FORM-2C (Frequency of Renal Monitoring – Creatinine and Cystatin C): An observational cohort study of primary care patients with reduced eGFR.

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Monitoring is the mainstay of chronic kidney disease management in primary care. There is little evidence on how best to monitor.To compare the effectiveness of eGFR derived from creatinine or […]

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Identifying safe care processes when GPs work in or alongside emergency departments: realist evaluation.

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Increasing pressure on emergency services has led to the development of different models of care delivery including GPs working in or alongside emergency departments (EDs), but with a lack of […]

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Increasing uptake of NHS Health Checks: an RCT using GP computer prompts.

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Public Health England wants to increase the uptake of the NHS Health Check (NHSHC), a cardiovascular disease prevention programme. Most invitations are sent by letter, but opportunistic invitations may be […]

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Cardiovascular disease risk prediction in older people: a qualitative study.

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Despite cardiovascular disease (CVD) risk prediction equations becoming more widely available for people aged 75 years and over, views of older people on CVD risk assessment are unknown.To explore older […]

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Cost-effectiveness of oral ondansetron for children with acute gastroenteritis in primary care: a randomised controlled trial.

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Acute gastroenteritis is a common childhood disease with substantial medical and indirect costs, mostly because of referral, hospitalization and parental absence from work.To determine the cost-effectiveness of adding oral ondansetron […]

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Implementing social prescribing in primary care in areas of high socioeconomic deprivation: process evaluation of the ‘Deep End’ community links worker programme.

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Social prescribing involving primary care-based ‘link workers’ is a key UK health policy which aims to reduce health inequalities. However, the process of implementation of the link worker approach has […]

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Integrating primary care and social services for older adults with multimorbidity: A qualitative study.

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Growing demand from an ageing population, chronic preventable disease and multimorbidity has resulted in complex health and social care needs requiring more integrated services. Integrating primary care with social services […]

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Attitudes of transgender men and non-binary people to cervical screening: a cross-sectional mixed-methods study in the UK.

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Transgender men and non-binary people assigned female at birth (TMNB) who have not had surgery to remove the cervix are recommended to undertake cervical screening with the same frequency as […]

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GPs’ mindlines on deprescribing antihypertensives in older patients with multimorbidity: a qualitative study in English general practice.

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Optimal management of hypertension in older patients with multimorbidity is a cornerstone of primary care practice. Despite emphasis on personalised approaches to treatment in older patients, there is little guidance […]

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Use of methenamine hippurate to prevent urinary tract infections in community adult women: a systematic review and meta-analysis.

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Urinary tract infections (UTIs) are often treated with antibiotics and are a source of antibiotic overuse.To systematically review randomised controlled trials (RCTs) of adult women in the community with a […]

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Understanding the benefits and limitations of continuous, risk-based, consultation peer-review in out-of-hours general practice: A qualitative interview study.

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Systems to detect and minimise unwarranted variation in clinician practice are crucial to ensure increasingly multidisciplinary healthcare workforces are supported to practice to their full potential. Such systems are limited […]

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General practice responses to opioid prescribing feedback: a qualitative process evaluation.

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The rise in opioid prescribing in primary care represents a significant public health challenge, associated with increased psychosocial problems, hospitalisations and mortality. We developed and implemented an evidence-based bi-monthly feedback […]

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Transformation of primary care during the COVID-19 pandemic: experiences of healthcare professionals in eight European countries.

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Primary care has a crucial role in responding to the COVID-19 pandemic as the first point of patient care and gatekeeper to secondary care. Qualitative studies exploring the experiences of […]

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Barriers to postpartum diabetes screening: a qualitative synthesis of clinicians’ views.

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Gestational diabetes mellitus (GDM) is an important risk factor for developing type 2 diabetes mellitus (T2DM) later in life. Postpartum screening provides an opportunity for early detection and management of […]

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Experiences of general practice care for self-harm: a qualitative study of young people’s perspectives.

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Self-harm is a growing concern and rates of self-harm in young people presenting to general practice are rising. There is however an absence of evidence on young people’s experiences of […]

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Factors affecting primary care practitioners’ alcohol-related discussions with older adults: Qualitative study.

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Risk of harm from drinking is heightened in later life, due to age-related sensitivities to alcohol. Primary care services have a key role in supporting older people to make healthier […]

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General Practitioners’ use and understanding of the quantitative benefits and harms of treatments for common long-term conditions: a qualitative interview study.

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To support shared decision making and improve the management of polypharmacy, it is recommended that GPs take into account quantitative information on the benefits and harms of treatments. Quantitative evidence […]

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Implementing advance care planning in heart failure: a qualitative study of primary healthcare professionals.

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Advance care planning (ACP) can improve the quality of life of patients suffering from heart failure (HF). However, primary care healthcare professionals (HCPs) find ACP difficult to engage with and […]

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Is continuity of primary care declining in England? Practice-level longitudinal study from 2012 to 2017.

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Continuity of care is a core principle of primary care related to improved patient outcomes and reduced healthcare costs. Evidence suggests continuity of care in England is declining.To confirm reports […]

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Navigating possible endometriosis in primary care: a qualitative study of GP perspectives.

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Endometriosis affects approximately 10% of women, with well-documented delays between initial presentation with symptoms and diagnosis. In England, women typically seek help first in primary care, making this setting pivotal […]

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Potentially inappropriate primary care prescribing in people with chronic kidney disease: a cross-sectional analysis of a large population cohort.

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Many drugs should be avoided or require dose-adjustment in chronic kidney disease (CKD). Previous estimates of potentially inappropriate prescribing rates have been based on data on a limited number of […]

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Smoking cessation intervention in Australian general practice: a secondary analysis of a cluster randomised controlled trial.

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GPs have limited capacity to routinely provide smoking cessation support. New strategies are needed to reach all smokers within this setting.To evaluate the effect of a pharmacist-coordinated interdisciplinary smoking cessation […]

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The role of the prescriber in supporting patients to discontinue benzodiazepines: A qualitative study.

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Given the prevalence of long-term benzodiazepine (BZDs) prescribing, increased monitoring through the implementation of prescription monitoring programs (PMPs) may be the necessary impetus to promote BZD deprescribing. Despite evidence promoting […]

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Trends in the prescription of drugs used for insomnia in Australian general practice, 2011-2018.

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Despite an increase in the prevalence of sleep problems, few studies have investigated changes in the prescribing of drugs often used for managing insomnia.To explore changes in the pattern of […]

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Prevalence of erectile dysfunction in male survivors of cancer: a systematic review and meta-analysis of cross-sectional studies.

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Prevalence of erectile dysfunction (ED) in male survivors of cancer across cancer types has not been systematically analysed.To estimate the prevalence of ED in all types of cancer and identify […]

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Targeted encouragement of GP consultations for possible cancer symptoms: a randomised controlled trial.

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For some common cancers, survival is lower in the UK than in comparable high-income countries.To assess the effectiveness of a targeted postal intervention (to promote awareness of cancer symptoms and […]

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Treatment burden for patients with multimorbidity: cross-sectional study with exploration of a single-item measure.

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Treatment burden is the effort required of patients to look after their health, and the impact this has on their wellbeing. Quantitative data on treatment burden for patients with multimorbidity […]

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CA125 test result, test-to-diagnosis interval, and stage in ovarian cancer at diagnosis: a retrospective cohort study using electronic health records.

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In the UK, the cancer antigen 125 (CA125) test is recommended as a first-line investigation in women with symptoms of possible ovarian cancer.To compare time between initial primary care CA125 […]

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Chest x-ray sensitivity and lung cancer outcomes: A retrospective observational study.

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Chest x-ray (CXR) is the first line investigation for lung cancer in many healthcare systems. Understanding of the consequences of false negative CXRs on time to diagnosis, stage and survival […]

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Impact of COVID-19 on Migrants’ Access to Primary Care and Implications for Vaccine Roll Out: A National Qualitative Study.

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The COVID-19 pandemic has prompted considerable changes in delivery of UK primary care, including rapid digitalisation, yet the impact upon marginalised migrant groups is unknown.To understand the impact of the […]

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