Qualitative evaluation of the influence of Acute Oxaliplatin-Induced Peripheral Neuropathy on Quality of Life and Activities of Daily Life.

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Oxaliplatin often causes acute or chronic peripheral neuropathy in patients with an intestinal or pancreatic tumor, but in-depth insights in its influence on quality of life (QoL) are lacking. We explored the influence of acute Oxaliplatin Induced Peripheral Neuropathy (OIPN) on daily QoL in these patients.we performed semi-structured interviews with a purposive sample of patients with a receiving Oxaliplatin and possibly experiencing acute OIPN. Interviews were audio-recorded, transcribed verbatim and coded by two researchers. Data were analyzed by using the constant comparative method for content analysis, with ATLAS.ti software.after 9 patients saturation took place. In total, 11 patients were interviewed. Four themes were extracted from the data: 1) adverse effects 2) physical (un)well-being, 3) emotional aspects, 4) treatment aspects. All participants were suffering from acute OIPN to a certain extent, leading to restrictions in daily activities like household chores, but also to a decrease in mobility and independency. Other adverse effects, like general malaise and gastro-intestinal side effects also influenced the participants’ well-being, as did the diagnosis and prognosis of their disease.acute OIPN, together with other side effects of chemotherapeutic treatment and the difficulties that come with the diagnosis of cancer and its prognosis, largely influences the patients’ daily QoL. Managing expectations (by patient education) seems important.

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