Atrial fibrillation (AF) constitutes an increasing health problem in the aging population. Animal models reflecting human phenotypes are needed to understand the mechanisms of AF, as well as to test […]» Read more
RNAi effectors (e.g., siRNA, shRNA, and miRNA) can efficiently trigger the silencing of specific genes, and its genomic alteration functions allowed to pursue clinical trials in distinct areas, including infectious […]» Read more
G-CSFR antagonism reduces mucosal injury and airways fibrosis in a virus-dependent model of severe asthma.
Asthma is a chronic disease that displays heterogeneous clinical and molecular features. A phenotypic subset of late-onset severe asthmatics has debilitating fixed airflow obstruction, increased neutrophilic inflammation and a history […]» Read more
Anti-inflammatory effects of alpha 7 nicotinic acetylcholine receptors through interacting with adenylyl cyclase 6.
Alpha 7 nicotinic acetylcholine receptors (CHRNA7) suppress inflammation through diverse pathways in immune cells, so is potentially involved in a number of inflammatory diseases. However, the detailed mechanisms underlying CHRNA7’s […]» Read more
Recent biochemical and pharmacological studies have reported that in several tissues and cell types, microsomal prostaglandin E2 synthase (mPGES) and peroxisome proliferator-activated receptor-γ (PPAR-γ) expression are modulated by a variety […]» Read more
Inactivation of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes intracellular Ca2+ accumulation, which activates calcineurin-mediated nuclear factor of activated T-lymphocytes (NFAT)/NF-κB pathways, results in the phenotypic […]» Read more
KV 1.3 channels are novel determinants of macrophage-dependent endothelial dysfunction in a mouse model with angiotensin II-induced hypertension.
KV 1.3 potassium channels are expressed in vascular smooth muscle cells (VSMCs), where they contribute to proliferation rather than contraction and participate in vascular remodeling. KV 1.3 channels are also […]» Read more
Increased expression of C1r, C1s and C3 in kidney cells play an important role in the pathogenesis of kidney fibrosis. Our studies suggest that activation of complement in kidney cells […]» Read more
Aging is associated with progressive metabolic dysregulation. Rutin has reported as a metabolic regulating chemical with a poor solubility. At present, we use Na-Rutin investigating the effect and mechanisms of […]» Read more
Therapeutic effect of kaempferol on atopic dermatitis by attenuation of T cell activity via interaction with Multidrug resistance-associated protein 1.
Kaempferol is a natural flavonoid widely investigated in various fields due to its anti-oxidant, anti-cancer, and anti-inflammatory activities but few studies have shown its inhibitory effect on T cell activation. […]» Read more
TRV130 partial agonism and capacity to induce antinociceptive tolerance revealed through reducing available μ opioid receptor number.
β-arrestin2 recruitment to μ receptors may contribute to the development opioid analgesics side effects. This possibility led to the development of TRV130 and PZM21, opioids reportedly biased against β-arrestin2 recruitment […]» Read more
Rostral cuneiform nucleus and the defense reaction: Direct and indirect midbrain-medullary serotonin mechanisms in baroreflex inhibition.
The activation of the defense reaction inhibits the baroreflex response through the intermediate rostro-ventromedial medulla (B3 raphe) and nucleus tractus solitarius (NTS) regions. Our aim was to determine whether and […]» Read more
The Popeye Domain Containing Protein 1 (POPDC1), a tight junction-associated transmembrane protein with a unique binding site for cAMP, has been shown to act as a tumour suppressor in cancer […]» Read more
Dysregulation of mitophagy and mitochondrial homeostasis in cancer stem cells: Novel mechanism for anti-CSCs Targeted Cancer Therapy.
Despite the potential of cancer medicine, cancer stem cells (CSCs) associated with chemoresistance and disease recurrence are the significant challenges currently opposing the efficacy of available cancer treatment options. Mitochondrial […]» Read more
Cysteinyl leukotrienes (CysLTs) are inflammatory lipid mediators that play a central role in the pathophysiology of several inflammatory diseases. Recently, there has been an increased interest in determining how these […]» Read more
It is well established that both smokers and patients with COPD are at a significantly heightened risk of cardiovascular disease (CVD), although the mechanisms underpinning the onset and progression of […]» Read more
Beneficial effects of atorvastatin on sex-specific cognitive impairment induced by a cerebral microhaemorrhage in a murine model.
Cerebral microhaemorrhages (CMH) are associated with cognitive decline in humans. In rodents, CMHs induce cognitive impairment in male mice only along with sex-specific cortical and hippocampal modifications affecting neural, glial […]» Read more
Itching is the most frequent pathology in dermatology which has grievous impacts on people’s mental health and social life. Transient receptor potential vanilloid 3 (TRPV3) channel is a promising target […]» Read more
Retinal degeneration, characterized by the progressive death of retinal neurons, is the most common cause of visual impairment. Oxysterols are the cholesterol derivatives produced via enzymatic and/or free radical oxidation […]» Read more
Therapeutic efficacy of α7 ligands after acute ischemic stroke is linked to conductive states of α7 nAChRs.
Targeting α7 nicotinic acetylcholine receptors (nAChRs) in neuroinflammatory disorders including acute ischemic stroke (AIS) holds significant therapeutic promise. However, therapeutically-relevant signaling mechanisms remain unidentified. Activation of neuronal α7 nAChRs triggers […]» Read more
Detrimental effects of adolescent escalating low-dose Δ9 -tetrahydrocannabinol lead to a specific bio-behavioural profile in adult male rats.
Clinical research shows that adolescent cannabis use associates with adult psychopathology. Experimental studies demonstrate the long-lasting effects of adolescent THC on adult rats, mostly using higher THC doses. The present […]» Read more
Efficient expression of concatenated α1β2δ and α1β3δ GABAA receptors, their pharmacology and stoichiometry.
δ-containing GABAA receptors are notorious for being difficult to study in vitro due to heterogeneity of expressed receptor populations and low GABA-evoked current amplitudes. Thus, there are some misconception and […]» Read more
SGIP1 is involved in regulation of emotionality, mood, and nociception and tunes in vivo signaling of Cannabinoid Receptor 1.
Src homology 3-domain growth factor receptor-bound 2-like endophilin interacting protein 1 (SGIP1) interacts with cannabinoid receptor 1 (CB1R). SGIP1 is abundantly and principally expressed within the nervous system. SGIP1 and […]» Read more
The pathophysiology of coronary artery spasm (CAS), with its associated ischaemic crises, is currently poorly understood, and treatment is frequently ineffective. In view of increasing evidence that platelet-based defects may […]» Read more
Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX-5461 on pulmonary arterial hypertension and associated vascular remodeling.
CX-5461 is a novel selective RNA polymerase I (Pol I) inhibitor. Previously we found that CX-5461 could inhibit pathological arterial remodeling caused by angioplasty and transplantation. In the present study, […]» Read more
Targeting the CB2 receptor and other endocannabinoid elements to delay disease progression in amyotrophic lateral sclerosis.
Cannabinoids form a singular group of plant-derived compounds, endogenous lipids and synthetic derivatives with multiple therapeutic effects exerted by targeting different elements of the so-called endocannabinoid system. One of their […]» Read more
A novel oncotherapy strategy, direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer.
Cancer cachexia and cancer-associated thrombosis are potentially fatal outcomes of advanced cancer. Nevertheless, thrombin expression in NSCLC primary tumor tissues and the association between prognosis of NSCLC patients remain largely […]» Read more
SGLT2 Inhibition by Canagliflozin Ameliorates Diet-induced Obesity by Promoting Intra-adipose Sympathetic innervation.
Sodium glucose cotransporter 2 (SGLT2) inhibitor is a hypoglycemic agent that acts by increasing urinary glucose excretion and promoting enhanced usage of fat. However, the underlying mechanism is poorly understood. […]» Read more
Compartmentation of β2 -Adrenergic Receptor Stimulated cAMP Responses by Phosphodiesterases Type 2 and 3 in Cardiac Ventricular Myocytes.
In cardiac myocytes, cAMP produced by both β1 and β2 -adrenergic receptors (ARs) results in an increase in L-type Ca2+ channel activity and myocyte contraction. However, only cAMP produced by […]» Read more
Harmine alleviates atherogenesis by inhibiting disturbed flow-mediated endothelial activation via PTPN14/YAP.
Disturbed flow induces endothelial dysfunction and contributes to uneven distribution of atherosclerotic plaque. Emerging evidence suggests that harmine, a natural small molecule in extracts of Peganum harmala, has potent beneficial […]» Read more