Gut microbiome transfer (GMT; also referred to as faecal microbiota transplantation or FMT) has been propelled from fringe therapy to mainstream science as a highly effective treatment for recurrent Clostridioides […]» Read more
Mutations in the genes coding for succinate dehydrogenase (SDHx) are the most frequent germline alterations in pheochromocytomas and paragangliomas. Evidence for the advantages associated with pre-symptomatic screening for SDHx mutation […]» Read more
Disorders of the glucose metabolism correlate with the phenotype and the severity in women with polycystic ovary syndrome.
Different polycystic ovary syndrome (PCOS) phenotypes are correlated with different clinical severity levels. Insulin resistance correlates with higher severity. In a retrospective study, 130 patients with polycystic ovary syndrome were […]» Read more
Moderate renal impairment does not preclude the accuracy of 24 hour urine normetanephrine measurements for suspected pheochromoctyoma.
24 hour urine nor/metanephrine(urine NM-MN) measurements are a recommended first step in pheochromocytoma diagnosis. We hypothesized the presence of renal impairment(CKD) significantly confounds the results obtained in a UNM-UMN collection, […]» Read more
A randomized controlled trial of a lifestyle intervention with longitudinal follow up on ovarian dysmorphology in women with polycystic ovary syndrome.
Effects of lifestyle modification on reproductive function in polycystic ovary syndrome (PCOS) remains poorly elucidated. We compared the effects of a pulse-based diet (lentils, beans, split-peas, and chickpeas) with Therapeutic […]» Read more
In Graves’ ophthalmopathy (GO), fibrosis in extraocular muscles (EOMs) may be related to intravenous glucocorticoid (ivGC)-resistant diplopia. Signal intensity (SI) of magnetic resonance imaging (MRI) T1 mapping can quantify properties […]» Read more
Primary aldosteronism (PA) contributed to the cardiovascular disease and metabolic alterations independent of the blood pressure level. Evidence exist that aldosterone excess also affect calcium and mineral homeostasis. PA subjects […]» Read more
Management of Insulin Autoimmune Hypoglycemia: Single center experience from Western India with systematic review of world literature.
Awareness about Insulin Autoimmune Hypoglycemia (IAH) and its management remains limited.We describe two cohorts: Cohort 1 (n=7) included patients with IAH from a tertiary care center in India. Cohort 2 […]» Read more
Appropriate timing for a biochemical evaluation after adrenalectomy for unilateral aldosterone-producing adenoma.
The over-secretion of plasma aldosterone by unilateral aldosterone-producing adenoma (APA) can be cured by adrenalectomy. However, the time needed for the endocrine environment to normalize remains unclear.To clarify adequate timing […]» Read more
The Natural History of Congenital Hypothyroidism with Delayed TSH Elevation in Neonatal Intensive Care Newborns.
To assess the clinical and neurological outcomes in newborns with primary congenital hypothyroidism presented with delayed TSH elevation (dTSH), and to define parameters that may predict the evolution of transient […]» Read more
Denosumab is often used in men with advanced prostate cancer to prevent skeletal related events, but can be associated with severe hypocalcaemia. Our objective was to review the pathophysiology, identify […]» Read more
Risk factors for development of diabetes mellitus (Type 3c) after partial pancreatectomy: a systematic review.
Type 3c diabetes mellitus (T3cDM) occurring post pancreatectomy can be challenging to treat due to the frequent combination of decreased circulating levels of insulin and glucagon and concurrent exocrine insufficiency. […]» Read more
Effect of L-thyroxine administration before breakfast versus at bedtime on hypothyroidism: a meta-analysis.
To compare the effects of L-thyroxine (L-T4) administration before breakfast and administration at bedtime on hypothyroidism.The PubMed, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang […]» Read more
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Ultrasound-guided Fine Needle Aspiration or Core Needle Biopsy for diagnosing follicular thyroid carcinoma?
We evaluated the preoperative diagnostic values of ultrasound (US), fine needle aspiration (FNA), and core needle biopsy (CNB) leading to surgery in patients with FTC.From October 1994 to July 2016, […]» Read more
A Value-based Healthcare approach: Health Related Quality of Life and Psychosocial Functioning in Women with Turner Syndrome.
As part of the value-based health care program in our hospital a set of patient reported outcome measures was developed together with patients and implemented in the dedicated Turner Syndrome […]» Read more
Pregnancy in patients with macroprolactinomas has been associated with a higher risk of pituitary tumour growth. However, the incidence and risk factors remain unclear. We aimed to evaluate the evolution […]» Read more
Correlation between glucose metabolism and serum steroid hormones in patients with polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is associated with an increased prevalence of dysglycaemia, which includes impaired glucose tolerance and type 2 diabetes mellitus (T2DM). Patients with PCOS demonstrate abnormal patterns of […]» Read more
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Cancer-derived Immunoglobulin G: A Novel Marker for Differential Diagnosis and Relapse Prediction in Parathyroid Carcinoma.
A differential diagnosis between malignant and benign parathyroid lesions is difficult due to their overlapping clinicopathological characteristics. As such, molecular markers are urgently needed. Cancer-derived immunoglobulin G (CIgG) is a […]» Read more
Pancreatic neuroendocrine neoplasms (pNENs) are a group of endocrine tumors arising in the pancreas and deemed to be the most common neuroendocrine tumors. The pathogenesis of pNENs remains unknown. Long […]» Read more
Prognostic role of parafibromin staining and CDC73 mutation in patients with parathyroid carcinoma: a systematic review and meta-analysis based on individual patient data.
Parathyroid carcinoma (PC) is a rare malignant neoplasm with a relatively poor prognosis. The loss of parafibromin expression or the presence of CDC73 mutation has been found to be remarkably […]» Read more
Testosterone Replacement Therapy (TRT) is indicated for symptomatic male hypogonadism. However, the safety and efficacy profiles across different ethnicities for long term TRT remain unclear.To measure the impact of ethnicity […]» Read more
Effects of tibolone or continuous combined oestradiol and norethisterone acetate on lipids, HDL subfractions and apolipoproteins in post-menopausal women in a two-year, randomised, double-blind, placebo-controlled trial.
To compare the effects of 1) tibolone, 2) continuous combined oestrogen plus progestogen and 3) placebo on plasma lipid and lipoprotein markers of cardiovascular risk in healthy post-menopausal women.randomised, single-centre, […]» Read more
Congenital Hyperinsulinism (CHI) is a rare disease of hypoglycaemia but is the most common form of recurrent and severe hypoglycaemia causing brain injury and neurodisability in children. The management of […]» Read more
Eating, Sleeping and Sexual Function Disorders in Women with Polycystic Ovary Syndrome (PCOS): a systematic review and meta-analysis.
We aim to evaluate the association of PCOS with eating, sleeping and sexual function disorders.A comprehensive search including MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic […]» Read more
Maternal, Cord, and Three-Year-Old Child Serum Thyroid Hormone Concentrations in the Health Outcomes and Measures of the Environment (HOME) Study.
Maternal thyroid function during pregnancy may influence offspring thyroid function, though relations between maternal and child thyroid function are incompletely understood. We sought to characterize relations between maternal, cord, and […]» Read more
Sunlight exposure of the skin is associated with both risks and benefits. On one hand, sunlight ultraviolet (UV) radiation can cause skin cancer through signature DNA mutations. On the other […]» Read more
Bone mineral density and fractures in congenital adrenal hyperplasia: Findings from the dsd-LIFE study.
In patients with congenital adrenal hyperplasia (CAH) type and doses of glucocorticoids used as well as sex hormone secretion during puberty have important actions on bone mineral density (BMD) in […]» Read more
Severe growth failure associated with a novel heterozygous nonsense mutation in the GHR transmembrane domain leading to elevated growth hormone binding protein.
To report a novel mutation in GHR and to characterize a novel mechanism of nonclassical growth hormone insensitivity.Laron syndrome (LS) is a well described disorder of growth hormone insensitivity due […]» Read more