A Genomewide Pharmacogenetic Study of Growth Hormone Responsiveness.

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Individual patients vary in their response to growth hormone (GH). No large scale genomewide studies have looked for genetic predictors of GH responsiveness.To identify genetic variants associated with GH responsiveness.Genomewide […]

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The immune profile of pituitary adenomas and a novel immune classification for predicting immunotherapy responsiveness.

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The tumor immune microenvironment is associated with clinical outcomes and immunotherapy responsiveness.To investigate the intratumoral immune profile of pituitary adenomas (PAs) and its clinical relevance and to explore a novel […]

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Distinct Phenotypes of Islet Antigen-specific CD4+ T Cells among the Three Subtypes of Type 1 Diabetes.

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Type 1 diabetes (T1D) is classified into three subtypes: acute onset (AT1D), slowly progressive (SP1D), and fulminant (FT1D). The differences in the type of cellular autoimmunity within each subtype remain […]

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Decline in muscle strength and performance predicts fracture risk in elderly women and men.

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Muscle strength and performance are associated with fractures. However, the contribution of their rate of decline is unclear.To assess the independent contribution of the rate of decline in muscle strength […]

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Primary care provider involvement in thyroid cancer survivorship care.

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To understand PCP involvement and confidence in thyroid cancer survivorship care.Setting/Participants: We surveyed PCPs identified by thyroid cancer patients from the Georgia and LA SEER registries (n=162, response rate 56%). […]

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Frailty in patients with mild autonomous cortisol secretion is higher than in patients with nonfunctioning adrenal tumors.

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Mild autonomous cortisol secretion (MACS) affects up to 50% of patients with adrenal adenomas. Frailty is a syndrome characterized by the loss of physiological reserves and an increase in vulnerability, […]

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Vitamin D status and risk of all-cause and cause-specific mortality in a large cohort: results from the UK Biobank.

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Although an inverse association between vitamin D status and mortality has been reported in observational studies, the precise association shape and optimal vitamin D status remain undetermined.To investigate the association […]

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Pregnancy per- and polyfluoroalkyl substance concentrations and postpartum health in Project Viva, a prospective cohort.

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Per- and polyfluoroalkyl substances (PFAS) are environmental chemicals linked to weight gain and type 2 diabetes.We examined the extent to which PFAS plasma concentrations during pregnancy were associated with postpartum […]

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Role of a novel angiogenesis FKBPL-CD44 pathway in preeclampsia risk stratification and mesenchymal stem cell treatment.

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Preeclampsia is a leading cardiovascular complication in pregnancy lacking effective diagnostic and treatment strategies.To investigate the diagnostic and therapeutic potential of the angiogenesis markers, FKBPL-CD44, in preeclampsia pathogenesis.FKBPL and CD44 […]

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Osteosarcopenia in reproductive-aged women with polycystic ovary syndrome: a multicenter case-control study.

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Osteosarcopenia (loss of skeletal muscle and bone mass and/or function usually associated with aging) shares pathophysiological mechanisms with polycystic ovary syndrome (PCOS). However, the relationship between osteosarcopenia and PCOS remains […]

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Estrone is a strong predictor of circulating estradiol in women aged 70 years and older.

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After menopause estradiol (E2) is predominately an intracrine hormone circulating in very low serum concentrations.To examine determinants of E2 concentrations in women beyond 70 years.A cross-sectional, community based, study.5325 women, […]

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The vicious circle of left ventricular dysfunction and diabetes: from pathophysiology to emerging treatments.

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Diabetes and heart failure (HF) are two deadly and strictly related epidemic disorders. Aim of this review is to present an updated discussion of the epidemiology, pathophysiology, clinical presentation and […]

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Glucocorticoid excess in patients with pheochromocytoma compared to paraganglioma and other forms of hypertension.

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Catecholamines and adrenocortical steroids are important regulators of blood pressure. Bidirectional relationships between adrenal steroids and catecholamines have been established but whether this is relevant to patients with pheochromocytoma is […]

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Reduced Calcium Sensing Receptor (CaSR) Expression is Epigenetically Deregulated in Parathyroid Adenomas.

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Reduced CaSR expression has been implicated in parathyroid tumorigenesis but the underlying mechanism remains elusive. Accordingly, we aimed to explore the epigenetic changes (DNA methylation and histone modifications) involved in […]

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Normal Insulin-Like Growth Factor 1 During Somatostatin Receptor Ligand Treatment Predicts Surgical Cure in Acromegaly.

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Treatment with somatostatin receptor ligands (SRLs) is often given before pituitary surgery to patients with acromegaly.To study whether the response to treatment with.SRLs is predictive of surgical outcome.Retrospective, observational study.Tertiary […]

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Newborn screening TSH values <15 mIU/L are not associated with long-term hypothyroidism or cognitive impairment.

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It is unclear whether newborns with mild TSH elevation (mTSHe) are at risk of neurocognitive impairment. We assessed whether mTSHe at birth persists during childhood and compared neurocognitive functioning to […]

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Co-administration of 5α-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids.

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Glucocorticoids (GC) are commonly prescribed, but their use is associated with adverse metabolic effects. 5a-reductase inhibitors (5aRI) are also frequently prescribed, mainly to inhibit testosterone conversion to dihydrotestosterone. However, they […]

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Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility?

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Implantation is a reproductive bottleneck in women, regulated by fluctuations in ovarian steroid hormone concentrations. However, other nuclear receptor ligands are modifiers of endometrial differentiation leading to successful pregnancy. In […]

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Effects of Hormone Replacement Therapy on Bone Mass after Allogeneic Hematopoietic Stem Cell Transplantation.

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This study aimed to assess the effects of hormone replacement therapy (HRT) on bone mineral density (BMD) in young females who underwent allogeneic hematopoietic stem cell transplantation (HSCT).The retrospective cohort […]

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Prostate cancer incidence under androgen deprivation: nationwide cohort study in trans women receiving hormone treatment.

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Trans women (male sex assigned at birth, female gender identity) mostly use anti-androgens combined with estrogens and can subsequently undergo vaginoplasty including orchiectomy. Because the prostate remains in situ after […]

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Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test.

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The Short Synacthen Test (SST) is the gold standard for diagnosing adrenal insufficiency. It requires invasive administration of Synacthen, venous sampling, and is resource-intensive.To develop a nasally administered SST, with […]

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The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility.

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To describe the prevalence of and factors associated with different thyroid dysfunction phenotypes in women who are asymptomatic preconception.Observational cohort study.A total of 49 hospitals across the United Kingdom between […]

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Disease control and gender predict the socioeconomic effects of acromegaly: a nationwide cohort study.

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To study the socioeconomic status in acromegaly in a population-based follow-up study.All incident cases of acromegaly (n=576) during the period 1977-2010 were included. For every patient, 100 persons were sampled […]

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