […]

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Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.

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Genomic analysis is essential for risk stratification in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Whole-genome sequencing is a potential replacement for conventional cytogenetic and sequencing approaches, […]

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A Pragmatic, Randomized Clinical Trial of Gestational Diabetes Screening.

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Gestational diabetes mellitus is common and is associated with an increased risk of adverse maternal and perinatal outcomes. Although experts recommend universal screening for gestational diabetes, consensus is lacking about […]

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A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis.

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Infection and increased systemic inflammation cause organ dysfunction and death in patients with decompensated cirrhosis. Preclinical studies provide support for an antiinflammatory role of albumin, but confirmatory large-scale clinical trials […]

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Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.

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The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adult […]

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Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia.

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Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal antibody against the interleukin-6 receptor, has resulted in better […]

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Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia.

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The muscarinic receptor agonist xanomeline has antipsychotic properties and is devoid of dopamine receptor-blocking activity but causes cholinergic adverse events. Trospium is a peripherally restricted muscarinic receptor antagonist that reduces […]

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