Interleukin-6 blockade with sarilumab in severe COVID-19 pneumonia with systemic hyperinflammation: an open-label cohort study.

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To assess the safety and efficacy of interleukin (IL)-6 blockade with sarilumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation.We conducted an open-label study of sarilumab in severe COVID-19 […]

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Population characteristics as important contextual factors in rheumatological trials: an exploratory meta-epidemiological study from an OMERACT Working Group.

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To explore whether trial population characteristics modify treatment responses across various interventions, comparators and rheumatic conditions.In this meta-epidemiological study, we included trials from systematic reviews available from the Cochrane Musculoskeletal […]

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Quantitative analysis of pulmonary vasculature in systemic sclerosis at spirometry-gated chest CT.

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To prospectively investigate whether differences in pulmonary vasculature exist in systemic sclerosis (SSc) and how they are distributed in patients with different pulmonary function.Seventy-four patients with SSc undergoing chest CT […]

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Clinical course and outcome of COVID-19 in patients with rheumatic diseases: are all biological disease-modifying antirheumatic drugs alike? Response to: ‘Increased risk for severe COVID-19 in patients with inflammatory rheumatic diseases treated with rituximab’ by Schulze-Koops et al.

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Click here to read the full article @ Annals of the rheumatic diseases

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Effectiveness of secukinumab versus an alternative TNF inhibitor in patients with axial spondyloarthritis previously exposed to TNF inhibitors in the Swiss Clinical Quality Management cohort.

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To compare effectiveness of treatment with secukinumab (SEC) with that of alternative tumour necrosis factor inhibitors (TNFis) in patients with axial spondyloarthritis (axSpA) after withdrawal from one or more TNFis.Patients diagnosed […]

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Telemedicine holds many promises but needs to be developed to be accepted by patients as an alternative to a visit to the doctor. Response to: ‘Patient acceptance of using telemedicine for follow-up of lupus nephritis in the COVID-19 outbreak’ by So et al.

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Click here to read the full article @ Annals of the rheumatic diseases

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Actions required to assure continuous supply of anti-rheumatic medication during the SARS-CoV-2/COVID-19 pandemic. Response to: ‘Treatment adherence behaviours in rheumatic diseases during pandemic COVID-19: a Latin American experience’ by Pineda-Sic et al.

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Click here to read the full article @ Annals of the rheumatic diseases

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Allopurinol versus febuxostat hypersensitivity reactions in the US elderly: differences in study outcomes and populations. Response to: ‘Correspondence to “Hypersensitivity reactions with allopurinol and febuxostat: a study using the Medicare claims data’ by Ma et al.

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Click here to read the full article @ Annals of the rheumatic diseases

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Hypersensitivity reactions with allopurinol versus febuxostat in the US elderly. Response to: ‘Confunding by indication and ethnicity difference? Comment on ‘Hypersensitivity reactions with allopurinol and febuxostat: a study using the Medicare claims data” by Hsu et al.

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Click here to read the full article @ Annals of the rheumatic diseases

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Genome-wide whole blood transcriptome profiling in a large European cohort of systemic sclerosis patients.

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The analysis of annotated transcripts from genome-wide expression studies may help to understand the pathogenesis of complex diseases, such as systemic sclerosis (SSc). We performed a whole blood (WB) transcriptome […]

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Combination of human umbilical cord mesenchymal stem (stromal) cell transplantation with IFN-γ treatment synergistically improves the clinical outcomes of patients with rheumatoid arthritis.

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To clarify the key role of circulating interferon-γ (IFN-γ) and to improve the clinical efficacy of mesenchymal stem cell (MSC) transplantation (MSCT) in patients with rheumatoid arthritis (RA).Study of wild-type […]

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Response to: ‘COVID-19 in patients with rheumatological diseases treated with Anti-TNF’ by Brito et al and ‘Clinical characteristics and outcomes of patients with COVID-19 and rheumatic disease in China ‘hot pot’ versus in US ‘hot pot’: similarity and difference’ by Zhao et al.

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Click here to read the full article @ Annals of the rheumatic diseases

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Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study.

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Increasing data about COVID-19 have been acquired from the general population. We aim to further evaluate the clinical characteristics of COVID-19 in patients with systemic autoimmune diseases (AIDs).We included all […]

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Machine learning algorithms reveal unique gene expression profiles in muscle biopsies from patients with different types of myositis.

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Myositis is a heterogeneous family of diseases that includes dermatomyositis (DM), antisynthetase syndrome (AS), immune-mediated necrotising myopathy (IMNM), inclusion body myositis (IBM), polymyositis and overlap myositis. Additional subtypes of myositis […]

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Prevalence of hospital PCR-confirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases.

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The susceptibility of patients with rheumatic diseases and the risks or benefits of immunosuppressive therapies for COVID-19 are unknown.We performed a retrospective study with patients under follow-up in rheumatology departments […]

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Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production.

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Porphyromonas gingivalis (P.g.) is discussed to be involved in triggering self-reactive immune responses. The aim of this study was to investigate the autocitrullinated prokaryotic peptidylarginine deiminase (PPAD) from P.g. CH2007 […]

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Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort.

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Current data suggest that COVID-19 is less frequent in children, with a milder course. However, over the past weeks, an increase in the number of children presenting to hospitals in […]

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MRI of sacroiliac joints for the diagnosis of axial SpA: prevalence of inflammatory and structural lesions in nulliparous, early postpartum and late postpartum women.

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To determine the prevalence of bone marrow oedema (BME) at the sacroiliac joint (SIJ) in early postpartum (EPP), nulliparous (NP) and late postpartum (LPP) women, and to identify factors associated […]

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Outcomes and treatment responses, including work productivity, among people with axial spondyloarthritis living in urban and rural areas: a mixed-methods study within a national register.

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To examine differences in clinical and patient-reported outcomes, including work, in individuals with axial spondyloarthritis (axSpA) living in rural and urban settings.Using a sequential, explanatory mixed-method design, data from the […]

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