Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection – Surveillance for Emerging Threats to Mothers and Babies Network, 22 state, local, and territorial health departments, March 29, 2020 -March 5, 2021.

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Pregnant women with coronavirus disease 2019 (COVID-19) are at increased risk for severe illness compared with nonpregnant women. Data to assess risk factors for illness severity among pregnant women with […]

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Novel Canine Coronavirus Isolated from a Hospitalized Pneumonia Patient, East Malaysia.

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During the validation of a highly sensitive pan-species coronavirus (CoV) semi-nested RT-PCR assay, we found canine CoV (CCoV) RNA in nasopharyngeal swabs from eight (2.5%) of 301 patients hospitalized with […]

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Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients.

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SARS-CoV-2 proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. 11 of 13 participants showed detectable levels of SARS-CoV-2 protein as […]

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Differential Cytokine Signatures of SARS-CoV-2 and Influenza Infection Highlight Key Differences in Pathobiology.

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Several inflammatory cytokines are upregulated in severe COVID-19. We compared cytokines in COVID-19 versus influenza in order to define differentiating features of the inflammatory response to these pathogens and their […]

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Factors Associated with Readmission in the US Following Hospitalization with COVID-19.

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Patients hospitalized for COVID-19 may experience complications following hospitalization and require readmission. This analysis estimates the rate and risk factors associated with COVID-19-related readmission and inpatient mortality.This is a retrospective […]

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Population-based estimates of post-acute sequelae of SARS-CoV-2 infection (PASC) prevalence and characteristics.

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Emerging evidence suggests many people have persistent symptoms after acute COVID-19 illness. Our objective was to estimate the prevalence and correlates of post-acute sequelae of SARS-CoV-2 infection (PASC).We employed a […]

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The effectiveness of the TWO-DOSE BNT162b2 vaccine: analysis of real-world data.

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COVID-19 mRNA vaccines were shown to be highly efficacious in preventing the disease in randomized controlled trials; nonetheless, evidence on the real-world effectiveness of this vaccine is limited. Study objective […]

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Reduced BNT162b2 mRNA vaccine response in SARS-CoV-2-naive nursing home residents.

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After BNT162b2 mRNA vaccination, antibody levels to spike, receptor binding domain (RBD) and virus neutralization were examined in 149 nursing home (NH) residents and 110 health care worker controls. SARS-CoV-2-naive […]

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Risk of SARS-CoV-2 reinfection in a university student population.

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We assess protection from previous SARS-CoV-2 infection in a population of 16,101 university students (2,021 with and 14,080 without previous infection). The risk of re-infection during the Spring 2021 semester […]

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Significant impact of COVID-19 on HIV care in hospitals affecting the first pillar of the HIV care continuum.

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During COVID-19 lockdown, the in-hospital number of HIV indicator conditions decreased disproportionally compared to other non-COVID-19 diseases which was accompanied by reduced HIV testing rates, number and proportion of positive […]

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Evaluating the Presence of Replication-Competent SARS-CoV-2 from Nursing Home Residents with Persistently Positive RT-PCR Results.

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Replication-competent virus has not been detected in individuals with mild to moderate COVID-19 more than 10 days after symptom onset. It is unknown whether these findings apply to nursing home […]

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Increased peripheral blood neutrophil activation phenotypes and NETosis in critically ill COVID-19 patients: a case series and review of the literature.

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Increased inflammation has been well defined in COVID-19, while definitive pathways driving severe forms of this disease remain uncertain. Neutrophils are known to contribute to immunopathology in infections, inflammatory diseases […]

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Adults Hospitalized with COVID-19 -United States, March-June and October-December 2020: Implications for the Potential Effects of COVID-19 Tier-1 Vaccination on Future Hospitalizations and Outcomes.

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Because of the increased risk for severe coronavirus disease 2019 (COVID-19), the Advisory Committee on Immunization Practices (ACIP) initially prioritized COVID-19 vaccination for persons in long-term care facilities (LTCF), persons […]

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Adverse pregnancy outcomes, maternal complications, and severe illness among U.S. delivery hospitalizations with and without a COVID-19 diagnosis.

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Evidence on risk for adverse outcomes from COVID-19 among pregnant women is still emerging. We examined the association between COVID-19 at delivery and adverse pregnancy outcomes, maternal complications, and severe […]

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Cruise ship travel in the era of COVID-19: A summary of outbreaks and a model of public health interventions.

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Cruise travel contributed to SARS-CoV-2 transmission when there were relatively few cases in the United States. By March 14, 2020, the Centers for Disease Control and Prevention (CDC) issued a […]

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Influenza Vaccination in Health Centers during the COVID-19 Pandemic-United States, November 7-27, 2020.

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Influenza vaccination is the most effective way to prevent influenza and influenza-associated complications including those leading to hospitalization. Resources otherwise used for influenza could support caring for patients with Coronavirus […]

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Results of a Shortened Quarantine Protocol on a Midwestern College Campus.

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A shortened quarantine protocol following SARS-CoV-2 exposure was implemented on a college campus. We assessed data on exposures, symptoms and tests on 1,152 individuals released from quarantine on Day 7. […]

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Trends over time in the risk of adverse outcomes among patients with SARS-CoV-2 infection.

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We aimed to describe trends in adverse outcomes among patients who tested positive for SARS-CoV-2 between February and September 2020 within a national healthcare system.We identified enrollees in the national […]

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Building a Virtual Global Knowledge Network during COVID-19: The Infection Prevention and Control Global Webinar Series.

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The 2019 coronavirus (COVID-19) pandemic has been an unprecedented global health challenge. Traditional modes of knowledge dissemination have not been feasible. A rapid solution was needed to share guidance and […]

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Changes in Emergency Medical Services before and during COVID-19 in the United States, January 2018-December 2020.

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As a result of the continuing surge of COVID-19, many patients have delayed or missed routine screening and preventive services. Medical conditions, such as coronary heart disease, mental health issues, […]

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Combination therapy with tocilizumab and dexamethasone cost-effectively reduces Coronavirus disease 2019 mortality.

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Recent randomized trials suggest that interleukin-6 inhibitors like tocilizumab have mortality benefit for patients with severe coronavirus disease-2019. We employed a decision tree to investigate their cost-effectiveness and found that […]

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Interacting Epidemics in Amazonian Brazil: Prior Dengue Infection Associated with Increased COVID-19 Risk in a Population-Based Cohort Study.

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Immunity after dengue virus (DENV) infection has been suggested to cross-protect from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mortality.We tested whether serologically proven prior DENV infection diagnosed […]

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Risk Factors For Infection And Health Impacts Of The Covid-19 Pandemic In People With Autoimmune Diseases.

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People with autoimmune or inflammatory conditions taking immunomodulatory/suppressive medications may have higher risk of novel coronavirus disease 2019 (COVID-19). Chronic disease care has also changed for many patients, with uncertain […]

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Role of epithelial-endothelial cell interaction in the pathogenesis of SARS-CoV-2 infection.

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The COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to threaten public health globally. Patients with severe COVID-19 disease progress to acute respiratory distress […]

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Improving the Outcomes of Immunocompromised Patients with COVID-19.

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Recent case studies have highlighted that certain immunocompromised individuals are at risk for prolonged SARS-CoV-2 replication, intra-host viral evolution of multiply-mutated variants, and poor clinical outcomes. The immunologic determinants of […]

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SARS-CoV-2 infection among healthcare workers in South Africa: a longitudinal cohort study.

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From April to September 2020, we investigated SARS-CoV-2 infections in a cohort of 396 healthcare workers (HCWs) from five departments at Chris Hani Baragwanath Hospital, South Africa. Overall, 34.6% of […]

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SARS-CoV-2 RNAemia predicts clinical deterioration and extrapulmonary complications from COVID-19.

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The determinants of COVID-19 disease severity and extrapulmonary complications (EPCs) are poorly understood. We characterized relationships between SARS-CoV-2 RNAemia and disease severity, clinical deterioration, and specific EPCs.We used quantitative (qPCR) […]

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Retrospective Detection of SARS-CoV-2 in Symptomatic Patients prior to Widespread Diagnostic Testing in Southern California.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused one of the worst pandemics in recent history. Few reports have revealed that SARS-CoV-2 was spreading in the United States as […]

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COVID-19 Mitigation Efforts and Testing During an In-Person Training Event – Uganda, October 12-29, 2020.

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Large public-health training events may result in SARS-CoV-2 transmission. Universal SARS-CoV-2 testing during trainings for the Uganda Population-based HIV Impact Assessment identified 28/475 (5.9%) individuals with COVID-19 among attendees; most […]

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COVID-19 Outbreaks at Two Construction Sites – New York City, October-November 2020.

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During October 23-November 16, 2020, the New York City Department of Health and Mental Hygiene investigated COVID-19 outbreaks at two construction sites. Challenges in adhering to the New York State […]

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