International multicentre observational study to assess the efficacy and safety of a 0.5 mg/kg/day starting dose of oral corticosteroids to treat bullous pemphigoid.

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European guidelines propose a 0.5 mg/kg/day dose of oral prednisone as initial treatment of bullous pemphigoid (BP). We assessed the safety and efficacy of this regimen depending on BP extent, […]

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British Association of Dermatologists guidelines for the management of people with cutaneous lupus erythematosus (CLE) 2021.

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The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the management of cutaneous lupus erythematosus (CLE) in the presence or absence of systemic lupus erythematosus (SLE) […]

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Long-term efficacy and safety of risankizumab for the treatment of moderate-to-severe plaque psoriasis: interim analysis of the LIMMitless open-label extension trial beyond 3 years of follow-up.

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Psoriasis is a chronic inflammatory skin disease requiring prolonged treatment. New biologic therapies require long-term evaluation to assess durability of their efficacy and safety profile over time.To evaluate long-term efficacy […]

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Multicentric EORTC retrospective study shows efficacy of Brentuximab Vedotin in Μycosis Fungoides and Sezary Syndrome patients with variable CD30 positivity.

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Brentuximab Vedotin (BV) was approved as therapy for Mycosis Fungoides (MF) based on ALCANZA trial. Since then few real-life data are available.The aim of this study was to evaluate efficacy […]

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Alcohol abuse associated with poor response to systemic therapies for psoriasis: findings from a prospective multicentre cohort study.

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Factors that might influence response to systemic treatment for moderate-to-severe psoriasis are varied, and generally, are poorly understood, aside from high body weight, suggesting that other unidentified factors may be […]

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Development and preliminary validation of the patient-reported Chronic Itch Burden Scale, assessing health-related quality of life in chronic pruritus.

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Chronic pruritus (CP) significantly affects patients’ health-related quality of life (HRQoL). Very few self-reported HRQoL questionnaires exploring CP were developed according to international guidelines thus limiting their use in pre-authorization […]

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Five-year maintenance of clinical response and improvements in health-related quality of life in patients with moderate-to-severe psoriasis treated with guselkumab: results from VOYAGE 1 and VOYAGE 2.

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Psoriasis is a chronic disease requiring long-term therapy.Physician- and patient-reported outcomes (PROs) were evaluated through week 252 in VOYAGE 1 and VOYAGE 2.A total of 1829 patients were randomized at […]

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Guidelines for Clinical Trials of Frontal Fibrosing Alopecia: Consensus Recommendations from the International FFA Cooperative Group (IFFACG).

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Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide, but lacks clear aetiology and robust clinical trial evidence for efficacy and safety of […]

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Mycosis fungoides-derived exosomes promote cell motility, are enriched with miR-155 and miR-1246, and their plasma cell-free expression may serve as potential biomarkers for disease burden.

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Literature regarding exosomes as mediators in intercellular communication to promote progression in mycosis fungoides (MF) is lacking.To characterize MF-derived exosomes and their involvement in the disease.Exosomes were isolated by ultracentrifugation […]

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Single-cell RNAseq profiling in a patient with discordant primary cutaneous B and T cell lymphoma reveals micromilieu-driven immune skewing.

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Primary cutaneous lymphomas comprise a heterogeneous group of B and T cell malignancies which often show an indolent course, but can progress to aggressive disease in a subset of patients. […]

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Forewarned is Forearmed: chronic spontaneous urticaria as a potential risk to effective SARS-COV-2 vaccine uptake and global public health.

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Chronic spontaneous urticaria and angioedema (CSU/A) is a common condition with an estimated global point prevalence of 0.7% (95% C.I, 0.2-1.4)(1), higher in non-White populations. Symptoms present as an ‘allergy […]

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Skin checks and skin cancer diagnosis in Australian general practice before and during the COVID pandemic, 2011-2020.

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Reports from several European countries suggest COVID-19 had a profound impact on referral for cancer diagnoses. A Dutch study using their National Cancer Registry reported that skin cancer diagnosis reduced […]

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Rarity of cutaneous findings among asymptomatic to mildly symptomatic COVID-19 patients admitted to a COVID Care facility in Delhi, India: An observational study.

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In the peak of COVID-19 pandemic, a 500 bedded COVID care center was started by the Government of the National Capital Territory of Delhi, with support of a non-profit organization […]

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Direct Comparison of Risankizumab and Fumaric Acid Esters in Systemic-Therapy-Naive Patients With Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial.

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Fumaric acid esters (FAEs; Fumaderm® ) are the most frequently prescribed first-line systemic treatment for moderate-to-severe plaque psoriasis in Germany. Risankizumab (Skyrizi® ) is a humanized IgG1 monoclonal antibody that […]

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Antibody responses to single-dose SARS-CoV-2 vaccination in patients receiving immunomodulators for immune-mediated inflammatory disease.

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There are few data on whether immunomodulator therapy attenuates humoral response to vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Some vaccines require two doses for maximum protection, with […]

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Comorbidities, Mortality and Survival in Patients with Pyoderma Gangrenosum: A Danish Nationwide Registry-Nested Case-Control Study.

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Pyoderma gangrenosum (PG) is an ulcerative skin disease associated with comorbidities and increased mortality. However, the literature on this topic is scarce.To investigate the mortality, prevalence and risk of comorbidities […]

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Domains and outcomes of the core outcome set of congenital melanocytic naevi for clinical practice and research, part 2 (the OCOMEN project).

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Congenital melanocytic naevi (CMN) can have a great impact on patients’ lives due to perceived stigmatization and the risk of melanoma development and neurological complications. Development of a core outcome […]

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Views on Mobile Health Apps for Skin Cancer Screening in the General Population: An In-Depth Qualitative Exploration of Perceived Barriers and Facilitators.

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Mobile health (mHealth) applications (apps) integrated with artificial Intelligence (AI) for skin cancer screening are increasingly reimbursed by health insurers. However, an in-depth exploration of the general public’s views towards […]

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Polymorphisms in eicosanoid-related biosynthesis enzymes associated with acute urticaria/angioedema induced by nonsteroidal anti-inflammatory drug hypersensitivity.

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Nonsteroidal anti-inflammatory drugs (NSAIDs), probably the most consumed medicines, are the main triggers of drug hypersensitivity, being NSAID-induced acute urticaria/angioedema (NIUA) the most frequent phenotype. NSAID-hypersensitivity is bred by cyclooxygenase […]

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