Risk of Hepatitis B Virus Reactivation in Patients Treated with Immunotherapy for Anti-cancer Treatment.

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Hepatitis B virus (HBV) reactivation is a well-known complication in patients with chronic hepatitis B (CHB) treated with cytotoxic chemotherapy. However, the risk of HBV reactivation through use of immune […]

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Long-Term Treatment of Eosinophilic Esophagitis with Budesonide Oral Suspension.

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We evaluated treatment withdrawal, long-term outcomes and safety of budesonide oral suspension (BOS) 2.0 mg b.i.d. in patients with eosinophilic esophagitis who completed a 12-week induction study.Induction full responders (≤6 […]

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Deficits in geriatric assessment associate with disease activity and -burden in older patients with inflammatory bowel disease.

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We aimed to perform geriatric assessment in older inflammatory bowel disease (IBD) patients to evaluate which IBD characteristics associate with deficits in geriatric assessment and the impact of deficits on […]

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Genetically predicted adiposity, diabetes and lifestyle factors in relation to diverticular disease.

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Adiposity, type 2 diabetes, alcohol and coffee consumption and smoking have been examined in relation to diverticular disease in observational studies. We conducted a Mendelian randomization study to assess the […]

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NON INVASIVE MONITORING AFTER AZATHIOPRINE WITHDRAWAL IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE IN DEEP REMISSION.

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There is uncertainty regarding the optimal duration of treatment with azathioprine (AZA) in ulcerative colitis (UC) and Crohn’s disease (CD). We analyzed the clinical course and predictors of relapse after […]

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Anti-TL1A Antibody PF-06480605 Safety and Efficacy for Ulcerative Colitis: A Phase 2a Single-Arm Study [102/120 characters including spaces].

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An immune component of inflammatory bowel disease is upregulated tumor necrosis factor-like ligand 1A (TL1A). Anti-TL1A antibodies such as PF-06480605 – a fully human immunoglobulin G1 monoclonal antibody – may […]

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Dynamic Changes in Ultrasound Quality for Hepatocellular Carcinoma Screening in Patients with Cirrhosis.

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Identifying patients in whom ultrasound may be inadequate to exclude the presence of hepatocellular carcinoma (HCC) can inform interventions to improve screening effectiveness.Characterize correlates of suboptimal ultrasound quality and changes […]

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Long-Lasting Dissociation of Esophageal Eosinophilia and Symptoms Following Dilation in Adults with Eosinophilic Esophagitis.

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Esophageal dilation improves dysphagia but not inflammation in eosinophilic esophagitis (EoE) patients. We investigated if dilation modifies the association between symptoms and esophageal eosinophil count (eos/hpf).Adults enrolled in a multisite, […]

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Long-Lasting Dissociation of Esophageal Eosinophilia and Symptoms Following Dilation in Adults with Eosinophilic Esophagitis.

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Esophageal dilation improves dysphagia but not inflammation in eosinophilic esophagitis (EoE) patients. We investigated if dilation modifies the association between symptoms and esophageal eosinophil count (eos/hpf).Adults enrolled in a multisite, […]

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Psychiatric comorbidities are highly prevalent in non-esophageal eosinophilic gastrointestinal diseases.

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The prevalence of psychiatric comorbidity in non-esophageal eosinophilic gastrointestinal disorders (EGIDs) has not been studied. We aimed to ascertain the prevalence of psychiatric diagnoses and psychiatric medication use in children, […]

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GREATER OVERLAP OF ROME IV DISORDERS OF GUT-BRAIN INTERACTIONS LEADS TO INCREASED DISEASE SEVERITY AND POORER QUALITY OF LIFE.

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Conditions such as irritable bowel syndrome (IBS), functional dyspepsia and functional constipation are among the prevalent gastrointestinal disorders classified as disorders of gut brain interaction (DGBI), which can adversely affect […]

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Characteristics and survival of patients with inflammatory bowel disease and post-colonoscopy colorectal cancers.

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Post-colonoscopy colorectal cancers (PCCRCs) account for up to 50% of colorectal cancers (CRCs) in patients with inflammatory bowel disease (IBD). We investigated characteristics of IBD patients with PCCRC and their […]

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Reevaluation of the Cardiovascular Safety Profile of Tegaserod: A Review of the Clinical Data.

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Tegaserod is a 5-HT4 receptor agonist approved for irritable bowel syndrome with constipation in females <65 years without a history of cardiovascular ischemic events.Safety data are presented from two external […]

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Tofacitinib for Biologic-Experienced Hospitalized Patients with Acute Severe Ulcerative Colitis: A Retrospective Case-Control Study.

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Despite rescue therapy, more than 30% of patients with acute severe ulcerative colitis (ASUC) require colectomy. Tofacitinib is a rapidly acting JAK inhibitor with proven efficacy in ulcerative colitis. Tofacitinib […]

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Cancer Risk in 47,241 Individuals with Celiac Disease – A Nationwide Cohort Study.

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Celiac disease (CD) is associated with increased mortality, in part due to cancer. Most studies investigating this cancer risk involved patients diagnosed before widespread increases in CD diagnosis rates and […]

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Differential clinical characteristics and mortality outcomes in persons with NAFLD and/or MAFLD.

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Metabolic dysfunction-associated fatty liver disease (MAFLD) establishes new criteria for diagnosing fatty liver disease independent of alcohol intake and concomitant viral hepatitis infection. However, the long-term outcomes of patients with […]

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Ileal Pouch Anal Anastomosis for the Management of Ulcerative Colitis is Associated with Significant Disability.

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Disability in patients with medically refractory ulcerative colitis (UC) after total proctocolectomy (TPC) with ileal pouch anal anastomosis (IPAA) is not well understood. The aim of this study was to […]

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Aminotransferases during treatment predict long-term survival in patients with autoimmune hepatitis type 1: a landmark analysis.

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Biochemical remission, important treatment goal in autoimmune hepatitis (AIH), has been associated with better long-term survival. The aim of this study was to determine the independent prognostic value of aminotransferases […]

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Distinct Clinical Physiologic Phenotypes of Patients with Laryngeal Symptoms Referred for Reflux Evaluation.

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Heterogeneous presentations and disease mechanisms among patients with laryngeal symptoms account for misdiagnosis of laryngopharyngeal reflux (LPR), variations in testing and suboptimal outcomes. We aimed to derive phenotypes of patients […]

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Effect of Exclusion Diets on Symptom Severity and the Gut Microbiota in Patients with Irritable Bowel Syndrome.

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Altered fecal microbiota have been reported in IBS, although studies vary which could be due to dietary effects. Many IBS patients may eliminate certain foods because of their symptoms, which […]

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Significant liver injury during hospitalization for COVID-19 is not associated with liver insufficiency or death.

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COVID-19 is associated with hepatocellular liver injury of uncertain significance. We aimed to determine whether development of significant liver injury during hospitalization is related to concomitant medications or processes common […]

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Optical evaluation for predicting cancer in large non-pedunculated colorectal polyps is accurate for flat lesions.

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The ability of optical evaluation to diagnose submucosal invasive cancer (SMIC) prior to endoscopic resection of large (≥ 20mm) non-pedunculated colorectal polyps (LNPCPs) is critical to inform therapeutic decisions. Prior […]

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The role of clips in preventing delayed bleeding after colorectal polyp resection: an individual patient data meta-analysis.

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Non-pedunculated colorectal polyps are normally endoscopically removed to prevent neoplastic progression. Delayed bleeding is the most common major adverse event. Clipping the resection defect has been suggested to reduce delayed […]

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Proton pump inhibitor use is not strongly associated with SARS-CoV-2 related outcomes: A nationwide study and meta-analysis.

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Proton pump inhibitor (PPI) use has been associated with increased risk of SARS-CoV-2 infection and severe outcomes. However, meta-analyses show unclear results leading to uncertainty regarding the safety of PPI […]

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Establishing Minimal Clinically Important Differences in Quality of Life Measures in Opioid-Induced Constipation.

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Opioids have a role in chronic pain management. However, opioid-induced constipation (OIC) may cause patients to skip or reduce opioid doses, leading to inadequate pain relief and negatively impacting quality […]

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Incidence of Hepatocellular Carcinoma in Patients with Non-alcoholic Fatty Liver Disease: A Systematic Review, Meta-analysis, and Meta-regression.

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Nonalcoholic fatty liver disease (NAFLD) may be a risk factor for hepatocellular carcinoma (HCC), but the extent of this association still needs to be addressed. Pooled-incidence rates of HCC across […]

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Predicting the need for step-up therapy after EUS-guided drainage of pancreatic fluid collections with lumen-apposing metal stents.

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A significant proportion of individuals with pancreatic fluid collections (PFCs) require step-up therapy after endoscopic drainage with lumen-apposing metal stents (LAMS). The aim of this study is to identify factors […]

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Tenofovir Alafenamide for Drug-Resistant Hepatitis B: A Randomized Trial for Switching from Tenofovir Disoproxil Fumarate.

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It remains unknown whether tenofovir alafenamide (TAF) could replace tenofovir disoproxil fumarate (TDF) in patients with drug-resistant hepatitis B virus (HBV).In this multi-center randomized non-inferiority trial, 174 patients with HBV […]

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Natural History and Disease Impact of Rome IV versus Rome III Irritable Bowel Syndrome: A Longitudinal Follow-up Study.

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Irritable bowel syndrome (IBS) is a chronic functional bowel disorder diagnosed using the Rome criteria, which have evolved since their original description 30 years ago. Little is known about the […]

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Prediction of Relapse After Anti-Tumor Necrosis Factor Cessation in Crohn’s Disease: Individual Participant Data Meta-Analysis of 1317 Patients From 14 Studies.

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Tools for stratification of relapse risk of Crohn’s disease (CD) after anti-tumor necrosis factor (TNF) therapy cessation are needed. We aimed to validate a previously developed prediction model from the […]

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