Maternal hyperthyroidism and pregnancy outcomes: A population-based cohort study.

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Maternal hyperthyroidism and antithyroid medications have been associated with adverse pregnancy and perinatal outcomes. This nationwide register-based study investigated the association of maternal hyperthyroidism and antithyroid drug (ATD) use with […]

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Dietary macronutrient regulation of acyl and desacyl ghrelin concentrations in children with Prader-Willi syndrome (PWS).

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The effects of dietary macronutrients on orexigenic and anorexigenic hormones in children are poorly understood.To explore effects of varying dietary macronutrients on appetite-regulating hormones [acyl ghrelin (AG) and desacyl ghrelin […]

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Obesity, menstrual irregularity and polycystic ovary syndrome in young women with type 1 diabetes: a population-based study.

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Type 1 diabetes (T1D) is associated with reproductive dysfunction, particularly in the setting of poor metabolic control. Improvements in contemporary management ameliorates these problems, albeit at the cost of increased […]

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Longitudinal changes in plasma sex hormone concentrations correlate with changes in CT-measured regional adiposity among Japanese American men over 10 years.

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Aging in male adults is typically accompanied by adiposity accumulation and changes in circulating sex hormone concentrations. We hypothesized that an aging-associated increase in estrogens and decrease in androgens would […]

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Aromatase deficiency: a case series of 46, XX Chinese children and a systematic review of the literature.

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Aromatase deficiency (AD) caused by cytochrome P450 family 19 subfamily A polypeptide 1 (CYP19A1) variants is characterized by a deficiency in androgen-to-oestrogen conversion.To investigate the clinical characteristics and accurate management […]

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Systematic Review and Meta-Analysis of the Metabolic Effects of Modified-Release Hydrocortisone versus Standard Glucocorticoid Replacement Therapy in Adults with Adrenal Insufficiency.

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Published studies exploring the metabolic effects of Modified-Release Hydrocortisone (MR-HC) replacement in patients with adrenal insufficiency (AI).To compare metabolic effects of MR-HC with Standard Glucocorticoid (SG) replacement in adults with […]

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Three years of Growth Hormone Treatment in Young Adults with Prader-Willi Syndrome previously treated with Growth Hormone in Childhood: Effects on Glucose Homeostasis and Metabolic Syndrome.

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Growth hormone (GH) has been approved for children with Prader-Willi syndrome (PWS) and significantly improves body composition in adults with PWS. Adults with PWS are predisposed to develop impaired glucose […]

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Similar safety and efficacy in previously treated adults with growth hormone deficiency randomised to once-weekly somapacitan or daily growth hormone.

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Somapacitan is a long-acting, reversible albumin-binding growth hormone (GH) derivative in development. This study aimed to evaluate the safety and efficacy of once-weekly somapacitan versus daily GH over 52¬†weeks in […]

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Relationship and sexual experiences in women with early onset oestrogen deficiency: comparison between women with Turner syndrome and premature ovarian insufficiency.

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Age at first date and sexual intercourse have been observed to be delayed in women with Turner syndrome (TS), with delayed puberty being the main factor. We sought to assess […]

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Effects of IVF therapies on metabolic, endocrine and inflammatory status in IVF-conceived pregnancy.

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In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and […]

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Spontaneous pregnancies in female survivors of childhood allogeneic haemopoietic stem cell transplants for hematological malignancies.

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Spontaneous pregnancies and live births are rarely reported after hematopoietic stem cell transplant (HSCT). We report spontaneous pregnancy outcomes of sexually active female survivors of childhood allogeneic HSCT, to provide […]

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Increased levels of inflammatory factors are associated with severity of polyneuropathy in type 1 diabetes.

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Distal symmetrical polyneuropathy (DSPN) is a severe common long-term complication of type 1 diabetes caused by impaired sensory-motor nerve function. As chronic low-grade inflammation may be involved in the pathogenesis […]

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Response of preterm infants with transient hypothyroxinemia of prematurity to the thyrotropin-releasing hormone stimulation test is characterized by a delayed decrease in thyroid stimulating hormone after the peak.

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We evaluated the response to the thyrotropin-releasing hormone (TRH) stimulation test in very low birth weight (VLBW) infants to elucidate the etiology of transient hypothyroxinemia of prematurity (THOP).We performed TRH […]

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The Use of Vitamin D in Preventing Post-thyroidectomy Hypocalcemia: An Endocrinologist Survey Study.

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To evaluate the use of preoperative vitamin D levels and postoperative vitamin D supplementation among endocrinologists for the prevention of post-thyroidectomy hypocalcemia.Endocrinologist members of the American Thyroid Association (ATA) were […]

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Sustained remission of Lynch syndrome-associated metastatic adrenocortical carcinoma following checkpoint inhibitor therapy-associated multiorgan autoimmunity.

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Adrenocortical carcinoma (ACC) is a rare and aggressive tumour with limited treatment options for metastatic disease1 . Immunotherapy with checkpoint inhibition, in particular anti-programmed death receptor 1 (PD-1)/programmed death-ligand-1 (PD-L1) […]

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New variant (Val597Ile) in transmembrane region of the TSH receptor with human chorionic gonadotropin hypersensitivity in familial gestational hyperthyroidism.

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Only two mutations at the Lysine 183 amino acid in the extracellular N-terminal domain of human TSH receptor (hTSHR) have been associated to hypersensitivity to hCG and familial gestational hyperthyroidism.A […]

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Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery.

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The objective of this study was to study associations of a wide range of halogenated biphenyls, dibenzo-p-dioxins, dibenzofurans, and diphenylethers with body mass index (BMI) and evaluate changes in their […]

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Development and validation of a web-based malignancy risk-stratification system of thyroid nodules.

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Previous publications on risk-stratification systems for malignant thyroid nodules were based on conventional ultrasound only. We aimed to develop a practical and simplified prediction model for categorizing the malignancy risk […]

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Subclinical thyroid dysfunction in 1st trimester of pregnancy: “disease” versus physiological (pulsatile) variation in TSH concentrations.

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There is no universal consensus regarding cut off points for TSH in pregnancy, so concentrations of 2.5 mIU/L or 4.0 mIU/L were suggested for 1st trimester (Endocrine Society (2012) and […]

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The Clinical Expression and Impact of Multiple Endocrine Neoplasia 1 During Pregnancy.

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Multiple endocrine neoplasia type 1 (MEN 1) is characterised by multi-system neoplasia including primary hyperparathyroidism and pituitary adenoma. Despite the adolescent onset of endocrinopathies, information regarding the impact of maternal […]

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