Early Prediction of Clinical Response to Anti-TNF Treatment using Multi-omics and Machine Learning in Rheumatoid Arthritis.

Bookmark this %label%

Advances in immunotherapy by blocking TNF have remarkably improved treatment outcomes for rheumatoid arthritis patients. Although treatment specifically targets TNF, the downstream mechanisms of immune suppression are not completely understood. […]

» Read more

Serological abnormalities that predict progression to systemic autoimmune rheumatic diseases in antinuclear antibody positive individuals.

Bookmark this %label%

We investigated the auto-antibody (auto-Ab) profiles in anti-nuclear antibody-positive (ANA+) individuals lacking Systemic Autoimmune Rheumatic Disease (SARD) and early SARD patients, to determine the key differences between these groups and […]

» Read more

All-cause and cause-specific mortality in patients with giant cell arteritis: a nationwide, population-based cohort study.

Bookmark this %label%

To investigate whether giant cell arteritis (GCA) is associated with increased all-cause and cause-specific mortality.A nationwide, population-based cohort study in Denmark using medical and administrative registries. GCA cases were defined […]

» Read more

MRI detected synovitis of the small joints predicts rheumatoid arthritis development in large joint undifferentiated inflammatory arthritis.

Bookmark this %label%

New onset undifferentiated large joint inflammatory arthritis can be diagnostically challenging. It is unknown how often these patients progress to rheumatoid arthritis (RA), and how they can be identified at […]

» Read more

Ultrasound of shoulder and knee improves the accuracy of the 2012 EULAR/ACR provisional classification criteria for polymyalgia rheumatica.

Bookmark this %label%

Recent studies suggest that the knee is frequently involved in polymyalgia rheumatica (PMR). In this study, we aimed to determine whether the ultrasound assessment of the shoulder and knee discriminates […]

» Read more

A novel model to assess disease activity in Takayasu arteritis based on 18F-FDG-PET/CT: a Chinese cohort study.

Bookmark this %label%

To investigate the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in assessing disease activity in Takayasu arteritis (TA).Ninety-one patients with TA, were recruited from a Chinese cohort. Clinical data, […]

» Read more

Brain white matter extracellular free-water increases are related to reduced neurocognitive function in systemic lupus erythematosus.

Bookmark this %label%

Brain white matter (WM) microstructural changes evaluated by diffusion MRI were well documented in patients with systemic lupus erythematosus (SLE). Yet, conventional diffusion tensor imaging technique fails to differentiate WM […]

» Read more

Revisiting characteristics, treatment and outcome of cardiomyopathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss).

Bookmark this %label%

Eosinophilic granulomatosis with polyangiitis (EGPA) is a necrotizing eosinophil-rich vasculitis. Specific cardiomyopathy (CM) was described in old studies as the most important predictor of mortality. We aimed to revisit EGPA-related […]

» Read more

Anti-nuclear matrix protein 2 antibody-positive inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash.

Bookmark this %label%

Myositis-specific autoantibodies (MSAs) define distinct clinical subsets of idiopathic inflammatory myopathies (IIMs). The anti-nuclear matrix protein 2 (NXP2) antibody, a MSA detected in juvenile/adult IIMs, has been reported to be […]

» Read more

Correlation between pain severity and levels of anxiety and depression in osteoarthritis patients: a systematic review and meta-analysis.

Bookmark this %label%

Osteoarthritis (OA) is a chronic degenerative musculoskeletal disease that causes articular damage and chronic pain, with a prevalence of up to 50% in individuals >60 years of age. Patients suffering […]

» Read more

Bidirectional association between systemic lupus erythematosus and macrophage activation syndrome: a nationwide population-based study.

Bookmark this %label%

To determine the bidirectional relationship between macrophage activation syndrome (MAS) and systemic lupus erythematosus (SLE).Using the 1997-2013 Taiwan’s National Health Insurance Research Database, we identified patients with newly diagnosed SLE […]

» Read more

Impact of the COVID-19 pandemic on treat to target strategies and physical consultations in > 7000 patients with inflammatory arthritis.

Bookmark this %label%

To explore the impact of the COVID-19 pandemic on treat-to-target strategies (disease activity, remission rates) and access to physical consultations in patients with inflammatory rheumatic disease. Furthermore, to explore characteristics […]

» Read more

Significance of eosinophilia in granulomatosis with polyangiitis: data from the French Vasculitis Study Group Registry.

Bookmark this %label%

To describe disease presentation and long-term outcome of granulomatosis with polyangiitis (GPA) patients according to blood eosinophils count (Eos) at vasculitis diagnosis.Data from newly diagnosed GPA patients registered in the […]

» Read more

Adverse effects related to methotrexate polyglutamate levels: adjudicated results from the cardiovascular inflammation reduction trial.

Bookmark this %label%

Methotrexate is widely used at low dosages (LD-MTX) for non-oncologic indications and is associated with a variety of adverse effects (AEs). We sought to determine whether concentrations of the active […]

» Read more

Efficacy and safety of switching from reference adalimumab to CT-P17 (100 mg/ml): 52-week randomised study in rheumatoid arthritis.

Bookmark this %label%

To compare the safety and efficacy of switching from reference adalimumab to adalimumab biosimilar CT-P17 with continuing reference adalimumab/CT-P17 in active rheumatoid arthritis (RA).This double-blind, phase III study randomised (1:1) […]

» Read more

Intravenous prostanoids in systemic sclerosis-associated pulmonary arterial hypertension: a single centre experience.

Bookmark this %label%

The current study evaluates survival rates among Systemic Sclerosis-associated Pulmonary Arterial Hypertension (SSc-PAH) patients on intravenous (IV) prostanoids, and short-term impact of IV prostanoids on clinical and haemodynamic parameters.Baseline demographics, […]

» Read more

Performance of finger systolic blood pressure measurement to detect digital occlusive arterial disease in systemic sclerosis.

Bookmark this %label%

Digital ulcers (DUs) related to digital occlusive arterial disease (DOAD) are frequent in patients with systemic sclerosis (SSc). Finger systolic blood pressure (FSBP) and digital-brachial pressure index (DBI) using laser […]

» Read more

Reactive arthritis and undifferentiated peripheral spondyloarthritis share human leucocyte antigen B27 subtypes and serum and synovial fluid cytokine profiles.

Bookmark this %label%

Peripheral SpA (pSpA) is comprised of ReA, PsA, enteritis-associated arthritis and undifferentiated pSpA (upSpA). ReA and upSpA share T cell oligotypes and metabolomics in serum and SF. We investigated HLA-B27 […]

» Read more

Myositis specific antibodies are associated with isolated anti-Ro-52 associated interstitial lung disease.

Bookmark this %label%

Anti-Ro-52 antibody positivity might be associated with the presence of interstitial lung disease (ILD) among patients with autoimmune features. However, the clinical significance of isolated anti-Ro-52 positivity (i.e., the presence […]

» Read more

Quantitative ultrasound to monitor the vascular response to tocilizumab in giant cell arteritis.

Bookmark this %label%

To characterize the effect of ultra-short glucocorticoids followed by Tocilizumab monotherapy on the intima-media thickness (IMT) in GCA.18 GCA patients received 500mg methylprednisolone intravenously on days 0-2, followed by Tocilizumab […]

» Read more
1 2 3 48