The Latest Metabolic Disorders Journal Articles

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Keep up to date with the latest research in metabolic disorders. Check out the latest metabolic disorders articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily.

  • Intact & C-terminal FGF-23 Assays- Do Kidney Function, Inflammation, & Iron Status Influence Relationships with Outcomes?
    Higher fibroblast growth factor-23 (FGF23) concentrations are associated with heart failure and mortality in diverse populations, but the strengths of associations differ markedly depending upon which assay is used.We sought to evaluate whether iron deficiency, inflammation, and kidney function account for differences in the strengths of associations between these two FGF23 assays with clinical outcomes.Case-cohort […]
  • Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline.
    This guideline will provide the practicing endocrinologist with an approach to assessment and treatment of dyslipidemia in patients with endocrine diseases, with the objective of prevention of cardiovascular events and triglyceride-induced pancreatitis. The guideline reviews data on dyslipidemia and ASCVD risk in patients with endocrine disorders and discusses the evidence for correction of dyslipidemia by […]
  • Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases.
    Prospective observational studies support the use of long-chain omega-3 polyunsaturated fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; however, randomised controlled trials, have often reported neutral findings. There is a long history of debate about the potential harmful effects of a high intake of omega-6 PUFAs, although this idea is not supported […]
  • Pharmacodynamic activity of the novel neurokinin-3 receptor antagonist SJX-653 in healthy men.
    SJX-653 is a novel neurokinin 3 receptor (NK3R) antagonist. The NK3 pathway is a central regulator of GnRH secretion and has also been implicated in the generation of hot flashes. Therefore decreases of LH and testosterone in men serve as sensitive pharmacodynamic (PD) markers of central NK3 antagonism.To characterize the safety, tolerability, pharmacokinetics, and pharmacodynamic […]
  • Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity.
    Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta cell glucose sensitivity.To understand the genetic determinants of pancreatic beta-cell glucose sensitivity using genome-wide […]
  • Effects of thyroid function on phosphodiester concentrations in skeletal muscle and liver: An in vivo NMRS study.
    Thyroid function is clinically evaluated by determination of circulating concentrations of TSH and fT4. However, a tissue-specific effector substrate of thyroid function is lacking. Energy-rich phosphorus-containing metabolites (PM) and phospholipids (PL) might be affected by thyroid hormone action and can be non-invasively measured by 31P nuclear magnetic resonance spectroscopy (NMRS).Measuring the actions of peripheral thyroid […]
  • Surgical and pharmacological outcomes in acromegaly: Real-life data from the Mexican Acromegaly Registry.
    Acromegaly registries constitute a valuable source of therapeutic outcome information in real-life.To analyze surgical and pharmacological outcomes in the Mexican Acromegaly Registry (MAR).Data was extracted from the MAR informatic platform. Surgical remission was defined by a postoperative post-glucose GH < 1 ng/mL and an IGF-1 < 1.2 x ULN. Pharmacological remission was defined by a basal […]
  • Inferior adrenal artery PI in fetuses with IUGR: value indicating early blood redistribution and steroidogenic response.
    To characterize the inferior adrenal artery (IAA) pulsatility index (PI) in intrauterine growth-restricted (IUGR) fetuses without brain sparing.Twenty-three IUGR fetuses with a normal Doppler cerebroplacental ratio (CPR) and 23 normal controls were included in this prospective cross-sectional study. The PI of the IAA was recorded using routine transabdominal Doppler ultrasound. The differences in Doppler characteristics, […]
  • Predictors of chronic LH-testosterone axis suppression in male macroprolactinomas with normoprolactinemia on cabergoline.
    Data regarding prevalence, predictors, and mechanisms of persistent hypogonadotropic hypogonadism (HH) in males with a macroprolactinoma who achieve normoprolactinemia on dopamine-agonist therapy is limited. None of the previous studies provide cut-offs to predict the achievement of eugonadism.To evaluate the prevalence of persistent HH and its determinants in males with a macroprolactinoma who achieve normoprolactinemia on […]
  • Association of the obesity paradox with objective physical activity in patients at high risk of sudden cardiac death.
    To investigate the obesity paradox and its interrelationship with objective physical activity (PA) in patients at high risk of sudden cardiac death (SCD).782 patients with implantable cardioverter-defibrillators (ICDs)/cardiac resynchronization therapy defibrillators (CRTDs) in the SUMMIT registry were retrospectively analysed and grouped by body mass index (BMI) (kg/m2): normal weight (18.5≤BMI<25) and overweight or Class I […]
  • Maternal obesity influences placental nutrient transport, inflammatory status and morphology in human term placenta.
    Maternal obesity has a significant impact on placental development. However, this impact on placenta’s structure and function (i.e. nutrient transport, and hormone and cytokine production) is a controversial subject.We hypothesized that maternal obesity is associated with morphologic, secretory and nutrient-related changes and elevated levels of inflammation in the placenta.We collected samples of placental tissue from […]
  • Inhibition of BRAF Sensitizes Thyroid Carcinoma to Immunotherapy by Enhancing TsMHC-II-mediated Immune Recognition.
    Multiple mechanisms play roles in restricting the ability of T-cells to recognize and eliminate tumor cells.To identify immune escape mechanisms involved in papillary thyroid carcinoma (PTC) to optimize immunotherapy.iTRAQ analysis was conducted to identify proteins differentially expressed in PTC samples with or without BRAFV600E mutation. Molecular mechanisms regulating tumor cell evasion were investigated by in […]
  • Genome-wide association for HbA1c in Malay identified deletion on SLC4A1 that influences HbA1c independent of glycemia.
    HbA1c level is used to screen and diagnose diabetes. Genetic determinants of HbA1c can vary across populations and many of the genetic variants influencing HbA1c level were specific to populations.To discover genetic variants associated with HbA1c level in non-diabetic Malay individuals.We conducted a genome-wide association analysis for HbA1c using two Malay studies, the Singapore Malay […]
  • The oncocytic variant of poorly differentiated thyroid carcinoma shows a specific immune-related gene expression profile.
    Poorly differentiated thyroid cancer (PDTC) is a rare, follicular cell-derived neoplasm with unfavorable prognosis. The oncocytic variant of PDTC may be associated with even more adverse outcome than classical PDTC cases, but its specific molecular features are largely unknown. Our aim was to explore the immune-related gene expression profile of oncocytic and classical PDTC, in […]
  • Hip structural analysis reveals impaired hip geometry in girls with type 1 diabetes.
    Among patients with type 1 diabetes (T1D), the risk of hip fracture is up to six-fold greater than that of the general population. However, the cause of this skeletal fragility remains poorly understood.To assess differences in hip geometry and imaging-based estimates of bone strength between youth with and without T1D using dual-energy x-ray absorptiometry (DXA)-based […]
  • Predictors of the Response to Dopaminergic Therapy in Patients with Prolactinoma.
    Withdrawal of dopamine agonist (DA) therapy in patients with prolactinoma who are controlled by a small dose of medication is recommended by several guidelines. So far, the likelihood of reaching withdrawal conditions based on baseline characteristics remains uncertain.We retrospectively examined early clinical, radiological, or biochemical features that may predict the likelihood of reaching withdrawal conditions […]
  • The 15-epilipoxin-A4 pathway (ATL) with prophylactic aspirin in preventing preeclampsia: a longitudinal-cohort study.
    The benefit of aspirin in preventing preeclampsia is increasingly recognised, however, its mechanism of action remains unclear. Non-obstetric studies have described an anti-inflammatory effect of aspirin through 15-epilipoxin-A4(ATL). However, the anti-inflammatory mechanism of aspirin in the prevention of preeclampsia remains unknown.To examine the (1) difference in longitudinal endogenous lipoxin-A4(En-Lipoxin-A4) concentration in low-risk(LR) and high-risk(HR) pregnancies, […]
  • Intensity modulated radiotherapy (IMRT) for pituitary somatotroph adenomas.
    To summarize our experience in the treatment of pituitary somatotroph adenomas by fractionated intensity modulated radiotherapy (IMRT), describe the treatment outcomes and determine predictors.Patients with pituitary somatotroph adenoma treated by IMRT in our institution from Aug 2009 to Jan 2019 were reviewed. A total of 113 patients (37 were male) were included in this study. […]
  • Approach to the Treatment of a Patient with an Aggressive Pituitary Tumor.
    A small subset of pituitary adenomas grow despite maximal treatment with standard therapies; namely, surgery and radiotherapy. These aggressive tumors demonstrate two patterns of growth: they may be locally aggressive or metastasize distantly, either hematogenously or through the spinal fluid. Further surgery and radiotherapy may be helpful for palliation of symptoms, but they are rarely […]
  • Loneliness and type 2 diabetes incidence: findings from the English Longitudinal Study of Ageing.
    Loneliness is associated with all-cause mortality and coronary heart disease. However, the prospective relationship between loneliness and type 2 diabetes onset is unclear.We conducted a longitudinal observational population study with data on 4112 diabetes-free participants (mean age 65.02 ± 9.05) from the English Longitudinal Study of Ageing. Loneliness was assessed in 2004-2005 using the revised University of […]
  • A human randomized controlled trial comparing metabolic responses to single and repeated hypoglycemia in type 1 diabetes.
    Hypoglycemia hinders optimal glycemic management in type 1 diabetes (T1D). Long diabetes duration and hypoglycemia impair hormonal counterregulatory responses to hypoglycemia. Our study was designed to test whether i) the metabolic responses and insulin sensitivity are impaired, and ii) affected by short-lived antecedent hypoglycemia in participants with T1D.In a randomized, crossover, 2×2-factorial design, nine male […]
  • The renal extraction and the natriuretic action of GLP-1 in humans depend on interaction with the GLP-1 receptor.
    The natriuretic effect of GLP-1 in humans is independent of changes in renal plasma flow (RPF) and glomerular filtration rate (GFR) but may involve suppression of angiotensin II (ANG II) and a significant (~45%) renal extraction of GLP-1. The current study was designed to investigate the consequences for the renal extraction and the natriuretic effect […]
  • A human randomized controlled trial comparing metabolic responses to single and repeated hypoglycemia in type 1 diabetes.
    Hypoglycemia hinders optimal glycemic management in type 1 diabetes (T1D). Long diabetes duration and hypoglycemia impair hormonal counterregulatory responses to hypoglycemia. Our study was designed to test whether i) the metabolic responses and insulin sensitivity are impaired, and ii) affected by short-lived antecedent hypoglycemia in participants with T1D.In a randomized, crossover, 2×2-factorial design, nine male […]
  • The renal extraction and the natriuretic action of GLP-1 in humans depend on interaction with the GLP-1 receptor.
    The natriuretic effect of GLP-1 in humans is independent of changes in renal plasma flow (RPF) and glomerular filtration rate (GFR) but may involve suppression of angiotensin II (ANG II) and a significant (~45%) renal extraction of GLP-1. The current study was designed to investigate the consequences for the renal extraction and the natriuretic effect […]
  • Associations of BMI and Serum Urate with Developing Dementia: A Prospective Cohort Study.
    Recent studies suggested that higher BMI and serum urate levels were associated with lower risk of developing dementia. However, these reverse relationships remain controversial, and whether serum urate and BMI confound each other is not well established.To investigate the independent associations of BMI and urate, as well as their interaction with the risk of developing […]
  • Plasma Epinephrine Contributes to the Development of Experimental Hypoglycemia-Associated Autonomic Failure.
    Recurrent hypoglycemia blunts counter-regulatory responses to subsequent hypoglycemic episodes, a syndrome known as hypoglycemia-associated autonomic failure (HAAF). Since adrenergic receptor blockade has been reported to prevent HAAF, we investigated whether the hypoglycemia-associated rise in plasma epinephrine contributes to pathophysiology and reported interindividual differences in susceptibility to HAAF.To assess the role of hypoglycemia-associated epinephrine responses in […]
  • Association of Vitamin D Pathway Gene CYP27B1 and CYP2R1 Polymorphisms with Autoimmune Endocrine Disorders: A Meta-Analysis.
    Studies on organ-specific autoimmune endocrine disorders showed correlations between disease risks and vitamin D pathways gene variants, such as CYP27B1 rs10877012 and rs4646536, or CYP2R1 rs10741657 single nucleotide polymorphisms. However, previous works presented inconsistent conclusions. Our study aimed at assessing the association of CYP27B1 and CYP2R1 polymorphisms with autoimmune endocrine disorder susceptibility using the meta-analysis […]
  • Bone development in transgender adolescents treated with GnRH analogues and subsequently gender affirming hormones.
    Hormonal interventions in adolescents with gender dysphoria may have adverse effects such as reduced bone mineral accrual.To describe bone mass development in adolescents with gender dysphoria treated with gonadotropin-releasing hormone analogues (GnRHa), subsequently combined with gender affirming hormones.Observational prospective study..51 transgirls and 70 transboys receiving GnRHa and 36 transgirls and 42 transboys receiving GnRHa and […]
  • The Measurement of Insulin Clearance.
    Insulin clearance has recently been highlighted as a fundamental aspect of glucose metabolism, as it has been hypothesized that its impairment could be related to an increased risk of developing type 2 diabetes. This review focuses on methods used to calculate insulin clearance: from the early surrogate indices employing C-peptide:insulin molar ratio, to direct measurement […]
  • Evaluating the low-dose ACTH stimulation test (LDST) in neonates: Ideal times for cortisol measurement.
    Low-dose adrenocorticotropic hormone stimulation testing (LDST) can be used to diagnose central adrenal insufficiency. However, uncertainty remains over optimal times to draw serum cortisol levels.To determine optimal times to draw serum cortisol levels for the LDST in neonates.A retrospective chart review of LDSTs performed on neonates between January 1, 2009-September 30, 2017.CHEO, a tertiary-care outborn […]
  • ARMC5 alterations in patients with sporadic neuroendocrine tumors and multiple endocrine neoplasia type 1 (MEN1).
    Adrenal lesions are frequent among patients with sporadic neuroendocrine tumors (spNETs) or multiple endocrine neoplasia type 1 (MEN1). ARMC5-inactivating variants cause adrenal tumors and possibly other neoplasms.To investigate a large cohort spNETs or MEN1 patients for changes in the ARMC5 gene.111 patients, 94 with spNET and 17 with MEN1 were screened for ARMC5 germline alterations. […]
  • Exercise training reduces inflammation of adipose tissue in the elderly: cross-sectional and randomized interventional trial.
    Metabolic disturbances and a pro-inflammatory state associated with aging and obesity may be mitigated by physical activity or nutrition interventions.The aim of this study is to assess whether physical fitness/exercise training (ET) alleviates inflammation in adipose tissue (AT), particularly in combination with omega-3 supplementation, and whether changes in AT induced by ET can contribute to […]
  • ICPis -induced autoimmune polyendocrine syndrome type 2: a review of the literature and a protocol for optimal management.
    Immune checkpoint inhibitors (ICPis) targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1) and its ligand (PD-L1) are now approved to treat a variety of cancers. However, ICPis therapy is associated with a risk of immune-related adverse events (irAEs). Autoimmune polyendocrine syndrome type 2 (APS-2) is a rare endocrine irAE.Several databases (PubMed, […]
  • Early Diagnosed Gestational Diabetes Mellitus Is Associated with Adverse Pregnancy Outcomes: A Prospective Cohort Study.
    The significance of an early diagnosis of gestational diabetes mellitus(GDM) with oral glucose tolerance test (OGTT) has not been determined.To investigate GDM diagnosed by early and standard OGTTs and determine adverse maternal and neonatal outcomes associated with early GDM diagnosis.The Early Diagnosis of Gestational Diabetes Mellitus study is a prospective cohort study. Each participant in […]
  • Nomogram-Based Preoperative Score for Predicting Clinical Outcome in Unilateral Primary Aldosteronism.
    More than half of patients diagnosed with unilateral primary aldosteronism (UPA) suffer from persisting hypertension after unilateral adrenalectomy.To develop and validate a nomogram-based preoperative score (NBPS) to predict clinical outcomes after unilateral adrenalectomy for UPA.The NBPS was developed in an Asian cohort by incorporating predictors independently associated with remission of hypertension after unilateral adrenalectomy for […]
  • Letter to the Editor from Run Yu: “Approach to the Patient: Perioperative Management of the Patient with Pheochromocytoma or Sympathetic Paraganglioma”.
    I have read with great interest the Approach to the Patient article by Berends et al on perioperative management of pheochromocytoma. An otherwise excellent review on this complex topic, the article by Berends et al did not sufficiently address, and might have even perpetuated, two long-held misconceptions on perioperative management of pheochromocytoma. The first misconception […]
  • Are the Different Diabetes Subgroups Correlated With All-Cause, Cancer-related, and Cardiovascular-related Mortality?
    Numerous studies have shown that cardiovascular disease (CVD) represents the most important cause of mortality among people with diabetes mellitus (DM). However, no studies have evaluated the risk of CVD-related mortality among different DM subgroups.We aimed to examine all-cause, CVD-related, and cancer-related mortality for different DM subgroups.We included participants (age ≥ 20 years) from the […]
  • Clinical characteristics and long-term follow-up of patients with diabetes due to PTF1A enhancer mutations.
    Biallelic mutations in the PTF1A enhancer are the commonest cause of isolated pancreatic agenesis. These patients do not have severe neurological features associated with loss-of-function PTF1A mutations. Their clinical phenotype and disease progression have not been well characterised.To evaluate phenotype and genotype characteristics and long-term follow-up of patients with PTF1A enhancer mutations.Twelve tertiary paediatric endocrine […]
  • Optimizing DXA to Assess Skeletal Health: Key Concepts for Clinicians.
    The diagnosis of osteoporosis and assessment of fracture risk prior to a sentinel fracture was transformed by the widespread clinical use of dual-energy x-ray absorptiometry (DXA) for the assessment of bone mineral density (BMD).This review is based on a collection of primary and review literature gathered from a PubMed search of “dual energy X-ray absorptiometry”, […]
  • Follistatin-like 1 as a novel adipo-myokine related to insulin resistance and physical activity.
    FSTL-1 is considered to be an adipokine or myokine that could be a potential regulator of metabolism. Our purpose is to investigate the relationship between circulating FSTL-1 levels and insulin resistance (IR) in type 2 diabetes mellitus (T2DM) and to identify the regulatory factors.FSTL-1 expression in C57BL/6J and db/db mice was examined by qRT-PCR and […]
  • Organisation of the human pancreas in health and in diabetes.
    For much of the last century, our knowledge regarding the pancreas in type 1 and type 2 diabetes was largely derived from autopsy studies of individuals with these disorders or investigations utilising rodent models of either disease. While many important insights emanated from these efforts, the mode for investigation has increasingly seen change due to […]
  • Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity.
    All forms of diabetes mellitus involve the loss or dysfunction of pancreatic beta cells, with the former predominating in type 1 diabetes and the latter in type 2 diabetes. Deeper understanding of the coupling mechanisms that link glucose metabolism in these cells to the control of insulin secretion is therefore likely to be essential to […]
  • The clinical consequences of heterogeneity within and between different diabetes types.
    Advances in molecular methods and the ability to share large population-based datasets are uncovering heterogeneity within diabetes types, and some commonalities between types. Within type 1 diabetes, endotypes have been discovered based on demographic (e.g. age at diagnosis, race/ethnicity), genetic, immunological, histopathological, metabolic and/or clinical course characteristics, with implications for disease prediction, prevention, diagnosis and […]
  • Are the Different Diabetes Subgroups Correlated With All-Cause, Cancer-related, and Cardiovascular-related Mortality?
    Numerous studies have shown that cardiovascular disease (CVD) represents the most important cause of mortality among people with diabetes mellitus (DM). However, no studies have evaluated the risk of CVD-related mortality among different DM subgroups.We aimed to examine all-cause, CVD-related, and cancer-related mortality for different DM subgroups.We included participants (age ≥ 20 years) from the […]
  • Clinical characteristics and long-term follow-up of patients with diabetes due to PTF1A enhancer mutations.
    Biallelic mutations in the PTF1A enhancer are the commonest cause of isolated pancreatic agenesis. These patients do not have severe neurological features associated with loss-of-function PTF1A mutations. Their clinical phenotype and disease progression have not been well characterised.To evaluate phenotype and genotype characteristics and long-term follow-up of patients with PTF1A enhancer mutations.Twelve tertiary paediatric endocrine […]
  • Optimizing DXA to Assess Skeletal Health: Key Concepts for Clinicians.
    The diagnosis of osteoporosis and assessment of fracture risk prior to a sentinel fracture was transformed by the widespread clinical use of dual-energy x-ray absorptiometry (DXA) for the assessment of bone mineral density (BMD).This review is based on a collection of primary and review literature gathered from a PubMed search of “dual energy X-ray absorptiometry”, […]
  • Follistatin-like 1 as a novel adipo-myokine related to insulin resistance and physical activity.
    FSTL-1 is considered to be an adipokine or myokine that could be a potential regulator of metabolism. Our purpose is to investigate the relationship between circulating FSTL-1 levels and insulin resistance (IR) in type 2 diabetes mellitus (T2DM) and to identify the regulatory factors.FSTL-1 expression in C57BL/6J and db/db mice was examined by qRT-PCR and […]
  • Organisation of the human pancreas in health and in diabetes.
    For much of the last century, our knowledge regarding the pancreas in type 1 and type 2 diabetes was largely derived from autopsy studies of individuals with these disorders or investigations utilising rodent models of either disease. While many important insights emanated from these efforts, the mode for investigation has increasingly seen change due to […]
  • Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity.
    All forms of diabetes mellitus involve the loss or dysfunction of pancreatic beta cells, with the former predominating in type 1 diabetes and the latter in type 2 diabetes. Deeper understanding of the coupling mechanisms that link glucose metabolism in these cells to the control of insulin secretion is therefore likely to be essential to […]
  • The clinical consequences of heterogeneity within and between different diabetes types.
    Advances in molecular methods and the ability to share large population-based datasets are uncovering heterogeneity within diabetes types, and some commonalities between types. Within type 1 diabetes, endotypes have been discovered based on demographic (e.g. age at diagnosis, race/ethnicity), genetic, immunological, histopathological, metabolic and/or clinical course characteristics, with implications for disease prediction, prevention, diagnosis and […]
  • Cross-sectional and Prospective Associations of Rest-Activity Rhythms With Metabolic Markers and Type 2 Diabetes in Older Men.
    Disruption of rest-activity rhythms is cross-sectionally associated with metabolic disorders, including type 2 diabetes, yet it remains unclear whether it predicts impaired glucose metabolism and homeostasis. The aim of this study is to examine the cross-sectional and prospective associations between rest-activity rhythm characteristics and glycemic measures in a cohort of older men.Baseline rest-activity rhythms were […]
  • Gut microbiota profile and selected plasma metabolites in type 1 diabetes without and with stratification by albuminuria.
    Abnormal gut microbiota and blood metabolome profiles have been reported both in children and adults with uncomplicated type 1 diabetes as well as in adults with type 1 diabetes and advanced stages of diabetic nephropathy. In this study we aimed to investigate the gut microbiota and a panel of targeted plasma metabolites in individuals with […]
  • A Prospective Study Of Children 0-7 Years With Cah And Adrenal Insufficiency Treated With Hydrocortisone Granules.
    Children with congenital adrenal hyperplasia (CAH) and adrenal insufficiency (AI) require daily hydrocortisone replacement with accurate dosing.Prospective study of efficacy and safety of hydrocortisone granules in children with AI and CAH monitored by 17-OHP saliva profiles.17 children with CAH (9 male) and 1 with hypopituitarism (male) aged from birth to 6 years, had their hydrocortisone […]
  • The Close Link of Pancreatic Iron With Glucose Metabolism and With Cardiac Complications in Thalassemia Major: A Large Multicenter, Observational Study.
    We systematically explored the link of pancreatic iron with glucose metabolism and with cardiac complications in a cohort of 1,079 patients with thalassemia major (TM) enrolled in the Extension-Myocardial Iron Overload in Thalassemia (E-MIOT) project.MRI was used to quantify iron overload (T2* technique) and cardiac function (cine images) and to detect macroscopic myocardial fibrosis (late […]
  • Biomarkers of inflammation and glomerular filtration rate in individuals with recent-onset type 1 and type 2 diabetes.
    While inflammation has been associated with kidney function in long-standing diabetes, its possible association in newly-diagnosed diabetes is unknown.To investigate cross-sectional and prospective associations between biomarkers of inflammation and kidney function in recent-onset diabetes.The study included individuals with type 1 and type 2 diabetes with known diabetes duration of &1 year from the German Diabetes […]
  • Association between body size phenotypes and subclinical atherosclerosis.
    The underlying relationship between body mass index (BMI), cardiometabolic disorders and subclinical atherosclerosis (SA) is poorly understood.To evaluate the association between body size phenotypes and SA.Cross-sectional.Cardiovascular disease-free cohort.Middle-aged asymptomatic subjects (n=3,909). Six cardiometabolic body size phenotypes were defined based on the presence of at least one cardiometabolic abnormality (blood pressure, fasting blood glucose, triglycerides, low […]
  • Fluid Restriction Therapy for Chronic Siad; Results of a Prospective Randomised Controlled Trial.
    Fluid restriction (FR) is the recommended first-line treatment for syndrome of inappropriate antidiuresis (SIAD), despite the lack of prospective data to support its efficacy.A prospective non-blinded randomised controlled trial of FR versus no treatment in chronic SIAD.46 patients with chronic asymptomatic SIAD were randomised to either FR (1 liter/day) or no specific hyponatremia treatment (NoTx) […]
  • Persisting muscle dysfunction in Cushing’s syndrome despite biochemical remission.
    Glucocorticoid-induced myopathy is a characteristic symptom of endogenous Cushing’s syndrome. Its long-term outcome is largely unknown.To evaluate long-term muscle function following remission of endogenous Cushing’s syndrome.Observational longitudinal cohort study.Tertiary care hospitals and specialized outpatient clinic.As part of the prospective multicenter German Cushing’s Registry we assessed muscle strength in patients with overt endogenous Cushing’s syndrome. We […]
  • Dynamics of Islet Autoantibodies During Prospective Follow-Up from Birth up to 15 Years of Age.
    We set out to characterize the dynamics of islet autoantibodies over the first 15 years of life in children carrying genetic susceptibility to type 1 diabetes (T1D). We assessed also systematically the role of zinc transporter 8 autoantibodies (ZnT8A) in this context.HLA-predisposed children (N=1006, 53.0% boys) recruited from the general population in 1994-1997 were observed […]
  • Maintenance of Acromegaly Control in Patients Switching From Injectable Somatostatin Receptor Ligands to Oral Octreotide.
    The phase 3 CHIASMA OPTIMAL trial (NCT03252353) evaluated efficacy and safety of oral octreotide capsules (OOCs) in patients with acromegaly who previously demonstrated biochemical control while receiving injectable somatostatin receptor ligands (SRLs).In this double-blind study, patients (N = 56) stratified by prior SRL dose were randomly assigned 1:1 to OOC or placebo for 36 weeks. […]