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To evaluate the extent to which internationally agreed treat-to-target (T2T) recommendations were applied in clinical practice in patients with axial spondyloarthritis (axSpA).Data were used from a web-based patient registry for […]
» Read moreAdvances in immunotherapy by blocking TNF have remarkably improved treatment outcomes for rheumatoid arthritis patients. Although treatment specifically targets TNF, the downstream mechanisms of immune suppression are not completely understood. […]
» Read moreTo assess the prevalence of avascular necrosis (AVN) in a large cohort of patients with idiopathic inflammatory myopathies (IIM) and define the major associated risk factors.We retrospectively reviewed the electronic […]
» Read moreWe investigated the auto-antibody (auto-Ab) profiles in anti-nuclear antibody-positive (ANA+) individuals lacking Systemic Autoimmune Rheumatic Disease (SARD) and early SARD patients, to determine the key differences between these groups and […]
» Read moreTo investigate whether physical activity interferes with joint homeostasis in the presence of distant inflammation originating at barrier tissues such as skin or gut.Eight-week-old male C57/Bl6 mice were treated with […]
» Read moreTo investigate whether giant cell arteritis (GCA) is associated with increased all-cause and cause-specific mortality.A nationwide, population-based cohort study in Denmark using medical and administrative registries. GCA cases were defined […]
» Read moreNew onset undifferentiated large joint inflammatory arthritis can be diagnostically challenging. It is unknown how often these patients progress to rheumatoid arthritis (RA), and how they can be identified at […]
» Read moreRecent studies suggest that the knee is frequently involved in polymyalgia rheumatica (PMR). In this study, we aimed to determine whether the ultrasound assessment of the shoulder and knee discriminates […]
» Read moreTo investigate the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in assessing disease activity in Takayasu arteritis (TA).Ninety-one patients with TA, were recruited from a Chinese cohort. Clinical data, […]
» Read moreBrain white matter (WM) microstructural changes evaluated by diffusion MRI were well documented in patients with systemic lupus erythematosus (SLE). Yet, conventional diffusion tensor imaging technique fails to differentiate WM […]
» Read moreEosinophilic granulomatosis with polyangiitis (EGPA) is a necrotizing eosinophil-rich vasculitis. Specific cardiomyopathy (CM) was described in old studies as the most important predictor of mortality. We aimed to revisit EGPA-related […]
» Read moreTo assess the efficacy of the novel anti-IL-23 monoclonal antibody Guselkumab in a real-life observational cohort of patients with early Psoriatic arthritis (PsA).We conducted an observational study on patients with […]
» Read moreMyositis-specific autoantibodies (MSAs) define distinct clinical subsets of idiopathic inflammatory myopathies (IIMs). The anti-nuclear matrix protein 2 (NXP2) antibody, a MSA detected in juvenile/adult IIMs, has been reported to be […]
» Read moreOsteoarthritis (OA) is a chronic degenerative musculoskeletal disease that causes articular damage and chronic pain, with a prevalence of up to 50% in individuals >60 years of age. Patients suffering […]
» Read moreThe pathogenesis of calcinosis cutis, a disabling complication of systemic sclerosis (SSc), is poorly understood and effective treatments are lacking. Inorganic pyrophosphate (PPi) is a key regulator of ectopic mineralization, […]
» Read moreScleromyositis remains incompletely characterized owing in part to its heterogeneity. The purpose of this study was to explore the role of autoantibody profiles to define subsets of scleromyositis.Subjects with scleromyositis […]
» Read moreNo large-scale registration study has comprehensively evaluated the activities of daily living (ADL) in patients with Behçet’s disease (BD).The Japanese government provided us with a dataset of confirmed or suspected […]
» Read moreTo determine the bidirectional relationship between macrophage activation syndrome (MAS) and systemic lupus erythematosus (SLE).Using the 1997-2013 Taiwan’s National Health Insurance Research Database, we identified patients with newly diagnosed SLE […]
» Read moreDigital pitting scars (DPS) are frequent, but little studied in SSc to date.An analysis of SSc patients enrolled in the EUSTAR database. Primary objectives were to 1) examine DPS prevalence, […]
» Read moreTo explore the impact of the COVID-19 pandemic on treat-to-target strategies (disease activity, remission rates) and access to physical consultations in patients with inflammatory rheumatic disease. Furthermore, to explore characteristics […]
» Read moreTo describe disease presentation and long-term outcome of granulomatosis with polyangiitis (GPA) patients according to blood eosinophils count (Eos) at vasculitis diagnosis.Data from newly diagnosed GPA patients registered in the […]
» Read moreMethotrexate is widely used at low dosages (LD-MTX) for non-oncologic indications and is associated with a variety of adverse effects (AEs). We sought to determine whether concentrations of the active […]
» Read moreFMF is an autoinflammatory disease of genetic origin. Colchicine is the mainstay of treatment for the prevention of attacks and long-term complications but 5-10% of FMF patients are resistant to […]
» Read moreTo compare the safety and efficacy of switching from reference adalimumab to adalimumab biosimilar CT-P17 with continuing reference adalimumab/CT-P17 in active rheumatoid arthritis (RA).This double-blind, phase III study randomised (1:1) […]
» Read moreThe current study evaluates survival rates among Systemic Sclerosis-associated Pulmonary Arterial Hypertension (SSc-PAH) patients on intravenous (IV) prostanoids, and short-term impact of IV prostanoids on clinical and haemodynamic parameters.Baseline demographics, […]
» Read moreDigital ulcers (DUs) related to digital occlusive arterial disease (DOAD) are frequent in patients with systemic sclerosis (SSc). Finger systolic blood pressure (FSBP) and digital-brachial pressure index (DBI) using laser […]
» Read morePeripheral SpA (pSpA) is comprised of ReA, PsA, enteritis-associated arthritis and undifferentiated pSpA (upSpA). ReA and upSpA share T cell oligotypes and metabolomics in serum and SF. We investigated HLA-B27 […]
» Read moreAnti-Ro-52 antibody positivity might be associated with the presence of interstitial lung disease (ILD) among patients with autoimmune features. However, the clinical significance of isolated anti-Ro-52 positivity (i.e., the presence […]
» Read moreWe compared survival and causes of death in Western Australian (WA) anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and polyarteritis nodosa (PAN) patients with controls and the WA population.In this data […]
» Read moreTo characterize the effect of ultra-short glucocorticoids followed by Tocilizumab monotherapy on the intima-media thickness (IMT) in GCA.18 GCA patients received 500mg methylprednisolone intravenously on days 0-2, followed by Tocilizumab […]
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