Effectiveness and Safety of Thermal Ablation in the Treatment of Primary Hyperparathyroidism: A Multicenter Study.

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To evaluate the effectiveness and safety of thermal ablation for primary hyperparathyroidism (pHPT).From January 2015 to March 2020, data pertaining to patients who received thermal ablation for pHPT at 4 […]

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Properly collected plasma metanephrines excludes PPGL after false positive screening tests.

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False positive results are common for pheochromocytoma/paraganglioma(PPGL) real-world screening.Determine the correlation between screening urine and seated plasma metanephrines in outpatients where PPGL was absent, compared to meticulously prepared and supine-collected […]

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Adolescent Tri-ponderal Mass Index Growth Trajectories and Incident Diabetes Mellitus in Early Adulthood.

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Studies have reported the influence of adolescent obesity on development of adult diabetes, but the effect of the growth pattern during this period has rarely been explored. Also, the tri-ponderal […]

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Clinical practice guidelines on the diagnosis and management of polycystic ovary syndrome: A systematic review and quality assessment study.

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Clinical practice guidelines (CPGs) are key instruments to implement the practice of evidence-based medicine. We aimed to evaluate the methodological quality and variations in CPGs recommendations on the diagnosis and […]

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HDL Containing Apolipoprotein C-III is Associated with Insulin Sensitivity: a Multi-Center Cohort Study.

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HDL in humans is composed of a heterogeneous group of particles varying in protein composition as well as biological effects.We investigated the prospective associations between HDL subspecies containing and lacking […]

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Preoperative amlodipine is efficacious in preventing intraoperative HDI in pheochromocytoma- pilot RCT.

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Preoperative blockade with α-blockers is recommended in patients with pheochromocytoma/paraganglioma (PPGL). The data on calcium channel blockade (CCB) in PPGL is scarce. We aimed to compare the efficacy of CCB […]

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New Horizons -Addressing Healthcare Disparities in Endocrine Disease: Bias, Science, and Patient Care.

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Unacceptable healthcare disparities in endocrine disease have persisted for decades, and 2021 presents a difficult evolving environment. The COVID-19 pandemic has highlighted the gross structural inequities that drive health disparities, […]

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Predictive value of serum lipid for intravenous immunoglobulin resistance and coronary artery lesion in Kawasaki disease.

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Intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs) prediction are pivotal topic of interests in Kawasaki disease (KD). However, data on the predictive value of lipid profile for both […]

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Clinical and hormonal profiles correlate with molecular characteristics in patients with 11β-hydroxylase deficiency.

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Given the rarity of 11β-hydroxylase deficiency (11βOHD), there is a paucity of data about the differences in clinical and biochemical characteristics of classic (C-11βOHD) and non-classic 11βOHD (NC-11βOHD).To characterize a […]

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Psychological distress and sleep disturbance throughout thyroid nodules screening, diagnosis and treatment.

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Many controversies exist regarding screening and treatment of thyroid cancer (TC), especially papillary thyroid microcarcinoma (PTMC). The aim of this study was to evaluate patients’ psychological distress and sleep disturbance […]

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Maternal adiposity and energy balance after normotensive and preeclamptic pregnancies.

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Preeclampsia is a major pregnancy complication associated with long-term maternal cardiometabolic disease. Research generally is focused on metabolic and pathophysiological changes during pregnancy, however, there is much less focus on […]

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Effect of Leptin Therapy on Survival in Generalized and Partial Lipodystrophy: A Matched Cohort Analysis.

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Data quantifying the impact of metreleptin therapy on survival in nonHIVrelated generalized lipodystrophy (GL) and partial lipodystrophy (PL) are unavailable.This study aimed to estimate the treatment effect of metreleptin on […]

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Plasma Cortisol and Risk of Atrial Fibrillation: A Mendelian Randomization Study.

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Atrial fibrillation (AF), cardiac arrhythmias and related risk factors are common in patients with Cushing’s syndrome, or clinical chronic hypercortisolism. While hypercortisolism may be associated with AF, this association has […]

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Prenatal exposure to bisphenols and phthalates and postpartum depression: The role of neurosteroid hormone disruption.

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Postpartum depression (PPD) is a serious psychiatric disorder. While causes remain poorly understood, perinatal sex hormone fluctuations are an important factor, and allopregnanolone in particular has emerged as a key […]

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A polygenic risk score to predict future adult short stature amongst children.

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Adult height is highly heritable, yet no genetic predictor has demonstrated clinical utility compared to mid-parental height.To develop a polygenic risk score for adult height and evaluate its clinical utility.A […]

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Basal ganglia calcification is associated with local and systemic metabolic mechanisms in adult hypoparathyroidism.

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Hypoparathyroidism is characterized by low serum calcium, increased serum phosphorus, and inappropriately low or decreased serum parathyroid hormone, which may be associated with soft tissue calcification in the basal ganglia […]

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Denosumab reduces lesional Fluoride skeletal burden on Na[18F]F PET-CT in patients with Fibrous Dysplasia/McCune-Albright syndrome.

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The correlation between Fibrous Dysplasia/McCune-Albright syndrome (FD/MAS) skeletal disease burden on Na[18F]F-PET-CT and serum bone turnover markers (BTMs) was recently described. The effect of treatment on lesional fluoride burden in […]

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Exceptionality of Distant Metastases in Node-Negative Hereditary and Sporadic Medullary Thyroid Cancer: Lessons Learned.

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Risk factors of lymph node and distant metastases have rarely been analyzed in hereditary and sporadic medullary thyroid cancer (MTC) using large genetic-clinical data sets.This comprehensive investigation aimed to explore […]

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Population vitamin D stores are increasing in Tasmania and this is associated with less BMD loss over 10 years.

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Vitamin D deficiency is a common, modifiable determinant of musculoskeletal health. There are limited data that examine the longitudinal change in population 25-hydroxyvitamin D (25(OH)D) and none that evaluate the […]

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Recurrence-free survival analysis in locally advanced pheochromocytoma: first appraisal.

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Locally advanced pheochromocytoma (LAP) behavior remains unknown.To characterize this population and its recurrence-free survival (RFS).A retrospective multicentric study run within the ENDOCAN-COMETE network and GTE from 2003 to 2018.11 French […]

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Diminishing value from multiple serial bone densitometry in women receiving anti-resorptive medication for osteoporosis.

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The value of serial bone mineral density (BMD) monitoring while on osteoporosis therapy is controversial.We determined the percentage of women classified as suboptimal-responders to therapy with anti-resorptive medications according to […]

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Bone Material Strength index as measured by Impact Microindentation is low in Patients with Primary Hyperparathyroidism.

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In primary hyperparathyroidism (PHPT) bone mineral density (BMD) is typically decreased in cortical bone and relatively preserved in trabecular bone. An increased fracture rate is observed however not only at […]

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Health-related quality of life in patients with early-detected central congenital hypothyroidism.

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Central congenital hypothyroidism (CH) requires lifelong medical treatment. The majority of children with central CH have multiple pituitary hormone deficiencies (MPHD), but in some cases central CH is isolated. Most […]

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Predictors of Bilateral Disease in Pediatric Differentiated Thyroid Cancer.

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Total thyroidectomy is recommended for children with papillary thyroid carcinoma, partly because of a high prevalence of bilateral disease. Identifying characteristics that predict bilateral disease might identify candidates for more […]

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One year of GH treatment for growth failure in children with anorexia nervosa: a randomized placebo-controlled trial.

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Children with anorexia nervosa (AN) are at risk of adult height deficit due to prolonged low height velocity (HV).To investigate the effects of human growth hormone (GH) injections on HV […]

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