Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial.

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To determine the efficacy and safety of dalteparin postoperative bridging treatment versus placebo for patients with atrial fibrillation or mechanical heart valves when warfarin is temporarily interrupted for a planned […]

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Hospital admission and mortality rates for non-covid diseases in Denmark during covid-19 pandemic: nationwide population based cohort study.

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To determine the incidence of hospital admissions and associated mortality rates for non-covid medical conditions during the covid-19 pandemic.Nationwide, population based cohort study.Denmark from 13 March 2019 to 27 January […]

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Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries.

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To estimate the direct and indirect effects of the covid-19 pandemic on mortality in 2020 in 29 high income countries with reliable and complete age and sex disaggregated mortality data.Time […]

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Risk of clinical sequelae after the acute phase of SARS-CoV-2 infection: retrospective cohort study.

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To evaluate the excess risk and relative hazards for developing incident clinical sequelae after the acute phase of SARS-CoV-2 infection in adults aged 18-65.Retrospective cohort study.Three merged data sources from […]

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Behavioral interventions to improve population health outreach for hepatitis C screening: randomized clinical trial.

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To evaluate whether opt out framing, messaging incorporating behavioral science concepts, or electronic communication increases the uptake of hepatitis C virus (HCV) screening in patients born between 1945 and 1965.Pragmatic […]

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Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study.

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To estimate the real world effectiveness of the Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1-S vaccines against confirmed covid-19 symptoms (including the UK variant of concern B.1.1.7), admissions to hospital, and deaths.Test […]

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Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study.

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To estimate the real world effectiveness of the Pfizer-BioNTech BNT162b2 and Oxford-AstraZeneca ChAdOx1-S vaccines against confirmed covid-19 symptoms (including the UK variant of concern B.1.1.7), admissions to hospital, and deaths.Test […]

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Public health impact of delaying second dose of BNT162b2 or mRNA-1273 covid-19 vaccine: simulation agent based modeling study.

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To estimate population health outcomes with delayed second dose versus standard schedule of SARS-CoV-2 mRNA vaccination.Simulation agent based modeling study.Simulated population based on real world US county.The simulation included 100 000 […]

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Public health impact of delaying second dose of BNT162b2 or mRNA-1273 covid-19 vaccine: simulation agent based modeling study.

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To estimate population health outcomes with delayed second dose versus standard schedule of SARS-CoV-2 mRNA vaccination.Simulation agent based modeling study.Simulated population based on real world US county.The simulation included 100 000 […]

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Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study.

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To investigate the use of repurposed and adjuvant drugs in patients admitted to hospital with covid-19 across three continents.Multinational network cohort study.Hospital electronic health records from the United States, Spain, […]

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Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study.

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To investigate the use of repurposed and adjuvant drugs in patients admitted to hospital with covid-19 across three continents.Multinational network cohort study.Hospital electronic health records from the United States, Spain, […]

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Primary trabeculectomy for advanced glaucoma: pragmatic multicentre randomised controlled trial (TAGS).

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To determine whether primary trabeculectomy or primary medical treatment produces better outcomes in term of quality of life, clinical effectiveness, and safety in patients presenting with advanced glaucoma.Pragmatic multicentre randomised […]

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Primary trabeculectomy for advanced glaucoma: pragmatic multicentre randomised controlled trial (TAGS).

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To determine whether primary trabeculectomy or primary medical treatment produces better outcomes in term of quality of life, clinical effectiveness, and safety in patients presenting with advanced glaucoma.Pragmatic multicentre randomised […]

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Treatment timing and the effects of rhythm control strategy in patients with atrial fibrillation: nationwide cohort study.

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To investigate whether the results of a rhythm control strategy differ according to the duration between diagnosis of atrial fibrillation and treatment initiation.Longitudinal observational cohort study.Population based cohort from the […]

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Accuracy of the Hospital Anxiety and Depression Scale Depression subscale (HADS-D) to screen for major depression: systematic review and individual participant data meta-analysis.

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To evaluate the accuracy of the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D) to screen for major depression among people with physical health problems.Systematic review and individual […]

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Suicide and self-harm in adult survivors of critical illness: population based cohort study.

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To analyse the association between survival from critical illness and suicide or self-harm after hospital discharge.Population based cohort study using linked and validated provincial databases.Ontario, Canada between January 2009 and […]

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Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study.

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To assess rates of cardiovascular and haemostatic events in the first 28 days after vaccination with the Oxford-AstraZeneca vaccine ChAdOx1-S in Denmark and Norway and to compare them with rates […]

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Closed incision negative pressure wound therapy versus standard dressings in obese women undergoing caesarean section: multicentre parallel group randomised controlled trial.

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To determine the effectiveness of closed incision negative pressure wound therapy (NPWT) compared with standard dressings in preventing surgical site infection (SSI) in obese women undergoing caesarean section.Multicentre, pragmatic, randomised, […]

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Risk of colorectal cancer in first degree relatives of patients with colorectal polyps: nationwide case-control study in Sweden.

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To assess the risk of colorectal cancer (CRC) in first degree relatives (parents and full siblings) of patients with precursor lesions (polyps) for CRC.Case-control study.Linkage to the multi-generation register and […]

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