Investigate clinical and morphologic characteristics of serous retinal disturbances in patients taking extracellular signal-regulated kinase (ERK) inhibitors.Of 61 patients receiving ERK inhibitors for treatment of metastatic cancer, this study included […]» Read more
Differentiating Exudative Macular Degeneration and Polypoidal Choroidal Vasculopathy Using Optical Coherence Tomography B-scan.
Although polypoidal choroidal vasculopathy (PCV) is best diagnosed with indocyanine green angiography (ICGA), ICGA is often unavailable or not ordered. Optical coherence tomography (OCT) is widely available, and OCT B-scan […]» Read more
Selective Ophthalmic artery chemotherapy with melphalan in the management of unilateral retinoblastoma: a prospective study.
To prospectively determine the efficacy and assess potential side effects of melphalan selective ophthalmic artery chemotherapy (SOAC) as first-line treatment for unilateral retinoblastoma.Phase II non-randomized prospective study.Patients with unilateral retinoblastoma […]» Read more
Age, Gender, and Laterality of Retinal Vascular Occlusion: A Retrospective Study from the IRIS® Registry.
Retinal vascular occlusion is a leading cause of profound irreversible visual loss, but the understanding of the disease is insufficient. We systematically investigated the age, gender, and laterality at the […]» Read more
Early predictive factors of visual loss at 1-year in neovascular age-related macular degeneration under anti-VEGF in the GEFAL study.
To evaluate early predictive factors of visual loss in patients treated with anti-vascular endothelial growth factor (VEGF) injections under as-needed regimen for neovascular age-related macular degeneration (AMD).Post-hoc analysis from the […]» Read more
Clinical Characteristics and Outcomes of Eyes with Intraocular Inflammation after Brolucizumab: Post Hoc Analysis of HAWK and HARRIER.
This analysis of the pivotal phase III HAWK and HARRIER trials aimed to provide insights on the timing of presentation, management, and outcomes of intraocular inflammation (IOI)-related adverse events (AEs), […]» Read more
Machine learning can predict anti-VEGF treatment demand in a Treat-and-Extend regimen for patients with nAMD, DME and RVO associated ME.
To assess the potential of machine learning to predict low and high treatment demand in real life in patients with nAMD, RVO and DME treated according to a TER.Retrospective cohort […]» Read more
We present novel OCT findings of presumed acute digoxin photoreceptor toxicity in the setting of concurrent amiodarone use. Discontinuation of medications resulted in symptom abatement, vision improvement, and reversal of […]» Read more
Risk factors for Severe Bleeding Complications in Vitreoretinal Surgery and the Role of Antiplatelet or Anticoagulant Agents.
To evaluate the influences and risk factors for severe bleeding complications during vitreoretinal surgery, and to investigate the role of antiplatelet (AP) and anticoagulant (AC) agents.Prospective trial STUDY POPULATION: This […]» Read more
To characterize the clinical features of occlusive retinal vasculitis (ORV).Retrospective case series.42 patients with ORV.A retrospective chart review identified all patients with ORV seen by the University of Colorado uveitis […]» Read more
Despite improvements in surgical management and final anatomic success, retinal detachment following pediatric open globe injury has poor functional outcomes. Younger patient age is an important presenting characteristic associated with […]» Read more
Ocular outcomes after treatment of cytomegalovirus (CMV) retinitis using adoptive immunotherapy with CMV-specific cytotoxic T-lymphocytes.
To describe ocular outcomes in eyes with CMV retinitis treated with adoptive immunotherapy using systemic administration of CMV-specific cytotoxic T-lymphocytes (CMV-CTLs) DESIGN: Retrospective cohort study SUBJECTS: Patients with active CMV […]» Read more
Photodynamic Therapy (PDT) for Retinal Hemangioblastoma: Treatment Outcomes in 17 Consecutive Patients.
To report the efficacy of photodynamic therapy (PDT) for management of retinal hemangioblastoma.Retrospective case series.Seventeen patients with retinal hemangioblastoma treated with PDT.The medical records of 17 patients with retinal hemangioblastoma […]» Read more
Evolving treatment patterns and outcomes of neovascular age-related macular degeneration over a decade.
Management of neovascular age-related macular degeneration (nAMD) has evolved over the last decade with several treatment regimens and different medications. This study describes the treatment patterns and, importantly, visual outcomes […]» Read more
Non ICGA treatment criteria for Suboptimal Anti VEGF Response for Polypoidal Choroidal Vasculopathy: APOIS PCV Workgroup Report 2.
To develop and validate optical coherence tomography (OCT) and color fundus photography (CFP) criteria in differentiating polypoidal choroidal vasculopathy (PCV) from typical neovascular age-related macular degeneration (nAMD) in eyes with […]» Read more
Perifoveal Chorioretinal Atrophy following Subretinal Voretigene Neparvovec-rzyl for RPE65-mediated Leber Congenital Amaurosis.
To report an anatomic change observed in a series of patients who underwent subretinal injection of voretigene neparvovec-rzyl (VN) for RPE65-mediated Leber congenital amaurosis.Multi-center retrospective chart review.Patients who underwent subretinal […]» Read more
To highlight recognizable patterns of subretinal fibrosis in the enhanced S-cone syndrome (ESCS).Retrospective case series.47 patients with subretinal fibrosis identified from 101 clinically diagnosed ESCS patients, confirmed by full field-electroretinography […]» Read more
Epiretinal Membrane Surgery After Retinal Detachment Repair: Visual Acuity Outcomes and Optical Coherence Tomography Analysis.
To assess visual acuity (VA) outcomes of epiretinal membrane (ERM) surgery following primary rhegmatogenous retinal detachment (RD) repair.Retrospective, consecutive case series.Eyes undergoing pars plana vitrectomy (PPV) with membrane peel (MP) […]» Read more
Timing of Complete Polypoidal Regression Following Intravitreous Aflibercept Treatments in Polypoidal Choroidal Vasculopathy.
To understand timing of complete polypoidal regression on indocyanine green angiography (ICGA) after aflibercept injections in polypoidal choroidal vasculopathy (PCV).Multicenter prospective study PARTICIPANTS: Adults with treatment-naïve PCV METHODS: After IRB […]» Read more
Recurrent neovascular age-related macular degeneration after discontinuation of VEGF inhibitors managed in a treat and extend regimen.
To investigate the recurrence rate of active macular neovascularization in patients with neovascular age-related macular degeneration (nAMD) previously followed in a treat and extend regimen where treatment had been stopped […]» Read more
To determine frequency of hypercoagulability testing and hypercoagulable states in CRVO patients under 50 years of age.Retrospective cohort study.Deidentified patients under 50 years of age newly diagnosed with CRVO from […]» Read more
Optical Coherence Tomography Signs of Early Atrophy in Age-related Macular Degeneration: Inter-Reader Agreement. CAM Report 6.
To determine the inter-reader agreement for incomplete and complete retinal pigment epithelium and outer retinal atrophy (iRORA and cRORA respectively) and their related features in age-related macular degeneration (AMD).Inter-reader agreement […]» Read more
Identifying peripapillary radial capillary plexus alterations in Parkinson’s disease using optical coherence tomography angiography.
To compare radial peripapillary capillary plexus vascular parameters and retinal nerve fiber layer (RNFL) thickness between Parkinson’s disease (PD) and controls.Prospective cross-sectional study.One hundred and fifty-one eyes of 81 PD […]» Read more
We report the impact of SMS reminder on follow-up visit compliance among patients who are on treatment for diabetic macular edema. The randomization based on intervention did not show any […]» Read more
Based on over 21 million intravitreal injections performed in the past 7 years, the utilization of bevacizumab has significantly decreased across all included payers. The percentage use has been lowest […]» Read more
Vitreous and Chorioretinal Lesions in People Who Inject Drugs Hospitalized with Bloodstream and Related Infections.
To determine the prevalence of and characterize vitreous and chorioretinal lesions, identify causative organisms, and correlate symptoms with ophthalmic involvement in people who inject drugs (PWID) hospitalized with bloodstream infection […]» Read more
Subthreshold Nanosecond Laser in Age-Related Macular Degeneration: Observational Extension Study to the LEAD Clinical Trial.
To evaluate the long-term effect of subthreshold nanosecond laser (SNL) treatment on progression to late age-related macular degeneration (AMD).Observational extension study to a randomized, sham-controlled trial.Two-hundred and twelve participants with […]» Read more
Epiretinal Membrane Surgery Using Intraoperative OCT-guided Membrane Removal in the DISCOVER Study versus Conventional Membrane Removal.
To provide a comparative assessment of clinical outcomes between subjects undergoing intraoperative optical coherence tomography (OCT) and conventional surgery for pars plana vitrectomy (PPV) with epiretinal membrane (ERM) peel.Case-control retrospective […]» Read more
Longitudinal Assessment of Ellipsoid Zone Integrity, Subretinal Hyperreflective Material, and Sub-RPE Disease in Neovascular AMD.
To longitudinally assess the effect of anti-vascular endothelial growth factor (VEGF) treatment on ellipsoid zone (EZ) integrity, subretinal hyperreflective material (SHRM), and the sub-retinal pigment epithelium (sub-RPE) compartment in eyes […]» Read more
Genotype and Long-term Clinical Course of Bietti Crystalline Dystrophy in Korean and Japanese Patients.
To investigate the genotype and long-term clinical phenotype of patients with Bietti crystalline dystrophy (BCD) in Korea and Japan.Retrospective case series.We analyzed the cases of 62 patients with clinical features […]» Read more