Pulmonary Arterial Pruning and Longitudinal Change in Percent Emphysema and Lung Function: the COPDGene Study.

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Pulmonary endothelial damage has been shown to preceed the development of emphysema in animals, and vascular changes in humans have been observed in COPD and emphysema.Is intraparenchymal vascular pruning associated with longitudinal progression of emphysema on CT or decline in lung function over 5 years?The COPDGene Study enrolled ever-smokers with and without COPD in 2008-2011. The percent of emphysema-like lung was assessed at baseline and after 5 years on non-contrast CT as the percentage of lung voxels

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Authors: C L Pistenmaa, P Nardelli, S Y Ash, C E Come, A A Diaz, F N Rahaghi, R G Barr, K A Young, G L Kinney, J P Simmons, R C Wade, J M Wells, J E Hokanson, G R Washko, Estépar R San José, COPDGene Investigators