Coronavirus Disease 2019 (COVID-19): A Systematic Review of 133 Children Presented with Kawasaki-like Multisystem Inflammatory Syndrome.

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Kawasaki-like disease (KLD) and multisystem inflammatory syndrome in children (MIS-C) are considered as challenges for pediatric patients under the age of 18 infected with coronavirus disease 2019 (COVID-19).A systematic search […]

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Cerebrospinal fluid and serum interleukins 6 and 8 during the acute and recovery phase in COVID-19 neuropathies patients.

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This case series describes three patients affected by SARS-CoV-2 who developed polyradiculoneuritis as a probable neurological complication of COVID-19. A diagnosis of Guillain Barré syndrome was made on the basis […]

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Betacoronaviruses genome analysis reveals evolution toward specific codons usage: implications for SARS-CoV-2 mitigation strategies.

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Since the start of the COVID-19 pandemic, the SARS-CoV-2 has rapidly widespread worldwide becoming one of the major global public health issues of the last centuries. Currently, COVID-19 vaccine rollouts […]

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Optimal Uses of Pooled Testing for COVID-19 incorporating imperfect test performance and pool dilution effect: An Application to Congregate Settings in Los Angeles County.

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Pooled testing is a potentially efficient alternative strategy for COVID-19 testing in congregate settings. We evaluated the utility and cost-savings of pooled testing based on imperfect test performance and potential […]

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Comparable endemic coronavirus nucleoprotein-specific antibodies in mild and severe Covid-19 patients.

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The severity of disease of Covid-19 is highly variable, ranging from asymptomatic to critical respiratory disease and death. Potential cross-reactive immune responses between SARS-CoV-2 and endemic coronavirus (eCoV) may hypothetically […]

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Decreased In-Hospital Mortality Associated with Aspirin Administration in Hospitalized Patients Due to Severe COVID-19.

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Hypercoagulability and thrombosis caused by COVID-19 is related to the higher mortality rate. Because of limited data on antiplatelet effect, we aimed to evaluate the impact of aspirin add-on therapy […]

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Diagnostic accuracy of the Cepheid Xpert Xpress and the Abbott ID NOW assay for rapid detection of SARS-CoV-2: A systematic review and meta-analysis.

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Rapid and accurate diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is essential to prevent the spread of the virus. We investigated the diagnostic accuracy of the Xpert […]

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Informing the Global COVID-19 Response by Estimating Excess Deaths in Italy During the COVID-19 and 1918 Influenza Pandemics.

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We compared all-cause mortality in Italy July- December 1918 and January- June 2020, when the COVID-19 pandemics peaks occurred, using publicly available data from the Italian National Institute of Statistics. […]

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SARS-CoV-2 ORF9b Antagonizes Type I and III Interferons by Targeting Multiple Components of the RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING Signaling Pathways.

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The suppression of the type I and III interferon (IFN) responses by SARS-CoV-2 contributes to the pathogenesis of COVID-19. The strategy used by SARS-CoV-2 to evade antiviral immunity needs further […]

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Treatment Patterns in US Patients Hospitalized With COVID-19 and Pulmonary Involvement.

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This study describes the baseline characteristics and treatment patterns of US patients hospitalized with a diagnosis of coronavirus disease 2019 (COVID-19) and pulmonary involvement. Patients hospitalized with pulmonary involvement due […]

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Coronavirus genomic nsp14-ExoN, structure, role, mechanism, and potential application as a drug target.

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The recent coronavirus disease 2019 (COVID-19), causing a global pandemic with devastating effects on healthcare and social-economic systems, has no special antiviral therapies available for human coronaviruses (CoVs). The severe […]

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