A placebo-controlled randomised trial of budesonide for primary biliary cholangitis following an insufficient response to UDCA.

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In patients with primary biliary cholangitis (PBC) the utility of budesonide, a synthetic corticosteroid displaying high first-pass metabolism, is unresolved. In a placebo-controlled, double-blind trial, we evaluated the added-value of […]

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Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models.

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polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative genes participate in protein biogenesis and/or transport. Post-translational modifications (PTMs) are implicated […]

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RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma.

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Background and Aims Mutational profiling of patient tumors has suggested that hepatocellular carcinoma (HCC) development is mainly driven by loss-of-function mutations in tumor suppressor genes. p90 Ribosomal S6 kinase 2 […]

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Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling.

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Angiocrine signaling by liver sinusoidal endothelial cells (LSEC) regulates liver functions such as liver growth, metabolic maturation, and regeneration. Recently, we identified GATA4 as the master regulator of LSEC specification […]

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ENDPOINTS AND DESIGN OF CLINICAL TRIALS IN PATIENTS WITH DECOMPENSATED CIRRHOSIS: POSITION PAPER OF THE LIVERHOPE CONSORTIUM.

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Management of decompensated cirrhosis is currently geared towards the treatment of complications once they occur. To date there is no established disease-modifying therapy aimed at halting progression of the disease […]

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On-treatment serum albumin level can guide long-term treatment in patients with cirrhosis and uncomplicated ascites.

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The ANSWER study reported that long-term albumin administration to patients with cirrhosis and uncomplicated ascites improves survival. Such treatment led serum albumin to increase within a month, remaining stable thereafter. […]

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Gadoxetic acid-enhanced MRI of macrotrabecular-massive hepatocellular carcinoma and its prognostic implications.

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Despite the clinical and genetic significance of macrotrabecular-massive hepatocellular carcinoma (MTM-HCC), its imaging findings have not been described. This study aimed to characterize the imaging findings of MTM-HCC by gadoxetic […]

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Increased mortality in HIV/HCV-coinfected compared to HCV-monoinfected patients in the DAA era due to non-liver-related death.

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Direct acting antivirals (DAA) lead to high sustained virological response (SVR) rates and decreased the risk of disease progression. We compared SVR rates and all-cause, liver- and non-liver-related deaths, liver-related […]

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Clinical features and evolution of bacterial infection-related acute-on-chronic liver failure.

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Bacterial infections can trigger the development of organ failure/s and acute-on-chronic liver failure (ACLF). Different geographic variations in their bacteriology and clinical practices could lead to different epidemiology, phenotypes and […]

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Impact of COVID-19 on global hepatitis C elimination efforts.

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COVID-19 has placed significant strain on national healthcare systems at a critical moment in the context of hepatitis elimination. Mathematical models can be used to evaluate the possible impact of […]

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Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis.

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Increased hepatocyte death contributes to the pathology of acute and chronic liver diseases. The role of hepatocyte pyroptosis and extracellular inflammasome release in liver disease is unknown.We used primary mouse […]

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Epidemiological pattern, incidence and outcomes of COVID-19 in liver transplant patients.

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The incidence and outcomes of coronavirus disease 2019 (Covid-19) in immunocompromised patients are a matter of debate.Prospective nationwide study including a consecutive cohort of liver transplant patients with Covid-19 recruited […]

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Epidemiological pattern, incidence and outcomes of COVID-19 in liver transplant patients.

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The incidence and outcomes of coronavirus disease 2019 (Covid-19) in immunocompromised patients are a matter of debate.Prospective nationwide study including a consecutive cohort of liver transplant patients with Covid-19 recruited […]

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Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity.

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Chronic overconsumption of high-carbohydrate diet leads to steatosis and its associated metabolic disorder, and eventually non-alcoholic fatty liver disease. Carbohydrate responsive element binding protein (ChREBP) and insulin regulate de novo […]

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MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma.

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Hepatocellular carcinoma (HCC) is a cancer with multiple etiologies, and widespread prevalence. Largely refractory to current treatments, HCC is the fourth leading cause of cancer related deaths, world-wide. MicroRNAs (miRNAs) […]

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p53 haploinsufficiency and increased mTOR signaling define a subset of aggressive hepatocellular carcinoma.

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p53 mutations occur frequently in human hepatocellular carcinoma (HCC). Activation of the mammalian target of rapamycin (mTOR) pathway is also associated with HCC. However, it is still unknown whether these […]

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Update of the simplified criteria for autoimmune hepatitis: evaluation of the methodology for immunoserological testing.

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The simplified criteria for the diagnosis of autoimmune hepatitis (AIH) include immunofluorescence testing (IFT) of antinuclear and smooth muscle autoantibodies (ANA and SMA) on rodent tissue sections. We aimed to […]

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Association of inflammatory biomarkers with clinical outcomes in nivolumab-treated patients with advanced hepatocellular carcinoma.

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Nivolumab, a programmed death (PD)-1 (PD-1) inhibitor, demonstrated durable responses, manageable safety, and increased survival in patients with advanced hepatocellular carcinoma (HCC). Our retrospective analysis studied the immunobiology and potential […]

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