Site intended for healthcare professionals only
Aspirin and cyclooxygenase 2 (COX-2) inhibitors have been associated with a reduced risk of colorectal polyps and cancer in observational and randomized studies. The effect of celecoxib, a COX-2 inhibitor, […]
» Read moreHigh-flow nasal oxygen is recommended as initial treatment for acute hypoxemic respiratory failure and is widely applied in patients with COVID-19.To assess whether helmet noninvasive ventilation can increase the days […]
» Read moreHearing loss is common in older adults and associated with adverse health and social outcomes.To update the evidence review on screening for hearing loss in adults 50 years or older […]
» Read moreHearing loss is common in older adults and associated with adverse health and social outcomes.To update the evidence review on screening for hearing loss in adults 50 years or older […]
» Read moreThe effect of continuing vs withdrawing treatment with semaglutide, a glucagon-like peptide 1 receptor agonist, on weight loss maintenance in people with overweight or obesity is unknown.To compare continued once-weekly […]
» Read moreTracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information is available on adverse peri-intubation events.To evaluate the incidence and nature of […]
» Read moreThrombotic events are commonly reported in critically ill patients with COVID-19. Limited data exist to guide the intensity of antithrombotic prophylaxis.To evaluate the effects of intermediate-dose vs standard-dose prophylactic anticoagulation […]
» Read moreLittle is known about long-term sequelae of COVID-19.To describe the consequences at 4 months in patients hospitalized for COVID-19.In a prospective uncontrolled cohort study, survivors of COVID-19 who had been […]
» Read moreStroke is the fifth leading cause of death and a leading cause of disability in the United States, affecting nearly 800 000 individuals annually.Sudden neurologic dysfunction caused by focal brain ischemia […]
» Read moreAtrial fibrillation (AF) is the most common heart rhythm disturbance, continues to increase in incidence, and results in significant morbidity and mortality. The marine omega-3 fatty acids, eicosapentaenoic acid (EPA) […]
» Read moreStroke is the fifth leading cause of death and a leading cause of disability in the United States, affecting nearly 800 000 individuals annually.Sudden neurologic dysfunction caused by focal brain ischemia […]
» Read moreAtrial fibrillation (AF) is the most common heart rhythm disturbance, continues to increase in incidence, and results in significant morbidity and mortality. The marine omega-3 fatty acids, eicosapentaenoic acid (EPA) […]
» Read moreControl of the global COVID-19 pandemic will require the development and deployment of safe and effective vaccines.To evaluate the immunogenicity of the Ad26.COV2.S vaccine (Janssen/Johnson & Johnson) in humans, including […]
» Read moreThe US Preventive Services Task Force (USPSTF) is updating its 2013 lung cancer screening guidelines, which recommend annual screening for adults aged 55 through 80 years who have a smoking […]
» Read moreLung cancer is the second most common cancer and the leading cause of cancer death in the US. In 2020, an estimated 228 820 persons were diagnosed with lung cancer, and […]
» Read moreCervical spondylotic myelopathy is the most common cause of spinal cord dysfunction worldwide. It remains unknown whether a ventral or dorsal surgical approach provides the best results.To determine whether a […]
» Read moreThe US Preventive Services Task Force (USPSTF) is updating its 2013 lung cancer screening guidelines, which recommend annual screening for adults aged 55 through 80 years who have a smoking […]
» Read moreCommunity-dwelling older adults with dementia have a high prevalence of psychotropic and opioid use. In these patients, central nervous system (CNS)-active polypharmacy may increase the risk for impaired cognition, fall-related […]
» Read moreLung cancer is the leading cause of cancer-related death in the US.To review the evidence on screening for lung cancer with low-dose computed tomography (LDCT) to inform the US Preventive […]
» Read moreIvermectin is widely prescribed as a potential treatment for COVID-19 despite uncertainty about its clinical benefit.To determine whether ivermectin is an efficacious treatment for mild COVID-19.Double-blind, randomized trial conducted at […]
» Read moreThe COVID-19 pandemic has resulted in a persistent shortage of personal protective equipment; therefore, a need exists for hospitals to reprocess filtering facepiece respirators (FFRs), such as N95 respirators.To perform […]
» Read moreThe prevalence of irritable bowel syndrome (IBS) in the United States is between 7% and 16%, most common in women and young people, with annual direct costs estimated at more […]
» Read moreThe prevalence of irritable bowel syndrome (IBS) in the United States is between 7% and 16%, most common in women and young people, with annual direct costs estimated at more […]
» Read moreBlinatumomab is a CD3/CD19-directed bispecific T-cell engager molecule with efficacy in children with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL).To evaluate event-free survival in children with high-risk first-relapse B-ALL […]
» Read moreStandard chemotherapy for first relapse of B-cell acute lymphoblastic leukemia (B-ALL) in children, adolescents, and young adults is associated with high rates of severe toxicities, subsequent relapse, and death, especially […]
» Read moreStandard chemotherapy for first relapse of B-cell acute lymphoblastic leukemia (B-ALL) in children, adolescents, and young adults is associated with high rates of severe toxicities, subsequent relapse, and death, especially […]
» Read moreConvalescent plasma is a proposed treatment for COVID-19.To assess clinical outcomes with convalescent plasma treatment vs placebo or standard of care in peer-reviewed and preprint publications or press releases of […]
» Read moreConvalescent plasma is a proposed treatment for COVID-19.To assess clinical outcomes with convalescent plasma treatment vs placebo or standard of care in peer-reviewed and preprint publications or press releases of […]
» Read moreRefinement of criteria for multisystem inflammatory syndrome in children (MIS-C) may inform efforts to improve health outcomes.To compare clinical characteristics and outcomes of children and adolescents with MIS-C vs those […]
» Read moreWeight loss improves cardiometabolic risk factors in people with overweight or obesity. Intensive lifestyle intervention and pharmacotherapy are the most effective noninvasive weight loss approaches.To compare the effects of once-weekly […]
» Read more