Paraneoplastic vs. non-paraneoplastic anti-Hu associated dysmotility: a case series and literature review.

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This work aimed to report the demographic and clinical characteristics of two new cases with non-paraneoplastic anti-Hu-associated gut motility impairment, and perform a thorough revision covering anti-Hu-associated paraneoplastic (PGID) and non-paraneoplastic (nPGID) gastrointestinal dysmotility.Several case series have clearly established a relationship between certain type of cancers, the development of circulating anti-Hu antibodies, and the concomitant usually severe gastrointestinal dysmotility; in contrast, a few studies focused on anti-Hu-associated nPGID.We searched for studies regarding anti-Hu-associated gastrointestinal manifestations and extracted data concerning clinical characteristics of patients, including specific demographic, oncological, neurological, gastrointestinal, histological, and treatment response features.Forty-nine articles with a total of 59 cases of anti-Hu-associated gastrointestinal dysmotility were analyzed. The patients’ age at symptom onset significantly differed between PGID and nPGID (median 61 vs 31 years, p 

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Authors: Simone Rossi, Elena Merli, Rita Rinaldi, Gaia Deleonardi, Vincenzo Mastrangelo, Anna Simona Sasdelli, Alessandro Di Federico, Maria Guarino, Vincenzo Donadio, Loris Pironi, Francesco Gelsomino, Roberto De Giorgio, Roberto D’Angelo