Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement.

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The purpose of this study is to develop consensus on key points that would support the use of systemic bevacizumab for the treatment of recurrent respiratory papillomatosis (RRP), and to provide preliminary guidance surrounding the use of this treatment modality.Delphi method-based survey series.A multidisciplinary, multi-institutional panel of physicians with experience using systemic bevacizumab for the treatment of RRP was established. The Delphi method was used to identify and obtain consensus on characteristics associated with systemic bevacizumab use across five domains: 1) patient characteristics; 2) disease characteristics; 3) treating center characteristics; 4) prior treatment characteristics; and 5) prior work-up.The international panel was composed of 70 experts from 12 countries, representing pediatric and adult otolaryngology, hematology/oncology, infectious diseases, pediatric surgery, family medicine, and epidemiology. A total of 189 items were identified, of which consensus was achieved on Patient Characteristics (9), Disease Characteristics (10), Treatment Center Characteristics (22), and Prior Workup Characteristics (18).This consensus statement provides a useful starting point for clinicians and centers hoping to offer systemic bevacizumab for RRP and may serve as a framework to assess the components of practices and centers currently using this therapy. We hope to provide a strategy to offer the treatment and also to provide a springboard for bevacizumab’s use in combination with other RRP treatment protocols. Standardized delivery systems may facilitate research efforts and provide dosing regimens to help shape best-practice applications of systemic bevacizumab for patients with early-onset or less-severe disease phenotypes.5. Laryngoscope, 2021.

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This is an abstract of the clinical research article “Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement.” This clinical research article was published in the medical journal The Laryngoscope on 2021-01-06 and has been categorised as belonging to the clinical specialty of ENT. To read the full clinical research article or obtain a PDF (if available) use the links directly above. To discover more of the latest ENT clinical research articles from the medical journal The Laryngoscope please click the link below. For more of the latest ENT research articles from other leading medical journals click the link that says ENT next to the stethoscope icon at the top of the page. You can further filter clinical research articles by sub-specialties within ENT using the navigation menu at the top of the page.