Origin, HDV genotype and persistent viremia determine outcome and treatment response in patients with chronic hepatitis Delta.

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Hepatitis delta virus (HDV) infection causes severe chronic liver disease in Hepatitis B virus (HBV) infected individuals. Factors associated with poor prognosis are largely unknown.The French National Reference Centre for […]

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Personalized surveillance for hepatocellular carcinoma in cirrhosis – using machine learning adapted to HCV status.

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To develop algorithms based on machine learning predictive approaches to refine individualized predictions of hepatocellular carcinoma (HCC) risk according to HCV eradication in patients with cirrhosis included in the French […]

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Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma.

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Abnormal activation of mTORC1 signaling occurs at high frequency in hepatocellular carcinoma (HCC). However, the underlying mechanisms remain elusive. In this study, we identified ventricular zone expressed pleckstrin homology domain-containing […]

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Suboptimal reliability of liver biopsy evaluation has implications for randomized clinical trials.

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Liver biopsies are a critical component of pivotal studies in nonalcoholic steatohepatitis (NASH) constituting main inclusion criteria, risk stratification factors and endpoints. We evaluated the reliability of NASH Clinical Research […]

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Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.

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Selective elimination of virus-infected hepatocytes occurs through virus-specific CD8 T-cells recognizing peptide-loaded MHC molecules. Here, we report that virus-infected hepatocytes are also selectively eliminated through a cell-autonomous mechanism.We generated recombinant […]

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Multi-generational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p.

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The global obesity epidemic is threatening human health. How maternal obesity affects the incidence of offspring hepatocellular carcinoma (HCC) remains unknown. We investigated this association and the underlying mechanism.Diethylnitrosamine (DEN) […]

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Beta-amyloid deposition around hepatic bile ducts is a novel pathobiological and diagnostic feature of biliary atresia.

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Biliary atresia (BA) is a poorly understood deadly liver disease, often diagnosed late, is incurable and frequently requires liver transplantation. In this study, we aim to investigate the underlying pathomechanisms […]

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Similar risk of hepatocellular carcinoma during long-term entecavir or tenofovir therapy in Caucasian patients with chronic hepatitis B.

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The incidence of hepatocellular carcinoma (HCC) was recently reported to be lower in Asian chronic hepatitis B (CHB) patients treated with tenofovir disoproxil fumarate (TDF) than entecavir (ETV), but this […]

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Blocking integrin α4β7-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis.

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The heterodimeric integrin receptor α4β7 regulates CD4 T cell recruitment to inflamed tissues, but its role in the pathogenesis of nonalcoholic steatohepatitis (NASH) is unknown. Here we examined the role […]

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Clinical outcome and hemodynamic changes following HCV eradication with oral antiviral therapy in patients with clinically significant portal hypertension.

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Clinically significant portal hypertension (CSPH, HVPG≥10mmHg) persists 24 weeks after sustained virological response (SVR) in up to 78% of patients with HCV-related cirrhosis treated with direct acting antivirals. These patients […]

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Single-cell genomics and spatial transcriptomics: discovery of novel cell states and cellular interactions in liver physiology and disease biology.

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Transcriptome analysis allows the study of gene expression of human tissues and it is a valuable tool to characterize liver function, gene expression changes during liver disease, identify prognostic markers […]

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Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes.

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Non-alcoholic fatty liver disease (NAFLD) is rising in young adults, with potential implications for reproductive-aged women. Whether NAFLD during pregnancy confers more serious risks for maternal or perinatal health is […]

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Model for end-stage liver disease-sodium underestimates 90-day mortality risk in patients with acute-on-chronic liver failuare.

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The Model for End-stage Liver Disease with sodium correction (MELD-Na) is designed to prioritize liver transplantation (LT). MELD-Na predicts 90-day mortality in cirrhosis but it is unclear whether MELD-Na captures […]

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Single cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma.

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Intrahepatic cholangiocarcinoma (ICC) is the second most common liver malignancy. ICC typically features a remarkably cellular heterogeneity and dense stromal reaction. Therefore, a comprehensive understanding of cellular diversity and the […]

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Diverse effects of hepatic steatosis on fibrosis progression and functional cure in virologically quiescent chronic hepatitis B.

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Concomitant non-alcoholic fatty liver disease is common in patients with chronic hepatitis B (CHB) infection, although its impact on liver-related outcomes remains controversial. We aimed to study the effect of […]

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Efficacy of NS5A inhibitors against unusual and potentially difficult-to-treat HCV subtypes commonly found in sub Saharan Africa and South East Asia.

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The efficacy of NS5A inhibitors against several less common subtypes of hepatitis C virus (HCV) is poorly characterised. Some subtypes including 3b, 3g, 6u and 6v commonly harbour amino acid […]

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