Five-year maintenance of clinical response and improvements in health-related quality of life in patients with moderate-to-severe psoriasis treated with guselkumab: results from VOYAGE 1 and VOYAGE 2.

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Psoriasis is a chronic disease requiring long-term therapy.Physician- and patient-reported outcomes (PROs) were evaluated through week 252 in VOYAGE 1 and VOYAGE 2.A total of 1829 patients were randomized at […]

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Guidelines for Clinical Trials of Frontal Fibrosing Alopecia: Consensus Recommendations from the International FFA Cooperative Group (IFFACG).

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Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide, but lacks clear aetiology and robust clinical trial evidence for efficacy and safety of […]

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Mycosis fungoides-derived exosomes promote cell motility, are enriched with miR-155 and miR-1246, and their plasma cell-free expression may serve as potential biomarkers for disease burden.

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Literature regarding exosomes as mediators in intercellular communication to promote progression in mycosis fungoides (MF) is lacking.To characterize MF-derived exosomes and their involvement in the disease.Exosomes were isolated by ultracentrifugation […]

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Single-cell RNAseq profiling in a patient with discordant primary cutaneous B and T cell lymphoma reveals micromilieu-driven immune skewing.

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Primary cutaneous lymphomas comprise a heterogeneous group of B and T cell malignancies which often show an indolent course, but can progress to aggressive disease in a subset of patients. […]

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Forewarned is Forearmed: chronic spontaneous urticaria as a potential risk to effective SARS-COV-2 vaccine uptake and global public health.

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Chronic spontaneous urticaria and angioedema (CSU/A) is a common condition with an estimated global point prevalence of 0.7% (95% C.I, 0.2-1.4)(1), higher in non-White populations. Symptoms present as an ‘allergy […]

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Skin checks and skin cancer diagnosis in Australian general practice before and during the COVID pandemic, 2011-2020.

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Reports from several European countries suggest COVID-19 had a profound impact on referral for cancer diagnoses. A Dutch study using their National Cancer Registry reported that skin cancer diagnosis reduced […]

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Rarity of cutaneous findings among asymptomatic to mildly symptomatic COVID-19 patients admitted to a COVID Care facility in Delhi, India: An observational study.

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In the peak of COVID-19 pandemic, a 500 bedded COVID care center was started by the Government of the National Capital Territory of Delhi, with support of a non-profit organization […]

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Direct Comparison of Risankizumab and Fumaric Acid Esters in Systemic-Therapy-Naive Patients With Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial.

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Fumaric acid esters (FAEs; Fumaderm® ) are the most frequently prescribed first-line systemic treatment for moderate-to-severe plaque psoriasis in Germany. Risankizumab (Skyrizi® ) is a humanized IgG1 monoclonal antibody that […]

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Antibody responses to single-dose SARS-CoV-2 vaccination in patients receiving immunomodulators for immune-mediated inflammatory disease.

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There are few data on whether immunomodulator therapy attenuates humoral response to vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Some vaccines require two doses for maximum protection, with […]

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Comorbidities, Mortality and Survival in Patients with Pyoderma Gangrenosum: A Danish Nationwide Registry-Nested Case-Control Study.

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Pyoderma gangrenosum (PG) is an ulcerative skin disease associated with comorbidities and increased mortality. However, the literature on this topic is scarce.To investigate the mortality, prevalence and risk of comorbidities […]

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Domains and outcomes of the core outcome set of congenital melanocytic naevi for clinical practice and research, part 2 (the OCOMEN project).

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Congenital melanocytic naevi (CMN) can have a great impact on patients’ lives due to perceived stigmatization and the risk of melanoma development and neurological complications. Development of a core outcome […]

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Views on Mobile Health Apps for Skin Cancer Screening in the General Population: An In-Depth Qualitative Exploration of Perceived Barriers and Facilitators.

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Mobile health (mHealth) applications (apps) integrated with artificial Intelligence (AI) for skin cancer screening are increasingly reimbursed by health insurers. However, an in-depth exploration of the general public’s views towards […]

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Polymorphisms in eicosanoid-related biosynthesis enzymes associated with acute urticaria/angioedema induced by nonsteroidal anti-inflammatory drug hypersensitivity.

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Nonsteroidal anti-inflammatory drugs (NSAIDs), probably the most consumed medicines, are the main triggers of drug hypersensitivity, being NSAID-induced acute urticaria/angioedema (NIUA) the most frequent phenotype. NSAID-hypersensitivity is bred by cyclooxygenase […]

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Diagnostic performance of high throughput sequencing of the T-cell receptor beta gene for the diagnosis of cutaneous T-cell lymphoma.

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The early diagnosis of cutaneous T-cell lymphomas (CTCL) may be challenging and based on a combination of clinical, biological, histological, and molecular criteria (1). View the full article @ The […]

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Proof-of-concept for clinical effects of oral rilzabrutinib, the first Bruton tyrosine kinase inhibitor for pemphigus vulgaris: the phase 2 BELIEVE study.

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Bruton tyrosine kinase (BTK) inhibition targets B-cell and other non-T-cell immune cells implicated in pemphigus pathophysiology, an autoimmune disease driven by anti-desmoglein autoantibodies. Rilzabrutinib is a new reversible, covalent BTK […]

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Reporting of randomized controlled trial abstracts in dermatology journals according to CONSORT guidelines.

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Clinicians often only read the abstracts of studies1,2 so accurate and complete reporting of randomized clinical trial (RCT) abstract is essential. The Consolidated Standards of Reporting Trials extension for Abstracts […]

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Global Guidelines in Dermatology Mapping Project (GUIDEMAP): a scoping review of dermatology clinical practice guidelines.

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Clinical practice guidelines (CPGs), statements that include recommendations intended to optimise patient care, play a critical role in standardising and improving treatment outcomes based on best evidence. It is currently […]

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The impact of the COVID-19 pandemic on skin cancer incidence and treatment in England, 2020.

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The first UK national COVID-19 lockdown began 23rd March 2020. Immediately, almost all outpatient healthcare service requests temporarily focused exclusively on urgent referrals and two-week-wait urgent cancer referrals with restrictions […]

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Development of a condition-specific patient-reported outcome measure for measuring symptoms and appearance in vascular malformations: the OVAMA questionnaire.

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The symptoms and appearance of vascular malformations can severely harm a patient’s quality of life. The aim of treatment of vascular malformations generally is to improve condition-specific symptoms and/or appearance. […]

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Efficacy of secukinumab and adalimumab in psoriatic arthritis patients with concomitant moderate to severe plaque psoriasis: Results from the EXCEED, a randomised, double-blind head-to-head monotherapy study.

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Secukinumab (an interleukin [IL]-17A inhibitor) has demonstrated significantly higher efficacy vs. etanercept (a tumour necrosis factor inhibitor) and ustekinumab (an IL-12/23 inhibitor) in patients with moderate to severe plaque psoriasis.To […]

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