Smoking has been associated with reduced risk of thyroid cancer, but whether the association varies between higher- and lower-risk cancers remains unclear.We recruited 1013 people diagnosed with thyroid cancer and […]» Read more
Long-term response to cabergoline and multi-modal treatment in men with macroprolactinoma: does size really matter?
To study the outcome of men with macroprolactinoma following cabergoline treatment based on tumour size.Retrospective cohort study.The study included 94 men, divided into 3 groups according to adenoma diameter: 10-19 mm […]» Read more
Male Pituitary-Gonadal axis dysfunction in Post-acute COVID-19 Syndrome. Prevalence and associated factors: A Mediterranean Case Series.
SARS-CoV-2 through ACE2 receptor could harm testes function. The objectives were to analyze the prevalence of low serum testosterone (LT) and impaired fertility potential (Leydig and Sertoli cells dysfunction, respectively) […]» Read more
Predictors of prolonged hypotension requiring vasopressor support after resection of pheochromocytoma and paraganglioma.
Prolonged hypotension is a common complication after resection of pheochromocytoma (PCC) or paraganglioma (PGL). The objective of our study was to identify preoperative or intraoperative clinical factors that can predict […]» Read more
Apparent failed and discordant adrenal vein sampling: a potential confounding role of cortisol co-secretion?
Adrenal vein sampling (AVS) and CT often show confusingly discordant lateralization results in primary aldosteronism (PA). We tested a biochemical algorithm using AVS data to detect cortisol co-secretion as a […]» Read more
Association of Vitamin D Deficiency with COVID-19 Infection Severity: Systematic Review and Meta-analysis.
We sought to evaluate the association between vitamin D deficiency and severity of COVID-19 infection.Multiple databases from January 1st, 2019 to December 3rd , 2020 were searched for observational studies […]» Read more
Children with Multiple Endocrine Neoplasia type 2B: not tall and marfanoid, but short with normal body proportions.
Multiple Endocrine Neoplasia 2B (MEN2B) is characterized by early-onset medullary thyroid carcinoma (MTC), pheochromocytoma and several non-endocrine manifestations. Unfortunately, MEN2B is often diagnosed late, after development of clinically significant MTC. […]» Read more
Clinical implications of age and excellent response to therapy in patients with high-risk differentiated thyroid carcinoma.
Patients with American Thyroid Association (ATA) high-risk differentiated thyroid carcinoma (DTC) have poor clinical outcomes. This study aimed to evaluate the clinical implications of age and response to therapy classification […]» Read more
Microarchitectural parameters and bone mineral density in patients with Tumor-Induced Osteomalacia by HR-pQCT and DXA.
Tumor-induced Osteomalacia (TIO) is a rare paraneoplastic condition characterized by decreased tubular phosphate reabsorption. The purpose of this study is to evaluate bone mineral density (BMD) and microarchitecture in six […]» Read more
Performance evaluation of scoring systems for predicting post-operative hypertension cure in primary aldosteronism.
Hypertension cure following adrenalectomy in unilateral primary aldosteronism is not guaranteed. Its likelihood is associated with pre-operative parameters which have been variably combined in six different predictive scoring systems. The […]» Read more
Society for Endocrinology UK Guidance On The Initial Evaluation Of A Suspected Difference or Disorder Of Sex Development (DSD) (Revised 2021).
It is paramount that any child or adolescent with a suspected difference or disorder of sex development (DSD) is assessed by an experienced clinician with adequate knowledge about the range […]» Read more
Long-term efficacy and safety of percutaneous ethanol injection (PEI) in cystic thyroid nodules. A systematic review and meta-analysis.
Percutaneous ethanol injection (PEI) is used for the treatment of benign cystic thyroid nodules. This systematic review and meta-analysis aimed to obtain strong evidence of its long-term efficacy and safety.PubMed, […]» Read more
Occurrence of pituitary hormone deficits in relation with both pituitary and hypothalamic doses after radiotherapy for skull base meningioma.
Little accurate information is available regarding the risk of hypopituitarism after irradiation of skull base meningiomas.Retrospective study in a single centre.48 patients with a skull base meningioma and normal pituitary […]» Read more
Head-to-head comparison between 18 F-DOPA PET/CT and 68 Ga-DOTA peptides PET/CT in detecting intestinal neuroendocrine tumours: a systematic review and meta-analysis.
The imaging of intestinal neuroendocrine tumours (NETs) relies on functional PET tracers; these tumours can be studied by means of both 68 Ga-DOTA peptides and 18 F-DOPA PET/CT. As yet, […]» Read more
The incidence of papillary thyroid carcinoma (PTC) has increased over recent decades. This apparent epidemic has been attributed to the overdiagnosis of small PTC ≤ 10mm in diameter (PTMC) incidentally […]» Read more
Characteristics of bone metabolism in postmenopausal women with newly diagnosed type 2 diabetes mellitus.
The characteristics of bone metabolism in T2DM are still controversial. This study aims to recognize bone turnover features in patients with newly diagnosed T2DM who have never been treated with […]» Read more
Prevalence of thyroid dysfunction in postpartum women with suboptimal iodine and selenium and adequate iron status.
Postpartum women experience thyroid dysfunction at twice the prevalence of the general population. Adequate biosynthesis of thyroid hormones depends on three trace elements: iodine, selenium and iron. This study aimed […]» Read more
Predictors of 30-Day Readmissions for Adrenal Insufficiency: A Retrospective National Database Study.
The aim of this study is to describe rates and characteristics of non-elective 30-day readmission among patients hospitalized for adrenal insufficiency and to assess predictors of readmission.We analyzed the 2018 […]» Read more
Non-thiazide diuretics and hospitalization due to hyponatremia: a population-based case-control study.
Diuretics are often implicated in hyponatremia. While thiazides constitute one of the most common causes of hyponatremia, data on loop-diuretics and potassium-sparing agents are limited and partly conflicting. The objective […]» Read more
Low bone mineral density (BMD) is a frequent and invalidating consequence of chronic undernourishment in patients with Anorexia Nervosa (AN). The aim of this study was to assess prevalence and […]» Read more
Bone turnover markers are associated with the PTH levels in different subtypes of pseudohypoparathyroidism type 1 patients.
Bone responsiveness to parathyroid hormone (PTH) in different subtypes of pseudohypoparathyroidism type 1 (PHP1) remains controversial. We aimed to investigate this phenomenon using bone turnover markers (BTMs) in a large […]» Read more
Benefits and harms of hemithyroidectomy, total or near total thyroidectomy in 1-4cm differentiated thyroid cancer.
For 1-4cm differentiated thyroid cancer (DTC), current ATA guideline recommended hemithyroidectomy (HT) as an acceptable alternative initial procedure to total or near total thyroidectomy (TT). The aim of this study […]» Read more
Previous studies suggested IgG4 levels were associated with the development of Graves’ ophthalmopathy (GO). The present study investigated the role of IgG4 levels in glucocorticoid (GC) treatment in GO patients.Sixty-nine […]» Read more
Radiofrequency ablation (RFA) is a well-tolerated approach to treating benign thyroid nodules (TNs), but no index can predict its success. Other than size decrease, little is known about TN appearance […]» Read more
Free thyroxine in early pregnancy is an independent negative predictor of 3rd trimester HbA1c. Odense Child Cohort.
Lower thyroid function outside pregnancy is associated with increased risk of type 2 diabetes mellitus. The relationship between thyroid function in early pregnancy and glucose status in 3rd trimester has […]» Read more
Neck lymph node (LN) metastasis is a common feature of pediatric papillary thyroid cancer, and LN ratio (LNR) is defined as the ratio of the number of positive LNs excised […]» Read more
Thyroid nodules in childhood-onset Hashimoto’s thyroiditis: Frequency, risk factors, follow-up course, and genetic alterations of thyroid cancer.
We evaluated the frequency, risk factors, and the follow-up outcomes of thyroid nodules, and genetic alterations in thyroid cancer, in youth with childhood-onset Hashimoto thyroiditis (HT) residing in an iodine-sufficient […]» Read more
Weight-based thyroid dosing vs fixed-dosing during pregnancy for subclinical hypothyroidism: A retrospective cohort study.
Thyroid hormones play a crucial role in fetal growth and neurocognitive development. Our aim was to compare a weight-based dosing method of starting thyroxine to a fixed-dose method in newly […]» Read more
Eligibility for growth hormone therapy in children born small for gestational age is substantially lower than expected.
Growth hormone therapy is indicated for children who are both born “small-for-gestational-age” (SGA) and do not achieve adequate catch-up growth (ACUG).To evaluate the actual incidence of infants born SGA and […]» Read more
The Clinical Outcomes of COVID-19 infection in Patients with a History of Thyroid Cancer: A Nationwide Study.
There are scarce published data in differentiated thyroid cancer patients about new coronavirus disease 2019 (COVID-19) disease outcomes and mortality. Here, we evaluated COVID-19 infection outcomes and mortality in thyroid […]» Read more