Admission to high-acuity intensive care units (ICUs) has been associated with improved outcomes compared to low-acuity ICUs, although the mechanism for these findings is unclear.Do high-acuity ICUs more effectively implement […]» Read more
Place of Death for Individuals with Chronic Lung Disease: Trends and Associated Factors from 2003 to 2017 in the United States.
Chronic lung disease is a common cause of mortality, yet little is known about where individuals with chronic lung disease die.What are the trends and factors associated with place of […]» Read more
EFFECTIVENESS AND SAFETY OF SUPERVISED HOME-BASED PHYSICAL TRAINING IN PATIENTS WITH COPD ON LONG-TERM HOME OXYGEN THERAPY: A RANDOMIZED TRIAL.
Patients with chronic obstructive pulmonary disease (COPD) in advanced disease stage who need long-term home oxygen therapy (LTHOT) have difficulty participating in outpatient pulmonary rehabilitation (PR) programs due to the […]» Read more
Use of Intravenous Immunoglobulin G in HIT patients is not associated with increased rates of thrombosis: A population-based study.
Comparison of Hospitalized Patients with Acute Respiratory Distress Syndrome Caused by COVID-19 and H1N1.
Since the outbreak of Coronavirus Disease 2019 (COVID-19) in China in December 2019, considerable attention has been focused on its elucidation. However, it is also important for clinicians and epidemiologists […]» Read more
Children with congenital heart disease (CHD) have an increased risk of neurocognitive impairment. No prior studies have evaluated the role of obstructive sleep apnea (OSA), which is associated with neurocognitive […]» Read more
Pulmonary involvement in lymphatic anomalies (LA) is associated with significant morbidity and mortality. Recently described Dynamic Contrast Enhanced Magnetic Resonance lymphangiography (DCMRL) is capable of imaging the lymphatic system in […]» Read more
Isolated pulmonary embolism is associated with a high risk of arterial thrombotic disease – Results from the VTEval Study.
Isolated PE is associated with a higher burden of atherosclerotic disease than other manifestations of venous thromboembolism (VTE).We hypothesized that the presence of isolated PE may signal a chronically elevated […]» Read more
Randomized trial on the effects of high-dose zopiclone on OSA severity, upper airway physiology and alertness.
Recent studies indicate that standard doses of hypnotics reduce or do not change the apnea-hypopnea index (AHI) or pharyngeal muscle activity. A 1-month trial of nightly zopiclone (7.5mg) modestly reduced […]» Read more
Acute exacerbation (AE) of chronic obstructive pulmonary disease (COPD) may be accompanied by the deterioration of cardiovascular comorbidities, as evidenced by the increased incidence of acute cardiovascular events.Whether preceding AE […]» Read more
INCREASED CHITOTRIOSIDASE IS ASSOCIATED WITH ASPERGILLUS AND FREQUENT EXACERBATIONS IN SOUTH-EAST ASIANS WITH BRONCHIECTASIS.
and Research Question: Chitinase activity is an important innate immune defence mechanism against infection including fungi. The two human chitinases: chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase) are associated to […]» Read more
Minimal clinically important differences for patient-reported outcome measures of fatigue in patients with COPD after pulmonary rehabilitation.
Fatigue is a burdensome and prevailing symptom in patients with chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation (PR) improves fatigue however, interpreting when such improvement is clinically relevant is challenging. […]» Read more
Interstitial lung disease (ILD) results in high morbidity and healthcare utilization. Diagnostic delays remain common and often occur in non-pulmonology settings. Screening for ILD in these settings has the potential […]» Read more
Diffusing Capacity is an Independent Predictor of Outcomes in Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease.
Patients with chronic obstructive pulmonary disease (COPD) who develop pulmonary hypertension (PH) have worse mortality than those with COPD alone. Predictors of poor outcomes in COPD-PH are not well described. […]» Read more
Pulmonary hypertension (PH) adversely impact patient´s exercise capacity in interstitial lung disease (ILD). Pulmonary vascular and right ventricular (RV) dysfunction impact, however, have traditionally been thought to be mild, and […]» Read more
Maternal distress during pregnancy and recurrence in early childhood predicts atopic dermatitis and asthma in childhood.
Using data from a provincial newborn screen and healthcare database for 12,587 children born in 2004, maternal distress was defined as: prenatal, and self-limiting, recurrent or late-onset postpartum. Atopic dermatitis […]» Read more
Change in V̇O2peak in response to aerobic exercise training and the relationship with exercise prescription in people with COPD: A systematic review and meta-analysis.
We investigated the effect of aerobic training and exercise prescription on peak oxygen uptake (V̇O2peak) in COPD.A systematic review was performed using MEDLINE, EMBASE, CINAHL and Cochrane databases for all […]» Read more
A physiological approach to the analysis of hemodynamic data in pulmonary hypertension (PH) has the advantage of reducing the large number (well over 100) of potential causal illnesses into four […]» Read more
Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder and subjective excessive daytime sleepiness (EDS) is the cardinal symptom for which many individuals seek medical advice. Positive airway pressure […]» Read more
Pharmacodynamic and pathophysiologic changes in critically ill adults receiving cefepime may increase the risk of adverse events. This study evaluated the impact of cefepime exposure on neurotoxicity development in critically […]» Read more
Treating Severe Obesity to Reduce Dyspnea in Patients with Chronic Lung Disease: A Pilot Mixed Methods Study.
Risk factors of infectious complications after endobronchial ultrasound-guided transbronchial biopsy.
Infectious complications after endobronchial ultrasound-guided transbronchial biopsy with a guide sheath (EBUS-GS-TBB) are serious in that they may delay or change scheduled subsequent therapy. The aim of this study was […]» Read more
Financial Justification for Interventional Pulmonology Programs: Terminology and Programmatic Models.
Interventional pulmonology programs provide clinical benefit to patients and are financially sustainable. In order to appreciate and illustrate the economic value of interventional pulmonology programs to hospital systems, physicians must […]» Read more
Diuretics have been reported as effective for reducing obstructive sleep apnea (OSA) severity by preventing fluid retention and reducing rostral fluid shift. The benefit of diuretics might vary depending upon […]» Read more
Simulation Training for Critical Care Airway Management: Assessing Translation to Clinical Practice Using a Small Video Recording Device.
Critical care airway management (CCAM) is a key skill for critical care physicians. Simulation based training (SBT) may be an effective modality in training intensivists in CCAM.This study examines whether […]» Read more
Despite a lack of evidence, ambulatory oxygen therapy is frequently prescribed for patients with interstitial lung disease (ILD) and exertional desaturation. Patients often prefer portable oxygen concentrators to oxygen cylinders. […]» Read more
Independent validation of early-stage NSCLC prognostic scores incorporating epigenetic and transcriptional biomarkers with gene-gene interactions and main effects.
DNA methylation and gene expression are promising biomarkers of various cancers, including non-small cell lung cancer (NSCLC). Besides main effects of biomarkers, the progression of complex diseases is also influenced […]» Read more