Broadening the scope of pediatric intensive interdisciplinary pain treatment to promote future resilience and psychological flexibility.

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This journal recently published a paper by Wager and colleagues, entitled “Long-term outcomes of children with severe chronic pain: Comparison of former patients with a community sample” (Wager et al., […]

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High-frequency spinal cord stimulation as rescue therapy for chronic pain patients with failure of conventional spinal cord stimulation.

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This study aims to evaluate the efficacy of 10-kHz high-frequency (HF10) devices as a rescue treatment in patients with failure of conventional spinal cord stimulation (SCS) therapy for chronic pain […]

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Opioids: A ‘crisis’ of too much or not enough – or simply how rich you are and where you live?

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The ‘Opioid Crisis’, which originated in Western countries, has been misrepresented and is misinforming the global public. For 20 years, since the advent of the synthetic opioids, 25,000 Americans, on average, […]

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Pain regulation during mindfulness meditation: phenomenological fingerprints in novices and experts practitioners.

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The way people respond to pain is based on psychological mechanisms, beliefs and expectations. Mindfulness meditation (MM) has been shown to regulate pain and mental suffering through different mechanisms such […]

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‘Reassurance and health care seeking in people with persistent musculoskeletal low back pain consulting orthopaedic spine practitioners: A prospective cohort study’.

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Guidelines recommend self-management for most people living with persistent musculoskeletal low back pain (PMLBP) when surgery is ruled out. Conveying this message to patients can be challenging. This study examined […]

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Expanding frontiers in telehealth: video assisted at-home application of capsaicin 8% patch.

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In recent years, the delivery of health services has undergone a major paradigm shift towards expanded outpatient services and widespread use of telemedicine. Post herpetic neuralgia (PHN) is a treatment […]

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Visual illusions modulate body perception disturbance and pain in Complex Regional Pain Syndrome: A randomised trial.

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Effective treatment of longstanding Complex Regional Pain Syndrome (CRPS) is a challenge, as causal mechanisms remain elusive. People with CRPS frequently report distorted subjective perceptions of their affected limb. Evidence […]

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Commentary to “Challenges and opportunities in translational pain research – an opinion paper of the working group on translational pain research of the European Pain Federation (EFIC)” by Mouraux et al.

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Preclinical and clinical pain science have since long suffered from lack of joint ventures that, as securely as possible, have approached problems that are relevant for the understanding of clinical […]

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Subcutaneous tanezumab for osteoarthritis: Is the early improvement in pain and function meaningful and sustained?

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To evaluate if early improvements in pain and function with subcutaneous tanezumab are meaningful and sustained over 24 weeks.Patients with moderate-to-severe osteoarthritis (hip or knee) in Europe and Japan were […]

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Does muscular or mental fatigue have an influence on the nociceptive flexion reflex? a randomized cross-over study in healthy people.

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Fatigue is a widespread complaint in both healthy and diseased individuals (Engberg et al., 2017; Finsterer et al., 2014) that is often described as an overwhelming sense of tiredness, lack […]

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Feasibility Randomized-Controlled Trial of Online Acceptance and Commitment Therapy for Painful Peripheral Neuropathy in People Living with HIV: The OPEN Study.

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Neuropathic pain negatively affects quality of life among people living with HIV (PLWH). This study examined the feasibility of conducting a full-scale randomized-controlled trial of online acceptance and commitment therapy […]

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Preoperative Sleep Quality And Adverse Pain Outcomes After Total Hip Arthroplasty.

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Sleep disturbance is thought to aggravate acute postoperative pain. The influence of preoperative sleep problems on pain control in the long-term and development of chronic postsurgical pain is largely unknown.This […]

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Lower levels of physical activity are associated with pain progression in older adults, a longitudinal study.

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While pain is common in older adults, the association with physical activity is unclear. Currently, the role physical activity plays in impacting pain developing over time is not well-defined.Latent transition […]

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N-acylethanolamine-hydrolyzing acid amidase: a new potential target to treat paclitaxel-induced neuropathy.

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Although paclitaxel is an effective chemotherapeutic agent used to treat multiple types of cancer (e.g., breast, ovarian, neck, and lung), it also elicits paclitaxel-induced peripheral neuropathy (PIPN), which represents a […]

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Intact pain modulation through manipulation of controllability and expectations in aging.

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Pain expectation and controllability can modulate pain processing. However, little is known about age-related effects on these cognitive factors involved in pain control. This study assessed age-related brain changes associated […]

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European clinical practice recommendations on opioids for chronic noncancer pain – Part 2: Special situations.

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Opioid use for chronic non-cancer pain (CNCP) is under debate. In the absence of pan-European guidance on this issue, a position paper was commissioned by the European Pain Federation (EFIC).The […]

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Challenges and opportunities in translational pain research – An opinion paper of the working group on translational pain research of the European pain federation (EFIC).

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For decades, basic research on the underlying mechanisms of nociception has held promise to translate into efficacious treatments for patients with pain. Despite great improvement in the understanding of pain […]

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Development and Validation of the Brief Assessment of Distress about Pain.

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The experience of pain is a complex interaction of somatic, behavioral, affective, and cognitive components. Negative psychological states (e.g., anxiety, fear, and depression) are intertwined with pain and contribute to […]

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Long-term outcomes of children with severe chronic pain: Comparison of former patients with a community sample.

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Findings on the short- and long-term effectiveness of intensive interdisciplinary pain treatment (IIPT) for children with severe chronic functional pain are promising. However, a definitive appraisal of long-term effectiveness cannot […]

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Role of the endocannabinoid system in a mouse model of Fragile X undergoing neuropathic pain.

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Neuropathic pain is a complex condition characterized by sensory, cognitive and affective symptoms that magnify the perception of pain. The underlying pathogenic mechanisms are largely unknown and there is an […]

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The effect of experimental pain on the excitability of the corticospinal tract in humans: a systematic review and meta-analysis.

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Pain influences motor control. Previous reviews observed that pain reduces the excitability of corticospinal projections to muscles tested with transcranial magnetic stimulation. However, the independent effect of the type of […]

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