Macaques are emerging as a critical animal model in transfusion medicine, owing to their evolutionary similarity to humans and perceived utility in discovery and translational science. However, little is known […]» Read more
A mutated factor X activatable by thrombin corrects bleedings in vivo in a rabbit model of antibody-induced hemophilia A.
Rendering coagulation factor X sensitive to thrombin was proposed as a strategy that can bypass the need for factor VIII. In this paper, this non-replacement strategy was evaluated in vitro […]» Read more
MYD88 in the driver’s seat of B-cell lymphomagenesis: from molecular mechanisms to clinical implications.
More than 50 subtypes of B-cell non-Hodgkin lymphoma are recognized in the most recent World Health Organization classification of 2016. The current treatment paradigm, however, is largely based on ‘one-size-fits-all’ […]» Read more
ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia.
Differentiation therapies achieve remarkable success in acute promyelocytic leukemia, a subtype of acute myeloid leukemia. However, excluding acute promyelocytic leukemia, clinical benefits of differentiation therapies are negligible in acute myeloid […]» Read more
Src family kinase-mediated vesicle trafficking is critical for neutrophil basement membrane penetration.
Leukocyte recruitment into inflamed tissue is highly dependent on the activation and binding of integrins to their respective ligands, followed by the induction of various signaling events within the cell […]» Read more
Rare variants lowering the levels of coagulation factor X are protective against ischemic heart disease.
Hematopoietic alterations in chronic heart failure patients by somatic mutations leading to clonal hematopoiesis.
Predisposed genomic instability in pre-treatment bone marrow evolves to therapy-related myeloid neoplasms in malignant lymphoma.
Kinetics of cytokine receptor internalization under steady-state conditions affects growth of neighboring blood cells.
Repurposing pyridoxamine for therapeutic intervention of intravascular cell-cell interactions in mouse models of sickle cell disease.
Adherent neutrophils on vascular endothelium positively contribute to cell-cell aggregation and vaso-occlusion in sickle cell disease. In the present study, we demonstrated that pyridoxamine, a derivative of vitamin B6, might […]» Read more
Ambient and household air pollution is a major health problem, contributing globally and annually to approximately 7 millions of all-cause avoidable deaths, shortening of life expectancy and significant direct and […]» Read more
Prevailing evidence suggests a decisive role of platelet-derived growth factors (PDGFs) and their receptors in primary myelofibrosis. While PDGF receptor β (PDGFRβ) expression is increased in bone marrow stromal cells […]» Read more
Prolonged survival in the absence of disease-recurrence in advanced-stage follicular lymphoma following chemo-immunotherapy: 13-year update of the prospective, multicenter randomized GITMO-IIL trial.
A prospective trial conducted in the period 2000-2005 showed no survival advantage for high-dose chemotherapy with rituximab and autograft (R-HDS) versus conventional chemotherapy with rituximab (CHOP-R) as first-line therapy in […]» Read more
EVI1 triggers metabolic reprogramming associated with leukemogenesis and increases sensitivity to L-asparaginase.
Metabolic reprogramming of leukemia cells is important for survival, proliferation, and drug resistance under conditions of metabolic stress in the bone marrow. Deregulation of cellular metabolism, leading to development of […]» Read more
Mental fatigue after allogeneic hematopoietic stem cell transplantation is associated with cognitive dysfunction, but not central nervous system inflammation.
Severe bleeding and absent ADP-induced platelet aggregation associated with inherited combined CalDAG-GEFI and P2Y12 deficiencies.
Hydroxyurea to lower TCD velocities and prevent primary stroke: the Uganda NOHARM sickle cell anemia cohort.
DA-EPOCH-R combined with high-dose methotrexate in patients with newly diagnosed stage II-IV CD5-positive diffuse large B-cell lymphoma: a single-arm, open-label, phase 2 study.
CD5-positive diffuse large B-cell lymphoma (CD5+ DLBCL) is characterized by poor prognosis and a high frequency of central nervous system relapse after standard immunochemotherapy. We conducted a phase 2 study […]» Read more
Quantification of minimal disseminated disease by quantitative PCR and digital PCR for NPM-ALK as prognostic factor in children with anaplastic large cell lymphoma.
Detection of minimal disseminated disease is a validated prognostic factor in ALK-positive anaplastic large cell lymphoma. We previously reported that quantification of minimal disease by quantitative real-time PCR in bone […]» Read more
Abstract: Click here to read the full article @ Haematologica» Read more
The new small tyrosine-kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs.
Abstract: Tyrosine kinases have been implicated in promoting tumorigenesis of several human cancers. Exploiting these vulnerabilities has been shown to be an effective anti-tumor strategy as demonstrated for example by […]» Read more
Abstract: Protection from acute lymphoblastic leukemia relapse in the central nervous system is crucial to survival and quality of life for leukemia patients. Current central nervous system directed therapies cause […]» Read more
Abstract: Click here to read the full article @ Haematologica» Read more
Bleeding disorders in adolescents with heavy menstrual bleeding in a multicentre prospective US cohort.
Abstract: Heavy menstrual bleeding is common in adolescents. The frequency and predictors of bleeding disorders in adolescents, especially with anovulatory bleeding, are unknown. Adolescents referred for heavy menstrual bleeding underwent […]» Read more
Vitamin K-dependent carboxylation of coagulation factors: insights from a cell-based functional study.
Abstract: Vitamin K-dependent carboxylation is a posttranslational modification essential for the biological function of coagulation factors. Defects in carboxylation are mainly associated with bleeding disorders. With the discovery of new […]» Read more
Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma.
Abstract: The BCL-2 specific inhibitor, venetoclax/ABT-199 has exhibited remarkable clinical activity in nearly all cases of chronic lymphocytic leukemia. In contrast, responses are usually much less in diffuse large B-cell […]» Read more
Pre-treatment maximum standardized uptake value predicts outcome after frontline therapy in patients with advanced stage follicular lymphoma.
Abstract: The impact of pre-treatment maximum standardized uptake value (SUVmax) on the outcome following specific frontline regimens has not been explored. We performed a retrospective analysis of 346 patients with […]» Read more
Abstract: Transferrin receptor 1 (Tfr1) mediates the endocytosis of diferric transferrin in order to transport iron, and Tfr1 has been suggested to play an important role in hematopoiesis. To study […]» Read more