Sebaceous tumours: A prototypical class of skin tumour for universal germline genetic testing.

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Lynch syndrome (LS) is an adult-onset cancer predisposition caused by a germline pathogenic variant affecting one of four mismatch repair (MMR) genes (MLH1, MSH2, MSH6, or PMS2). The vast majority of LS gene carriers are unknown yet may benefit from risk-reducing interventions such as targeted cancer screening and aspirin chemoprevention, the latter being associated with a persistent and long-term reduction in colorectal cancer (CRC) incidence.

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Authors: R Gallon, N Kibbi, S Cook, M Santibanez-Koref, M S Jackson, J Burn, N Rajan