In human retina, photoreceptor cell death (PCD) is a slow but conspicuous event, which continues with aging. Rods die earlier than cones, the latter continue to alter in a subtle […]» Read more
Neuroimaging studies in patients with bipolar disorder have suggested that a neuropathological process may be effective in this disease. Neurodegenerative changes in the retina can be followed by optical coherence […]» Read more
To determine the association of plasma homocysteine levels with retinal layer thickness in a large community cohort of older adults.The Rugao Longevity and Ageing Study is an observational, prospective and […]» Read more
Recently updated global diabetic retinopathy screening guidelines: commonalities, differences, and future possibilities.
Diabetic retinopathy (DR) is a global health burden. Screening for sight-threatening DR (STDR) is the first cost-effective step to decrease this burden. We analyzed the similarities and variations between the […]» Read more
Association of central serous chorioretinopathy with single nucleotide polymorphisms in complement factor H gene in Iranian population.
To investigate the association of two different single nucleotide polymorphisms (SNPs) in the complement factor H (CFH) gene with central serous chorioretinopathy (CSCR) in the Iranian population.This is a case-control […]» Read more
We investigated in vivo light-induced photoreceptor damage in retinitis pigmentosa (RP) using spectral-domain optical coherence tomography (SD-OCT) images.We retrospectively reviewed patients with genetic diagnosis of EYS-associated RP. The outer nuclear […]» Read more
Capturing the clinical decision-making processes of expert and novice diabetic retinal graders using a ‘think-aloud’ approach.
Diabetic eye screening programmes have been developed worldwide based on evidence that early detection and treatment of diabetic retinopathy are crucial to preventing sight loss. However, little is known about […]» Read more
Extended real-world experience with the ILUVIEN® (fluocinolone acetonide) implant in the United Kingdom: 3-year results from the Medisoft® audit study.
This study aimed to assess the long-term effectiveness of the 0.2 μg/day fluocinolone acetonide (FAc) implant over ≥3 years for patients with diabetic macular oedema.A retrospective audit of pseudo-anonymised data from […]» Read more
To inspect the inter-reader agreement of different diagnostic modalities in identifying choroidal neovascularization (CNV) activity secondary to angioid streaks (AS) and to analyze the prevalence of subretinal hyper-reflective material (SHRM) […]» Read more
To determine visual outcomes and prevalence of amblyogenic risk factors in children with Apert, Crouzon, Pfeiffer and Saethre-Chotzen syndromes.We conducted a single-centre, retrospective chart review of patients assessed at our […]» Read more
Sickle cell retinopathy is often initially asymptomatic even in proliferative stages, but can progress to cause vision loss due to vitreous haemorrhages or tractional retinal detachments. Challenges with access and […]» Read more
Diagnostic accuracy of current machine learning classifiers for age-related macular degeneration: a systematic review and meta-analysis.
The objective of this study was to systematically review and meta-analyze the diagnostic accuracy of current machine learning classifiers for age-related macular degeneration (AMD). Artificial intelligence diagnostic algorithms can automatically […]» Read more
Newer insights into the clinical profile of posterior lenticonus in children and its surgical, visual, refractive outcomes.
To analyze the clinical profile of patients with posterior lenticonus and their surgical, visual, and refractive outcomes.Retrospective interventional case series of 84 eyes of 63 patients with posterior lenticonus. The […]» Read more
Continued anti-VEGF treatment does not prevent recurrences in eyes with stable neovascular age-related macular degeneration using a treat-and-extend regimen: a retrospective case series.
The continuation of anti-vascular endothelial growth factor (anti-VEGF) treatment after achieving stability in patients with neovascular age-related macular degeneration has generally been advocated. In our own patients, we thought to […]» Read more
Partial lamellar sclerouvectomy surgery for anteriorly located uveal tumour resection: a 20-year experience.
To investigate the results of partial lamellar sclerouvectomy (PLSU) for anteriorly located uveal tumours.We reviewed the tumour features, histopathologic findings, complications, visual acuity outcomes, eye preservation, metastasis, and mortality data […]» Read more
Efficacy of montelukast in preventing seasonal recurrence of vernal keratoconjunctivitis in children.
Vernal keratoconjunctivitis is a chronic, seasonally exacerbated, allergic inflammation of the eye. The study aims to evaluate the efficacy and safety of oral montelukast in treating vernal keratoconjunctivitis in pediatric […]» Read more
Evaluation of a computer-based facial dysmorphology analysis algorithm (Face2Gene) using standardized textbook photos.
Genetic syndromes often have ocular involvement. Ophthalmologists may have difficulty identifying dysmorphic features in genetic syndrome evaluations. We investigated the sensitivity and specificity of Face2Gene (F2G), a digital image analysis […]» Read more
Pressure on capacity in ophthalmology alongside the coronavirus (COVID-19) pandemic led to the development of the COVID-19 Urgent Eyecare Service (CUES), allowing patients to receive a prompt ophthalmic consultation, including […]» Read more
Retinal neurodegeneration is an early pathological change in diabetic retinopathy (DR). Early-stage retinal neurodegeneration is usually asymptomatic. This study aims to identify circulating microRNAs (miRNAs) as sensitive biomarkers for early […]» Read more
The aim of this review was to discuss frequently encountered themes such as cataract surgery in presence of age-related macular degeneration (AMD), dementia, Immediate Sequential Bilateral Cataract Surgery (ISBCS), discussing […]» Read more
Skin redraping for correction of lower eyelid epiblepharon combined with medial epicanthal fold: a retrospective analysis of 286 Asian children.
This study was performed to evaluate the clinical effect of skin redraping on lower eyelid epiblepharon accompanied by a medial epicanthal fold.This retrospective case series involved 572 eyes of 286 […]» Read more
Blepharoptosis (ptosis) is among the most common disorders of the upper eyelid encountered in both optometric and ophthalmic practice. The unilateral or bilateral drooping of the upper eyelid that characterises […]» Read more
To determine the near-term risk of stroke following a retinal artery occlusion (RAO).The risk of stroke was assessed in two manners; with a self-controlled case series (SCCS) and a propensity […]» Read more
Utilisation of optical coherence tomography and optical coherence tomography angiography to assess retinal neovascularisation in diabetic retinopathy.
To evaluate the use of optical coherence tomography angiography (OCTA), structural OCT and fundus fluorescein angiography (FFA) to distinguish neovascularisation elsewhere (NVE) from intra retinal microvascular abnormalities (IRMA) and their […]» Read more
REALITY is an international observational retrospective registry of LHON patients evaluating the visual course and outcome in Leber hereditary optic neuropathy (LHON).Demographics and visual function data were collected from medical […]» Read more
One-year visual outcome of secondary piggyback pinhole device implantation in pseudophakic eyes with irregular corneal astigmatism and iris trauma.
Retrospective case series evaluating the efficacy and safety of implanting XtraFocus™ pinhole device in pseudophakic patients with irregular corneal astigmatism with concurrent or standalone iris defect.Electronic case records were searched […]» Read more
Long term outcomes of transcutaneous non-image guided bleomycin sclerotherapy in orbital/adnexal lymphatic malformations: a protocol-based management in 69 eyes.
To study the efficacy and the long-term outcomes of treating micro and macrocystic orbital and/or adnexal lymphatic malformations (OA-LM) with protocol-based bleomycin sclerotherapy.A retrospective interventional study of 69 eyes having […]» Read more
Susac’s syndrome, a rare autoimmune vasculo-occlusive disease, may pose a diagnostic challenge and result in a devastating ocular and systemic outcome. Our study identifies a new retinal finding and evaluates […]» Read more
The performance of iPad-based noise-field perimeter versus Humphrey Field Analyser in detecting glaucomatous visual field loss.
To conduct a preliminary evaluation of the feasibility of visual field fast (VFF), a free iPad-based noise-field perimeter, in detecting glaucomatous scotomas versus the clinical-standard Humphrey visual field (HVF) test. […]» Read more
First described by Gaucher and associates in 2008 in eyes with high myopia, dome-shaped maculopathy (DSM) is an anterior convex protrusion of the macula towards the vitreous cavity observable on […]» Read more