Report of a cluster of cases of toxic anterior-segment syndrome after implantation of a specific intraocular lens model.

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To report a cluster of cases of toxic anterior-segment syndrome (TASS) in eyes implanted with a specific foldable acrylic intraocular lens (IOL) model.Retrospective case series.The medical records were reviewed for seven eyes of four patients diagnosed with TASS after cataract surgery at Shimane University and Matsue Red Cross Hospital between July and November 2020.Among the 162 eyes implanted with the Lentis Comfort/LS-313 MF15 IOL, acute anterior chamber (AC) inflammation with fibrin formation developed 1 to 15 days after uneventful surgeries in seven (4.3%) eyes (cataract surgery alone, n=4 eyes; combined cataract and minimally invasive glaucoma surgery, n=3 eyes). Other than local steroid use, fibrin membrane removal, YAG laser membranotomy, pars plana vitrectomy, and AC washout were performed to treat inflammation and/or secondary angle closure due to pupillary obstruction.We experienced a cluster of TASS cases in eyes implanted with the Lentis Comfort/LS-313 MF15 IOL in a short period of time. To the best of our knowledge, this report is the first report of TASS associated with this IOL.

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Authors: Katsue Imamachi, Kazunobu Sugihara, Yoshifumi Ikeda, Yotaro Matsuoka, Masaki Tanito