Trends in diabetes medication use in Australia, Canada, England, and Scotland: a repeated cross-sectional analysis in primary care.

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Several new classes of glucose-lowering medications have been introduced in the past two decades. Some, such as sodium-glucose cotransporter 2 inhibitors (SGLT2s), have evidence of improved cardiovascular outcomes, while others, […]

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Prevalence and Predictors of Potentially Inappropriate Prescribing in Middle-Aged Adults: Repeated Cross-Sectional Study.

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Potentially inappropriate prescribing (PIP) is common in older adults and known to be associated with polypharmacy and multimorbidity. Less is known about the prevalence and causes of PIP in middle-aged […]

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Which patients miss appointments with general practice and why? A systematic review.

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Missed GP appointments have considerable time and cost implications for healthcare services.This systematic review aims to explore the rate of missed primary care appointments, what the reported reasons are for […]

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NHS Health Checks: Equity and outcomes 2009-17: An observational study.

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The NHS Health Check cardiovascular prevention programme is now 10 years old.We describe NHS Heath Check attendance, new diagnoses and treatment in relation to equity indicators.Using a national general practice […]

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Nortriptyline for pain in knee osteoarthritis in general practice: a double blind randomised controlled trial.

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Osteoarthritis (OA) of the knee is a common cause of chronic pain. The currently available analgesics have limited efficacy and may be poorly tolerated.To investigate the analgesic efficacy of nortriptyline […]

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The impact of severe mental illness on healthcare use and health outcomes for people with type 2 diabetes.

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People with severe mental illnesses (SMI) have reduced life expectancy compared with the general population. Diabetes is a major contributor to this disparity with higher prevalence and poorer outcomes in […]

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Natural history of non-bullous impetigo: a systematic review of time to resolution or improvement without antibiotic treatment.

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Non-bullous impetigo is typically treated with antibiotics. However, the duration of symptoms without their use has not been established, which hampers informed decision making about antibiotic use.To determine the natural […]

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Comorbidity in chronic kidney disease: a large cross-sectional study of prevalence in Scottish primary care.

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Chronic kidney disease (CKD) is commonly comorbid with hypertension, diabetes, and cardiovascular disease (CVD). However, the extent of comorbidity in CKD across a range of concordant (shared pathophysiology and/or treatment) […]

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Diagnosing community-acquired pneumonia via a smartphone-based algorithm: a prospective cohort study in primary and acute-care consultations.

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Community-acquired pneumonia (CAP) is an essential consideration in patients presenting to primary care with respiratory symptoms; however, accurate diagnosis is difficult when clinical and radiological examinations are not possible, such […]

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Domestic abuse among female doctors: thematic analysis of qualitative interviews in the UK.

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Doctors can be victim-survivors of domestic abuse (DA), but how this impacts their work and wellbeing, and whether they face barriers to seeking help is not well understood.To understand single […]

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Factors predicting statin prescribing for primary prevention: a historical cohort study.

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Initiation of statins for the primary prevention of cardiovascular disease (CVD) should be based on CVD risk estimates, but their use is suboptimal.To investigate the factors influencing statin prescribing when […]

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Implementation of remote consulting in UK primary care following the COVID-19 pandemic: a mixed-methods longitudinal study.

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To reduce contagion of COVID-19, in March 2020 UK general practices implemented predominantly remote consulting via telephone, video, or online consultation platforms.To investigate the rapid implementation of remote consulting and […]

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Neuromuscular exercise for chronic musculoskeletal pain in older people: a randomised controlled trial in primary care in Hong Kong.

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Exercise therapy is commonly prescribed by primary care physicians (PCPs) in the management of chronic musculoskeletal (MSK) pain.To evaluate the clinical effectiveness of a supervised neuromuscular (NM) exercise programme in […]

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Inappropriate direct oral anticoagulant prescriptions in patients with non-valvular atrial fibrillation: cross-sectional analysis of the French CACAO cohort study in primary care.

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Direct oral anticoagulants (DOACs) account for an increasing proportion of prescriptions in patients with non-valvular atrial fibrillation (NVAF) in primary care. Inappropriate dosing of DOACs is a common problem, with […]

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Use of a personalised depression intervention in primary care to prevent anxiety: a secondary study of a cluster randomised trial.

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In the predictD-intervention, GPs used a personalised biopsychosocial programme to prevent depression. This reduced the incidence of major depression by 21.0%, although the results were not statistically significant.To determine whether […]

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Association of prior lymphopenia with mortality in pneumonia: a cohort study in UK primary care.

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Lymphopenia (reduced lymphocyte count) during infections, such as pneumonia, is common and is associated with increased mortality. Little is known about the relationship between lymphocyte count before developing infections and […]

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Behaviour change techniques in personalised care planning for older people: a systematic review.

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Personalised care planning (PCP) interventions have the potential to provide better outcomes for older people and are a key focus in primary care practice. Behaviour change techniques (BCTs) can maximise […]

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Maternal depression and non-specific health complaints in the offspring: a cross-sectional study in Danish primary care.

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Maternal depression has been linked to adverse outcomes in the offspring. Existing literature is mainly based on parental reports, which can be an unreliable source when the parent has depression.To […]

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Orthopaedic corticosteroid injections and risk of acute coronary syndrome: a cohort study.

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Corticosteroid injections (CSIs) are a common treatment for arthritis and other musculoskeletal conditions.To determine whether there is an increased incidence of acute coronary syndrome (ACS) following intra-articular and soft-tissue CSI.Cohort […]

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Time from presentation to pre-diagnostic chest X-ray in patients with symptomatic lung cancer: a cohort study using electronic patient records from English primary care.

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National guidelines in England recommend prompt chest X-ray (within 14 days) in patients presenting in general practice with unexplained symptoms of possible lung cancer, including persistent cough, shortness of breath, […]

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Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998-2017.

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Prostate cancer is a leading cause of cancer- related death. Interpreting the results from trials of screening with prostate-specific antigen (PSA) is complex in terms of defining optimal prostate cancer […]

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Matching depression management to severity prognosis in primary care: results of the Target-D randomised controlled trial.

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Mental health treatment rates are increasing, but the burden of disease has not reduced. Tools to support efficient resource distribution are required.To investigate whether a person-centred e-health (Target-D) platform matching […]

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Changing media depictions of remote consulting in COVID-19: analysis of UK newspapers.

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Remote consulting was introduced quickly into UK general practice in March 2020 as an emergency response to COVID-19. In July 2020, ‘remote-first’ became long-term government policy.To explore how this change […]

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Primary care consultation length by deprivation and multimorbidity in England: an observational study using electronic patient records.

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Longer GP consultations are recommended as one way of improving care for people with multimorbidity. In Scotland, patients who are multimorbid and living in deprived areas do not have longer […]

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Respiratory infections in children: an appropriateness study of when parents should home care or seek medical help.

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Children with respiratory tract infections (RTIs) use more primary care appointments than any other group, but many parents are unsure if, and when, they should seek medical help and report […]

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Estimating lung cancer risk from chest X-ray and symptoms: a prospective cohort study.

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Chest X-ray (CXR) is the first-line investigation for lung cancer in many countries but previous research has suggested that the disease is not detected by CXR in approximately 20% of […]

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Identifying patients at risk of psychosis: a qualitative study of GP views in South West England.

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Early intervention in people with an at-risk mental state for psychosis can decrease the rates of transition to psychosis. GPs play a key role in the identification of this patient […]

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Association of multimorbidity with higher levels of urinary incontinence: a cross-sectional study of 23 089 individuals aged ≥15 years residing in Spain.

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One can assume a relatively high prevalence of urinary incontinence (UI) in people with multimorbidity. However, literature in this area is scarce. There is a need for further robust research […]

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GPs’ perspectives on acne management in primary care: a qualitative interview study.

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Acne is a common skin condition, affecting most adolescents at some point. While guidelines recommend topical treatments first-line, long courses of oral antibiotics are commonly prescribed.To explore GPs’ perspectives on […]

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Impact of multimorbidity on healthcare costs and utilisation: a systematic review of the UK literature.

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Managing multimorbidity is complex for both patients and healthcare systems. Patients with multimorbidity often use a variety of primary and secondary care services. Country-specific research exploring the healthcare utilisation and […]

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