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Anoctamin 1 (Ano1, also named TMEM16A) Ca2+ -activated Cl- channels contribute to the pathogenesis of colorectal cancer. Honokiol is known to inhibit cell proliferation and tumor growth in colorectal cancer. […]
» Read moreObesity is a risk factor for the development of chronic kidney disease independent of diabetes, hypertension and other comorbidities. Obesity-associated nephropathy has been linked to dysregulation of the cell energy […]
» Read moreOpioid use disorder is a worldwide societal problem and public health burden. Strategies for treating opioid use disorder can be divided those that target the opioid receptor system and those […]
» Read moreA high proportion of depressed patients fail to respond to antidepressant drug treatment. Treatment-resistant depression (TRD) is a major challenge for the psychopharmacology of mood disorders. Only in the past […]
» Read moreSince the start of the coronavirus SARS-Cov-2 pandemic, a disease that has become one of the world’s greatest global health challenges, the role of the immune system has been at […]
» Read moreEmerging data shows pregnant women with COVID-19 are at significantly higher risk of severe outcomes compared to non-pregnant women of similar age. This review discusses the invaluable insight revealed from […]
» Read moreThe development of several drugs that target the calcitonin gene-related peptide (CGRP) system has been a major breakthrough in the pharmacological management of migraine. These are divided into two major […]
» Read moreDepression and anxiety commonly occur in chronic pain states, and the co-existence of these diseases worsen outcomes for both disorders and may reduce treatment adherence and response. Despite the advances […]
» Read moreNeointimal hyperplasia (NIH) is the fundamental cause for vascular diseases, and vascular smooth muscle cell (VSMC) dysregulation has been widely implicated in NIH. Neutrophil elastase (NE) has been suggested as […]
» Read moreSepsis induced by bacteria or viruses can result in multi-organ dysfunction, which is a major cause of death in intensive care units. Current treatments are only supportive and there are […]
» Read moreSepsis induced by bacteria or viruses can result in multi-organ dysfunction, which is a major cause of death in intensive care units. Current treatments are only supportive and there are […]
» Read moreCurrent therapeutic approaches for Parkinson’s disease (PD) are based around treatments that alleviate symptoms but do not slow or prevent disease progression. As such, alternative strategies are needed. A promising […]
» Read moreNeuroendocrine, behavioural, and autonomic responses to stressful stimuli are orchestrated by complex neural circuits. The caudal nucleus of the solitary tract (cNTS) in the dorsomedial hindbrain is uniquely positioned to […]
» Read moreClassical pharmacological bioassays generally use observed effects from a concentration series, at a single equilibrium time point to construct a concentration-effect curve, representing one experiment. However, if the full kinetic […]
» Read moreMesenchymal stem/stromal cells (MSCs) are multipotent progenitor cells of mesodermal origin. Due to their capacity for self-renewal and differentiation into several cell types, MSCs have been extensively studied in experimental […]
» Read moreHistone deacetylases (HDAC) are enzymes that regulate several processes, such as transcription, cell proliferation, differentiation and development. HDACs are classified as either Zn2+ -dependent or NAD+ -dependent enzymes. Experimental and […]
» Read moreFentanyl is a key therapeutic used in anaesthesia and pain management. It is also increasingly used illicitly and is responsible for a large and growing number of opioid overdose deaths, […]
» Read morePeople that develop extra-cranial cancers often display comorbid neurological disorders, such as anxiety, depression, and cognitive impairment, even before commencement of chemotherapy. This suggests bidirectional crosstalk between non-central nervous system […]
» Read moreNeuropathic pain places a devastating health burden, with effective therapies or drugs being scarce. We aimed to investigate the potential antiallodynic and antihyperalgesic effects of apigenin, a natural flavonoid with […]
» Read moreAntigen-binding fragment (Fab ) reversal agents (RAs) were developed to reverse, in situations of bleeding emergency, the anticoagulant activity of JNJ-64179375 (JNJ-9375), a monoclonal antibody that specifically binds exosite-1 on […]
» Read moreHeart failure is associated with high morbidity and mortality, and new therapeutic targets are needed. Preclinical data suggest that pharmacological activation of protein kinase G (PKG) can reduce maladaptive ventricular […]
» Read moreEnteric neurogenic/inflammation contributes to bowel dysmotility in obesity. Here, we examined the role of NLRP3 in colonic neuromuscular dysfunctions in mice with high fat diet (HFD)-induced obesity.Wild-type C57BL/6J and NLRP3-KO […]
» Read moreGlutamate receptor mediated enhanced excitatory neurotransmission is typically associated with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). Kynurenic acid (KYNA) and quinolinic acid (QUIN) are two important tryptophan-kynurenine pathway […]
» Read moreThe 3′,5′-cyclic guanosine monophosphate (cGMP) pathway triggers cytoprotective responses and improves cardiomyocyte survival during myocardial ischemia and reperfusion (I/R) injury. These beneficial effects were attributed to NO-sensitive guanylyl cyclase (GC) […]
» Read moreGlucagon-like peptide 1 (GLP-1) is well known as a gut hormone, but also acts as a neuropeptide, produced in a discrete population of caudal brainstem neurons that project widely throughout […]
» Read moreNeurosteroids influence neuronal function and have multiple promising clinical applications. Direct modulation of postsynaptic neurotransmitter receptors by neurosteroids is well characterized, but neurosteroid presynaptic effects remain poorly understood. Here we […]
» Read moreMany pain-triggering nociceptor neurons express TRPV1 or TRPA1, cation-selective channels with large pores that enable permeation of QX-314, a cationic analogue of lidocaine. Co-application of QX-314 with TRPV1 or TRPA1 […]
» Read moreMethoxphenidine (MXP) is a dissociative-based novel psychoactive designer drug. Although fatal accidents from MXP abuse have been reported, recreational use of the drug continues. We aim to provide scientific support, […]
» Read moreNitric oxide (NO) activates sGC for cGMP production, but in disease sGC becomes insensitive toward NO activation. What changes occur to sGC during its inactivation in cells is not clear.We […]
» Read morePseudomonas aeruginosa is a main cause of ventilator-associated pneumonia (VAP) with drug-resistant bacteria. Bacteriophage therapy has experienced resurgence to compensate for the limited development of novel antibiotics. However, phage therapy […]
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