Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer.

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Osimertinib is standard-of-care therapy for previously untreated epidermal growth factor receptor (EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC). The efficacy and safety of osimertinib as adjuvant therapy are unknown.In this […]

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Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer.

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We previously reported that olaparib led to significantly longer imaging-based progression-free survival than the physician’s choice of enzalutamide or abiraterone among men with metastatic castration-resistant prostate cancer who had qualifying […]

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Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma.

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Platinum-based chemotherapy is standard-of-care first-line treatment for advanced urothelial carcinoma. However, progression-free survival and overall survival are limited by chemotherapy resistance.In a phase 3 trial, we randomly assigned patients with […]

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Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis.

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The efficacy and safety of combination therapy with eflornithine and sulindac, as compared with either drug alone, in delaying disease progression in patients with familial adenomatous polyposis are unknown.We evaluated […]

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Nonmetastatic, Castration-Resistant Prostate Cancer and Survival with Darolutamide.

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Darolutamide is a structurally distinct androgen-receptor inhibitor that is approved for the treatment of nonmetastatic, castration-resistant prostate cancer. In the planned primary analysis of a phase 3 trial, the median […]

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Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis.

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Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease characterized by progressive surfactant accumulation and hypoxemia. It is caused by disruption of granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling, which pulmonary alveolar […]

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Phase 1-2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine.

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NVX-CoV2373 is a recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike glycoproteins and Matrix-M1 adjuvant.We initiated a randomized, placebo-controlled, phase 1-2 trial […]

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A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes.

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A closed-loop system of insulin delivery (also called an artificial pancreas) may improve glycemic outcomes in children with type 1 diabetes.In a 16-week, multicenter, randomized, open-label, parallel-group trial, we assigned, […]

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Drug-Coated Balloons for Dysfunctional Dialysis Arteriovenous Fistulas.

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Standard percutaneous transluminal angioplasty is the current recommended treatment for dysfunctional hemodialysis fistulas, yet long-term outcomes of this treatment are poor. Drug-coated balloons delivering the antirestenotic agent paclitaxel may improve […]

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Drug-Coated Balloons for Dysfunctional Dialysis Arteriovenous Fistulas.

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Standard percutaneous transluminal angioplasty is the current recommended treatment for dysfunctional hemodialysis fistulas, yet long-term outcomes of this treatment are poor. Drug-coated balloons delivering the antirestenotic agent paclitaxel may improve […]

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