Predictive models for cardiovascular and kidney outcomes in patients with type 2 diabetes: systematic review and meta-analyses.

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To inform a clinical practice guideline (BMJ Rapid Recommendations) considering sodium glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists for treatment of adults with type 2 diabetes, we summarised the […]

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Axial flow ventricular assist devices in cardiogenic shock complicating acute myocardial infarction.

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Cardiogenic shock (CS) remains the leading cause of death in patients hospitalised with acute myocardial infarction with mortality as high as 40%-50% prior to hospital discharge. The failure of inotropic […]

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Intensive low-density lipoprotein cholesterol lowering in cardiovascular disease prevention: opportunities and challenges.

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Elevated levels of low-density lipoprotein cholesterol (LDL-C) are associated with increased risk of coronary heart disease and stroke. Guidelines for the management of dyslipidaemia from the European Society of Cardiology […]

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Addition of cystatin C predicts cardiovascular death better than creatinine in intensive care.

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Decreased kidney function increases cardiovascular risk and predicts poor survival. Estimated glomerular filtration rate (eGFR) by creatinine may theoretically be less accurate in the critically ill. This observational study compares […]

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Risk of left atrial appendage thrombus and stroke in patients with atrial fibrillation and mitral regurgitation.

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To investigate the association of mitral regurgitation (MR) on thromboembolic risk of patients with non-valvular atrial fibrillation (NVAF) undergoing transoesophageal echocardiography (TEE)-guided cardioversion.Data for consecutive patients who underwent TEE-guided cardioversion […]

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P2Y12 inhibitor monotherapy after coronary stenting according to type of P2Y12 inhibitor.

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To compare P2Y12 inhibitor monotherapy after 3-month dual antiplatelet therapy (DAPT) with 12-month DAPT according to the type of P2Y12 inhibitor in patients undergoing percutaneous coronary intervention (PCI).The Smart Angioplasty […]

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Management considerations in the adult with surgically modified d-transposition of the great arteries.

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Dextro-transposition of the great arteries (D-TGA) has undergone a significant evolution in surgical repair, leading to survivors with vastly different postsurgical anatomy which in turn guides their long-term cardiovascular morbidity […]

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Anti-interleukin 1 agents for the treatment of recurrent pericarditis: a systematic review and meta-analysis.

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Corticosteroid-dependent and colchicine-resistant recurrent pericarditis (RP) is a challenging management problem, in which conventional anti-inflammatory therapy (nonsteroidal anti-inflammatory drugs, colchicine, corticosteroids) is unable to control the disease. Recent data suggest […]

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Norepinephrine, plasma renin activity and cardiovascular mortality in systolic heart failure.

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We analysed the circulating levels and prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP), norepinephrine (NE), epinephrine (E), plasma renin activity (PRA) and aldosterone in patients with systolic heart failure […]

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Prasugrel versus ticagrelor in patients with myocardial infarction undergoing percutaneous coronary intervention.

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The comparative efficacy and safety of prasugrel and ticagrelor in patients with myocardial infarction (MI) treated with percutaneous coronary intervention (PCI) remain unclear. We aimed to investigate the association of […]

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Incidence, predictors and mortality risk of new heart failure in patients hospitalised with atrial fibrillation.

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To determine the incidence, risk predictors and relative mortality risk of incident heart failure (HF) in patients following atrial fibrillation (AF) hospitalisation.The Western Australian Hospitalisation Morbidity Data Collection was used […]

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Implantable cardiac defibrillator events in patients with arrhythmogenic right ventricular cardiomyopathy.

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Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with a risk of sudden cardiac death. Optimal risk stratification is still under debate. The main purpose of this long-term, single-centre observation was […]

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Hospital variation of 30-day readmission rate following transcatheter aortic valve implantation.

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Thirty-day readmission rate is one of the hospital quality metrics. Outcomes of transcatheter aortic valve implantation (TAVI) have improved significantly, but it remains unclear whether hospital-level variance in 30-day readmission […]

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