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Obesity increases the risk of both cesarean delivery and surgical-site infection. Despite widespread use, it is unclear whether prophylactic negative pressure wound therapy reduces surgical-site infection after cesarean delivery in […]
» Read moreThere is wide variability among emergency medical systems (EMS) with respect to transport to hospital during out-of-hospital cardiac arrest (OHCA) resuscitative efforts. The benefit of intra-arrest transport during resuscitation compared […]
» Read moreThe standard schedule of national immunization programs for infants may not be sufficient to protect extremely and very preterm infants.To evaluate the immunogenicity of routine vaccinations administered to preterm infants.A […]
» Read moreThere is wide variability among emergency medical systems (EMS) with respect to transport to hospital during out-of-hospital cardiac arrest (OHCA) resuscitative efforts. The benefit of intra-arrest transport during resuscitation compared […]
» Read moreControlling blood pressure (BP) reduces the risk for cardiovascular disease.To determine whether BP control among US adults with hypertension changed from 1999-2000 through 2017-2018.Serial cross-sectional analysis of National Health and […]
» Read moreTraumatic brain injury (TBI) is the leading cause of death and disability due to trauma. Early administration of tranexamic acid may benefit patients with TBI.To determine whether tranexamic acid treatment […]
» Read moreThe US Merit-based Incentive Payment System (MIPS) is a major Medicare value-based payment program aimed at improving quality and reducing costs. Little is known about how physicians’ performance varies by […]
» Read moreIntegration of physician practices into health systems composed of hospitals and multispecialty practices is increasing in the era of value-based payment. It is unknown how clinicians who affiliate with such […]
» Read moreMany adults with obstructive sleep apnea (OSA) use device treatments inadequately and remain untreated.To determine whether combined palatal and tongue surgery to enlarge or stabilize the upper airway is an […]
» Read moreEvidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.To determine whether hydrocortisone improves outcome for patients with severe COVID-19.An ongoing adaptive platform trial testing multiple interventions within […]
» Read moreAcute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone use might attenuate lung injury in these […]
» Read moreEffective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory […]
» Read moreCoronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option.To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill […]
» Read moreCoronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option.To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill […]
» Read moreAcute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone use might attenuate lung injury in these […]
» Read moreEffective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory […]
» Read moreIn patients who undergo mechanical ventilation during surgery, the ideal tidal volume is unclear.To determine whether low-tidal-volume ventilation compared with conventional ventilation during major surgery decreases postoperative pulmonary complications.Single-center, assessor-blinded, […]
» Read moreOutcomes of postoperative atrial fibrillation (AF) after noncardiac surgery are not well defined.To determine the association of new-onset postoperative AF vs no AF after noncardiac surgery with risk of nonfatal […]
» Read moreSevere obesity and its related diseases, such as type 2 diabetes, hypertension, dyslipidemia, and sleep apnea, are very common in the United States, but currently very few patients with these […]
» Read moreIn patients who undergo mechanical ventilation during surgery, the ideal tidal volume is unclear.To determine whether low-tidal-volume ventilation compared with conventional ventilation during major surgery decreases postoperative pulmonary complications.Single-center, assessor-blinded, […]
» Read moreAfter percutaneous coronary intervention (PCI), patients with CYP2C19*2 or *3 loss-of-function (LOF) variants treated with clopidogrel have increased risk of ischemic events. Whether genotype-guided selection of oral P2Y12 inhibitor therapy […]
» Read moreSevere asthma exacerbations cause significant morbidity and costs. Whether vitamin D3 supplementation reduces severe childhood asthma exacerbations is unclear.To determine whether vitamin D3 supplementation improves the time to a severe […]
» Read moreSevere asthma exacerbations cause significant morbidity and costs. Whether vitamin D3 supplementation reduces severe childhood asthma exacerbations is unclear.To determine whether vitamin D3 supplementation improves the time to a severe […]
» Read moreAfter percutaneous coronary intervention (PCI), patients with CYP2C19*2 or *3 loss-of-function (LOF) variants treated with clopidogrel have increased risk of ischemic events. Whether genotype-guided selection of oral P2Y12 inhibitor therapy […]
» Read moreRemdesivir demonstrated clinical benefit in a placebo-controlled trial in patients with severe coronavirus disease 2019 (COVID-19), but its effect in patients with moderate disease is unknown.To determine the efficacy of […]
» Read moreMental health comorbidities are increasing worldwide and worsen outcomes for people with diabetes, especially when care is fragmented.To assess whether collaborative care vs usual care lowers depressive symptoms and improves […]
» Read moreThe combination of ascorbic acid, corticosteroids, and thiamine has been identified as a potential therapy for septic shock.To determine whether the combination of ascorbic acid, corticosteroids, and thiamine attenuates organ […]
» Read moreMental health comorbidities are increasing worldwide and worsen outcomes for people with diabetes, especially when care is fragmented.To assess whether collaborative care vs usual care lowers depressive symptoms and improves […]
» Read moreIncreasing rates of preventable sexually transmitted infections (STIs) in the US pose substantial burdens to health and well-being.To update evidence for the US Preventive Services Task Force (USPSTF) on effectiveness […]
» Read moreApproximately 20 million new cases of bacterial or viral sexually transmitted infections (STIs) occur each year in the US, and about one-half of these cases occur in persons aged 15 […]
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