To evaluate the extent to which internationally agreed treat-to-target (T2T) recommendations were applied in clinical practice in patients with axial spondyloarthritis (axSpA).Data were used from a web-based patient registry for […]» Read more
Early Prediction of Clinical Response to Anti-TNF Treatment using Multi-omics and Machine Learning in Rheumatoid Arthritis.
Advances in immunotherapy by blocking TNF have remarkably improved treatment outcomes for rheumatoid arthritis patients. Although treatment specifically targets TNF, the downstream mechanisms of immune suppression are not completely understood. […]» Read more
To assess the prevalence of avascular necrosis (AVN) in a large cohort of patients with idiopathic inflammatory myopathies (IIM) and define the major associated risk factors.We retrospectively reviewed the electronic […]» Read more
Serological abnormalities that predict progression to systemic autoimmune rheumatic diseases in antinuclear antibody positive individuals.
We investigated the auto-antibody (auto-Ab) profiles in anti-nuclear antibody-positive (ANA+) individuals lacking Systemic Autoimmune Rheumatic Disease (SARD) and early SARD patients, to determine the key differences between these groups and […]» Read more
To investigate whether physical activity interferes with joint homeostasis in the presence of distant inflammation originating at barrier tissues such as skin or gut.Eight-week-old male C57/Bl6 mice were treated with […]» Read more
All-cause and cause-specific mortality in patients with giant cell arteritis: a nationwide, population-based cohort study.
To investigate whether giant cell arteritis (GCA) is associated with increased all-cause and cause-specific mortality.A nationwide, population-based cohort study in Denmark using medical and administrative registries. GCA cases were defined […]» Read more
MRI detected synovitis of the small joints predicts rheumatoid arthritis development in large joint undifferentiated inflammatory arthritis.
New onset undifferentiated large joint inflammatory arthritis can be diagnostically challenging. It is unknown how often these patients progress to rheumatoid arthritis (RA), and how they can be identified at […]» Read more
Ultrasound of shoulder and knee improves the accuracy of the 2012 EULAR/ACR provisional classification criteria for polymyalgia rheumatica.
Recent studies suggest that the knee is frequently involved in polymyalgia rheumatica (PMR). In this study, we aimed to determine whether the ultrasound assessment of the shoulder and knee discriminates […]» Read more
A novel model to assess disease activity in Takayasu arteritis based on 18F-FDG-PET/CT: a Chinese cohort study.
To investigate the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in assessing disease activity in Takayasu arteritis (TA).Ninety-one patients with TA, were recruited from a Chinese cohort. Clinical data, […]» Read more
Brain white matter extracellular free-water increases are related to reduced neurocognitive function in systemic lupus erythematosus.
Brain white matter (WM) microstructural changes evaluated by diffusion MRI were well documented in patients with systemic lupus erythematosus (SLE). Yet, conventional diffusion tensor imaging technique fails to differentiate WM […]» Read more
Revisiting characteristics, treatment and outcome of cardiomyopathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss).
Eosinophilic granulomatosis with polyangiitis (EGPA) is a necrotizing eosinophil-rich vasculitis. Specific cardiomyopathy (CM) was described in old studies as the most important predictor of mortality. We aimed to revisit EGPA-related […]» Read more
To assess the efficacy of the novel anti-IL-23 monoclonal antibody Guselkumab in a real-life observational cohort of patients with early Psoriatic arthritis (PsA).We conducted an observational study on patients with […]» Read more
Anti-nuclear matrix protein 2 antibody-positive inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash.
Myositis-specific autoantibodies (MSAs) define distinct clinical subsets of idiopathic inflammatory myopathies (IIMs). The anti-nuclear matrix protein 2 (NXP2) antibody, a MSA detected in juvenile/adult IIMs, has been reported to be […]» Read more
Correlation between pain severity and levels of anxiety and depression in osteoarthritis patients: a systematic review and meta-analysis.
Osteoarthritis (OA) is a chronic degenerative musculoskeletal disease that causes articular damage and chronic pain, with a prevalence of up to 50% in individuals >60 years of age. Patients suffering […]» Read more
The pathogenesis of calcinosis cutis, a disabling complication of systemic sclerosis (SSc), is poorly understood and effective treatments are lacking. Inorganic pyrophosphate (PPi) is a key regulator of ectopic mineralization, […]» Read more
Scleromyositis remains incompletely characterized owing in part to its heterogeneity. The purpose of this study was to explore the role of autoantibody profiles to define subsets of scleromyositis.Subjects with scleromyositis […]» Read more
No large-scale registration study has comprehensively evaluated the activities of daily living (ADL) in patients with Behçet’s disease (BD).The Japanese government provided us with a dataset of confirmed or suspected […]» Read more
Bidirectional association between systemic lupus erythematosus and macrophage activation syndrome: a nationwide population-based study.
To determine the bidirectional relationship between macrophage activation syndrome (MAS) and systemic lupus erythematosus (SLE).Using the 1997-2013 Taiwan’s National Health Insurance Research Database, we identified patients with newly diagnosed SLE […]» Read more
Digital pitting scars are associated with a severe disease course and death in systemic sclerosis: a study from the EUSTAR cohort.
Digital pitting scars (DPS) are frequent, but little studied in SSc to date.An analysis of SSc patients enrolled in the EUSTAR database. Primary objectives were to 1) examine DPS prevalence, […]» Read more
Impact of the COVID-19 pandemic on treat to target strategies and physical consultations in > 7000 patients with inflammatory arthritis.
To explore the impact of the COVID-19 pandemic on treat-to-target strategies (disease activity, remission rates) and access to physical consultations in patients with inflammatory rheumatic disease. Furthermore, to explore characteristics […]» Read more
Significance of eosinophilia in granulomatosis with polyangiitis: data from the French Vasculitis Study Group Registry.
To describe disease presentation and long-term outcome of granulomatosis with polyangiitis (GPA) patients according to blood eosinophils count (Eos) at vasculitis diagnosis.Data from newly diagnosed GPA patients registered in the […]» Read more
Adverse effects related to methotrexate polyglutamate levels: adjudicated results from the cardiovascular inflammation reduction trial.
Methotrexate is widely used at low dosages (LD-MTX) for non-oncologic indications and is associated with a variety of adverse effects (AEs). We sought to determine whether concentrations of the active […]» Read more
FMF is an autoinflammatory disease of genetic origin. Colchicine is the mainstay of treatment for the prevention of attacks and long-term complications but 5-10% of FMF patients are resistant to […]» Read more
Efficacy and safety of switching from reference adalimumab to CT-P17 (100 mg/ml): 52-week randomised study in rheumatoid arthritis.
To compare the safety and efficacy of switching from reference adalimumab to adalimumab biosimilar CT-P17 with continuing reference adalimumab/CT-P17 in active rheumatoid arthritis (RA).This double-blind, phase III study randomised (1:1) […]» Read more
Intravenous prostanoids in systemic sclerosis-associated pulmonary arterial hypertension: a single centre experience.
The current study evaluates survival rates among Systemic Sclerosis-associated Pulmonary Arterial Hypertension (SSc-PAH) patients on intravenous (IV) prostanoids, and short-term impact of IV prostanoids on clinical and haemodynamic parameters.Baseline demographics, […]» Read more
Performance of finger systolic blood pressure measurement to detect digital occlusive arterial disease in systemic sclerosis.
Digital ulcers (DUs) related to digital occlusive arterial disease (DOAD) are frequent in patients with systemic sclerosis (SSc). Finger systolic blood pressure (FSBP) and digital-brachial pressure index (DBI) using laser […]» Read more
Reactive arthritis and undifferentiated peripheral spondyloarthritis share human leucocyte antigen B27 subtypes and serum and synovial fluid cytokine profiles.
Peripheral SpA (pSpA) is comprised of ReA, PsA, enteritis-associated arthritis and undifferentiated pSpA (upSpA). ReA and upSpA share T cell oligotypes and metabolomics in serum and SF. We investigated HLA-B27 […]» Read more
Myositis specific antibodies are associated with isolated anti-Ro-52 associated interstitial lung disease.
Anti-Ro-52 antibody positivity might be associated with the presence of interstitial lung disease (ILD) among patients with autoimmune features. However, the clinical significance of isolated anti-Ro-52 positivity (i.e., the presence […]» Read more
We compared survival and causes of death in Western Australian (WA) anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and polyarteritis nodosa (PAN) patients with controls and the WA population.In this data […]» Read more
To characterize the effect of ultra-short glucocorticoids followed by Tocilizumab monotherapy on the intima-media thickness (IMT) in GCA.18 GCA patients received 500mg methylprednisolone intravenously on days 0-2, followed by Tocilizumab […]» Read more