Considerable heterogeneity persists in the conduct and reporting of statistical analyses in the medical literature. Authors submitting manuscripts to CHEST are encouraged to adhere to the following guidelines where possible. […]» Read more
Cross-sectional studies are observational studies that analyze data from a population at a single point in time. They are often used to measure the prevalence of health outcomes, understand determinants […]» Read more
Economic evaluations, including cost-effectiveness analyses, are frameworks for decision-making. They help to illustrate tradeoffs between selecting one choice over another. This form of analysis is of great power and value […]» Read more
Medical tests are procedures intended to detect, diagnose, characterize, or monitor a specific medical condition. Understanding the accuracy of a medical test is a critical part of informed decision-making in […]» Read more
Randomized controlled trials (RCTs) are considered the highest level of evidence to establish causal associations in clinical research. There are many RCT designs and features that can be selected to […]» Read more
Reductions in genotyping costs and improvements in computational power have made conducting genome-wide association studies (GWAS) standard practice for many complex diseases. GWAS is the assessment of genetic variants across […]» Read more
Sample Size Estimation in Clinical Research: From Randomized Controlled Trials to Observational Studies.
Sample size determination is an essential step in planning a clinical study. It is critical to understand that different study designs need different methods of sample size estimation. Although there […]» Read more
Self-reported measures of health-related quality of life (HRQOL) are increasingly used in clinical management and evaluation of patient outcomes. HRQOL measures are used to monitor patient progress and treatment response, […]» Read more
Survival (time-to-event) analysis is commonly used in clinical research. Key features of performing a survival analysis include checking proportional hazards assumptions, reporting CIs for hazards ratios and relative risks, graphically […]» Read more
Early Changes over Time in the Radiographic Assessment of Lung Edema (RALE) Score are Associated with Survival in Acute Respiratory Distress Syndrome.
The Radiographic Assessment of Lung Edema (RALE) score has been proposed to assess the severity of acute respiratory distress syndrome (ARDS) and treatments targeted at reducing pulmonary edema such as […]» Read more
We have entered the era of “big data” and with that the explosion of interest in prediction modeling. With this explosion comes the challenge of evaluating statistical prediction models, both […]» Read more
We report the clinical history, laboratory findings, and imaging features of coronavirus disease 2019 (COVID-19) in a neonate whose mother was also a patient. The newborn was the youngest patient […]» Read more
When a review is performed following predefined steps (ie, systematically) and its results are quantitatively analyzed, it is called meta-analysis. Publication of meta-analyses has increased exponentially in pubmed.gov; using the […]» Read more
Case-control studies are one of the major observational study designs for performing clinical research. The advantages of these study designs over other study designs are that they are relatively quick […]» Read more
Causal directed acyclic graphs (cDAGs) have become popular tools for researchers to better examine biases related to causal questions. DAGs comprise a series of arrows connecting nodes that represent variables […]» Read more
Cohort studies are types of observational studies in which a cohort, or a group of individuals sharing some characteristic, are followed up over time, and outcomes are measured at one […]» Read more
Can acute cough characteristics from sound recordings differentiate common respiratory illnesses in children? A comparative prospective study.
Acute respiratory illnesses cause substantial morbidity worldwide. Cough is a common symptom in these childhood respiratory illnesses but there is currently no large cohort data on whether various cough characteristics […]» Read more
Feasibility of a 5G-based robot-assisted remote ultrasound system for cardiopulmonary assessment of COVID-19 patients.
Traditional methods for cardiopulmonary assessment of Coronavirus Disease 2019 (COVID-19) patients pose risks to, both, patients and examiners. This necessitates a remote examination of such patients without sacrificing information quality.Assess […]» Read more
The Effect of Tumor Size and Histology on Outcomes Following Segmentectomy vs. Lobectomy for Clinically Node-negative Non-small Cell Lung Cancer.
The interaction between tumor size and the comparative prognosis of lobar and sublobar resection has been poorly defined.The purpose of this study was to characterize the relationship between tumor size […]» Read more
To reduce the spread of SARS-CoV-2, many pulmonary function testing (PFT) laboratories have been closed or have significantly reduced their testing capacity. As these mitigation strategies may be necessary for […]» Read more
Impact of a multimodal telemonitoring intervention on CPAP adherence in symptomatic low-cardiovascular risk sleep apnea: a randomized controlled trial.
One of the major challenges in treating obstructive sleep apnea (OSA) is to achieve adequate continuous positive airway pressure (CPAP) adherence. Telemonitoring has the potential to provide individualized management and […]» Read more
Incidence, risk factors, and effects on outcome of ventilator-associated pneumonia in patients with traumatic brain injury. Analysis of a large, multicenter, prospective, observational longitudinal study.
No large prospective data are available on ventilator-associated pneumonia (VAP) in patients with traumatic brain injury (TBI).To evaluate the incidence, timing and risk factors of VAP after TBI and its […]» Read more
Tools to promote shared decision making in lung cancer screening using low-dose computerized tomography: a systematic review.
Decisions about lung cancer screening are inherently complex and create a need for methods to convey the risks and benefits of screening to patients.What kind of decision aids or tools […]» Read more
Mixed Venous Oxygen Saturation is a Better Prognosticator than Cardiac Index in Pulmonary Arterial Hypertension.
European Society of Cardiology and European Respiratory Society (ESC/ERS) guidelines include thermodilution cardiac index (TDCI) and mixed venous oxygen saturation (SvO2) as two of the three hemodynamic determinations used in […]» Read more
Effect of antiviral therapy on the outcome of mechanically ventilated patients with herpes simplex virus type 1 in bronchoalveolar lavage fluid: a retrospective cohort study.
Herpes simplex virus type 1 (HSV-1) is frequently detected in the bronchoalveolar lavage fluid (BAL) of mechanically ventilated patients.The aim of the study was to investigate whether antiviral therapy is […]» Read more
Association between nocturnal hypoxemia and cancer incidence in patients investigated for obstructive sleep apnea. Data from a large multicenter French cohort.
Previous studies have yielded inconsistent findings regarding the association between obstructive sleep apnea (OSA) and cancer in humans.Is there an association between indices of sleep-disordered breathing severity and cancer incidence […]» Read more
Standardized Management for Hypoxemic Respiratory Failure and ARDS: Systematic Review & Meta-analysis.
Treatment of hypoxemic respiratory failure (HRF) and Acute Respiratory Distress Syndrome (ARDS) is complex. Standardized management of HRF and ARDS may improve adherence to evidence informed practice and improve outcomes.To […]» Read more
Systemic capillary leak syndrome is a rare disorder characterized by dysfunctional inflammatory response, endothelial dysfunction, and extravasation of fluid from the vascular space to the interstitial space leading to shock, […]» Read more
Development of Learning Curves for Bronchoscopy Results of a Multicentre Study of Pulmonary Trainees.
There are currently no reference standards for the development of competency in bronchoscopy.The aims of this study were to 1) develop learning curves for bronchoscopy skill development and 2) estimate […]» Read more
Two immunocompromised patients with diffuse alveolar hemorrhage as a complication of severe COVID-19.
Diffuse alveolar hemorrhage (DAH) is a severe and potentially life-threatening disease manifestation. Besides autoimmune diseases such as anti-neutrophil cytoplasmatic antibody (ANCA) associated vasculitis and anti-glomerular basement membrane (anti-GBM) syndrome pulmonary […]» Read more