Individual patients vary in their response to growth hormone (GH). No large scale genomewide studies have looked for genetic predictors of GH responsiveness.To identify genetic variants associated with GH responsiveness.Genomewide […]» Read more
The immune profile of pituitary adenomas and a novel immune classification for predicting immunotherapy responsiveness.
The tumor immune microenvironment is associated with clinical outcomes and immunotherapy responsiveness.To investigate the intratumoral immune profile of pituitary adenomas (PAs) and its clinical relevance and to explore a novel […]» Read more
Distinct Phenotypes of Islet Antigen-specific CD4+ T Cells among the Three Subtypes of Type 1 Diabetes.
Type 1 diabetes (T1D) is classified into three subtypes: acute onset (AT1D), slowly progressive (SP1D), and fulminant (FT1D). The differences in the type of cellular autoimmunity within each subtype remain […]» Read more
Muscle strength and performance are associated with fractures. However, the contribution of their rate of decline is unclear.To assess the independent contribution of the rate of decline in muscle strength […]» Read more
To understand PCP involvement and confidence in thyroid cancer survivorship care.Setting/Participants: We surveyed PCPs identified by thyroid cancer patients from the Georgia and LA SEER registries (n=162, response rate 56%). […]» Read more
Adrenal insufficiency requires lifelong corticoid replacement therapies. However, current therapies are not able to replace the physiological circadian pattern of the adrenal cortex and are associated with many metabolic, vascular, […]» Read more
Frailty in patients with mild autonomous cortisol secretion is higher than in patients with nonfunctioning adrenal tumors.
Mild autonomous cortisol secretion (MACS) affects up to 50% of patients with adrenal adenomas. Frailty is a syndrome characterized by the loss of physiological reserves and an increase in vulnerability, […]» Read more
Vitamin D status and risk of all-cause and cause-specific mortality in a large cohort: results from the UK Biobank.
Although an inverse association between vitamin D status and mortality has been reported in observational studies, the precise association shape and optimal vitamin D status remain undetermined.To investigate the association […]» Read more
Recent studies discovered a role of apolipoprotein M (apoM) in energy metabolism, and observational analyses in humans suggest an association with type 2 diabetes. The causal relationship remained however elusive.To […]» Read more
The effect of diet on insulin resistance (IR) in polycystic ovary syndrome (PCOS) is controversial. Thus, we conducted this systematic review and meta-analysis to evaluate whether diet could reduce IR […]» Read more
Pregnancy per- and polyfluoroalkyl substance concentrations and postpartum health in Project Viva, a prospective cohort.
Per- and polyfluoroalkyl substances (PFAS) are environmental chemicals linked to weight gain and type 2 diabetes.We examined the extent to which PFAS plasma concentrations during pregnancy were associated with postpartum […]» Read more
Role of a novel angiogenesis FKBPL-CD44 pathway in preeclampsia risk stratification and mesenchymal stem cell treatment.
Preeclampsia is a leading cardiovascular complication in pregnancy lacking effective diagnostic and treatment strategies.To investigate the diagnostic and therapeutic potential of the angiogenesis markers, FKBPL-CD44, in preeclampsia pathogenesis.FKBPL and CD44 […]» Read more
It is well recognized that some hypothyroid patients on levothyroxine (LT4) remain symptomatic, but why patients are susceptible to this condition, why symptoms persist and what is the role of […]» Read more
Osteosarcopenia in reproductive-aged women with polycystic ovary syndrome: a multicenter case-control study.
Osteosarcopenia (loss of skeletal muscle and bone mass and/or function usually associated with aging) shares pathophysiological mechanisms with polycystic ovary syndrome (PCOS). However, the relationship between osteosarcopenia and PCOS remains […]» Read more
After menopause estradiol (E2) is predominately an intracrine hormone circulating in very low serum concentrations.To examine determinants of E2 concentrations in women beyond 70 years.A cross-sectional, community based, study.5325 women, […]» Read more
Burgeoning evidence over the last 25 years has identified myriad synthetic chemicals with the capacity to alter various aspects of hormone synthesis and action. These endocrine-disrupting chemicals (EDCs) have been […]» Read more
The vicious circle of left ventricular dysfunction and diabetes: from pathophysiology to emerging treatments.
Diabetes and heart failure (HF) are two deadly and strictly related epidemic disorders. Aim of this review is to present an updated discussion of the epidemiology, pathophysiology, clinical presentation and […]» Read more
Glucocorticoid excess in patients with pheochromocytoma compared to paraganglioma and other forms of hypertension.
Catecholamines and adrenocortical steroids are important regulators of blood pressure. Bidirectional relationships between adrenal steroids and catecholamines have been established but whether this is relevant to patients with pheochromocytoma is […]» Read more
Reduced Calcium Sensing Receptor (CaSR) Expression is Epigenetically Deregulated in Parathyroid Adenomas.
Reduced CaSR expression has been implicated in parathyroid tumorigenesis but the underlying mechanism remains elusive. Accordingly, we aimed to explore the epigenetic changes (DNA methylation and histone modifications) involved in […]» Read more
Normal Insulin-Like Growth Factor 1 During Somatostatin Receptor Ligand Treatment Predicts Surgical Cure in Acromegaly.
Treatment with somatostatin receptor ligands (SRLs) is often given before pituitary surgery to patients with acromegaly.To study whether the response to treatment with.SRLs is predictive of surgical outcome.Retrospective, observational study.Tertiary […]» Read more
Newborn screening TSH values <15 mIU/L are not associated with long-term hypothyroidism or cognitive impairment.
It is unclear whether newborns with mild TSH elevation (mTSHe) are at risk of neurocognitive impairment. We assessed whether mTSHe at birth persists during childhood and compared neurocognitive functioning to […]» Read more
Co-administration of 5α-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids.
Glucocorticoids (GC) are commonly prescribed, but their use is associated with adverse metabolic effects. 5a-reductase inhibitors (5aRI) are also frequently prescribed, mainly to inhibit testosterone conversion to dihydrotestosterone. However, they […]» Read more
Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility?
Implantation is a reproductive bottleneck in women, regulated by fluctuations in ovarian steroid hormone concentrations. However, other nuclear receptor ligands are modifiers of endometrial differentiation leading to successful pregnancy. In […]» Read more
Inferior petrosal sinus sampling (IPSS) is used to diagnose Cushing’s disease (CD) when dexamethasone-suppression and CRH tests, and pituitary MRI, are negative or give discordant results. However, IPSS is an […]» Read more
Effects of Hormone Replacement Therapy on Bone Mass after Allogeneic Hematopoietic Stem Cell Transplantation.
This study aimed to assess the effects of hormone replacement therapy (HRT) on bone mineral density (BMD) in young females who underwent allogeneic hematopoietic stem cell transplantation (HSCT).The retrospective cohort […]» Read more
Prostate cancer incidence under androgen deprivation: nationwide cohort study in trans women receiving hormone treatment.
Trans women (male sex assigned at birth, female gender identity) mostly use anti-androgens combined with estrogens and can subsequently undergo vaginoplasty including orchiectomy. Because the prostate remains in situ after […]» Read more
We have searched the literature for information on the risk of breast cancer (BC) in relation to gender, breast development and gonadal function in the following eight populations: 1) Females […]» Read more
Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test.
The Short Synacthen Test (SST) is the gold standard for diagnosing adrenal insufficiency. It requires invasive administration of Synacthen, venous sampling, and is resource-intensive.To develop a nasally administered SST, with […]» Read more
The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility.
To describe the prevalence of and factors associated with different thyroid dysfunction phenotypes in women who are asymptomatic preconception.Observational cohort study.A total of 49 hospitals across the United Kingdom between […]» Read more
Disease control and gender predict the socioeconomic effects of acromegaly: a nationwide cohort study.
To study the socioeconomic status in acromegaly in a population-based follow-up study.All incident cases of acromegaly (n=576) during the period 1977-2010 were included. For every patient, 100 persons were sampled […]» Read more