Increased salience network connectivity following manual therapy is associated with reduced pain in chronic low back pain patients.

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Chronic low back pain (cLBP) has been associated with changes in brain plasticity. Non-pharmacological therapies such as Manual Therapy (MT) have shown promise for relieving cLBP. However, translational neuroimaging research […]

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OPTIMIZATION OF SPINAL MANIPULATIVE THERAPY PROTOCOLS: A FACTORIAL RANDOMIZED TRIAL WITHIN A MULTIPHASE OPTIMIZATION FRAMEWORK.

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Spinal manipulative therapy (SMT) is a common nonpharmacologic treatment for low back pain (LBP). Although generally supported by systematic reviews and practice guidelines, clinical trials evaluating SMT have been characterized […]

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Transcutaneous Electric Nerve Stimulation reduces acute postoperative pain and analgesic use after open inguinal hernia surgery: a randomized, double-blind, placebo-controlled trial.

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In this randomized, double-blind, placebo-controlled trial, we evaluated the role of transcutaneous electrical nerve stimulation (TENS) in the multimodal treatment (non-opioid analgesics and kinesiotherapy) of postoperative pain following open inguinal […]

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Cross-sectional study of prevalence, characterization and impact of chronic pain disorders in workers.

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Chronic pain prevention and treatment constitute a challenge for occupational health. The aim of this study was to provide data on workers in a variety of jobs and multiple contexts […]

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Transcranial direct current stimulation of the dorsolateral prefrontal cortex alters emotional modulation of spinal nociception.

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Emotion has a strong modulatory effect on pain perception and spinal nociception. Pleasure inhibits pain and nociception, whereas displeasure facilitates pain and nociception. Dysregulation of this system has been implicated […]

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Involvement of TACAN, a mechanotransducing ion channel, in inflammatory but not neuropathic hyperalgesia in the rat.

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TACAN (Tmem120A), a mechanotransducing ion channel highly expressed in a subset of nociceptors, has recently been shown to contribute to detection of noxious mechanical stimulation. In the present study we […]

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A cost-effectiveness analysis of an internet-delivered pain management program delivered with different levels of clinician support: Results from a randomised controlled trial.

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There is growing interest in the potential of internet-delivered pain management programs (PMPs) to increase access to care for people with chronic pain. However, very few economic evaluations of these […]

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Analgesic Effects of Topical Amitriptyline in Patients with Chemotherapy-Induced Peripheral Neuropathy: Mechanistic Insights from Studies in Mice.

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Oral amitriptyline hydrochloride (amitriptyline) is ineffective against some forms of chronic pain and is often associated with dose-limiting adverse events. We evaluated the potential effectiveness of high-dose topical amitriptyline in […]

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Longitudinal transcriptomic profiling in carrageenan-induced rat hind paw peripheral inflammation and hyperalgesia reveals progressive recruitment of innate immune system components.

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Pain is a common but potentially debilitating symptom, often requiring complex management strategies. To understand the molecular dynamics of peripheral inflammation and nociceptive pain, we investigated longitudinal changes in behavior, […]

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II. Indices of Pain Intensity Derived From Ecological Momentary Assessments and Their Relationships With Patient Functioning: An Individual Patient Data Meta-analysis.

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Pain intensity is a complex and dynamic experience. A focus on assessing patients’ average pain levels may miss important aspects of pain that impact functioning in daily life. In this […]

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Assessment of Chronic Pain Management in the Treatment of Opioid Use Disorder: Gaps in Care and Implications for Treatment Outcomes.

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Chronic pain is a significant comorbid condition among individuals with opioid use disorder (OUD). However, due to conflicting perceptions of responsibility, structural barriers, and a lack of widely applied standards […]

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III. Detecting Treatment Effects in Clinical Trials With Different Indices of Pain Intensity Derived From Ecological Momentary Assessment.

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Pain intensity represents the primary outcome in most pain clinical trials. Identifying methods to measure aspects of pain that are most sensitive to treatment may facilitate discovery of effective interventions. […]

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Does Threat Enlarge Nociceptive Reflex Receptive Fields?

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Threat-induced pain modulation can increase survival by amplifying physiological and behavioral reactions towards danger. Threat can also modulate spinal nociception, suggesting engagement of endogenous top-down circuitry. A unique method to […]

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Prior pain exposure and mere possession of a placebo analgesic predict placebo analgesia: Findings from a randomised, double-blinded, controlled trial.

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A recent study found that merely possessing a placebo analgesic reduces pain. The current study tested for a possible moderator of this effect. Specifically, does the mere possession of a […]

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Investigating the true effect of psychological variables measured prior to arthroplastic surgery on post-surgical outcomes: a p-curve analysis.

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Patients’ pre-surgical psychological profiles have been posited to predict pain and function following arthroplastic surgery of the hip and knee. Nevertheless, findings are conflicting, and this may be rooted in […]

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Pain Intensity as a Lagging Indicator of Patient Improvement: Longitudinal Relationships with Sleep, Psychiatric Distress, and Function in Multidisciplinary Care.

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Despite a common assumption that reductions in chronic pain intensity must precede improvements in other pain-relevant domains, there has been limited empirical inquiry into the temporal ordering of improvements in […]

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Median nerve stimulation as a non-pharmacological approach to bypass analgesic tolerance to morphine: a proof-of-concept study in mice.

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Analgesic tolerance to opioids contributes to the opioid crisis by increasing the quantity of opioids prescribed and consumed. Thus, there is a need to develop non-opioid-based pain-relieving regimens as well […]

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Molecular pathways linking oxylipins to nociception in rats.

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Oxylipins are lipid peroxidation products that participate in nociceptive, inflammatory, and vascular responses to injury. Effects of oxylipins depend on tissue-specific differences in accumulation of precursor polyunsaturated fatty acids and […]

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CHRONIC OPIOID THERAPY: A SCOPING LITERATURE REVIEW ON EVOLVING CLINICAL AND SCIENTIFIC DEFINITIONS.

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The management of chronic non-cancer pain (CNCP) with Chronic Opioid Therapy (COT) is controversial. There is a lack of consensus on how COT is defined resulting in unclear clinical guidance. […]

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I. Indices of Pain Intensity derived from Ecological Momentary Assessments: Rationale and Stakeholder Preferences.

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Pain assessment that fully represents patients’ pain experiences is essential for chronic pain research and management. The traditional primary outcome measure has been a patient’s average pain intensity over a […]

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Transcranial direct current stimulation accelerates the onset of exercise-induced hypoalgesia: a randomised controlled study.

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Exercise-induced hypoalgesia (EIH) describes acute reductions in pain that occur following exercise. Current evidence suggests that the magnitude of EIH is small-to-moderate at best, warranting exploration of novel avenues to […]

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Altered brainstem pain modulating circuitry functional connectivity in chronic painful Temporomandibular Disorder.

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Evidence in preclinical models of chronic pain and human psychophysical investigations has suggested that alterations in endogenous brainstem pain-modulation circuit functioning are critical for the initiation and maintenance of pain. […]

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Chronic Pain and Premature Aging – The Moderating Role of Physical Exercise.

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Chronic pain induces a multitude of harmful effects; recently it has been suggested that chronic pain is also associated with premature aging, manifested in shortened telomere length (TL). However, evidence […]

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The Time Course of Facial Expression Recognition Using Spatial Frequency Information: Comparing Pain and Core Emotions.

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We are able to recognise others’ experience of pain from their facial expressions. However, little is known about what makes the recognition of pain possible and whether it is similar […]

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Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain.

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The management of persistent postsurgical pain and neuropathic pain remains a challenge in the clinic. Local anesthetics have been widely used as simple and effective treatment for these two disorders, […]

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DACC Resting State Functional Connectivity as a Predictor of Pain Symptoms Following Motor Vehicle Crash: A Preliminary Investigation.

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There is significant heterogeneity in pain outcomes following motor vehicle crashes (MVCs), such that a sizeable portion of individuals develop symptoms of chronic pain months after injury while others recover. […]

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Acceptance and Commitment Therapy for Primary Headache Sufferers: A Randomized Controlled Trial of Efficacy.

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Prevention of headaches via avoidance of triggers remains the main behavioral treatment suggestion for headache management despite trigger avoidance resulting in increases in potency, lifestyle restrictions, internal locus of control […]

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Predictors of Mucosal and Muscle Pain in Vulvodynia: A Cross-Sectional Analysis from the National Vulvodynia Registry.

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Diagnostic criteria for provoked vestibulodynia (PVD) rely on mucosal pain in the vulvar vestibule, with less emphasis on pain from pelvic floor muscles. It is unknown how psychosocial variables associated […]

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Transcranial direct current stimulation and visual illusion effect according to sensory phenotypes in patients with spinal cord injury and neuropathic pain.

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Treatment of neuropathic pain (NP) in patients with spinal cord injury (SCI) remains a major challenge. The aim of the present study is to investigate if the effect of transcranial […]

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