G-CSFR antagonism reduces mucosal injury and airways fibrosis in a virus-dependent model of severe asthma.

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Asthma is a chronic disease that displays heterogeneous clinical and molecular features. A phenotypic subset of late-onset severe asthmatics has debilitating fixed airflow obstruction, increased neutrophilic inflammation and a history […]

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Anti-inflammatory effects of alpha 7 nicotinic acetylcholine receptors through interacting with adenylyl cyclase 6.

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Alpha 7 nicotinic acetylcholine receptors (CHRNA7) suppress inflammation through diverse pathways in immune cells, so is potentially involved in a number of inflammatory diseases. However, the detailed mechanisms underlying CHRNA7’s […]

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IL-17 induced inflammation modulates mPGES-1/PPAR-γ pathway in monocytes/macrophages.

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Recent biochemical and pharmacological studies have reported that in several tissues and cell types, microsomal prostaglandin E2 synthase (mPGES) and peroxisome proliferator-activated receptor-γ (PPAR-γ) expression are modulated by a variety […]

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Inactivation of SERCA2 Cys674 accelerates aortic aneurysms by suppressing PPARγ.

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Inactivation of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes intracellular Ca2+ accumulation, which activates calcineurin-mediated nuclear factor of activated T-lymphocytes (NFAT)/NF-κB pathways, results in the phenotypic […]

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KV 1.3 channels are novel determinants of macrophage-dependent endothelial dysfunction in a mouse model with angiotensin II-induced hypertension.

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KV 1.3 potassium channels are expressed in vascular smooth muscle cells (VSMCs), where they contribute to proliferation rather than contraction and participate in vascular remodeling. KV 1.3 channels are also […]

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Therapeutic effect of kaempferol on atopic dermatitis by attenuation of T cell activity via interaction with Multidrug resistance-associated protein 1.

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Kaempferol is a natural flavonoid widely investigated in various fields due to its anti-oxidant, anti-cancer, and anti-inflammatory activities but few studies have shown its inhibitory effect on T cell activation. […]

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TRV130 partial agonism and capacity to induce antinociceptive tolerance revealed through reducing available μ opioid receptor number.

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β-arrestin2 recruitment to μ receptors may contribute to the development opioid analgesics side effects. This possibility led to the development of TRV130 and PZM21, opioids reportedly biased against β-arrestin2 recruitment […]

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Rostral cuneiform nucleus and the defense reaction: Direct and indirect midbrain-medullary serotonin mechanisms in baroreflex inhibition.

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The activation of the defense reaction inhibits the baroreflex response through the intermediate rostro-ventromedial medulla (B3 raphe) and nucleus tractus solitarius (NTS) regions. Our aim was to determine whether and […]

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Dysregulation of mitophagy and mitochondrial homeostasis in cancer stem cells: Novel mechanism for anti-CSCs Targeted Cancer Therapy.

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Despite the potential of cancer medicine, cancer stem cells (CSCs) associated with chemoresistance and disease recurrence are the significant challenges currently opposing the efficacy of available cancer treatment options. Mitochondrial […]

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Beneficial effects of atorvastatin on sex-specific cognitive impairment induced by a cerebral microhaemorrhage in a murine model.

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Cerebral microhaemorrhages (CMH) are associated with cognitive decline in humans. In rodents, CMHs induce cognitive impairment in male mice only along with sex-specific cortical and hippocampal modifications affecting neural, glial […]

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Therapeutic efficacy of α7 ligands after acute ischemic stroke is linked to conductive states of α7 nAChRs.

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Targeting α7 nicotinic acetylcholine receptors (nAChRs) in neuroinflammatory disorders including acute ischemic stroke (AIS) holds significant therapeutic promise. However, therapeutically-relevant signaling mechanisms remain unidentified. Activation of neuronal α7 nAChRs triggers […]

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Detrimental effects of adolescent escalating low-dose Δ9 -tetrahydrocannabinol lead to a specific bio-behavioural profile in adult male rats.

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Clinical research shows that adolescent cannabis use associates with adult psychopathology. Experimental studies demonstrate the long-lasting effects of adolescent THC on adult rats, mostly using higher THC doses. The present […]

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Efficient expression of concatenated α1β2δ and α1β3δ GABAA receptors, their pharmacology and stoichiometry.

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δ-containing GABAA receptors are notorious for being difficult to study in vitro due to heterogeneity of expressed receptor populations and low GABA-evoked current amplitudes. Thus, there are some misconception and […]

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SGIP1 is involved in regulation of emotionality, mood, and nociception and tunes in vivo signaling of Cannabinoid Receptor 1.

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Src homology 3-domain growth factor receptor-bound 2-like endophilin interacting protein 1 (SGIP1) interacts with cannabinoid receptor 1 (CB1R). SGIP1 is abundantly and principally expressed within the nervous system. SGIP1 and […]

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Impairment of platelet nitric oxide signaling in coronary artery spasm: role of hydrogen sulphide.

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The pathophysiology of coronary artery spasm (CAS), with its associated ischaemic crises, is currently poorly understood, and treatment is frequently ineffective. In view of increasing evidence that platelet-based defects may […]

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Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX-5461 on pulmonary arterial hypertension and associated vascular remodeling.

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CX-5461 is a novel selective RNA polymerase I (Pol I) inhibitor. Previously we found that CX-5461 could inhibit pathological arterial remodeling caused by angioplasty and transplantation. In the present study, […]

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Targeting the CB2 receptor and other endocannabinoid elements to delay disease progression in amyotrophic lateral sclerosis.

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Cannabinoids form a singular group of plant-derived compounds, endogenous lipids and synthetic derivatives with multiple therapeutic effects exerted by targeting different elements of the so-called endocannabinoid system. One of their […]

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A novel oncotherapy strategy, direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer.

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Cancer cachexia and cancer-associated thrombosis are potentially fatal outcomes of advanced cancer. Nevertheless, thrombin expression in NSCLC primary tumor tissues and the association between prognosis of NSCLC patients remain largely […]

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SGLT2 Inhibition by Canagliflozin Ameliorates Diet-induced Obesity by Promoting Intra-adipose Sympathetic innervation.

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Sodium glucose cotransporter 2 (SGLT2) inhibitor is a hypoglycemic agent that acts by increasing urinary glucose excretion and promoting enhanced usage of fat. However, the underlying mechanism is poorly understood. […]

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Compartmentation of β2 -Adrenergic Receptor Stimulated cAMP Responses by Phosphodiesterases Type 2 and 3 in Cardiac Ventricular Myocytes.

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In cardiac myocytes, cAMP produced by both β1 and β2 -adrenergic receptors (ARs) results in an increase in L-type Ca2+ channel activity and myocyte contraction. However, only cAMP produced by […]

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Harmine alleviates atherogenesis by inhibiting disturbed flow-mediated endothelial activation via PTPN14/YAP.

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Disturbed flow induces endothelial dysfunction and contributes to uneven distribution of atherosclerotic plaque. Emerging evidence suggests that harmine, a natural small molecule in extracts of Peganum harmala, has potent beneficial […]

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