Differentiating Exudative Macular Degeneration and Polypoidal Choroidal Vasculopathy Using Optical Coherence Tomography B-scan.

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Although polypoidal choroidal vasculopathy (PCV) is best diagnosed with indocyanine green angiography (ICGA), ICGA is often unavailable or not ordered. Optical coherence tomography (OCT) is widely available, and OCT B-scan […]

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Selective Ophthalmic artery chemotherapy with melphalan in the management of unilateral retinoblastoma: a prospective study.

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To prospectively determine the efficacy and assess potential side effects of melphalan selective ophthalmic artery chemotherapy (SOAC) as first-line treatment for unilateral retinoblastoma.Phase II non-randomized prospective study.Patients with unilateral retinoblastoma […]

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Early predictive factors of visual loss at 1-year in neovascular age-related macular degeneration under anti-VEGF in the GEFAL study.

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To evaluate early predictive factors of visual loss in patients treated with anti-vascular endothelial growth factor (VEGF) injections under as-needed regimen for neovascular age-related macular degeneration (AMD).Post-hoc analysis from the […]

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Clinical Characteristics and Outcomes of Eyes with Intraocular Inflammation after Brolucizumab: Post Hoc Analysis of HAWK and HARRIER.

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This analysis of the pivotal phase III HAWK and HARRIER trials aimed to provide insights on the timing of presentation, management, and outcomes of intraocular inflammation (IOI)-related adverse events (AEs), […]

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Risk factors for Severe Bleeding Complications in Vitreoretinal Surgery and the Role of Antiplatelet or Anticoagulant Agents.

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To evaluate the influences and risk factors for severe bleeding complications during vitreoretinal surgery, and to investigate the role of antiplatelet (AP) and anticoagulant (AC) agents.Prospective trial STUDY POPULATION: This […]

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Ocular outcomes after treatment of cytomegalovirus (CMV) retinitis using adoptive immunotherapy with CMV-specific cytotoxic T-lymphocytes.

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To describe ocular outcomes in eyes with CMV retinitis treated with adoptive immunotherapy using systemic administration of CMV-specific cytotoxic T-lymphocytes (CMV-CTLs) DESIGN: Retrospective cohort study SUBJECTS: Patients with active CMV […]

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Photodynamic Therapy (PDT) for Retinal Hemangioblastoma: Treatment Outcomes in 17 Consecutive Patients.

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To report the efficacy of photodynamic therapy (PDT) for management of retinal hemangioblastoma.Retrospective case series.Seventeen patients with retinal hemangioblastoma treated with PDT.The medical records of 17 patients with retinal hemangioblastoma […]

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Evolving treatment patterns and outcomes of neovascular age-related macular degeneration over a decade.

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Management of neovascular age-related macular degeneration (nAMD) has evolved over the last decade with several treatment regimens and different medications. This study describes the treatment patterns and, importantly, visual outcomes […]

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Non ICGA treatment criteria for Suboptimal Anti VEGF Response for Polypoidal Choroidal Vasculopathy: APOIS PCV Workgroup Report 2.

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To develop and validate optical coherence tomography (OCT) and color fundus photography (CFP) criteria in differentiating polypoidal choroidal vasculopathy (PCV) from typical neovascular age-related macular degeneration (nAMD) in eyes with […]

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Perifoveal Chorioretinal Atrophy following Subretinal Voretigene Neparvovec-rzyl for RPE65-mediated Leber Congenital Amaurosis.

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To report an anatomic change observed in a series of patients who underwent subretinal injection of voretigene neparvovec-rzyl (VN) for RPE65-mediated Leber congenital amaurosis.Multi-center retrospective chart review.Patients who underwent subretinal […]

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Recognizable Patterns of Submacular Fibrosis in the Enhanced S-Cone Syndrome.

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To highlight recognizable patterns of subretinal fibrosis in the enhanced S-cone syndrome (ESCS).Retrospective case series.47 patients with subretinal fibrosis identified from 101 clinically diagnosed ESCS patients, confirmed by full field-electroretinography […]

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Epiretinal Membrane Surgery After Retinal Detachment Repair: Visual Acuity Outcomes and Optical Coherence Tomography Analysis.

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To assess visual acuity (VA) outcomes of epiretinal membrane (ERM) surgery following primary rhegmatogenous retinal detachment (RD) repair.Retrospective, consecutive case series.Eyes undergoing pars plana vitrectomy (PPV) with membrane peel (MP) […]

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Timing of Complete Polypoidal Regression Following Intravitreous Aflibercept Treatments in Polypoidal Choroidal Vasculopathy.

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To understand timing of complete polypoidal regression on indocyanine green angiography (ICGA) after aflibercept injections in polypoidal choroidal vasculopathy (PCV).Multicenter prospective study PARTICIPANTS: Adults with treatment-naïve PCV METHODS: After IRB […]

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Recurrent neovascular age-related macular degeneration after discontinuation of VEGF inhibitors managed in a treat and extend regimen.

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To investigate the recurrence rate of active macular neovascularization in patients with neovascular age-related macular degeneration (nAMD) previously followed in a treat and extend regimen where treatment had been stopped […]

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Optical Coherence Tomography Signs of Early Atrophy in Age-related Macular Degeneration: Inter-Reader Agreement. CAM Report 6.

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To determine the inter-reader agreement for incomplete and complete retinal pigment epithelium and outer retinal atrophy (iRORA and cRORA respectively) and their related features in age-related macular degeneration (AMD).Inter-reader agreement […]

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Identifying peripapillary radial capillary plexus alterations in Parkinson’s disease using optical coherence tomography angiography.

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To compare radial peripapillary capillary plexus vascular parameters and retinal nerve fiber layer (RNFL) thickness between Parkinson’s disease (PD) and controls.Prospective cross-sectional study.One hundred and fifty-one eyes of 81 PD […]

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Vitreous and Chorioretinal Lesions in People Who Inject Drugs Hospitalized with Bloodstream and Related Infections.

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To determine the prevalence of and characterize vitreous and chorioretinal lesions, identify causative organisms, and correlate symptoms with ophthalmic involvement in people who inject drugs (PWID) hospitalized with bloodstream infection […]

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Subthreshold Nanosecond Laser in Age-Related Macular Degeneration: Observational Extension Study to the LEAD Clinical Trial.

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To evaluate the long-term effect of subthreshold nanosecond laser (SNL) treatment on progression to late age-related macular degeneration (AMD).Observational extension study to a randomized, sham-controlled trial.Two-hundred and twelve participants with […]

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Epiretinal Membrane Surgery Using Intraoperative OCT-guided Membrane Removal in the DISCOVER Study versus Conventional Membrane Removal.

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To provide a comparative assessment of clinical outcomes between subjects undergoing intraoperative optical coherence tomography (OCT) and conventional surgery for pars plana vitrectomy (PPV) with epiretinal membrane (ERM) peel.Case-control retrospective […]

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Longitudinal Assessment of Ellipsoid Zone Integrity, Subretinal Hyperreflective Material, and Sub-RPE Disease in Neovascular AMD.

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To longitudinally assess the effect of anti-vascular endothelial growth factor (VEGF) treatment on ellipsoid zone (EZ) integrity, subretinal hyperreflective material (SHRM), and the sub-retinal pigment epithelium (sub-RPE) compartment in eyes […]

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