Impact of peri-procedural subcutaneous parathyroid hormone on control of hypocalcemia in APS-1/APECED patients undergoing invasive procedures.

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The monogenic disorder autoimmune polyendocrine syndrome type 1 (APS-1) or autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) manifests frequently with hypoparathyroidism, which requires treatment with oral supplementation with calcium and active vitamin D […]

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Temporal trends in craniopharyngioma management and long-term endocrine outcomes: a multicentre cross-sectional study.

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The optimal management of craniopharyngiomas remains controversial.To examine temporal trends in the management of craniopharyngioma with a focus on endocrine outcomes.This was a cross-sectional, multicentre study. Patients treated between 1951 […]

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Effect of Long-Term Glucocorticoid Therapy on Cardiac Functions in Children with Congenital Adrenal Hyperplasia.

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Glucocorticoids play an important role in cardiac physiology. Chronic exposure and higher doses may cause adverse effects on the myocardium, especially in young patients receiving long term therapy.Assess cardiac function […]

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Hyperthyroidism, and bone mineral density : dissecting the causal association with Mendelian randomization analysis.

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Untreated hyperthyroidism is associated with accelerated bone turnover, low bone mineral density (BMD) and increased susceptibility to fragility fractures. Although treatment appears to improve or even reverse some of these […]

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Body composition in women with premature ovarian insufficiency using hormone therapy and the relation to cardiovascular risk markers: a case-control study.

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To compare body composition between women with premature ovarian insufficiency (POI) using hormone therapy and controls with normal ovarian function, and to correlate body composition with cardiovascular risk markers in […]

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A systematic review of anti-androgens and feminisation in transgender women.

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Anti-androgens are frequently used with estradiol in transgender women seeking feminisation. Anti-androgens act by various mechanisms to decrease the production or effects of testosterone, but it is unclear which anti-androgen […]

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Baseline levels of seminal reactive oxygen species predict improvements in sperm function following anti-oxidant therapy in men with infertility.

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Poor sperm function is a major cause of infertility. There is no drug therapy to improve sperm function. Semen oxidative stress is a recently identified pathway for sperm damage. Commercial […]

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Central hypothyroidism improves with age in very young children with Prader-Willi syndrome.

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Abnormalities in the hypothalamic-pituitary-thyroid (HPT) axis have been implicated in Prader-Willi syndrome (PWS); however, limited information is currently available on age-dependent alterations in the HPT axis. We herein investigated age-dependent […]

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Diagnostic performance of core needle biopsy as a first-line diagnostic tool for thyroid nodules according to ultrasound patterns: comparison with fine-needle aspiration using propensity score matching analysis.

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This study aimed to compare the diagnostic performance of core-needle biopsy (CNB) to fine-needle aspiration (FNA) as a first-line diagnostic tool in initially detected thyroid nodules, according to ultrasound (US) […]

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The role of gonadotropins in testicular and adrenal androgen biosynthesis pathways -insights from males with congenital hypogonadotropic hypogonadism on hCG/rFSH and on testosterone replacement.

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To delineate the role of gonadotropins in male androgen biosynthesis pathways DESIGN: Case-control study PATIENTS AND MEASUREMENTS: 25 males with congenital hypogonadotropic hypogonadism (CHH) underwent hCG/rFSH and testosterone treatment sequentially. […]

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Complement activation in polycystic ovary syndrome occurs in the post-prandial and fasted state, and is influenced by obesity and insulin sensitivity.

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Polycystic Ovary Syndrome (PCOS) is associated with metabolic risk. Complement proteins regulate inflammation and lipid clearance but their role in PCOS-associated metabolic risk is unclear. We sought to establish whether […]

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The predictive value of coexisting BRAFV600E and TERT promoter mutations on poor outcomes and high tumor aggressiveness in papillary thyroid carcinoma: a systematic review and meta-analysis.

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BRAFV600E mutation is highly prevalent in patients with papillary thyroid carcinoma (PTC), and TERT promoter (TERTp) mutation is strongly associated with cancer-related mortality. However, predictive power of the two mutations […]

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Higher prevalence of metabolic disorders in patients with bilateral primary aldosteronism than unilateral primary aldosteronism.

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Metabolic syndrome (MetS) is a frequent clinical condition in hypertension patients, and is more frequently reported in primary aldosteronism (PA). This study is aimed at investigating the prevalence of MetS […]

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Normocalcemic Primary Hyperthyroidism: An Update on Diagnostic and Management Challenges.

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Normocalcemic primary hyperparathyroidism likely represents a condition that may evolve into its hypercalcemic counterpart and recent studies have shown that patients can present with intermittent hypercalcemia. This milder biochemical entity […]

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Intra-individual comparison of 18 F-FDOPA and 68 Ga-DOTATOC PET/CT detection rate for metastatic assessment in patients with ileal neuroendocrine tumours.

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In patients with ileal neuroendocrine tumours (ileal-NETs), head-to-head evaluation of diagnostic performances of 68 Ga-DOTA-peptides and 18 F-fluorodihydroxyphenylalanine (18 F-FDOPA) positron emission tomography/computed tomography (PET/CT) has been performed in only […]

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A Detailed Appraisal of Renal manifestations in Primary Hyperparathyroidism from Indian PHPT Registry: Before and after curative parathyroidectomy.

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Primary hyperparathyroidism (PHPT) is a systemic disorder characterized by hypercalcemia and inappropriately elevated parathyroid hormone (PTH). Renal manifestations are one of the main presenting features both in symptomatic and asymptomatic […]

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Effects of Growth Hormone Receptor Antagonism and Somatostatin Analog Administration on Quality of Life in Acromegaly.

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Acromegaly is associated with impaired quality of life (QoL). We investigated the effects of biochemical control of acromegaly by growth hormone receptor antagonism vs. somatostatin analog therapy on QoL.Cross-sectional PATIENTS: […]

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Evaluation of the Role of Thyroid Scintigraphy in the Differential Diagnosis of Thyrotoxicosis.

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A differential diagnosis of thyrotoxicosis is crucial as the treatment of the main causes of this condition can vary significantly. Recently published diagnostic guidelines on thyrotoxicosis embrace the presence of […]

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Brain white matter lesions are associated with reduced hypothalamic volume and cranial radiotherapy in childhood onset craniopharyngioma.

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White matter lesions (WML) are caused by obstruction of small cerebral vessels associated with stroke risk. Craniopharyngioma (CP) patients suffer from increased cerebrovascular mortality.To investigate the effect of reduced HT […]

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