Mild COVID-19 infection-predicting symptomatic phase and outcome: A study from AIIMS, New Delhi.
Comprehensive management of mild COVID infection calls for better understanding of symptomatology in these group of patients as well as early identification and close monitoring of patients at risk, data on which is limited.To study association between inflammatory markers and clinical presentation with progression of disease and the duration of resolution of symptoms.This is a retrospective study that has been conducted at a designated COVID -19 medical ward at AIIMS, New Delhi.Fifty healthcare workers and their dependents who were admitted with asymptomatic and mild COVID-19 infection were included. Their records were retrospectively reviewed, entered into a predesigned proforma and analyzed.A total of 50 participants were included in the study of which 70% were healthcare workers. The patients were admitted with mild COVID illness out of which 22 (44%) were males. Most common symptom at presentation was fever (72%). Among patients who had mild disease versus those who progressed to moderate illness (n = 3), the patients with moderate illness were older [mean (SD): 57.33 (10.21) vs. 36.13 (14.05); P = 0.014] and had a longer duration of hospital stay [17 (1.41) days vs. 11.20 (3.86) days; P = 0.04]. Inflammatory markers, C-Reactive Protein (CRP) [2.46 vs. 0.20 (P = 0.024)], and Ferritin [306.15 vs. 72.53 (P = 0.023)] were higher in patients with moderate illness. There is also a significant correlation between the number of days taken for symptoms to resolve with Serum Ferritin (P = 0.007), CRP (P = 0.0256), and neutrophil lymphocyte ratio (NLR) (P = 0.044).Acute phase reactants/Inflammatory markers serve as good indicators of time taken to resolution of symptoms in acute COVID infection. NLR is a simple and inexpensive method to provide insight into symptomatic phase. These may be utility tools for primary care physician in the management in periphery and timely decision.
This is an abstract of the clinical research article “Mild COVID-19 infection-predicting symptomatic phase and outcome: A study from AIIMS, New Delhi.” This clinical research article was published in the medical journal Journal of family medicine and primary care on 2021-01-07 and has been categorised as belonging to the clinical specialty of Coronavirus. To read the full clinical research article or obtain a PDF (if available) use the links directly above. To discover more of the latest Coronavirus clinical research articles from the medical journal Journal of family medicine and primary care please click the link below. For more of the latest Coronavirus research articles from other leading medical journals click the link that says Coronavirus next to the stethoscope icon at the top of the page. You can further filter clinical research articles by sub-specialties within Coronavirus using the navigation menu at the top of the page.