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Atrial fibrillation (AF) constitutes an increasing health problem in the aging population. Animal models reflecting human phenotypes are needed to understand the mechanisms of AF, as well as to test […]
» Read moreRNAi effectors (e.g., siRNA, shRNA, and miRNA) can efficiently trigger the silencing of specific genes, and its genomic alteration functions allowed to pursue clinical trials in distinct areas, including infectious […]
» Read moreAsthma is a chronic disease that displays heterogeneous clinical and molecular features. A phenotypic subset of late-onset severe asthmatics has debilitating fixed airflow obstruction, increased neutrophilic inflammation and a history […]
» Read moreAlpha 7 nicotinic acetylcholine receptors (CHRNA7) suppress inflammation through diverse pathways in immune cells, so is potentially involved in a number of inflammatory diseases. However, the detailed mechanisms underlying CHRNA7’s […]
» Read moreRecent biochemical and pharmacological studies have reported that in several tissues and cell types, microsomal prostaglandin E2 synthase (mPGES) and peroxisome proliferator-activated receptor-γ (PPAR-γ) expression are modulated by a variety […]
» Read moreInactivation of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes intracellular Ca2+ accumulation, which activates calcineurin-mediated nuclear factor of activated T-lymphocytes (NFAT)/NF-κB pathways, results in the phenotypic […]
» Read moreKV 1.3 potassium channels are expressed in vascular smooth muscle cells (VSMCs), where they contribute to proliferation rather than contraction and participate in vascular remodeling. KV 1.3 channels are also […]
» Read moreIncreased expression of C1r, C1s and C3 in kidney cells play an important role in the pathogenesis of kidney fibrosis. Our studies suggest that activation of complement in kidney cells […]
» Read moreAging is associated with progressive metabolic dysregulation. Rutin has reported as a metabolic regulating chemical with a poor solubility. At present, we use Na-Rutin investigating the effect and mechanisms of […]
» Read moreKaempferol is a natural flavonoid widely investigated in various fields due to its anti-oxidant, anti-cancer, and anti-inflammatory activities but few studies have shown its inhibitory effect on T cell activation. […]
» Read moreβ-arrestin2 recruitment to μ receptors may contribute to the development opioid analgesics side effects. This possibility led to the development of TRV130 and PZM21, opioids reportedly biased against β-arrestin2 recruitment […]
» Read moreThe activation of the defense reaction inhibits the baroreflex response through the intermediate rostro-ventromedial medulla (B3 raphe) and nucleus tractus solitarius (NTS) regions. Our aim was to determine whether and […]
» Read moreThe Popeye Domain Containing Protein 1 (POPDC1), a tight junction-associated transmembrane protein with a unique binding site for cAMP, has been shown to act as a tumour suppressor in cancer […]
» Read moreDespite the potential of cancer medicine, cancer stem cells (CSCs) associated with chemoresistance and disease recurrence are the significant challenges currently opposing the efficacy of available cancer treatment options. Mitochondrial […]
» Read moreCysteinyl leukotrienes (CysLTs) are inflammatory lipid mediators that play a central role in the pathophysiology of several inflammatory diseases. Recently, there has been an increased interest in determining how these […]
» Read moreIt is well established that both smokers and patients with COPD are at a significantly heightened risk of cardiovascular disease (CVD), although the mechanisms underpinning the onset and progression of […]
» Read moreCerebral microhaemorrhages (CMH) are associated with cognitive decline in humans. In rodents, CMHs induce cognitive impairment in male mice only along with sex-specific cortical and hippocampal modifications affecting neural, glial […]
» Read moreItching is the most frequent pathology in dermatology which has grievous impacts on people’s mental health and social life. Transient receptor potential vanilloid 3 (TRPV3) channel is a promising target […]
» Read moreRetinal degeneration, characterized by the progressive death of retinal neurons, is the most common cause of visual impairment. Oxysterols are the cholesterol derivatives produced via enzymatic and/or free radical oxidation […]
» Read moreTargeting α7 nicotinic acetylcholine receptors (nAChRs) in neuroinflammatory disorders including acute ischemic stroke (AIS) holds significant therapeutic promise. However, therapeutically-relevant signaling mechanisms remain unidentified. Activation of neuronal α7 nAChRs triggers […]
» Read moreClinical research shows that adolescent cannabis use associates with adult psychopathology. Experimental studies demonstrate the long-lasting effects of adolescent THC on adult rats, mostly using higher THC doses. The present […]
» Read moreδ-containing GABAA receptors are notorious for being difficult to study in vitro due to heterogeneity of expressed receptor populations and low GABA-evoked current amplitudes. Thus, there are some misconception and […]
» Read moreSrc homology 3-domain growth factor receptor-bound 2-like endophilin interacting protein 1 (SGIP1) interacts with cannabinoid receptor 1 (CB1R). SGIP1 is abundantly and principally expressed within the nervous system. SGIP1 and […]
» Read moreThe pathophysiology of coronary artery spasm (CAS), with its associated ischaemic crises, is currently poorly understood, and treatment is frequently ineffective. In view of increasing evidence that platelet-based defects may […]
» Read moreCX-5461 is a novel selective RNA polymerase I (Pol I) inhibitor. Previously we found that CX-5461 could inhibit pathological arterial remodeling caused by angioplasty and transplantation. In the present study, […]
» Read moreCannabinoids form a singular group of plant-derived compounds, endogenous lipids and synthetic derivatives with multiple therapeutic effects exerted by targeting different elements of the so-called endocannabinoid system. One of their […]
» Read moreCancer cachexia and cancer-associated thrombosis are potentially fatal outcomes of advanced cancer. Nevertheless, thrombin expression in NSCLC primary tumor tissues and the association between prognosis of NSCLC patients remain largely […]
» Read moreSodium glucose cotransporter 2 (SGLT2) inhibitor is a hypoglycemic agent that acts by increasing urinary glucose excretion and promoting enhanced usage of fat. However, the underlying mechanism is poorly understood. […]
» Read moreIn cardiac myocytes, cAMP produced by both β1 and β2 -adrenergic receptors (ARs) results in an increase in L-type Ca2+ channel activity and myocyte contraction. However, only cAMP produced by […]
» Read moreDisturbed flow induces endothelial dysfunction and contributes to uneven distribution of atherosclerotic plaque. Emerging evidence suggests that harmine, a natural small molecule in extracts of Peganum harmala, has potent beneficial […]
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