VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome was recently discovered in 25 men with late-onset severe and refractory inflammatory syndromes and associated hematologic abnormalities. Various diseases have been described, […]» Read more
For the first time, to our knowledge, we present the case of a child with simultaneous occurrence of a C3-glomerulopathy and an anterior uveitis complicated with severe band keratopathy (BK). […]» Read more
Rheumatoid nodule1, one of the most characteristic manifestations of rheumatoid arthritis (RA), occurs in approximately 30% of patients, is generally associated with positive rheumatoid factor, smoking, and high disease activity2, […]» Read more
Canadian Rheumatologists’ Perspectives on Moderate Psoriatic Arthritis and Oligoarticular Psoriatic Arthritis.
Psoriatic arthritis (PsA) substantially impairs quality of life. Clinical trials generally focus on polyarticular PsA, but less is known about the assessment and management of oligoarticular and moderate PsA. An […]» Read more
The 75th Annual Meeting of The Canadian Rheumatology Association was held virtually on February 24-26, 2021. The program consisted of presentations covering original research, symposia, awards, and lectures. View the […]» Read more
Canadian Rheumatology Association recommendation for the use of COVID-19 vaccination for patients with autoimmune rheumatic diseases.
To develop guidance on the use of COVID-19 vaccines in patients with autoimmune rheumatic diseases (ARD).The Canadian Rheumatology Association (CRA) formed a multidisciplinary panel including rheumatologists, researchers, methodologists, vaccine experts […]» Read more
Colchicine has been considered a life-long therapy for Familial Mediterranean fever (FMF). Recent studies describe patients who discontinued colchicine, but data pertaining to predictors of success were not provided. The […]» Read more
Gastrointestinal adverse drug reaction profile of etanercept: real world data from patients and healthcare professionals.
We aimed to describe the nature and frequency of gastrointestinal adverse drug reactions (GI-ADRs) of etanercept (ETN) using patient-reported and healthcare professional (HCP)-registered data and compared this frequency with the […]» Read more
Majeed syndrome – Five cases with novel mutations from unrelated families in India with a review of literature.
Chronic recurrent multifocal osteomyelitis (CRMO) (OMIM # 259680) is a common genetically heterogenous autoinflammatory disease of the bone, first described in 1972 (1) with the typical mean age at diagnosis […]» Read more
Measuring physical function in psoriatic arthritis: comparing the Multi-Dimensional Health Assessment Questionnaire to the Health Assessment Questionnaire Disability Index.
To compare physical function scales of the Multi-Dimensional Health Assessment Questionnaire (MDHAQ) to the Health Assessment Questionnaire Disability Index (HAQDI) in patients with psoriatic arthritis (PsA), and examine whether either […]» Read more
Patient perspectives on outcome domains of medication adherence trials in inflammatory arthritis: an international OMERACT focus group study.
To describe the perspectives of patients with inflammatory arthritis (IA) on outcome domains of trials evaluating medication adherence interventions.Adult patients (≥18 years) with IA using disease-modifying anti-rheumatic drugs (DMARDs) from […]» Read more
Supporting Equity in Rheumatoid Arthritis Outcomes in Canada: Population-Specific Factors in Patient-Centered Care.
Health equity considerations have not been incorporated into prior Canadian Rheumatology Association guidelines. Our objective was to identify the challenges and possible solutions to mitigate threats to health equity in […]» Read more
Systemic sclerosis (SSc) is a multisystem disease with heterogeneity in presentation and prognosis. An international collaboration to develop new SSc subset criteria is underway. Our objectives were to identify systems […]» Read more
Systematic review and meta-analysis of the reproducibility of patient self-reported joint counts in rheumatoid arthritis.
To assess the reproducibility of patient-reported tender and swollen joint counts of RA patients compared to trained clinicians.We conducted a systematic literature review and meta-analysis of studies comparing patient-reported tender […]» Read more
Pooled Safety Results Through One Year of Two Phase-3 Trials of Guselkumab in Patients with Psoriatic Arthritis.
Evaluate safety of guselkumab (monoclonal antibody targeting IL-23p19) in psoriatic arthritis (PsA) patients through 1year (1Y) of the Phase-3 DISCOVER-1&2 trials.Patients with active PsA (N=1120; biologic-naïve except the118 TNFi-treated DISCOVER-1 […]» Read more
Predicting Response to Tocilizumab Monotherapy in Rheumatoid Arthritis: A Real-World Data Analysis Using Machine Learning.
Tocilizumab (TCZ) had similar efficacy when used as monotherapy or in combination with other treatments for rheumatoid arthritis (RA) in randomized controlled trials (RCT). We derived a remission prediction score […]» Read more
Safety of the Methotrexate-leflunomide Combination in Rheumatoid Arthritis: Results of a Multicentric, Registry-based, Cohort Study (Biobadabrasil).
To evaluate the safety of the methotrexate (MTX)-leflunomide (LEF) combination in rheumatoid arthritis (RA), comparing it with other therapeutic schemes involving conventional synthetic (cs-) and biologic (b-) disease modifying anti-rheumatic […]» Read more
Changes in Treatments and Outcomes After Implementation of a National Universal Access Program for Juvenile Idiopathic Arthritis.
To evaluate the clinical and demographic characteristics of patients with juvenile idiopathic arthritis (JIA) in Chile and compare treatments and outcomes before and after the introduction in 2010 of the […]» Read more
Correlation between Subjective and Objective Severity of Oral and Ocular Dryness in Primary Sjögren’s Syndrome.
Sjögren’s Syndrome is a common, autoimmune disease primarily affecting the eyes and mouth. With no single gold standard test for its diagnosis, accurate identification of patients with Sjögren’s Syndrome continues […]» Read more
Due to the recent pandemic, in person scheduled rheumatology appointments in many countries have been reserved for urgent cases only. Here we report the development of a multidimensional, patient completed […]» Read more
Impact of coping strategies on patient and physician perceptions of disease severity and disability in systemic sclerosis.
Systemic sclerosis (SSc) results in impaired function, disability, and reduced health-related quality of life (HRQL). We investigated the impact of coping strategies on the patient global assessment of health (PtGA) […]» Read more
Comparison of Men and Women With Axial Spondyloarthritis in the US-Based Corrona Psoriatic Arthritis/Spondyloarthritis Registry.
To compare patient characteristics and disease burden between men and women with axial spondyloarthritis (axSpA) in the US-based Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry.Patients aged ≥18 years with axSpA enrolled in […]» Read more
Development and Validation of Three Preliminary MRI Sacroiliac Joint Composite Structural Damage Scores in a 5-year Longitudinal Axial Spondyloarthritis Study.
In axial spondyloarthritis (axSpA), sacroiliac joint (SIJ) erosion is often followed by fat metaplasia in an erosion cavity (backfill), and subsequently ankylosis. We aimed to combine Spondyloarthritis Research Consortium of […]» Read more
Effects of denosumab in Japanese rheumatoid arthritis patients treated with conventional anti-rheumatic drugs: 36-month extension of a phase 3 study.
To evaluate safety and efficacy of long-term denosumab 60 mg every 6 (Q6M) or 3 months (Q3M) in rheumatoid arthritis (RA) patients.This 12-month, randomised, double-blind, placebo-controlled, multicentre phase 3 trial […]» Read more
Delays in the diagnosis and treatment of psoriatic arthritis (PsA) are common. These delays contribute to impairments in quality of life and joint damage. This study aims to calculate the […]» Read more
Test-retest reliability for HAQ-DI and SF-36 PF for the measurement of physical function in psoriatic arthritis.
Due to no existing data, we aimed to derive evidence to support test-retest reliability for the Health Assessment Questionnaire-Disability Index (HAQ-DI) and Medical Outcome Survey Short-Form-36 item physical functioning domain […]» Read more
To evaluate the association between ethnicity and neonatal lupus erythematosus (NLE), as well as specific NLE manifestations in a large multi-ethnic population.We conducted a cohort study of the children (≤1 […]» Read more
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) held a trainee symposium at its 2020 virtual meeting. Dermatology and rheumatology trainees presented their work on psoriasis […]» Read more
Reviewing disease activity indices in spondyloarthritis from the gender perspective: A systematic review and meta-analysis.
To determine whether the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Ankylosing Spondylitis Disease Activity Score (ASDAS) exhibited differences between women and men.We systematically searched MEDLINE, Embase, Web […]» Read more
Systemic Sclerosis and Associated Interstitial Lung Disease in Ontario, Canada: An Examination of Prevalence and Survival Over 10 Years.
Systemic sclerosis (SSc) is a rare autoimmune disease. Pulmonary complications of SSc are one of the leading causes of morbidity and mortality. The objective of this study was to determine […]» Read more