Honokiol inhibits proliferation of colorectal cancer cells by targeting Anoctamin 1/TMEM16A Ca2+ -activated Cl- channels.

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Anoctamin 1 (Ano1, also named TMEM16A) Ca2+ -activated Cl- channels contribute to the pathogenesis of colorectal cancer. Honokiol is known to inhibit cell proliferation and tumor growth in colorectal cancer. […]

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How environmental enrichment balances out neuroinflammation on chronic pain and comorbid depression and anxiety disorders.

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Depression and anxiety commonly occur in chronic pain states, and the co-existence of these diseases worsen outcomes for both disorders and may reduce treatment adherence and response. Despite the advances […]

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The development of inhibitors of LRRK2 as a therapeutic strategy for Parkinson’s disease: the current state of play.

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Current therapeutic approaches for Parkinson’s disease (PD) are based around treatments that alleviate symptoms but do not slow or prevent disease progression. As such, alternative strategies are needed. A promising […]

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The role of nucleus of the solitary tract GLP1 and PrRP neurons in stress: anatomy, physiology, and cellular interactions.

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Neuroendocrine, behavioural, and autonomic responses to stressful stimuli are orchestrated by complex neural circuits. The caudal nucleus of the solitary tract (cNTS) in the dorsomedial hindbrain is uniquely positioned to […]

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MESENCHYMAL STEM CELLS AND EXTRACELLULAR VESICLES FOR THE TREATMENT OF PAIN: CURRENT STATUS AND PERSPECTIVES.

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Mesenchymal stem/stromal cells (MSCs) are multipotent progenitor cells of mesodermal origin. Due to their capacity for self-renewal and differentiation into several cell types, MSCs have been extensively studied in experimental […]

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Sirtuins as pharmacological targets in neurodegenerative and neuropsychiatric disorders.

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Histone deacetylases (HDAC) are enzymes that regulate several processes, such as transcription, cell proliferation, differentiation and development. HDACs are classified as either Zn2+ -dependent or NAD+ -dependent enzymes. Experimental and […]

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Tumour brain: pre-treatment cognitive and affective disorders caused by peripheral cancers.

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People that develop extra-cranial cancers often display comorbid neurological disorders, such as anxiety, depression, and cognitive impairment, even before commencement of chemotherapy. This suggests bidirectional crosstalk between non-central nervous system […]

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Evidence for 5-HT1A receptor-mediated antiallodynic and antihyperalgesic effects of apigenin in mice suffering from mononeuropathy.

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Neuropathic pain places a devastating health burden, with effective therapies or drugs being scarce. We aimed to investigate the potential antiallodynic and antihyperalgesic effects of apigenin, a natural flavonoid with […]

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Translational PK/PD and model-informed development of JNJ-67842125, a Fab reversal agent for JNJ-64179375, a long-acting thrombin inhibitor.

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Antigen-binding fragment (Fab ) reversal agents (RAs) were developed to reverse, in situations of bleeding emergency, the anticoagulant activity of JNJ-64179375 (JNJ-9375), a monoclonal antibody that specifically binds exosite-1 on […]

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NLRP3 at the crossroads between immune/inflammatory responses and enteric neuroplastic remodeling in a mouse model of diet-induced obesity.

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Enteric neurogenic/inflammation contributes to bowel dysmotility in obesity. Here, we examined the role of NLRP3 in colonic neuromuscular dysfunctions in mice with high fat diet (HFD)-induced obesity.Wild-type C57BL/6J and NLRP3-KO […]

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Altered hippocampal kynurenine pathway metabolism contribute to hyperexcitability in human mesial temporal lobe epilepsy-hippocampal sclerosis.

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Glutamate receptor mediated enhanced excitatory neurotransmission is typically associated with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). Kynurenic acid (KYNA) and quinolinic acid (QUIN) are two important tryptophan-kynurenine pathway […]

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cGMP and mitochondrial K+ channels – Compartmentalized but closely connected in cardioprotection.

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The 3′,5′-cyclic guanosine monophosphate (cGMP) pathway triggers cytoprotective responses and improves cardiomyocyte survival during myocardial ischemia and reperfusion (I/R) injury. These beneficial effects were attributed to NO-sensitive guanylyl cyclase (GC) […]

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Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms.

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Neurosteroids influence neuronal function and have multiple promising clinical applications. Direct modulation of postsynaptic neurotransmitter receptors by neurosteroids is well characterized, but neurosteroid presynaptic effects remain poorly understood. Here we […]

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Methoxphenidine (MXP) induced abnormalities: Addictive and schizophrenia-related behaviours based on imbalance of neurochemicals in the brain.

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Methoxphenidine (MXP) is a dissociative-based novel psychoactive designer drug. Although fatal accidents from MXP abuse have been reported, recreational use of the drug continues. We aim to provide scientific support, […]

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Inhaled bacteriophage therapy in a porcine model of pneumonia caused by Pseudomonas aeruginosa during mechanical ventilation.

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Pseudomonas aeruginosa is a main cause of ventilator-associated pneumonia (VAP) with drug-resistant bacteria. Bacteriophage therapy has experienced resurgence to compensate for the limited development of novel antibiotics. However, phage therapy […]

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