Intravenous immunoglobulin treatment for patients with severe COVID-19: a retrospective multi-center study.

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Intravenous immunoglobulin (IVIG) is commonly used to treat severe COVID-19, although the clinical outcome of such treatment remains unclear. This study evaluated the effectiveness of IVIG treatment in severe COVID-19 […]

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Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among hospital workers – A multicentre cross-sectional study.

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Protecting healthcare workers (HCW) from Coronavirus Disease-19 (COVID-19) is critical to preserve the functioning of healthcare systems. We therefore assessed seroprevalence and identified risk factors for Severe Acute Respiratory Syndrome-Coronavirus-2 […]

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Long COVID and the brain network of Proust’s madeleine: targeting the olfactory pathway.

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We detail in this Commentary our hypothesis of functional brain dysfunction in patients with long Covid in relation with the impairment of olfactory pathways, and discuss possible implications for the […]

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Novel SARS-CoV-2 variants: the pandemics within the pandemic.

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Many new variants of SARS-CoV-2 have been termed Variants of Concern/Interest (VOC/I) because of their greater risk due to possibly: enhanced transmissibility and/or severity, immune escape, diagnostic and/or treatment failure, […]

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Spreading of a new SARS-CoV-2 N501Y spike variant in a new lineage.

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Our surveillance of the SARS-CoV-2 genomic epidemiology led us to detect several variants since summer 2020. We report the recent spread of a new SARS-CoV-2 spike 501Y variant.SARS-CoV-2 sequences obtained […]

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Outbreak investigation of symptomatic SARS-COV-2 VOC 202012/01-lineage B.1.1.7 infection in healthcare workers, Italy.

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In December 2020, Italy began a national immunization campaign using the BNT162b2 mRNA COVID-19 vaccine, prioritizing healthcare workers (HCWs). Immune serum from vaccinated subjects seems to (largely) retain titres of […]

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How the European In Vitro Diagnostic Regulation could negatively impact the European response to the next pandemic: an urgent call for action before May 2022.

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The Corona Virus Disease 2019 (COVID-19) pandemic has demonstrated that the ability for laboratories to quickly set up and implement labdeveloped tests (LDTs) is essential to respond to an emerging […]

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Early antibody response in healthcare professionals after two doses of SARS-CoV-2 mRNA vaccine (BNT162b2).

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Data on the immune response after two doses of BNT162b2 are so far limited. Previously infected individuals were excluded from pivotal clinical trials and the optimal dose regimen in this […]

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How to interpret and use COVID-19 serology and immunology tests.

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Although molecular tests are considered the gold standard for coronavirus disease 2019 (COVID-19) diagnostics, serological and immunological tests may be useful in specific settings.This review summarises the underlying principles and […]

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SARS-COV-2 antibody dynamics and B-cell memory response over-time in COVID-19 convalescent subjects.

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Worldwide spread of COVID-19 disease highlights the need for assessment of long-term humoral immunity in convalescent subjects. Our objectives were to evaluate long-term IgG SARS-CoV-2 antibody response and B-cell memory […]

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Antibody response to mRNA SARS-CoV-2 vaccine among kidney transplant recipients – Prospective cohort study.

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We aimed to evaluate rates of antibody response to mRNA SARS-CoV-2 vaccine among kidney transplant recipients, and to identify factors associated with reduced immunogenicity.A prospective cohort study including consecutive kidney […]

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Personalized prophylactic anticoagulation in hospitalized patients with Covid-19 – The role of anti-Xa monitoring.

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Due to the strong association between severe COVID-19 and a prothrombotic state, most experts suggest an intensified anticoagulation regimen, mostly including an intermediate dose of low-molecular heparin, even though there […]

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Clinical characteristics and factors associated with hospital admission or death in 43,103 adult outpatients with COVID-19 managed with the Covidom telesurveillance solution: a prospective cohort study.

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Studies on coronavirus disease 2019 (COVID-19) have mainly focused on hospitalized patients or those with severe disease. We aim to assess the clinical characteristics, outcomes and factors associated with hospital […]

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Efficacy and safety of tocilizumab in COVID-19 patients: A living systematic Review and meta-analysis: first update.

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Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19).To update data a living systematic review of the literature […]

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Diagnostic accuracy of loop mediated isothermal amplification coupled to nanopore sequencing (LamPORE) for the detection of SARS-CoV-2 infection at scale in symptomatic and asymptomatic populations.

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Rapid, high throughput diagnostics are a valuable tool, allowing the detection of SARS-CoV-2 in populations, in order to identify and isolate people with asymptomatic and symptomatic infections. Reagent shortages and […]

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Disinfectant effectiveness against SARS-CoV-2 and influenza viruses present on human skin: model-based evaluation.

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Disinfection effectiveness against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on human skin remains unclear due to the hazards of viral exposure. An evaluation model, which has been previously generated […]

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Long-term outcomes of patients following hospitalization for COVID-19: a prospective observational study.

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Few data regarding follow-up of patients after COVID-19 discharge are available. We aim to describe the long-term outcomes of survivors of hospitalization for COVID-19 followed up first at an outpatient […]

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Prevalence and clinical significance of relative bradycardia at hospital admission in patients with Coronavirus Disease 2019 (COVID-19).

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The clinical relevance of relative bradycardia in patients with Coronavirus Disease 2019 (COVID-19) has been poorly investigated. We evaluated the prevalence and clinical significance of relative bradycardia at hospital admission […]

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Not all COVID-19 pandemic waves are alike.

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We aimed to assess differences in patients’ profiles in the first two surges of the SARS-CoV-2 pandemic in Barcelona, Spain.We prospectively collected data from all adult patients with SARS-CoV-2 infection […]

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Seroprevalence of SARS-CoV-2 in Slovenia: results of two rounds of a nationwide population study on a probability-based sample, challenges and lessons learned.

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Seroprevalence surveys provide crucial information on cumulative SARS-CoV-2 exposure. This Slovenian nationwide population study is the first longitudinal 6-month serosurvey using probability-based sample across all age categories.Each participant supplied two […]

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14-Day survival among older adults with severe SARS-Cov2 infection treated with corticosteroid: a cohort study.

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To assess the effectiveness of corticosteroids among older adults with COVID-19 pneumonia requiring oxygen.We used routine care data from 36 hospitals in France and Luxembourg to assess the effectiveness of […]

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Community-acquired Pneumonia Severity Assessment Tools in Patients Hospitalized with COVID-19: a Validation and Clinical Applicability Study.

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To externally validate community acquired pneumonia (CAP) tools on patients hospitalized with COVID-19 pneumonia from two distinct countries, and compare its performance to recently developed COVID-19 mortality risk stratification tools.We […]

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Hydroxychloroquine in mild-to-moderate COVID-19: a placebo-controlled double blind trial.

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To determine whether hydroxychloroquine decreases the risk of adverse outcome in patients with mild-to-moderate COVID-19 at high risk of worsening.We conducted a multicentre randomized double-blind placebo-controlled trial evaluating hydroxychloroquine in […]

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Methodological evaluation of bias in observational COVID-19 studies on drug effectiveness.

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Observational studies may provide valuable evidence on real-world causal effects of drug effectiveness in patients with Coronavirus Disease 2019 (COVID-19). Since patients are usually observed from hospital admission to discharge […]

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Recommendations for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples.

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SARS-CoV-2 genotyping has been instrumental to monitor viral evolution and transmission during the pandemic. The quality of the sequence data obtained from these genotyping efforts depends on several factors, including […]

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SARS-CoV-2 specific T cell immunity in COVID-19 convalescent patients and unexposed controls measured by ex-vivo ELISpot assay.

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SARS-CoV-2 T-cell response characterization represents a crucial issue for defining the role of immune protection against COVID-19. The aim of the study was to assess the SARS-CoV-2 T-cell response in […]

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Sex-biased clinical presentation and outcomes from COVID-19.

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Males are disproportionately affected by severe disease and death from SARS-CoV-2 infection. In their recent article, Mussini et al. found that among people admitted with severe COVID-19, males had higher […]

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A real-life setting evaluation of the effect of remdesivir on viral load in COVID-19 patients admitted to a large tertiary center in Israel.

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The effectiveness of remdesivir, a Food and Drug Administration (FDA) approved drug for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has been repeatedly questioned during the current coronavirus disease 2019 (COVID-19) […]

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Seroprevalence of SARS-CoV-2 in blood donors from the Lodi Red Zone and adjacent Lodi metropolitan and suburban area.

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To define the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in blood donors (referred to the first lockdown area (Lodi Red-Zone) of the Lombardy region and in a […]

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