Pityriasis lichenoides: a clinical and pathological case series of 49 patients with an emphasis on follow-up.

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The classification of pityriasis lichenoides (PL) into pityriasis lichenoides et varioliformis acuta (PLEVA), PL chronica (PLC) or febrile ulceronecrotic Mucha-Habermann disease (FUMHD) mixes clinical and chronological features. In this retrospective monocentric study, we aimed to investigate the relevance of the classification in routine practice. We included 49 patients (25 women, median age 41 years). The lesions were papular in 76% of patients, necrotic in 12%, and mixed in 12%. We found three histological patterns: “classical” (65%), “lymphomatoid” (13%), and “mild” (22%). The “lymphomatoid” pattern was associated with necrotic presentation and the “mild’ pattern with papular lesions (p=0.012). Among the 27 patients with follow-up, 18% had relapses and 44% a chronic form. One patient had mycosis fungoides. Neither clinical nor histological aspects were correlated with disease progression. Clinical and histological pictures reflect more the intensity of epidermal injury rather than disease course. “Pityriasis lichenoides” should be preferred to the classical PLEVA/PLC classification.

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Authors: J Lupu, O Chosidow, P Wolkenstein, C Bergqvist, N Ortonne, S Ingen-Housz-Oro