DIETARY GLUTEN INTAKE IS NOT ASSOCIATED WITH RISK OF INFLAMMATORY BOWEL DISEASE IN U.S. ADULTS WITHOUT CELIAC DISEASE.

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Diet is thought to play a role in the development of inflammatory bowel disease (IBD), though the relationship between gluten intake and risk of IBD has not been explored. The […]

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PRIMER FOR DEVELOPMENT OF GUIDELINES FOR HELICOBACTER PYLORI THERAPY USING ANTIBIOTIC STEWARDSHIP.

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We provide a primer to assist in the difficult transition of Helicobacter pylori therapy guidelines to those that adhere to the principles of antimicrobial stewardship. This transition will entail abandonment […]

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Tailoring Surveillance Colonoscopy in Patients with Advanced Adenomas.

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Patients with advanced colorectal adenomas (AA) are directed to undergo intensive surveillance. However, the benefit derived from surveillance may be outweighed by the risk of death from non-colorectal cancer (CRC) […]

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Ultrasonography tight control and monitoring in Crohn’s disease during different biological therapies: a multicenter study.

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Bowel Ultrasonography (BUS) is a non-invasive tool for evaluating bowel activity in Crohn’s disease (CD) patients. Aim of our multicenter study was to assess whether BUS helps to monitor intestinal […]

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A Systematic Review of Monogenic Inflammatory Bowel Disease.

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Advances in genomic technologies have led to increasing reports of monogenic inflammatory bowel disease (IBD). However, there has not been a detailed evaluation of the characteristics of the published cases […]

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RELATIONSHIP BETWEEN GASTRIC EMPTYING RATE AND SIMULTANEOUSLY ASSESSED SYMPTOMS IN FUNCTIONAL DYSPEPSIA.

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The relevance of gastric emptying (GE) rate to symptom generation in functional dyspepsia and idiopathic gastroparesis is a matter of controversy. We aimed to evaluate the relationship between symptom severity […]

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Incidence of Hepatitis C Virus Infections Among Users of Human Immunodeficiency Virus Pre-Exposure Prophylaxis.

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Sexual transmission of hepatitis C virus (HCV) is well-documented among HIV-uninfected individuals. The use of HIV pre-exposure prophylaxis (PrEP) may be associated with engagement in activities that facilitate the transmission […]

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Effect of Endoscopic Bariatric and Metabolic Therapies on Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis.

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Weight loss via lifestyle intervention remains the mainstay of treatment for nonalcoholic fatty liver disease (NAFLD). Endoscopic bariatric and metabolic therapies (EBMTs) have recently been developed as an alternative treatment […]

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Treatment candidacy for pharmacologic therapies for NASH.

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Nonalcoholic steatohepatitis (NASH) has emerged as one of the important causes of cirrhosis and hepatocellular carcinoma, and over 50 therapeutic agents are in various Phases of clinical development. Recently, obeticholic […]

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Efficacy and Safety of Tofacitinib in Ulcerative Colitis Based on Prior Tumor Necrosis Factor Inhibitor Failure Status.

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Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). We summarize efficacy and safety data of tofacitinib 5 or 10 mg twice daily […]

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HCC prediction models in chronic hepatitis B: a systematic review of 14 models and external validation.

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The aim of our study was to characterize the performance of hepatocellular carcinoma (HCC) prediction models in chronic hepatitis B (CHB) patients through meta-analysis followed by external validation.We performed a […]

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Noncontrast MRI for Hepatocellular Carcinoma Detection: A Systematic Review and Meta-analysis – A Potential Surveillance Tool?

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This meta-analysis investigates the diagnostic performance of non-contrast magnetic resonance imaging (MRI) for the detection of hepatocellular carcinoma (HCC).A systematic review was performed to May 2020 for studies which examined […]

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Plasma-signature-MELD score to predict survival in severe alcoholic hepatitis.

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Severe alcoholic hepatitis (AH) is a highly lethal condition and it is still a challenge to predict the outcomes. We previously identified and validated a composite score of hepatic 123-gene […]

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Seroprevalence and determinants of Helicobacter pylori infection in the Hispanic Community Health Study/Study of Latinos.

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Helicobacter pylori infection is the primary known risk factor for gastric cancer. Despite the global decline in H. pylori prevalence, this infection remains a major public health concern in developing […]

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Five-year Efficacy and Safety of Ustekinumab Treatment in Crohn’s Disease: the IM-UNITI trial.

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The IM-UNITI study and long-term extension (LTE) evaluated the long-term efficacy, safety, and immunogenicity of subcutaneous ustekinumab maintenance therapy in patients with Crohn’s disease (CD). Here we report final results […]

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Patient Preferences for Hepatocellular Carcinoma Surveillance Parameters.

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Professional societies recommend abdominal ultrasound (US) with or without alpha fetoprotein (AFP) for hepatocellular cancer (HCC) surveillance; however, there are several emerging surveillance modalities, including abbreviated MRI and blood-based biomarker […]

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Adenoma Detection Rate (ADR) Irrespective of Indication is Comparable to Screening ADR: Implications for Quality Monitoring.

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Adenoma detection rate (ADR) is a key measure of colonoscopy quality. However, its efficient measurement can be challenging because many colonoscopies are performed for non-screening purposes. Measuring ADR without being […]

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Estimating global prevalence of metabolic dysfunction-associated fatty liver disease in overweight or obese adults.

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Metabolic dysfunction-associated fatty liver disease (MAFLD) is a new terminology updated from non-alcoholic fatty liver disease (NAFLD). In this study, we aim to estimate the global prevalence of MAFLD specifically […]

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Transient Elastography Accurately Screens for Compensated Advanced Chronic Liver Disease in Patients with Ongoing or Recent Alcohol Withdrawal.

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Liver stiffness measurement by transient elastography (TE) is a promising method for staging fibrosis in alcohol-related liver disease, but uncertainties remain regarding the influence of alcohol consumption and thus the […]

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UTILITY AND COST-EFFECTIVENESS OF A NON-ENDOSCOPIC APPROACH TO BARRETT’S ESOPHAGUS SURVEILLANCE AFTER ENDOSCOPIC THERAPY.

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A non-endoscopic approach to Barrett’s esophagus (BE) surveillance after radiofrequency ablation (RFA) would offer a less invasive method for monitoring. We assessed the test characteristics and cost-effectiveness of the Cytosponge® […]

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Spatial Evolution of Histologic and Endoscopic Healing in Left and Right Colon in Patients with Ulcerative Colitis.

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Despite increasing interest in histologic remission as a treatment target in ulcerative colitis (UC), the accuracy of histologic findings in left colon in detecting pancolonic histologic remission is unknown.In a […]

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Characterization of Prevalent, Post-Endoscopy, and Incident Esophageal Cancer in the United States: A Large Retrospective Cohort Study.

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Efforts to assess and improve the effectiveness of Barrett’s esophagus (BE) screening and surveillance are ongoing in the United States. Currently, there are limited population-based data in the United States […]

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Endoscopic phenotype of the J pouch in patients with inflammatory bowel disease: A new classification for pouch outcomes.

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Pouchitis is a common complication of ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis (UC) who have had colectomy. Pouchitis has been considered a single entity despite a broad […]

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Feasibility and safety of tethered capsule endomicroscopy in patients with Barrett’s esophagus in a multi-center study.

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Tethered capsule endomicroscopy (TCE) involves swallowing small tethered pill that implements optical coherence tomography (OCT) imaging, procuring high resolution images of the whole esophagus. Here, we demonstrate and evaluate the […]

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Primary Sclerosing Cholangitis-Associated Pouchitis: A Distinct Clinical Phenotype.

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Patients with primary sclerosing cholangitis (PSC) commonly undergo ileal pouch-anal anastomosis (IPAA) for medically-refractory ulcerative colitis (UC) or colorectal dysplasia. Pouchitis develops more frequently in patients with PSC, potentially leading […]

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Transient elastography assessed hepatic steatosis and fibrosis are associated with body composition in the United States.

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We examined transient elastography assessed hepatic steatosis and fibrosis distributions and relationships with body composition in a representative United States population sample.Liver stiffness and controlled attenuation parameter (CAP) were assessed […]

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Risk factors for early-onset colorectal cancer: A systematic review and meta-analysis.

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Despite the widespread increase in the incidence of early-onset colorectal cancer (EoCRC), the reasons for this increase remain unclear. The objective of this study was to determine risk factors for […]

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Age dependence of liver enzymes: an analysis of over 1,300,000 consecutive blood samples.

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Upper levels of normal (ULN) for alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) generally take sex into account, but not age. This simplification may lead to misclassification and […]

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Standard-volume plasma-exchange improves outcomes in patients with acute liver failure – A Randomized Controlled Trial.

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High volume plasma-exchange (HVPE) improves survival in patients with acute liver failure (ALF), but apprehension regarding volume overload and worsening of cerebral edema remain.In an open-label randomized controlled trial, 40 […]

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Trajectory of Serum Bilirubin Predicts Spontaneous Recovery in a Real-World Cohort of Patients with Alcoholic Hepatitis.

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Alcoholic hepatitis (AH) is a severe condition with poor short-term prognosis. Specific treatment with corticosteroids slightly improves short-term survival but is associated with infection and is not used in many […]

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