Paediatric Endocrinology

Keep up to date with the latest in paediatric endocrinology. Check out the latest articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily.

• Multicenter Trial of a Tubeless, On-Body Automated Insulin Delivery System With Customizable Glycemic Targets in Pediatric and Adult Participants With Type 1 Diabetes.8th June 2021
  Advances in diabetes technology have transformed the treatment paradigm for type 1 diabetes, yet the burden of disease is significant. We report on a pivotal safety study of the first tubeless, on-body automated insulin delivery system with customizable glycemic targets.This single-arm, multicenter, prospective study enrolled 112 children (age 6-13.9 years) and 129 adults (age 14-70 […]
• Prediction of type 1 diabetes at birth: cord blood metabolites versus genetic risk score in the MoBa cohort.4th June 2021
  Genetic markers are established as predictive of type 1 diabetes, but unknown early life environment is believed to be involved. Umbilical cord blood may reflect perinatal metabolism and exposures. We studied whether selected polar metabolites in cord blood contribute to prediction of type 1 diabetes.Using a targeted UHPLC-QQQ-MS platform, we quantified 27 low molecular weight […]
• Maternal Mid-pregnancy Leptin and Adiponectin Levels as Predictors of Autism Spectrum Disorder: A Prenatal Cohort Study.29th May 2021
  Autism spectrum disorders (ASD) are a group of conditions characterized by impaired social function and repetitive behaviors. Their etiology is largely unknown.To examine the associations of maternal 2 nd trimester and cord blood leptin and adiponectin levels with ASD in offspring.We used data from 1164 mother-child pairs enrolled in Project Viva, a prospective pre-birth cohort. […]
• Society for Endocrinology UK Guidance On The Initial Evaluation Of A Suspected Difference or Disorder Of Sex Development (DSD) (Revised 2021).25th May 2021
  It is paramount that any child or adolescent with a suspected difference or disorder of sex development (DSD) is assessed by an experienced clinician with adequate knowledge about the range of conditions associated with DSD and is discussed with the regional DSD service. In most cases, the paediatric endocrinologist within this service acts as the […]
• Reproductive hormone concentrations and associated anatomical responses: does soy formula affect minipuberty in boys?20th May 2021
  Soy formula feeding is common in infancy and is a source of high exposure to phytoestrogens, documented to influence vaginal cytology in female infants. Its influence on minipuberty in males has not been established.To assess the association between infant feeding practice and longitudinally measured reproductive hormones and hormone-responsive tissues in infant boys.The Infant Feeding and […]
• Prevalence of thyroid dysfunction in postpartum women with suboptimal iodine and selenium and adequate iron status.19th May 2021
  Postpartum women experience thyroid dysfunction at twice the prevalence of the general population. Adequate biosynthesis of thyroid hormones depends on three trace elements: iodine, selenium and iron. This study aimed to investigate thyroid dysfunction within a cohort of women at six months postpartum in relation to iodine, selenium and iron status.This cross-sectional study was part […]
• Additional Insulin is Required in Both the Early and Late Postprandial Periods for Meals High in Protein and Fat: A Randomised Trial.6th May 2021
  The pattern and quantity of insulin required for high protein high fat (HPHF) meals is not well understood.This study aimed to determine the amount and delivery pattern of insulin required to maintain euglycaemia for five hours after consuming a HPHF meal compared to a low protein low fat (LPLF) meal.Randomised cross-over clinical trial.Two Australian paediatric […]
• Randomised controlled trial evaluating the use of Zoledronic acid in Duchenne Muscular Dystrophy.6th May 2021
  Patients with glucocorticoid dependent Duchenne Muscular Dystrophy (DMD) have increased fracture risk and reduced bone mineral density (BMD), often precipitating mobility loss.To investigate use of Zoledronic acid (ZA) in DMD in improving BMD.Two arm, parallel, randomised controlled trial.Paediatric hospitals across Australia and New Zealand.Sixty-two (31 per arm) boys with glucocorticoid dependent DMD between 6-16 years.Five […]
• Acute hyperglycaemia does not have a consistent adverse effect on exercise performance in recreationally active young people with type 1 diabetes: a randomised crossover in-clinic study.4th May 2021
  In individuals with type 1 diabetes, chronic hyperglycaemia impairs aerobic fitness. However, the effect of acute marked hyperglycaemia on aerobic fitness is unclear, and the impact of insulin level has not been examined. In this study, we explored if acute hyperglycaemia with higher or low insulin levels affects [Formula: see text] and other exercise performance […]
• National Trends in Pediatric Admissions for Diabetic Ketoacidosis, 2006-2016.4th May 2021
  Diabetic ketoacidosis (DKA) rates in the US are rising. Prior studies suggest higher rates in younger populations, but no studies have evaluated national trends in pediatric populations and differences by subgroups. As such, we sought to examine national trends in pediatric DKA.We used the 2006, 2009, 2012, and 2016 Kids’ Inpatient Database (KID) to identify […]
• A community-based, multi-level, multi-setting, multi-component intervention to reduce weight gain among low socioeconomic status Latinx children with overweight or obesity: The Stanford GOALS randomised controlled trial.2nd May 2021
  There are few long-term studies of interventions to reduce in low socioeconomic status children with overweight or obesity. The Stanford GOALS trial evaluated a 3-year, community-based, multi-level, multi-setting, multi-component (MMM) systems intervention, to reduce weight gain among low socioeconomic status, Latinx children with overweight or obesity.We did a two-arm, parallel group, randomised, open-label, active placebo-controlled […]
• Free thyroxine in early pregnancy is an independent negative predictor of 3rd trimester HbA1c. Odense Child Cohort.30th April 2021
  Lower thyroid function outside pregnancy is associated with increased risk of type 2 diabetes mellitus. The relationship between thyroid function in early pregnancy and glucose status in 3rd trimester has not been investigated.To study the association between 1st trimester thyroid function and 3rd trimester glucose status.In the prospective study Odense Child Cohort (OCC), 1,041 women […]
• Prognostic value of lymph node ratio in children and adolescents with papillary thyroid cancer.29th April 2021
  Neck lymph node (LN) metastasis is a common feature of pediatric papillary thyroid cancer, and LN ratio (LNR) is defined as the ratio of the number of positive LNs excised to the total number of removed. Unlike in adults, few data are available regarding the clinical implication of LNR in the pediatric population. Our purpose […]
• Spike in Diabetic Ketoacidosis Rates in Pediatric Type 2 Diabetes During the COVID-19 Pandemic.27th April 2021
  The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) on the incidence of new-onset type 2 diabetes and diabetic ketoacidosis (DKA) is unclear. It is unknown whether the coincidence of DKA noted in adult patients with type 2 diabetes is an issue for youth during the coronavirus disease 2019 pandemic.A retrospective single-center medical record […]
• Aversion to Off-Label Prescribing in Clinical Pediatric Weight Management: The Quintessential Double Standard.26th April 2021
  Pediatric obesity is now recognized as a chronic disease; yet few treatment options exist besides lifestyle modification therapy and bariatric surgery. We describe the limited availability of FDA-approved anti-obesity medications for adolescents and compare this to what is available for adults. We offer a rationale for off-label prescribing to assist with lifestyle modification therapy. We […]
• Thyroid nodules in childhood-onset Hashimoto’s thyroiditis: Frequency, risk factors, follow-up course, and genetic alterations of thyroid cancer.24th April 2021
  We evaluated the frequency, risk factors, and the follow-up outcomes of thyroid nodules, and genetic alterations in thyroid cancer, in youth with childhood-onset Hashimoto thyroiditis (HT) residing in an iodine-sufficient country.A retrospective cohort study.A total of 213 patients (194 females, mean age 10.6 years at the time of HT diagnosis) were ultrasonographically evaluated. Thyroid nodules […]
• Timing of Pubertal Onset in Girls and Boys with Constitutional Delay.23rd April 2021
  The decision whether to treat a child with delayed puberty with sex steroids is primarily based on patient, family, and provider preference. Knowing when children with constitutional delay eventually enter puberty would inform this decision.To estimate and compare rates of pubertal entry, we conducted a retrospective cohort study by reviewing medical records of children evaluated […]
• Eligibility for growth hormone therapy in children born small for gestational age is substantially lower than expected.22nd April 2021
  Growth hormone therapy is indicated for children who are both born “small-for-gestational-age” (SGA) and do not achieve adequate catch-up growth (ACUG).To evaluate the actual incidence of infants born SGA and their actual ACUG.Birth weights data from the newborn registry at two hospitals were analyzed during four consecutive years. SGA was defined according to WHO parameters […]
• Sequencing cell-free fetal DNA in pregnant women with GCK-MODY: a proof-of-concept study.20th April 2021
  Persons with monogenic diabetes due to inactivating glucokinase (GCK) variants typically do not require treatment, except potentially during pregnancy. In pregnancy, fetal GCK genotype determines whether treatment is indicated, but non-invasive methods are not clinically available.To develop a method to determine fetal GCK genotype non-invasively using maternal cell-free fetal DNA.This was a proof-of-concept study which […]
• The Rapid Transition to Telemedicine and Its Effect on Access to Care for Patients With Type 1 Diabetes During the COVID-19 Pandemic.14th April 2021
  We compared the uptake of telemedicine for diabetes care across multiple demographic groups during the coronavirus disease 2019 pandemic to understand the impact of telemedicine adoption on access to care.The study analyzed demographic information of patients with type 1 diabetes seen between 1 January 2018 and 30 June 2020 at a single center. We compared […]
• Can placental growth factors explain birthweight variation in offspring of women with type 1 diabetes?11th April 2021
  Maternal hyperglycaemia alone does not explain the incidence of large offspring amongst women with type 1 diabetes. The objective of the study was to determine if there is an association between placental function, as measured by angiogenic factors, and offspring birthweight z score in women with type 1 diabetes.This cohort study included samples from 157 […]
• Associations Between Exposure to Gestational Diabetes Mellitus In Utero and Daily Energy Intake, Brain Responses to Food Cues, and Adiposity in Children.9th April 2021
  Children exposed to gestational diabetes mellitus (GDM) or maternal obesity in utero have an increased propensity to develop obesity. Little is known about the mechanisms underlying this phenomenon. We aimed to examine relationships between exposure to GDM or maternal obesity and daily energy intake (EI), brain responses to food cues within reward regions, and adiposity […]
• Clinical and hormonal profiles correlate with molecular characteristics in patients with 11β-hydroxylase deficiency.8th April 2021
  Given the rarity of 11β-hydroxylase deficiency (11βOHD), there is a paucity of data about the differences in clinical and biochemical characteristics of classic (C-11βOHD) and non-classic 11βOHD (NC-11βOHD).To characterize a multicenter pediatric cohort with 11βOHD.The clinical and biochemical characteristics were retrospectively retrieved. CYP11B1 gene sequencing was performed. Seventeen plasma steroids were quantified by liquid chromatography-mass […]
• A polygenic risk score to predict future adult short stature amongst children.31st March 2021
  Adult height is highly heritable, yet no genetic predictor has demonstrated clinical utility compared to mid-parental height.To develop a polygenic risk score for adult height and evaluate its clinical utility.A polygenic risk score was constructed based on meta-analysis of genome-wide association studies and evaluated on the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort.Participants […]
• Health-related quality of life in patients with early-detected central congenital hypothyroidism.29th March 2021
  Central congenital hypothyroidism (CH) requires lifelong medical treatment. The majority of children with central CH have multiple pituitary hormone deficiencies (MPHD), but in some cases central CH is isolated. Most pituitary hormone deficiencies are associated with impaired health-related quality of life (HRQoL). However, studies on HRQoL in central CH are lacking.to evaluate HRQoL and fatigue […]
• Predictors of Bilateral Disease in Pediatric Differentiated Thyroid Cancer.29th March 2021
  Total thyroidectomy is recommended for children with papillary thyroid carcinoma, partly because of a high prevalence of bilateral disease. Identifying characteristics that predict bilateral disease might identify candidates for more limited surgery.Investigate associations of preoperative or histopathological characteristics with bilateral disease in children with differentiated thyroid cancer.Retrospective cohort study (1998-2020).Two academic hospitals.Patients <19 years who […]
• Radioactive Iodine Treatment for Children and Young Adults with Thyroid Cancer in South Korea: A Population-Based Study.23rd March 2021
  This study investigated radioactive iodine treatment (RAIT) patterns and the secondary cancer incidence among child and young adult patients receiving RAIT after thyroidectomy for thyroid cancer.This population-based cohort study used the Health Insurance Review and Assessment database of South Korea to identify a total of 18,617 child and young adult patients (0-29 years) who underwent […]
• Genetic and clinical aspects of paediatric pheochromocytomas and paragangliomas.21st March 2021
  Few and conflicting reports have characterized the genetics of paediatric pheochromocytomas and paragangliomas (PPGL). This study aimed to investigate the clinical and genetic features of Brazilian children with PPGL.This study included 25 children (52% girls) with PPGL. The median age at diagnosis was 15 years (4-19). The median time of follow-up was 145 months. The genetic investigation […]
• Comprehensive identification of pathogenic gene variants in patients with neuroendocrine disorders.17th March 2021
  Congenital hypopituitarism (CH) can present in isolation or with other birth defects. Mutations in multiple genes can cause CH, and the use of a genetic screening panel could establish the prevalence of mutations in known and candidate genes for this disorder. It could also increase the proportion of patients that receive a genetic diagnosis.We conducted […]
• Two-year treatment with metformin during puberty does not preserve β-cell function in youth with obesity.17th March 2021
  Youth-onset type 2 diabetes is a disease of pubertal onset, associated with additional burden of pubertal insulin resistance on the β-cell.Evaluate the impact of metformin treatment during puberty, a critical window of cardiometabolic change, on insulin sensitivity (Si) and compensatory β-cell response in youth with obesity.Pediatric academic hospital clinical translational research center.Healthy youth in early […]
• Prenatal exposure to butyl paraben is associated with fat percentage in 7-year old boys.15th March 2021
  Parabens are used as preservatives in consumer products but are suspected of having endocrine-disrupting properties. A recent study reported an association between in utero exposure to butyl paraben and overweight in childhood, with a stronger trend in girls.We therefore studied the association between parabens in maternal urine in third trimester and fat percentage in children […]
• A Pragmatic, Randomized Clinical Trial of Gestational Diabetes Screening.11th March 2021
  Gestational diabetes mellitus is common and is associated with an increased risk of adverse maternal and perinatal outcomes. Although experts recommend universal screening for gestational diabetes, consensus is lacking about which of two recommended screening approaches should be used.We performed a pragmatic, randomized trial comparing one-step screening (i.e., a glucose-tolerance test in which the blood […]
• Recombinant Human Thyroid-Stimulating Hormone Versus Thyroid Hormone Withdrawal Preparation for Radioiodine Ablation in Differentiated Thyroid Cancer in Children, Adolescents, and Young Adults.11th March 2021
  Recombinant human TSH (rhTSH) is commonly used to prepare patients for postoperative radioiodine (I-131) ablation after surgery for differentiated thyroid cancer (DTC). In adults, rhTSH is associated with equivalent oncologic efficacy in comparison to thyroid hormone withdrawal (THW), but its use has not been well-studied in children. We aimed to measure time to disease progression […]
• Glycemic Outcome Associated With Insulin Pump and Glucose Sensor Use in Children and Adolescents With Type 1 Diabetes. Data From the International Pediatric Registry SWEET.3rd March 2021
  Insulin delivery methods, glucose-monitoring modalities, and related outcomes were examined in a large, international, diverse cohort of children and adolescents with type 1 diabetes from the Better Control in Pediatric and Adolescent Diabetes: Working to Create Centers of Reference (SWEET) -Registry.Participants with type 1 diabetes of ≥1 year, aged ≤18 years, and who had documented […]
• Cushing syndrome in a pediatric patient with a KCNJ5 variant and successful treatment with low dose ketoconazole.25th February 2021
  Pathogenic variants in KCNJ5, encoding the GIRK4 (Kir3.4) potassium channel, have been implicated in the pahogenesis of familial hyperaldosteronism (FH) type-III (FH-III) and sporadic primary hyperaldosteronism (PA). In addition to aldosterone, glucocorticoids (GCs) are often found in PA in association with KCNJ5 pathogenic variants, albeit at subclinical levels. However, to date no GIRK4 defects have […]
• Newborn Adiposity and Cord Blood C-Peptide as Mediators of the Maternal Metabolic Environment and Childhood Adiposity.23rd February 2021
  Excessive childhood adiposity is a risk factor for adverse metabolic health. The objective was to investigate associations of newborn body composition and cord C-peptide with childhood anthropometrics and explore whether these newborn measures mediate associations of maternal midpregnancy glucose and BMI with childhood adiposity.Data on mother/offspring pairs (N = 4,832) from the epidemiological Hyperglycemia and […]
• Fat mass accretion from birth to 5 years and metabolic homeostasis in childhood: The Healthy Start Study.22nd February 2021
  It is unclear how fat mass accretion in early life is related to glucose-insulin homeostasis.Examine associations of fat and fat-free mass accretion from birth to early childhood with glucose-insulin homeostasis in early childhood in a multi-ethnic cohort.Observational Healthy Start study with data collection from 2010-2020. Air displacement plethysmography at birth and 4.8 (SD 0.7) years […]
• A high proportion of novel ACAN mutations and their prevalence in a large cohort of Chinese short stature children.19th February 2021
  Aggrecan, encoded by ACAN gene, is the main proteoglycan component in the extracellular cartilage matrix. Heterozygous mutations in ACAN have been reported to cause idiopathic short stature. However, the prevalence of ACAN pathogenic variants in Chinese short stature patients and clinical phenotypes remain to be evaluated.We sought to determine the prevalence of ACAN pathogenic variants […]
• The association of passive smoking and dyslipidemia among adolescence in Japan: Results from A-CHILD Study.17th February 2021
  Passive smoking in childhood has been reported to be associated with dyslipidemia in Western countries. However, this association in Asian countries remains unclear. Further, no study has investigated the sex difference of the association. This study aimed to elucidate the association between passive smoking and dyslipidemia in boys and girls during adolescence in Japan.We used […]
• Long-term safety of growth hormone treatment in childhood: Two large observational studies NordiNet ® IOS and ANSWER.11th February 2021
  GH treatment has a generally good safety profile; however, concerns of increased mortality risk in adulthood have been raised.Assessing the long-term safety of GH treatment in clinical practice.Two multicenter longitudinal observational studies: NordiNet® International Outcome Study (2006-2016, Europe) and ANSWER Program (2002-2016, USA).Data collected from 676 clinics.Pediatric patients treated with GH, classified into three risk […]
• Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children.1st February 2021
  Multisystem inflammatory syndrome in children (MIS-C) is the most severe pediatric disease associated with severe acute respiratory syndrome coronavirus 2 infection, potentially life-threatening, but the optimal therapeutic strategy remains unknown.To compare intravenous immunoglobulins (IVIG) plus methylprednisolone vs IVIG alone as initial therapy in MIS-C.Retrospective cohort study drawn from a national surveillance system with propensity score-matched […]
• Skeletal Disproportion in Girls with Turner Syndrome and Longitudinal Change with Growth Promoting Therapy.7th January 2021
  Short stature in Turner Syndrome (TS) may be accompanied by skeletal disproportion. This retrospective study investigates growth and disproportion from early childhood to adult height.Data were collected from 59 girls prior to growth hormone (rhGH) treatment and in 30 girls followed-up longitudinally. Standard deviation scores (SDS) for height (Ht), sitting height (SH) and sub-ischial leg […]
• Serum Galectin-3 and Subsequent Risk of Coronary Heart Disease in Subjects With Childhood-Onset Type 1 Diabetes: A Cohort Study.7th January 2021
  To study whether serum galectin-3 and other biomarkers of inflammation predict coronary heart disease (CHD) in subjects with long-standing childhood-onset type 1 diabetes.A population-based nationwide cohort of 299 subjects with type 1 diabetes diagnosed in Norway at <15 years of age during 1973-1982. They were examined in 2002-2003 at a mean age of 33 years […]
• First-appearing islet autoantibodies for type 1 diabetes in young children: maternal life events during pregnancy and the child’s genetic risk.6th January 2021
  Psychological stress has long been considered a possible trigger of type 1 diabetes, although prospective studies examining the link between psychological stress or life events during pregnancy and the child’s type 1 diabetes risk are rare. The objective of this study was to examine the association between life events during pregnancy and first-appearing islet autoantibodies […]
• Long-term efficacy and safety of gonadotropin-releasing hormone analog treatment in children with idiopathic central precocious puberty: a systematic review and meta-analysis.2nd January 2021
  To investigate the long-term efficacy and safety of gonadotropin-releasing hormone analog (GnRHa) treatment in children with idiopathic central precocious puberty (CPP) METHOD: The protocol was registered with International Prospective Register of Systematic Reviews (CRD42018102792). PubMed, EMBASE, and the Cochrane Library were searched for eligible comparative and single-arm studies.We identified a total of 98 studies that […]
• Congenital Glucagon-like peptide-1 deficiency in the pathogenesis of protracted diarrhea in Mitchell Riley syndrome.31st December 2020
  Mitchell Riley syndrome (MRS) due to RFX6 gene mutations is characterized by neonatal diabetes and protracted diarrhea. RFX6 gene encodes a transcription factor involved in enteroendocrine cell differentiation required for beta-cell maturation. In contrast to the pathway by which RFX6 mutations leads to diabetes, the mechanisms underlying protracted diarrhea are unknown.To assess whether glucagon-like peptide-1 […]
• Distant metastases from childhood differentiated thyroid carcinoma: clinical course and mutational landscape.31st December 2020
  Distant metastases (DM) from childhood differentiated thyroid carcinoma (DTC) are uncommon and published studies are limited.To describe the outcomes of patients with DM from childhood DTC and to evaluate the molecular landscape of these tumors.Retrospective study at a tertiary cancer center including patients with pediatric DTC (diagnosed at age ≤18 years from 1946-2019) and DM.We […]
• Approach to the virilizing girl at puberty.28th December 2020
  Virilization is the medical term for describing a female who develops characteristics associated with male hormones (androgens) at any age, or when a newborn girl shows signs of prenatal male hormone exposure at birth. In girls, androgen levels are low during pregnancy and childhood. A first physiologic rise of adrenal androgens is observed at the […]
• Multiple Endocrine Tumors Associated with Germline MAX Mutations: Multiple Endocrine Neoplasia Type 5?28th December 2020
  Pathogenic germline MAX variants are associated with pheochromocytoma and paraganglioma (PPGL), pituitary neuroendocrine tumors and, possibly, other endocrine and non-endocrine tumors.To report two families with germline MAX variants, pheochromocytomas (PC) and multiple other tumors.Clinical, genetic, immunohistochemical, and functional studies.University Hospitals in Australia.Two families with germline MAX variants.Usual clinical care.Phenotyping; germline and tumor sequencing; immunohistochemistry of […]
• Extended Use of the Control-IQ Closed-Loop Control System in Children With Type 1 Diabetes.23rd December 2020
  To further evaluate the safety and efficacy of the Control-IQ closed-loop control (CLC) system in children with type 1 diabetes.After a 16-week randomized clinical trial (RCT) comparing CLC with sensor-augmented pump (SAP) therapy in 101 children age 6-13 years old with type 1 diabetes, 22 participants in the SAP group initiated use of the CLC […]
• Testing, Monitoring, and Treatment of Thyroid Dysfunction in Pregnancy.22nd December 2020
  Both hyperthyroidism and hypothyroidism can have adverse effects in pregnancy. The most common causes of thyrotoxicosis in pregnancy are gestational transient thyrotoxicosis and Graves’ disease. It is important to distinguish between these entities as treatment options differ. Women of reproductive age diagnosed with Graves’ disease should be counseled regarding the impact of treatment options on […]
• Natural History of Thyroid Disease in Children with PTEN Hamartoma Tumor Syndrome.21st December 2020
  Thyroid ultrasound screening is recommended in children with PTEN hamartoma tumor syndrome (PHTS) due to increased risk of thyroid neoplasia, but the natural history of thyroid disease in children with PHTS is unclear.Determine the prevalence and natural history of thyroid disease in children with PHTS.Retrospective cohort study (1998-2019).Academic pediatric hospital.Individuals with genetically confirmed PHTS diagnosed […]
• Assessment of medication adherence in children and adults with congenital adrenal hyperplasia and the impact of knowledge and self-management.21st December 2020
  Congenital adrenal hyperplasia (CAH) is caused by a deficiency of one of the enzymes required for cortisol biosynthesis. The disease is classified as either classic (severe phenotype), subdivided into simple-virilizing (SV) and salt-wasting (SW), or non-classic (NC) CAH. The treatment regime involves life-long glucocorticoid replacement, especially in classic phenotype.We aimed to assess medication adherence, endocrine […]
• Syndromic Forms of Hyperinsulinaemic Hypoglycaemia A 15-year follow-up Study.21st December 2020
  Hyperinsulinaemic hypoglycaemia (HH) is one of the commonest causes of hypoglycaemia in children. The molecular basis includes defects in pathways that regulate insulin release. Syndromic conditions like Beckwith-Wiedemann (BWS), Kabuki (KS) and Turner (TS) are known to be associated with a higher risk for HH. This systematic review of children with HH referred to a […]
• The Effects of Vitamin D Supplementation During Infancy on Growth During the First Two Years of Life.21st December 2020
  The relationship between maternal and infant vitamin D and early childhood growth remains inadequately understood.To investigate how maternal and child 25-hydroxyvitamin D [25(OH)D] and vitamin D supplementation impact growth during the first 2 years of life.A randomized, double-blinded intervention study.A single-center study from pregnancy until offspring age 2 years.Altogether 812 term-born children with complete data, […]
• A Randomized Clinical Trial Assessing Continuous Glucose Monitoring (CGM) Use With Standardized Education With or Without a Family Behavioral Intervention Compared With Finger-stick Blood Glucose Monitoring in Very Young Children With Type 1 Diabetes.18th December 2020
  This study evaluated the effects of continuous glucose monitoring (CGM) combined with family behavioral intervention (CGM+FBI) and CGM alone (Standard-CGM) on glycemic outcomes and parental quality of life compared with blood glucose monitoring (BGM) in children ages 2 to <8 years with type 1 diabetes.This was a multicenter (N = 14), 6-month, randomized controlled trial […]
• A Randomized Clinical Trial Assessing Continuous Glucose Monitoring (CGM) Use With Standardized Education With or Without a Family Behavioral Intervention Compared With Finger-stick Blood Glucose Monitoring in Very Young Children With Type 1 Diabetes.18th December 2020
  This study evaluated the effects of continuous glucose monitoring (CGM) combined with family behavioral intervention (CGM+FBI) and CGM alone (Standard-CGM) on glycemic outcomes and parental quality of life compared with blood glucose monitoring (BGM) in children ages 2 to <8 years with type 1 diabetes.This was a multicenter (N = 14), 6-month, randomized controlled trial […]
• Family history of type 2 diabetes and characteristics of children with newly diagnosed type 1 diabetes.17th December 2020
  Shared aetiopathogenetic factors have been proposed in type 1 diabetes and type 2 diabetes and both diseases have been shown to cluster in families. Characteristics related to type 2 diabetes have been described in patients with type 1 diabetes with a positive family history of type 2 diabetes. We wanted to characterise the family history […]
• Optimal Monitoring of Weekly IGF-I Levels During Growth Hormone Therapy With Once-Weekly Somapacitan.14th December 2020
  Somapacitan is a long-acting growth hormone (GH) in development for once-weekly treatment of GH deficiency (GHD). Optimal monitoring of insulin-like growth factor-I (IGF-I) levels must account for weekly IGF-I fluctuations following somapacitan administration.To develop and assess the reliability of linear models for predicting mean and peak IGF-I levels from samples taken on different days after […]
• Parent and Pediatrician Preferences for Type 1 Diabetes Screening in the U.S.11th December 2020
  The purpose of this study was to use a discrete-choice experiment methodology to understand the relative importance of the attributes of screening tests for type 1 diabetes among parents and pediatricians in the U.S.Online surveys presented hypothetical screening test profiles from which respondents chose their preferred test profile. Survey attributes were based on likely screening […]