Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial).

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To investigate the effectiveness of using convalescent plasma to treat moderate coronavirus disease 2019 (covid-19) in adults in India.Open label, parallel arm, phase II, multicentre, randomised controlled trial.39 public and […]

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Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study.

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To derive and validate a risk prediction algorithm to estimate hospital admission and mortality outcomes from coronavirus disease 2019 (covid-19) in adults.Population based cohort study.QResearch database, comprising 1205 general practices […]

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Targeting rehabilitation to improve outcomes after total knee arthroplasty in patients at risk of poor outcomes: randomised controlled trial.

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To evaluate whether a progressive course of outpatient physiotherapy offers superior outcomes to a single physiotherapy review and home exercise based intervention when targeted at patients with a predicted poor […]

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Fifteen year quality of life outcomes in men with localised prostate cancer: population based Australian prospective study.

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To assess treatment related changes in quality of life up to 15 years after diagnosis of localised prostate cancer.Population based, prospective cohort study with follow-up over 15 years.New South Wales, […]

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In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study.

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To estimate the incidence, risk factors, and outcomes associated with in-hospital cardiac arrest and cardiopulmonary resuscitation in critically ill adults with coronavirus disease 2019 (covid-19).Multicenter cohort study.Intensive care units at […]

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In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study.

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To estimate the incidence, risk factors, and outcomes associated with in-hospital cardiac arrest and cardiopulmonary resuscitation in critically ill adults with coronavirus disease 2019 (covid-19).Multicenter cohort study.Intensive care units at […]

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Risk of complicated birth at term in nulliparous and multiparous women using routinely collected maternity data in England: cohort study.

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To determine the rate of complicated birth at term in women classified at low risk according to the National Institute for Health and Care Excellence guideline for intrapartum care (no […]

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Menstrual cycle regularity and length across the reproductive lifespan and risk of premature mortality: prospective cohort study.

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To evaluate whether irregular or long menstrual cycles throughout the life course are associated with all cause and cause specific premature mortality (age <70 years).Prospective cohort study.Nurses’ Health Study II […]

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Central fatness and risk of all cause mortality: systematic review and dose-response meta-analysis of 72 prospective cohort studies.

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To quantify the association of indices of central obesity, including waist circumference, hip circumference, thigh circumference, waist-to-hip ratio, waist-to-height ratio, waist-to-thigh ratio, body adiposity index, and A body shape index, […]

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Emerging immunotherapies in multiple myeloma.

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Despite considerable advances in treatment approaches in the past two decades, multiple myeloma remains an incurable disease. Treatments for myeloma continue to evolve with many emerging immunotherapies. The first immunotherapy […]

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Opportunistic screening versus usual care for detection of atrial fibrillation in primary care: cluster randomised controlled trial.

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To investigate whether opportunistic screening in primary care increases the detection of atrial fibrillation compared with usual care.Cluster randomised controlled trial.47 intention-to-screen and 49 usual care primary care practices in […]

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Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries.

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To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide […]

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Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score.

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To develop and validate a pragmatic risk score to predict mortality in patients admitted to hospital with coronavirus disease 2019 (covid-19).Prospective observational cohort study.International Severe Acute Respiratory and emerging Infections […]

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A living WHO guideline on drugs for covid-19.

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What is the role of drug interventions in the treatment and prevention of covid-19?The first version on this living guidance focuses on corticosteroids. It contains a strong recommendation for systemic […]

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Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis.

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To determine the clinical manifestations, risk factors, and maternal and perinatal outcomes in pregnant and recently pregnant women with suspected or confirmed coronavirus disease 2019 (covid-19).Living systematic review and meta-analysis.Medline, […]

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Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study.

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To characterise the clinical features of children and young people admitted to hospital with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK and explore factors […]

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Risk of amputation with canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study.

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To estimate the rate of lower limb amputation among adults newly prescribed canagliflozin according to age and cardiovascular disease.Population based, new user, cohort study.Two commercial and Medicare claims databases, 2013-17.Patients […]

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Self-management interventions to reduce healthcare use and improve quality of life among patients with asthma: systematic review and network meta-analysis.

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To compare the different self-management models (multidisciplinary case management, regularly supported self-management, and minimally supported self-management) and self-monitoring models against usual care and education to determine which are most effective […]

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Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised clinical trial.

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To determine whether risk adapted intraoperative radiotherapy, delivered as a single dose during lumpectomy, can effectively replace postoperative whole breast external beam radiotherapy for early breast cancer.Prospective, open label, randomised […]

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Air pollution and family related determinants of asthma onset and persistent wheezing in children: nationwide case-control study.

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To identify risk factors (air pollution and family related) for the onset of asthma and persistent wheezing in children.Nationwide case-control study.Denmark.All Danish children born from 1997 to 2014 and followed […]

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Self-management interventions to reduce healthcare use and improve quality of life among patients with asthma: systematic review and network meta-analysis.

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To compare the different self-management models (multidisciplinary case management, regularly supported self-management, and minimally supported self-management) and self-monitoring models against usual care and education to determine which are most effective […]

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