Dopamine agonist treatment may result in hypersexuality in men. The aim of this study was to investigate for the first time female sexual functioning and depressive symptoms in women with […]» Read more
The risk of chronic kidney disease among women with polycystic ovary syndrome: A long-term population-based cohort study.
Results of studies focusing on chronic kidney disease (CKD) among women with polycystic ovary syndrome (PCOS) are insufficient and controversial. This study aimed to evaluate the incidence rate of CKD […]» Read more
Maternal hyperthyroidism and antithyroid medications have been associated with adverse pregnancy and perinatal outcomes. This nationwide register-based study investigated the association of maternal hyperthyroidism and antithyroid drug (ATD) use with […]» Read more
Dietary macronutrient regulation of acyl and desacyl ghrelin concentrations in children with Prader-Willi syndrome (PWS).
The effects of dietary macronutrients on orexigenic and anorexigenic hormones in children are poorly understood.To explore effects of varying dietary macronutrients on appetite-regulating hormones [acyl ghrelin (AG) and desacyl ghrelin […]» Read more
Obesity, menstrual irregularity and polycystic ovary syndrome in young women with type 1 diabetes: a population-based study.
Type 1 diabetes (T1D) is associated with reproductive dysfunction, particularly in the setting of poor metabolic control. Improvements in contemporary management ameliorates these problems, albeit at the cost of increased […]» Read more
Longitudinal changes in plasma sex hormone concentrations correlate with changes in CT-measured regional adiposity among Japanese American men over 10 years.
Aging in male adults is typically accompanied by adiposity accumulation and changes in circulating sex hormone concentrations. We hypothesized that an aging-associated increase in estrogens and decrease in androgens would […]» Read more
Aromatase deficiency: a case series of 46, XX Chinese children and a systematic review of the literature.
Aromatase deficiency (AD) caused by cytochrome P450 family 19 subfamily A polypeptide 1 (CYP19A1) variants is characterized by a deficiency in androgen-to-oestrogen conversion.To investigate the clinical characteristics and accurate management […]» Read more
Systematic Review and Meta-Analysis of the Metabolic Effects of Modified-Release Hydrocortisone versus Standard Glucocorticoid Replacement Therapy in Adults with Adrenal Insufficiency.
Published studies exploring the metabolic effects of Modified-Release Hydrocortisone (MR-HC) replacement in patients with adrenal insufficiency (AI).To compare metabolic effects of MR-HC with Standard Glucocorticoid (SG) replacement in adults with […]» Read more
Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity.
Vitamin D deficiency (VDD) has been proposed to play a role in Coronavirus Disease 2019 (COVID-19) pathophysiology. We aim to evaluate our implementation of a local protocol for treatment of […]» Read more
Three years of Growth Hormone Treatment in Young Adults with Prader-Willi Syndrome previously treated with Growth Hormone in Childhood: Effects on Glucose Homeostasis and Metabolic Syndrome.
Growth hormone (GH) has been approved for children with Prader-Willi syndrome (PWS) and significantly improves body composition in adults with PWS. Adults with PWS are predisposed to develop impaired glucose […]» Read more
Similar safety and efficacy in previously treated adults with growth hormone deficiency randomised to once-weekly somapacitan or daily growth hormone.
Somapacitan is a long-acting, reversible albumin-binding growth hormone (GH) derivative in development. This study aimed to evaluate the safety and efficacy of once-weekly somapacitan versus daily GH over 52 weeks in […]» Read more
Antenatal corticosteroids for threatened labor facilitate thyroid maturation among preterm neonates.
To examine the effect of Antenatal corticosteroids (ANS) on the maturation of thyroid function in the preterm infants.ANS reduce mortality and morbidities in preterm neonates. Organ maturation by the glucocorticoids […]» Read more
Relationship and sexual experiences in women with early onset oestrogen deficiency: comparison between women with Turner syndrome and premature ovarian insufficiency.
Age at first date and sexual intercourse have been observed to be delayed in women with Turner syndrome (TS), with delayed puberty being the main factor. We sought to assess […]» Read more
Effects of IVF therapies on metabolic, endocrine and inflammatory status in IVF-conceived pregnancy.
In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and […]» Read more
Data on the presentation and outcomes of patients with adrenal gland metastases are limited. Our objectives were to characterize the prevalence of adrenal metastases subtypes and investigate how varying clinical […]» Read more
Low arginine vasopressin levels in patients with diabetes insipidus are not associated with anaemia.
Arginine vasopressin (AVP) is released upon osmotic stimulation or hypovolemia in order to maintain water balance. A recent study showed a role of AVP in haematopoiesis by stimulating red blood […]» Read more
Kabuki syndrome (KS), caused by pathogenic variants in KMT2D or KDM6A, is associated with hyperinsulinemic hypoglycemia (HH) in 0.3-4% of patients. We characterized the clinical, biochemical and molecular data of […]» Read more
Spontaneous pregnancies in female survivors of childhood allogeneic haemopoietic stem cell transplants for hematological malignancies.
Spontaneous pregnancies and live births are rarely reported after hematopoietic stem cell transplant (HSCT). We report spontaneous pregnancy outcomes of sexually active female survivors of childhood allogeneic HSCT, to provide […]» Read more
Severe neonatal growth hormone deficiency (GHD) can cause recurrent hypoglycemia. Early diagnosis is warranted. The aim of the study was to analyze the GH content in screening cards of 25 […]» Read more
To assess the influence of a dietary sodium intake intervention on cortisol measurements within the general population.Cross-over intervention.630 adults without known Cushing syndrome, cardiovascular or renal disease completed a restricted […]» Read more
Increased levels of inflammatory factors are associated with severity of polyneuropathy in type 1 diabetes.
Distal symmetrical polyneuropathy (DSPN) is a severe common long-term complication of type 1 diabetes caused by impaired sensory-motor nerve function. As chronic low-grade inflammation may be involved in the pathogenesis […]» Read more
Response of preterm infants with transient hypothyroxinemia of prematurity to the thyrotropin-releasing hormone stimulation test is characterized by a delayed decrease in thyroid stimulating hormone after the peak.
We evaluated the response to the thyrotropin-releasing hormone (TRH) stimulation test in very low birth weight (VLBW) infants to elucidate the etiology of transient hypothyroxinemia of prematurity (THOP).We performed TRH […]» Read more
The Use of Vitamin D in Preventing Post-thyroidectomy Hypocalcemia: An Endocrinologist Survey Study.
To evaluate the use of preoperative vitamin D levels and postoperative vitamin D supplementation among endocrinologists for the prevention of post-thyroidectomy hypocalcemia.Endocrinologist members of the American Thyroid Association (ATA) were […]» Read more
Sustained remission of Lynch syndrome-associated metastatic adrenocortical carcinoma following checkpoint inhibitor therapy-associated multiorgan autoimmunity.
Adrenocortical carcinoma (ACC) is a rare and aggressive tumour with limited treatment options for metastatic disease1 . Immunotherapy with checkpoint inhibition, in particular anti-programmed death receptor 1 (PD-1)/programmed death-ligand-1 (PD-L1) […]» Read more
New variant (Val597Ile) in transmembrane region of the TSH receptor with human chorionic gonadotropin hypersensitivity in familial gestational hyperthyroidism.
Only two mutations at the Lysine 183 amino acid in the extracellular N-terminal domain of human TSH receptor (hTSHR) have been associated to hypersensitivity to hCG and familial gestational hyperthyroidism.A […]» Read more
Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery.
The objective of this study was to study associations of a wide range of halogenated biphenyls, dibenzo-p-dioxins, dibenzofurans, and diphenylethers with body mass index (BMI) and evaluate changes in their […]» Read more
Previous publications on risk-stratification systems for malignant thyroid nodules were based on conventional ultrasound only. We aimed to develop a practical and simplified prediction model for categorizing the malignancy risk […]» Read more
Subclinical thyroid dysfunction in 1st trimester of pregnancy: “disease” versus physiological (pulsatile) variation in TSH concentrations.
There is no universal consensus regarding cut off points for TSH in pregnancy, so concentrations of 2.5 mIU/L or 4.0 mIU/L were suggested for 1st trimester (Endocrine Society (2012) and […]» Read more
Genetic testing for hereditary hyperparathyroidism and familial hypocalciuric hypercalcaemia in a large UK cohort.
A retrospective review of patients referred for genetic testing over a 4 year period for suspected hereditary HPTH was performed. Genetic analysis was performed by next generation sequencing of the […]» Read more
Multiple endocrine neoplasia type 1 (MEN 1) is characterised by multi-system neoplasia including primary hyperparathyroidism and pituitary adenoma. Despite the adolescent onset of endocrinopathies, information regarding the impact of maternal […]» Read more