The Effects of Oral Energy-Dense Supplements on Nutritional Status in Nondiabetic Maintenance Hemodialysis Patients.

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Background and objectives: Fat-based energy-dense nutritional supplements may offer benefits over protein or carbohydrate dense supplements for patients receiving dialysis because of the adverse metabolic consequences of the latter. We […]

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Acute Kidney Injury in the Modern Era of Allogeneic Hematopoietic Stem Cell Transplantation.

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Background and objectives Acute kidney injury (AKI) is a major complication of allogeneic hematopoietic stem cell transplantation, increasing risk of non-relapse mortality. AKI etiology is often ambiguous due to heterogeneity […]

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Evidence For and Against Direct Kidney Infection by SARS-CoV-2 in Patients with COVID-19.

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Despite evidence of multi-organ tropism of SARS-CoV-2 in patients with COVID-19, direct viral kidney invasion has been difficult to demonstrate. The question of whether SARS-CoV-2 can directly infect the kidney […]

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Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Kidney Failure Patients Treated with Dialysis: A Systematic Review and Meta-Analysis.

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Patients with kidney failure have a high risk of cardiovascular disease due to cardiac remodeling, left ventricular fibrosis, and hyperaldosteronism, all of which can be potentially mitigated by mineralocorticoid receptor […]

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Reliability and Validity of the Patient Activation Measure in Kidney Disease: Results of Rasch Analysis.

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Despite the increasing prioritization of the promotion of patient activation in nephrology, its applicability to people with CKD is not well established. Before the Patient Activation Measure is universally adopted […]

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Latency, Anti-Bacterial Resistance Pattern, and Bacterial Infection-Related Glomerulonephritis.

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Background and objectives Bacterial infection-related glomerulonephritis occurs concurrent to or following known or unknown infections. It’s important to understand the clinical implications of the bacterial isolates, anti-microbial resistance patterns and […]

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HLA Alleles and Prognosis of PLA2R-Related Membranous Nephropathy.

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Background and objectives Associations between HLA alleles and susceptibility to PLA2R-related membranous nephropathy have been well defined previously in Chinese patients. However, the relationships between HLA alleles and kidney outcome […]

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Risk of COVID-19 Disease, Dialysis Unit Attributes, and Infection Control Strategy among London In-Center Hemodialysis Patients.

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Background Patients receiving in-center hemodialysis treatment face unique challenges during the COVID-19 pandemic, specifically the need to attend for treatment that prevents self-isolation. Dialysis unit attributes and isolation strategies that […]

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Association of Depressive Symptoms with Rapid Kidney Function Decline in Adults with Normal Kidney Function.

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The relationship of depressive symptoms with kidney function remains poorly investigated. We aimed to evaluate the prospective association between depressive symptoms and rapid decline in kidney function in Chinese adults […]

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Acute Kidney Injury Requiring Dialysis and Incident Dialysis Patient Outcomes in US Outpatient Dialysis Facilities.

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About 30% of patients with acute kidney injury (AKI) may require ongoing dialysis in the outpatient setting after hospital discharge. A 2017 CMS policy change allows Medicare beneficiaries with AKI […]

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Dialysis Facility Profit Status and Early Steps in Kidney Transplantation in the Southeastern United States.

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Dialysis facilities in the United States play a key role in access to kidney transplantation. Previous studies reported that patients treated at for-profit facilities are less likely to be waitlisted […]

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Prognostic Factors and Long-Term Outcome with ANCA-Associated Kidney Vasculitis in Childhood.

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Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is extremely rare in children. We report the clinico-pathological features, long-term outcomes, and prognostic factors of a large paediatric cohort of patients with ANCA-associated kidney […]

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Predictive Approaches for Acute Dialysis Requirement and Death in COVID-19.

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Acute Kidney Injury treated with dialysis initiation is a common complication of COVID-19 infection among hospitalized patients. However, dialysis supplies and personnel are often limited.Using data from adult hospitalized COVID-19 […]

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Early Humoral Responses of Hemodialysis Patients after COVID-19 Vaccination with BNT162b2.

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Background and objectives Patients receiving hemodialysis are at high risk for both SARS-CoV-2 infection and severe COVID-19 disease. A life-saving vaccine is available, but sensitivity to vaccines is generally lower […]

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Phase 1/2 Study of Lumasiran for Treatment of Primary Hyperoxaluria Type 1: A Placebo-Controlled Randomized Clinical Trial.

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In the rare disease primary hyperoxaluria type 1, overproduction of oxalate by the liver causes kidney stones, nephrocalcinosis, kidney failure, and systemic oxalosis. Lumasiran, an RNA interference therapeutic, suppresses glycolate […]

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Pharmacist-Led Mobile Health Intervention and Transplant Medication Safety: A Randomized Controlled Clinical Trial.

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Medication safety events are predominant contributors to suboptimal graft outcomes in kidney transplant recipients. The goal of this study was to examine the efficacy of improving medication safety through a […]

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Effect of Apabetalone on Cardiovascular Events in Diabetes, CKD, and Recent Acute Coronary Syndrome: Results from the BETonMACE Randomized Controlled Trial.

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CKD and type 2 diabetes mellitus interact to increase the risk of major adverse cardiovascular events (i.e., cardiovascular death, nonfatal myocardial infarction, or stroke) and congestive heart failure. A maladaptive […]

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Urinary Cell mRNA Profiles Predictive of Human Kidney Allograft Status.

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Immune monitoring of kidney allograft recipients and personalized therapeutics may help reach the aspirational goal of “one transplant for life.” The invasive kidney biopsy procedure, the diagnostic tool of choice, […]

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Understanding and Overcoming the Challenges Related to Cardiovascular Trials Involving Patients with Kidney Disease.

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Cardiovascular disease is a prevalent and prognostically important comorbidity among patients with kidney disease, and individuals with kidney disease make up a sizeable proportion (30%-60%) of patients with cardiovascular disease. […]

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